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All Journal Indonesian Journal of Applied Sciences Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Althea Medical Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Journal of Mathematical and Fundamental Sciences Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Farmasi Klinik Indonesia Indonesian Journal of Tropical and Infectious Disease Padjadjaran Journal of Dentistry Journal Of Vocational Health Studies Jurnal Kesehatan Prima Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Majalah Kedokteran Andalas Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Integrasi Kesehatan dan Sains Jurnal Ilmiah JKA (Jurnal Kesehatan Aeromedika) Jurnal Ilmu Kebidanan dan Kesehatan Media Dermato-Venereologica Indonesiana

Oki Suwarsa

Departemen Ilmu Kesehatan Kulit Dan Kelamin Universitas Padjadjaran/ RS. Dr. Hasan Sadikin Bandung

Author-ID : 397799

Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary

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HUBUNGAN ANTARA KECEMASAN IBU HAMIL DAN PENGETAHUAN TENTANG VIRUS CORONA DENGAN PEMERIKSAAN RUTIN KEHAMILAN DI BIDAN PRAKTIK MANDIRI BANDAR LAMPUNG Tiara Rica Dayani; Oki Suwarsa; Uni Gamayani
Jurnal Ilmu Kebidanan dan Kesehatan (Journal of Midwifery Science and Health) Vol. 13 No. 1 (2022): Jurnal Ilmu Kebidanan dan Kesehatan (Journal of Midwifery Science and Health)
Publisher : Sekolah Tinggi Ilmu Kesehatan Bakti Utama Pati

Wabah COVID-19 menyebabkan krisis global diseluruh Negara. Pandemi ini dengan cepat menyebaroleh sekelompok agen infeksius melalui beberapa metode interaksi dan mengancam kondisi kesehatan.Hal ini membawa dampak terganggunya pelayanan kesehatan maternal dan pemeriksaan rutin kehamilan(ANC) di masa pandemi COVID-19. Angka kematian ibu di Indonesia juga masih cukup tinggi. Salahsatu penyebab kematian ibu adalah komplikasi kehamilan yaitu sebesar 15%. Kesiapan pelayananberkualitas dalam masa pandemi termasuk pemeriksan rutin kehamilan diperlukan untuk mendeteksikomplikasi pada ibu hamil. Tujuan penelitian ini untuk mengetahui hubungan antara kecemasan ibuhamil dan pengetahuan virus corona dengan pemeriksaan rutin kehamilan. Penelitian ini menggunakanmetode studi case control yang merupakan penelitian epidemiologis analitik observasional yang bersifatretrospektif. Pengambilan sampel dengan teknik simple random sampling dengan jumlah sampel 62orang terdiri dari 31 kasus dan 31 kontrol. Analisis data yang digunakan yaitu analisis univariat danbivariat dengan uji chi square. Hasil uji statistik chi square menunjukkan bahwa terdapat hubungan antarakecemasan ibu hamil dengan pemeriksaan rutin kehamilan dengan nilai p=0,000 dan terdapat hubunganyang bermakna antara pengetahuan tentang virus corona dengan pemeriksaan rutin kehamilan dengannilai p=0,000. Kondisi pandemi covid-19 dapat menggangu pemantauan kesehatan ibu dalampemeriksaan rutin kehamilan sehingga perlu dilakukan penyuluhan dari petugas kesehatan.

Relationship between Knowledge, Attitude and Practice of Student’s Personal Hygiene with Scabies Incidence in Pesantren Darul Fatwa, Jatinangor, West Java, Indonesia Karinna Dwi Purnama; Dedi Rachmadi Sjambas; Oki Suwarsa
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Scabies is a parasitic infection caused by Sarcoptesscabiei Hominis varian and Acarina order. Sarcoptes scabiei infects both male and female in any age groups, ethnics, and socio-economic levels. Transmission of scabies can pass through by a direct contact from skin-to-skin or indirect contact through sharing bed, clothes, and towels. Pesantren as an educational institution supplies facilities that are shared thus making students susceptible to scabies infection. This study was conducted to discoverrelationshipbetween knowledge, attitude, and practice of student’s personal hygiene with scabies incidence.Methods: An analytic observational study was conducted from October to November 2015 in Pesantren Darul Fatwa, Jatinangor. Study was conducted with cross-sectional design and total sampling for the sample size. Total of 37 students whoparticipated in this study were 22 malesand 15 females. This study was begun with a stand alone-questionnaire, fill out on knowledge, attitude, and practice of personal hygiene that was supervised by researcher, and physical examination for scabies diagnosis that was performed by doctors.Results: Based on history taking and physical examination, 15 out of 37 students were diagnosed with scabies positive. All of them were males, dominated by 13 year old students, 1st and 2nd Junior High School students. Statistical analysis with chi-square test showed that there were no relationship between knowledge, attitude and practice of student’s personal hygiene with scabies incidence.Conclusions: There is no relationship between knowledge, attitude and practice of student’s personal hygiene with scabies incidence in Pesantren

Quality of Life in Children with Atopic Dermatitis Muhammad Akbar Wicaksana; Oki Suwarsa; Fenny Dwiyatnaningrum
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Atopic dermatitis (AD) is the most common chronic skin disease in children which caused significant morbidity and impaired quality of life (QoL). The main goal of AD therapy is to prevent flare -ups, prolong remission and increase QoL. Therefore, the study aimed to discover QoL in children with AD.Methods: The study was conducted at Pasundan Public Health Centre, Al Islam General Hospital and Kimia Farma Private Dermatology Clinic, from September to November 2015. This descriptive study used consecutive sampling with 24 outpatients who were admitted to the health facility and diagnosed as AD. A questionnaire on Infant Dermatitis Quality of Life for infants aged 0–4 years, and Children Dermatology Life Quality Index for children aged 5–16 years was used in this study to measure QoL.Results: Out of 24 patients, 9 patients aged 0–4 years had mean score of 4.44±4.36, and 15 patients aged 5–16 years had mean score of 5.80±3.95. Mean SCORAD Objective in patients aged 0–4 and 5–16 was 15.61±7.75 and 17.44±11.Conclusions: The QoL in children with AD vary among patients. Most of the patients have mild-moderate impairment in QoL.

Clinical Profile of Adverse Cutaneous Drug Reactions in Patients with Human Immunodeficiency Virus Puteri Nabilah Maharani; Oki Suwarsa; Susantina Prodjosoewojo
Althea Medical Journal Vol 7, No 4 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n4.1955

Background: Adverse cutaneous drug reactions (ACDRs) are common problems in patients during the treatment of various diseases. The clinical feature varies from mild manifestation such as morbilliform, urticaria, and contact dermatitis, to severe manifestation such as Stevens - Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Patients infected with the human immunodeficiency virus (HIV) have an increased risk of developing ACDRs due to immune system disruption. This study aimed to describe the clinical features of ACDRs in HIV patients and the drugs that cause ACDRs.Method: This study was a retrospective study using secondary data from medical records of HIV patients with ACDRs who visited Teratai Clinic of Dr. Hasan Sadikin General Hospital Bandung from 2014 to 2018. Total sampling was applied and results were presented in percentage.Results: There were 94 HIV patients with ACDRs out of 557 HIV patients. Adverse cutaneous drug reactions are commonly found in males aged 20-39 years old. The clinical features found were morbilliform (85.6%), SJS (8.9%), urticaria (4.4%), and erythroderma (1.1%). The most common drugs causing ACDRs were Cotrimoxazole (30%), Efavirenz (28.9%), and Nevirapine (16.7%).Conclusion: The prevalence of ACDRs in HIV patients in this study is 16.9%. The most common clinical features are morbilli form and SJS with Cotrimoxazole, Efavirenz, and Nevirapine causing most of the ACDRs.

Aktivitas IL-18, IL-4, dan IFN- pada Kultur Limfosit yang Distimulus oleh Staphylococcal enterotoxin B (SEB) sebagai Petanda Eksaserbasi Tingkat Seluler pada Penderita Dermatitis Atopik Oki Suwarsa
Indonesian Journal of Applied Sciences Vol 1, No 3 (2011)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijas.v1i3.1887

Staphylococcus aureus (S.aureus) has an important role in the pathogenesis of atopic dermatitis (AD). These role of S. aureus are related to various proteins such as staphylococcal enterotoxin B (SEB), a potent toxin. Interleukin (IL) -18 is an important regulator for interferon (IFN)g ,a cytokine produced by Th-1, and IL-4 produced by Th-2. Further studies are still needed to discover the mechanism of SEB in AD, particularly IL-18 level, and its activities towards IL-4 and IFN-g secretions, in regards of therapeutic strategy. The aim of this study is to analyze the activities of IL-18, IL-4, and IFN-g in the lymphocyte culture from AD patients, stimulated with SEB and the association between increased IL-18 level with increased IL-4 and IFNg level. Twenty AD patients (7 male and 13 female) and twenty healthy subjects (9 male, and 11 female) were involved in this study. Study was done in Dr. Hasan Sadikin General Hospital, Bandung, proceeded by experimental invitro test on the lymphocyte culture stimulated with SEB at Laboratorium Penelitian dan Pengujian Terpadu Universitas Gadjah Mada. The study was performed from 4January until 31March 2010. Lymphocytes from the peripheral blood of the study group and control group were isolated and cultured, then 3 methods were performed towards the cultured lytmphocyte, i.e., no exposure, exposed to PHA, and exposed to SEB. After being incubated for 72 hour, then IL-18, IL-4, and IFN-g levels from the supernatant of the lymphocyte culture were evaluated with ELISA method.Mean IL-18 level in the lymphocyte culture of AD group, with no exposure, exposed to PHA, and exposed to SEB were 54,62 pg/ml, 70,09 pg/ml, and 99,38 pg/ml, respectively, whereas, in the control group were 33,36 pg/ml, 39,03 pg/ml, dan 54,19 pg/ml, respectively. Mean IL-4 level in the study group were 0,32 pg/ml, 1,19 pg/ml, dan 2,43 pg/ml, and in the control group were 0,32 pg/ml, 0,78 pg/ml, and 3,02 pg/ml, respectively. Mean IFN-g level in the AD group were 12,75 pg/ml, 351,59 pg/ml, and 1293,17 pg/ml, while in the control group were 19,76 pg/ml, 562,81 pg/ml, and 1419,28 pg/ml, respectively. IL-18, IL-4, and IFN-g level in the AD group increased after being stimulated with SEB, (p<0,05), whereas in the control group increase only occured to IL-4, and IFN-g (p<0,05). There were correlation between increased IL-18 level with increased IL-4 level (p<0,05), however the increased of IL-18 level were not related to increased IFN-g level (p>0,05). The increased IL-18 level contributed more to the increased of IL-4 level than IFN-g level (p<0,05).The result of this study, is only IL-18 level increased in any methods performed, compared to control group (p<0,05). This finding leads to the conclusion that IL-18 level is the marker of AD exacerbation in the cellular level of the AD lymphocyte culture stimulated with SEB.****Staphylococcus aureus (S.aureus) berperan penting pada patogenesis dermatitis atopik (DA). Peran tersebut berhubungan dengan dihasilkannya berbagai protein antara lain toksin poten oleh S. aureus, yaitu staphyloccoccal enterotoxin B (SEB). Interleukin-18 (IL-18) merupakan regulator penting dari produksi sitokin Th-1 yaitu Interferon-g (IFN-g) dan Th-2 yaitu IL-4. Penelitian untuk mengetahui mekanisme SEB pada DA, khususnya kadar IL-18, dan pengaruh aktivitas IL-18 terhadap sekresi IL-4 dan IFN-g, untuk strategi pengobatan perlu dilakukan. Tujuan penelitian ini adalah untuk menganalisis aktivitas IL-18, IL-4, dan IFN-g pada kultur limfosit yang distimulus oleh SEB pada penderita DA, serta pengaruh kenaikan kadar IL-18 terhadap kenaikan kadar IL-4 dan IFN-g.Penelitian ini dilakukan pada 20 orang penderita DA (7 laki-laki dan 13 wanita) dan 20 orang sehat (9 laki-laki, dan 11 wanita) di RSUP. Dr. Hasan Sadikin Bandung, merupakan penelitian eksperimental secara invitro pada kultur limfosit yang distimulus oleh SEB di Laboratorium Penelitian dan Pengujian Terpadu Universitas Gadjah Mada. Dilakukan isolasi limfosit dari darah perifer kelompok DA dan kontrol, dilanjutkan dengan kultur limfosit, kemudian dilakukan 3 perlakuan yaitu tanpa paparan, dipapar dengan phytohemagglutinin (PHA), dan dipapar dengan SEB. Setelah dieramkan selama 72 jam, kemudian diperiksa kadar IL-18, IL-4, dan IFN-g dari supernatan kultur limfosit dengan metode ELISA.Kadar IL-18 rata-rata pada kultur limfosit tanpa paparan, paparan PHA, dan paparan SEB kelompok DA berturut-turut adalah 54,62 pg/ml, 70,09 pg/ml, dan 99,38 pg/ml. Sedangkan pada kelompok kontrol berturut-turut adalah 33,36 pg/ml, 39,03 pg/ml, dan 54,19 pg/ml. Kadar IL-4 rata-rata kelompok DA berturut-turut adalah 0,32 pg/ml, 1,19 pg/ml, dan 2,43 pg/ml, dan pada kelompok kontrol berturut-turut adalah 0,32 pg/ml, 0,78 pg/ml, dan 3,02 pg/ml. Kadar IFN-g rata-rata kelompok DA berturut-turut adalah 12,75 pg/ml, 351,59 pg/ml, dan 1293,17 pg/ml, dan pada kelompok kontrol berturut-turut adalah 19,76 pg/ml, 562,81 pg/ml, dan 1419,28 pg/ml. Pada kelompok DA, kadar IL-18, IL-4, dan IFN-g setelah dipapar SEB, meningkat dibanding dengan sebelum dipapar (p<0,05), sedangkan pada kelompok kontrol hanya kadar IL-4, dan IFN-g yang meningkat (p<0,05). Kenaikan kadar IL-18 berpengaruh terhadap kenaikan kadar IL-4 (p<0,05), tetapi tidak berpengaruh terhadap kenaikan kadar IFN-g (p>0,05). Kenaikan kadar IL-18 lebih berpengaruh pada kenaikan kadar IL-4 dibandingkan dengan IFN-g (p<0,05).Pada penelitian ini hanya kadar IL-18 kelompok DA yang meningkat lebih tinggi pada semua perlakuan, dibandingkan dengan kelompok kontrol (p<0,05), sehingga dapat disimpulkan bahwa IL-18 merupakan petanda adanya eksaserbasi tingkat seluler pada kultur limfosit DA yang distimulus oleh SEB.

Pengaruh Krim Asam Traneksamat terhadap Pembentukan Keriput dan Kadar Matriks Metaloproteinase-1 pada Mencit (Mus Musculus) Jantan Galur Balb/c yang Dipajan Sinar Ultraviolet B Andrew Citrawan; Oki Suwarsa; Hendra Gunawan; Sudigdo Adi; Ronny Lesmana; Achadiyani Achadiyani; Sunaryati S. Adi
Indonesian Journal of Clinical Pharmacy Vol 8, No 2 (2019)
Publisher : Universitas Padjadjaran

Pemberian asam traneksamat (AT) per oral telah terbukti dapat mengurangi keriput yang diinduksi oleh kulit kering pada mencit. Namun, dosis oral yang setara terlalu besar untuk digunakan pada manusia dalam jangka panjang karena dapat menimbulkan toksisitas, sehingga perlu dicari sediaan alternatif lain secara topikal seperti sediaan krim. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian krim AT terhadap pembentukan keriput pada kulit mencit jantan galur Balb/c yang dipajan sinar ultraviolet B (UVB). Penelitian dilakukan terhadap 24 ekor mencit di Laboratorium Farmakologi dan Terapi serta Laboratorium Sentral Universitas Padjadjaran pada bulan Februari hingga Mei 2018. Mencit dibagi secara acak ke dalam empat kelompok, yaitu satu kelompok kontrol (P0) hanya mendapatkan pajanan sinar UVB tanpa krim AT dan tiga kelompok perlakuan (P1, P2, dan P3) mendapat pajanan sinar UVB dan diberikan krim AT dengan konsentrasi masing-masing 3%, 4%, dan 5%. Setelah 10 minggu, dilakukan penilaian kondisi keriput pada kulit punggung mencit berdasarkan metode Bisett, dilanjutkan dengan biopsi kulit punggung mencit untuk pemeriksaan kadar matriks metaloproteinase-1 (MMP-1) dengan teknik western blot (WB). Diperoleh perbedaan nilai rata-rata skor keriput yang bermakna sebesar 2,1±0,105 pada kelompok P0, 1,1±0,167 pada P1 dan P2, serta 1,3±0,211 pada P3 (p=0,005). Diperoleh pula nilai rata-rata kadar MMP-1 yang bermakna, yakni sebesar 0,75±0,08 pada kelompok P0, serta 0,54±0,033, 0,40±0,052, dan 0,54±0,072 pada P1, P2, dan P3 secara berturut-turut (p=0,008). Berdasarkan hasil tersebut, dapat disimpulkan bahwa pemberian krim AT mampu memperlambat pembentukan keriput dan menurunkan kadar MMP-1 pada kulit punggung mencit jantan galur Balb/c yang dipajan sinar UVB.Kata kunci: Keriput, krim asam traneksamat, matriks metaloproteinase-1, sinar ultraviolet B The Effect of Tranexamic Acid Cream on Wrinkle Formation and Matrix Metalloproteinase-1 Levels on Male Balb/c Mice Skin Exposed to Ultraviolet B RadiationsAbstractOral tranexamic acid (TXA) has been proven to ameliorate wrinkle induced by skin dryness in hairless mouse. However, the equal human oral dose is too high and can induce toxicity if used in long term, and study of topical preparations for wrinkle treatment is limited. Therefore, this study was conducted using topical preparations as an alternative for oral treatment to examine the effects of TXA cream in wrinkle formation. Four weeks old of twenty-four male Balb/c mice, divided into four groups, then 3%, 4% and 5% TXA cream were administered on the back skin of mice in each group shortly after ultraviolet B (UVB) exposure, except for control group that only exposed to UVB lights without given any TXA creams. Wrinkle formation and matrix metalloproteinase (MMP-1) level were observed after 10 weeks of treatments. There were significant differences of wrinkle score, with mean value were 2.1±0.105 for control group, 1.1±0.167 for 3% and 4% groups, and 1.3±0.211 for 5% group (p=0.005). There were also significant differences of MMP-1, with mean value were 0.75±0.08 for control group, 0.54±0.033, 0.40±0.052, and 0.54±0.072 for 3%, 4% and 5% group, respectively (p=0.008). Based on significant differences of wrinkle score and MMP-1 level, it can be concluded that administration of TXA cream may able to delay wrinkle formation and reduce the MMP-1 level on the mice skin exposed to ultraviolet B.Keywords: Matrix metalloproteinase-1, tranexamic acid, ultraviolet B, wrinkle

Serum Level of IL-6, Reactive Oxygen Species and Cortisol in Patients with Recurrent Aphthous Stomatitis related Imbalance Nutrition Intake and Atopy Nanan Nur'aeny; Dida Akhmad Gurnida; Oki Suwarsa; Irna Sufiawati
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 3 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.3.3

One of the most common oral ulcerations is recurrent aphthous stomatitis (RAS), affecting approximately 20% of the general population worldwide. The etiology of RAS is still unclear but it is considered to be multifactorial, including imbalanced nutrition intake and allergic conditions such as atopy. The purpose of this study was to investigate the differences and correlation between the serum level of IL-6, reactive oxygen species (ROS), and cortisol in RAS patients. Our study was cross-sectional and used a consecutive sampling method. There were significant differences of IL-6 and ROS levels in all groups (p = 0.000, p = 0.049 respectively) and a significant correlation between cortisol and ROS in the RAS group without atopy (r = -0.985, p = 0.015). Serum IL-6 and ROS measurement may be used for detecting RAS caused by malnutrition or atopy but not cortisol for patients without psychological stress detected. This is consistent with the results of a very strong correlation with a negative value between cortisol and ROS in RAS without atopy.

Terapi Cairan dan Elektrolit pada Keadaan Gawat Darurat Penyakit Kulit Oki Suwarsa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 30 No. 2 (2018): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Kulit berfungi untuk melindungi tubuh dari kehilangan cairan dan elektrolit berlebihan. Pada penyakit nekrolisis epidermal toksik, sindrom Stevens-Johnson, Staphylococcal scalded skin syndrome, dan pemfigus vulgaris terjadi kegawatdaruratan disebabkan oleh terbentuknya bula yang luas, sehingga cairan hilang berlebihan melalui kulit. Tujuan: Terapi cairan dan elektrolit intravena bertujuan mengganti kekurangan air, elektrolit, dan zat makanan yang diperlukan tubuh. Telaah Kepustakaan: Pemberian cairan dan elektrolit harus berdasarkan penyebab, kemudian menentukan jenis, jumlah, serta kecepatan pemberian. Penatalaksanaan meliputi evaluasi status hemodinamik, memeriksa kadar elektrolit, analisis gas darah, memasang tekanan vena sentral, dan kateter urine untuk menghitung kehilangan cairan sehingga dapat diberikan cairan dan elektrolit yang tepat. Terapi suportif pada kegawatdaruratan penyakit kulit sama dengan pasien luka bakar, yaitu menggunakan ‘rule of nine’ untuk bula >10% total area permukaan tubuh.Cairan yang dianjurkan adalah NaCl 0,9%, Ringer laktat, dan dextrosa 5%.Simpulan: Prognosis terapi cairan dan elektrolit pada keadaan gawat darurat penyakit kulit tergantung terapi yang adekuat, kelengkapan unit luka bakar, pemberian cairan yang tepat, dan nutrisi tambahan.

The Positive Skin Prick Test not Correlate with Disease Severity and Quality of Life in Atopic Dermatitis Patients Oki Suwarsa; Erfina Rohana Sormin; Endang Sutedja; Hartati Purbo Dharmaji
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic dermatitis (AD) is a skin disease which cause stress to the patients. The chronic process of AD can cause physical, social, and psychological impairments. The severity of AD can also be affected by allergen exposures, which in turn will affect the quality of life of the patient. Skin prick test (SPT) can be used to evaluate allergen sensitization. Purpose: To evaluate correlation between SPT positivity to severity and quality of life of AD patients. Methods: The study was an observational cross-sectional study. Twenty five AD patients were recruited based on inclusion and exclusion criteria. Questionnaire was used to measure the quality of life of patients, and Scoring of Atopic Dermatitis (SCORAD) to measure the disease severity. Most of participants were women (80%), with median of age 26.84±13.71. Results: Positive SPT was obtained in 68% of patients, most of them were caused by house dust mites (55.2%). Seventy six percent of patients experienced mild AD, 12% moderate AD, and also 12% patients experienced severe AD. Significant correlation was observed between the severity and quality of life (p=0.001;r=0.617), while the SPT positivity has no correlation with the severity (p=0.912;r=-0.023) and quality of life (p=0.959;r=0.011). Conclusion: This study revealed that the severity of the disease has a correlation with quality of life, but SPT positivity has no significant correlation with severity and quality of life.

The Effect of Systemic Methotrexate and Cyclosporine Combination Therapy inPsoriasis Vulgaris Patients in Bandung, Indonesia Oki Suwarsa; Fatima Aulia Khairani; Syawalika Ulya Isneny; Erda Avriyanti; Hartati Purbo Dharmadji; Miranti Pangastuti; Endang Sutedja; Hendra Gunawan
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 3 (2021): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.3.2021.200-204

Background: Methotrexate (MTX) and cyclosporine have been used as effective systemic mono-therapy for psoriasis. Several factors are considered to switch monotherapy to combination therapy because monotherapy is no longer effective and has higher side effects. Hence,clinicians have avoided systemic therapy combinations due to its toxicity. However, some studies showed that this combination therapy could be usedeffectively for psoriasis patients. Purpose: This study aimed to analyze the efficacy and adverse effects of systemic MTX and cyclosporine combination therapy in Indonesian psoriasis vulgaris patients. Methods: The retrospective study assessed the effectiveness of 3 monthsmono-therapyand combination therapy of systemic MTX and cyclosporine in psoriasisvulgaris patients from 2016–2017 in Dermatology Clinic, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia. Result: Psoriasis area and severity index (PASI) score 90 were achieved in the group MTX (50%) and cyclosporine group (50%), while none in the combination group.However, eight patients (50%) in group MTX and cyclosporine reached the primary endpoint of PASI 50. One patient in cyclosporine group had adverse effects on kidney profiles. Nonetheless, other patients had no biochemical changes. But, there was no significant difference in the change of PASI between each group (p=0.102). Conclusion: We propose that combination therapy of MTX and cyclosporine is relatively safe and efficacious in treating Indonesian psoriasis vulgaris patients. This combination treatment isas effective as MTX or cyclosporinemono-therapy.

Co-Authors - Sudigdoadi, - Achadiyani Achmad Yudha Pranata, Achmad Yudha Achmad, Fariz Andrew Citrawan Dany Hilmanto Dedi Rachmadi Sjambas Devi Nursjamsi, Nadilla Carissa Dian Indriyani Dida Akhmad Gurnida Dida Akhmad Gurnida Dimas Erlangga Effendi, Rendy Ariezal Endang Sutedja Endang Sutedja Endang Sutedja Endang Sutedja Endang Sutedja Erda Avriyanti Erfina Rohana Sormin Eva Sri Rahayu Farid Husin Fatima Aulia Khairani Fenny Dwiyatnaningrum Fenny Dwiyatnaningrum, Fenny Feriza, Vina Firman Fuad Wirakusumah Gaga Irawan Nugraha Hadi Susiarno Hadi Susiarno Hartati Purbo Dharmadji Hartati Purbo Dharmadji Hartati Purbo Dharmadji, Hartati Purbo Hartati Purbo Dharmaji Hartati Purbo Dharmaji, Hartati Purbo Hendra Gunawan Insi Farisa Desy Arya Intan Karlina Irna Sufiawati Jayawarsa, A.A. Ketut Karinna Dwi Purnama Keni Istasaputri M. Lasiyati Yuswo Yani Maryam Nissa Hazari Maulinda, Shinta Metha Solihati Rayuna Miranti Pangastuti Muhammad Akbar Wicaksana Nanan Nur'aeny Nizami Hamada Nur Atik Nur'aeny, Nanan Nurwinda Saputri Pangastuti, Miranti Pati Aji Achdiat Ponpon Idjradinata Pratiwi, Auria Ekanti Purnama, Karinna Dwi Puteri Nabilah Maharani Raden Mohamad Rendy Ariezal Effendi Raden Tina Dewi Judistiani Rasmia Rowawi Reiva Farah Dwiyana Reti Hindritiani Ronny Lesmana Ruchiatan, Kartika Saputri, Nurwinda Siti Nurjanah Sjambas, Dedi Rachmadi Sri Mulyati Sudigdo Adi Sudigdo Adi Sunarjati Sudigdoadi Sunaryati S. Adi Susantina Prodjosoewojo Susiarno, Hadi Syawalika Ulya Isneny Tenny Putri Tiara Rica Dayani Uni Gamayani Vita Murniati Tarawan Vita Murniati Tarawan Vita Murniati Tarawan Wicaksana, Muhammad Akbar Yogi Faldian Yuli Kurniawati Yuni Susanti Pratiwi

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