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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Kamaya: Jurnal Ilmu Agama Adi Husada Nursing Journal Bio-Inoved : Jurnal Biologi-Inovasi Pendidikan Jurnal Riset Kesehatan Nasional LOSARI: Jurnal Pengabdian Kepada Masyarakat MAHESA : Malahayati Health Student Journal Jurnal Pijar MIPA JRKN Jurnal Pengabdian West Science Jurnal Pengabdian Kepada Masyarakat Itekes Bali West Science Nature and Technology Jurnal Pengabdian Masyarakat Sundaram Berita Biologi
Ida Ayu Manik Damayanti
Institut Teknologi Dan Kesehatan Bali
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EFEKTIVITAS EKSTRAK BUAH ANGGUR BALI (Vitis vinifera L. Var. Alphonso Lavallee) TERHADAP HISTOLOGI SEL BETA PANKREAS Mus musculus L. DENGAN HIPERGLIKEMIA Zabrina, Putu Tiara; Puspitasari, Lia; Damayanti, Ida Ayu Manik
Berita Biologi Vol 23 No 3 (2024): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2024.5508

Abstract

Hiperglikemia dapat menyebabkan malfungsi sel beta pankreas yang memicu stress oksidatif. Bahan makanan yang berkaitan dengan suplai antioksidan mampu menjadi profilaksis yang efektif melawan stress oksidatif pada diabetes. Salah satu tanaman yang memiliki aktivitas antioksidan tinggi adalah Anggur Bali (Vitis vinifera L. Var. Alphonso Lavallee). Penelitian ini bertujuan untuk mengetahui aktivitas antidiabetes buah anggur Bali (V. vinifera Var. Alphonso Lavallee) dan histopatologi sel beta pankreas Mus musculus L. yang diinduksi aloksan. Penelitian ini dilakukan dengan metode true experimental study design laboratorium dengan rancangan post test only control grup design. Model hiperglikemia dilakukan dengan cara diinduksi aloksan, setelah mengalami peningkatan kadar gula darah diberikan perlakuan glibenklamid dan ekstrak buah anggur Bali selama 21 hari. Hasil penelitian menunjukkan bahwa ekstrak etanol 96% buah anggur Bali dengan dosis 200 mg/kgBB dan 400 mg/kgBB dapat meningkatkan jumlah sel beta pankreas (p<0,05) dan dosis 800 mg/kgBB tidak dapat meningkatkan jumlah sel beta pankreas (p>0,05). Ekstrak etanol 96% buah anggur Bali dapat meningkatkan jumlah sel beta pankreas.
POTENSI EKSTRAK KULIT ANGGUR BALI (Vitis vinifera L. Var. Alphonso Lavallee) TERHADAP BERAT BADAN: SKRINING FITOKIMIA DAN STUDI IN VIVO Damayanti, Ida Ayu Manik; Antari, Ni Wayan Sukma; Megayanti, Sri Dewi
Berita Biologi Vol 24 No 1 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.9564

Abstract

Sebanyak 51,7% penduduk Indonesia mengonsumsi makanan berlemak/berkolesterol/gorengan sebanyak 1-6 kali per minggu. Pada umumnya masyarakat mengonsumsi beberapa obat sintetik untuk mengatasi masalah berat badan dengan efek samping yang sangat mungkin terjadi. Dalam upaya mengatasi hal tersebut, penelitian mengenai potensi bahan alami sebagai agen penurun berat badan menjadi sangat relevan. Salah satu bahan alami yang menarik perhatian adalah kulit anggur Bali (Vitis vinifera L. Var. Alphonso Lavallee). Penelitian ini bertujuan untuk mengeksplorasi potensi ekstrak kulit anggur Bali dalam menurunkan berat badan melalui skrining fitokimia dan studi in vivo dengan memanfaatkan sumber daya lokal dalam pengembangan strategi penanganan penurunan berat badan yang efektif. Design penelitian yang digunakan adalah true experimental study dengan posttest only control group design. Kelompok yang digunakan yaitu kontrol negative, kontrol positif, P1 (100 mg/kgBB), P2 (250 mg/kgBB), dan P3 (500 mg/kgBB). Skrining fitokimia ekstrak kulit anggur Bali menunjukkan bahwa kulit anggur Bali mengandung senyawa flavonoid, fenol, alkaloid, tanin dan terpenoid. Penelitian ini menunjukkan bahwa ekstrak kulit anggur Bali (Vitis vinifera L. Var. Alphonso Lavallee) memiliki potensi signifikan dalam menurunkan berat badan mencit yang diberikan pakan tinggi lemak. Kelompok P3 menunjukkan total penurunan paling tinggi sebesar 2,4% dari hari ke-0 hingga hari ke-21dibandingkan P1 dan P2.  
Balinese Local Plants in Regulating Body Weight: A Review Damayanti, Ida Ayu Manik; Megayanti, Sri Dewi; Wulansari, Nadya Treesna
Jurnal Pijar Mipa Vol. 20 No. 8 (2025): Special Issue
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i8.10650

Abstract

Obesity and overweight have become major global health concerns. In Indonesia, one in five school-aged children is overweight or obese, with increasing rates observed in Bali. Dietary imbalance, sedentary lifestyles, and metabolic dysregulation contribute to abnormal body weight gain. In light of the limitations of synthetic drugs, plant-derived bioactive compounds have attracted attention as safer and multi-target alternatives for regulating body weight. This review aims to synthesise current scientific evidence on the potential of Balinese local plants in regulating body weight, identify their bioactive compounds and underlying mechanisms, and highlight research gaps to guide future nutraceutical development. This systematic review, conducted in accordance with the PRISMA 2020 guidelines, examined literature published between 2020 and 2025 retrieved from PubMed, ScienceDirect, and Google Scholar. The keywords Balinese plants, body weight, obesity, anti-obesity, plant extract, and bioactive compounds, eight studies met the inclusion criteria. The identified Balinese local plants, including Clitoria ternatea, Zingiber cassumunar, Phyllanthus acidus, Murraya paniculata, Hibiscus rosa-sinensis, Elaeocarpus grandiflorus, Tagetes erecta, and Lagerstroemia speciosa, demonstrated significant potential in regulating body weight. Their mechanisms included AMPK activation, inhibition of pancreatic lipase, suppression of adipogenesis, induction of thermogenesis, and modulation of antioxidants. Balinese local plants exhibit multi-pathway potential in regulating body weight through metabolic and physiological modulation.
Phytochemical screening of Balinese grape (Vitis vinifera L. var. Alphonso Lavallee) peel extract: Resources local plant-based lessons in biology Ida Ayu Manik Damayanti; Ni Wayan Sukma Antari
BIO-INOVED : Jurnal Biologi-Inovasi Pendidikan Vol 7, No 2 (2025): June 2025
Publisher : Master Program of Biology Education, Universitas Lambung Mangkurat, Banjarmasin, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/bino.v7i2.22239

Abstract

The utilization of local natural resources for contextual and practical-based learning is an innovative approach in biology education. This study aimed to conduct a phytochemical screening of Balinese grape (Vitis vinifera L. var. Alphonso Lavallee) peel extract and integrate the findings into plant-based biology lessons. A mixed-method approach with a one-group pretest–posttest design was applied. Phytochemical tests identified the presence of flavonoids, phenols, alkaloids, tannins, and terpenoids. The integration of results into laboratory-based lessons led to an increase in students’ average scores from 66.70 to 78.48, as well as improvement in laboratory skills, cultural awareness, and appreciation of local biodiversity. These findings demonstrate that Balinese grape peel extract is a valuable educational tool for enhancing understanding of secondary metabolites and promoting scientific literacy. The future impact of this research includes the potential for in vitro and in vivo studies to assess the extract’s biological activity, and the implementation of local plant-based learning models that support sustainable education and preservation of indigenous knowledge.Abstrak. Pemanfaatan sumber daya alam lokal untuk pembelajaran kontekstual berbasis praktikum merupakan pendekatan inovatif dalam pendidikan biologi. Penelitian ini bertujuan untuk melakukan skrining fitokimia kulit anggur Bali (Vitis vinifera L. var. Alphonso Lavallee) serta mengintegrasikan hasilnya ke dalam pembelajaran berbasis sumber daya tumbuhan lokal. Penelitian ini menggunakan metode campuran dengan desain pra-eksperimen one-group pretest–posttest. Skrining fitokimia dilakukan terhadap senyawa flavonoid, fenol, alkaloid, tanin, dan terpenoid melalui uji pereaksi spesifik. Hasil skrining menunjukkan adanya kelima senyawa aktif tersebut, Integrasi hasil ke dalam pembelajaran laboratorium meningkatkan nilai rerata siswa dari 66,70 menjadi 78,48, serta memperkuat keterampilan laboratorium, kesadaran budaya, dan apresiasi terhadap biodiversitas lokal. Temuan ini menunjukkan bahwa penggunaan ekstrak kulit anggur Bali dapat meningkatkan literasi sains dan pemahaman peserta didik terhadap metabolit sekunder. Dampak jangka panjang dari penelitian ini mencakup potensi pengembangan studi in vitro dan in vivo untuk mengeksplorasi aktivitas biologis ekstrak serta penerapan pembelajaran berbasis sumber daya lokal yang mendukung pendidikan berkelanjutan dan pelestarian kearifan lokal.
Activity of Zuriat Fruit Extract (Hyphaene thebaica) on The DNA Fragmentation and Spermatozoa Quality of Male Mice (Mus musculus) Given Balinese Arak Ni Wayan Sukma Antari; Ida Ayu Manik Damayanti
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.11855

Abstract

Alcohol in the body is metabolized into acetaldehyde with the assistance of the enzyme alcohol dehydrogenase (ADH). Acetaldehyde, the metabolic byproduct of alcohol, plays a role in the formation of Reactive Oxygen Species (ROS). The effects of alcohol can lead to damage and death of spermatogenic cells caused by acetaldehyde, which is produced through the breakdown of alcohol by liver cells. Increased ROS levels generated by free radicals in sperm producing tissues may cause damage to the sperm membrane, thereby disrupting its stability and function. High concentrations of ROS may also exert toxic effects on sperm quality and function. This study aimed to examine the activity of Zuriat fruit (Hyphaene thebaica) extract on sperm quality and DNA fragmentation in male mice (Mus musculus) administered Balinese Arak. This research employed an experimental study design using a post-test only control group design. The results show that Zuriat fruit (Hyphaene thebaica) extract at doses of 1 g/kg body weight and 2 g/kg body weight significantly influenced sperm count, motility, viability, morphology, and DNA fragmentation (p < 0,05).
Plant-Based Natural Resource Management Strategies Using Fruits for Cholesterol Regulation Damayanti, Ida Ayu Manik; Wulansari, Nadya Treesna; Megayanti, Sri Dewi
West Science Nature and Technology Vol. 3 No. 04 (2025): West Science Nature and Technology
Publisher : Westscience Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58812/wsnt.v3i04.2630

Abstract

Cardiovascular diseases remain a leading cause of global mortality, with hypercholesterolemia representing a major modifiable risk factor. Growing interest has emerged in plant-based strategies, particularly fruit utilization, as sustainable approaches for cholesterol regulation. This study aimed to systematically review the pharmacological mechanisms of fruit-derived secondary metabolites involved in cholesterol lowering and to explore their relevance within plant-based natural resource management. A systematic literature review was conducted following PRISMA guidelines using ScienceDirect, PubMed, and Google Scholar databases. Evidence from in vivo and in vitro studies demonstrates that various fruits including Gedong Gincu mango, sweet orange, red dragon fruit, buni fruit, Rosa roxburghii, pineapple, Synsepalum dulcificum, mulberry, and Hiyung cayenne pepper contain bioactive secondary metabolites such as flavonoids, phenolics, anthocyanins, carotenoids, triterpenoids, alkaloids, saponins, dietary fiber, and antioxidant enzymes. These compounds exert cholesterol-lowering effects through multiple pharmacological pathways, including inhibition of cholesterol synthesis and absorption, enhancement of bile acid excretion, modulation of lipid metabolism–related gene expression, and reduction of oxidative stress and inflammation. Several fruit-based interventions showed significant reductions in total cholesterol and LDL levels, with some demonstrating efficacy comparable to conventional hypolipidemic agents. These findings highlight the potential of fruit-based natural resources as functional, sustainable, and scientifically supported strategies for cholesterol regulation and cardiovascular disease prevention.
Kombucha from Edible Plants as a Functional Beverage with Hypoglycemic Potential: A Review Wulansari, Nadya Treesna; Dharmapatni, Ni Wayan Kesari; Damayanti, Ida Ayu Manik
Jurnal Pijar MIPA Vol. 21 No. 2 (2026)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i2.10668

Abstract

Diabetes mellitus (DM) is an endocrine disorder caused by a deficiency or ineffective production of insulin by the pancreas, leading to abnormal blood glucose levels. Hypoglycemia is a significant complication of diabetes therapy, referring to the condition or mechanisms that lower blood glucose levels. Kombucha is a functional beverage known for its health benefits, particularly its potential to reduce blood glucose levels. The data collection strategy used in this review was a systematic review.  Ten articles were used in this systematic review. Several plants, including sappan wood, Rhizophora mucronata leaves, snake fruit, Cyperus rotundus L. rhizomes, black tea, green tea, Solanum betaceum Cav., strawberry, Syzygium polyanthum (Wight) Walp. leaves, and red ginger, have demonstrated potential hypoglycemic effects. The mechanisms involved include inhibition of α-glucosidase enzyme activity, reduction of fasting plasma glucose (FPG), and decreased blood glucose concentration. The presence of secondary metabolites in these plants, combined with the fermentation process involving microorganisms, contributes to their antidiabetic potential through hypoglycemic mechanisms and α-glucosidase inhibition.
Co-Authors A.A. Istri Mas, Padmiswari A.A.S. A. Sukmaningsih AA Istri Mas Padmiswari Abda Abda Adiana, I Nengah Adnyana, I Kadek Budi Ariani, Ni Komang Sri Aristadewi, Ida Ayu Mas Artana, I Wayan Budi Artha, I Wayan Oktapratama Asthadi Mahendra Bhandesa, Asthadi Mahendra Clarisa, Gusti Ayu Della Deni Redita, I Komang Dharmapatni , Ni Wayan Kesari Dira, Made Asmarani Dwi Arymbhi Sanjaya Gede Surya Indrawan Gede, Surya Indrawan Gusti Ayu Della Clarisa I Gusti Agung Tresna Wicaksana I Ketut Alit Adianta I Ketut Junitha I Ketut Swarjana I Made Bayu Jaya Kusuma I Putu Artawan I Putu Gde Yudara Sandra Putra I Putu Gede Sutrisna . I Wayan Budi Artana Ida Bagus Made Suaskara Ida Bagus Separsa Kusuma Kadek Buja Harditya Kadek Maya Cyntia Dewi Kadek Nuryanto Lumbantobing, Gita Vidya Natalia Maha Putra, I Nyoman Arya Mahaputra, I Nyoman Arya Mas Aristadewi, Ida Ayu Nadya Treesna Wulansari Ni Luh Putu Inca Buntari Agustini Ni Made Ayu Sukma Widyandari Ni Made Krisna Ayu Lestari Ni Wayan Ayu Eka Perantini Ni Wayan Desi Bintari Ni Wayan Kesari Dharmapatni Ni Wayan Sukma Antari Ni Wayan Sukma Antari Ni Wayan Sukma Antari Ni Wayan Sukma Antari, Ni Wayan Sukma Antari Nuryanto, Kadek Nyoman Eta Risnawati Padmiswari, A.A Istri Mas Padmiswari, A.A. Istri Mas Pramana, I Kadek Bagus Ari Putu Ekawati Ida Ayu Putu Indrayoni Putu Rima Sintyadewi Sanjana, I Wayan Sri Dewi Megayanti Sri Dewi Megayanti Sri Idayani Sri Idayani Strisanti, Ida Ayu Suptika Sukaningsih, Ni Wayan Sutrisna , I Putu Gede Sutrisna, Putu Gede Suweca, I Gede Tohir, Wa. Aniyda M. Wahyunadi, Ni Made Dewi Wicaksana, IGA Tresna Widiatmaja, Gusti Panji Widyas Pranata, Gst. Kade Adi Wulansari , Nadya Treesna Zabrina, Putu Tiara