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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan E-Journal Obstetric & Gynecology Udayana WMJ (Warmadewa Medical Journal) Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Indonesian Journal of Obstetrics & Gynecology Science ISM (Intisari Sains Medis) : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Babali Nursing Research Jurnal Syntax Transformation Jurnal Health Sains Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Social Service and Research Cermin Dunia Kedokteran Indonesian Journal of Perinatology Cermin Dunia Kedokteran
I Gde Sastra Winata
Departemen Obstetri Dan Ginekologi, Fakultas Kedokteran, Universitas Udayana
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : The Indonesian Biomedical Journal

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Preoperative Level of Insulin-Like Growth Factor Binding Protein 2 Predicts The Suboptimal Outcome After Primary Debulking Surgery in Patients with Advance Ovarian Cancer Pande Kadek Aditya Prayudi; I Gde Sastra Winata; I Nyoman Gede Budiana; Kade Yudi Saspriyana; I Nyoman Bayu Mahendra; Ketut Suwiyoga
The Indonesian Biomedical Journal Vol 15, No 6 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i6.2722

Abstract

BACKGROUND: The need for clinically useful biomarkers which can predict the surgical outcome after primary debulking surgery (PDS) in patients with advance ovarian cancer (AOC) is really important. Insulin-like growth factor-binding protein 2 (IGFBP2) is the main binding protein expressed by ovarian cancer cells, which plays a prominent role in promoting proliferation, driving invasion, and suppressing apoptosis. This study was conducted to assess the performance of IGFBP2 in predicting the surgical outcome after PDS in patients with AOC.METHODS: Twenty-four subjects with AOC (Stage IIIc/IV) who underwent PDS were recruited consecutively. Clinicopathologic data were obtained from subjects' medical records. Blood samples were withdrawn form each subject and preoperative level of IGFBP2 were measured using enzyme-linked immunosorbent assay (ELISA). Multivariate analysis was employed to test the performance of multiple predictors of surgical outcome.RESULTS: Eighteen patients (75%) had suboptimal outcome after PDS. Mean IGFBP2 level was significantly higher in the suboptimal group (1157.5±359.9 ng/mL vs. 679.1±504.5 ng/mL, p=0.018). In bivariate model, higher preoperative level of IGFBP2 predict the suboptimal outcome with good accuracy (AUC: 0.796, sensitivity: 83.3%, specificity: 83.3%, p=0.033, optimal threshold level 870 ng/mL). Higher IGFBP2 level was associated with higher risk of suboptimal outcome, although IGFBP2 was not an independent risk factor (adjusted OR: 5.0, 95% CI: 0.43-57.9, p=0.198).CONCLUSION: IGFBP2 is a novel and promising biomarker for surgical outcome prediction following PDS in AOC patients. Since it is predictive for suboptimal outcome, patients with higher preoperative level of IGFBP2 needs more thorough preoperative evaluation as well as meticulous surgical technique to optimize the surgical outcome.KEYWORDS: IGFBP2, advance ovarian cancer, PDS, surgical outcome, predictor
Co-Authors A.A.N. Anantasika Anak Agung Gede Putra Wiradnyana Anak Agung Ngurah Anantasika Anthony Stephen Halim Arlando Martino Anapaku Charles Richard Thene Clara Amanda Daniel Hadinata Susanto Desak Putu Oki Lestari Dewi, Putu Pradnya Paramitha Dolesgit, Ni Made Garnis DPG Jananuraga Maharddhika Endang Sri Widiyanti Eric Gradiyanto Ongko Ernest T. B. Sianturi Ernest TB Sianturi Felyanto, Felyanto Fenyta Christyani FLORENCIA Florencia Desiree I Gede Indra Kumara I Gede Mahendra Adiguna Dira I Gede Mega Putra I Gusti Ayu Putri Kartika, I Gusti Ayu I Gusti Bagus Mulia Agung Pradnyaandara I Ketut Surya Negara I Ketut Suwiyoga I Made Darmayasa I Nyoman Bayu Mahendra I Nyoman Gede Budiana I Nyoman Gede Budiana I Nyoman Hariyasa Sanjaya I Wayan Agus Surya Pradnyana I Wayan Artana Putra I Wayan Megadhana I Wayan Parsa Ida Bagus Arjuna Ida Bagus Gde Fajar Manuaba IGN. Wiranta Permadi Ika Widi Astuti, Ika Widi Ines Kurniaty Hartono Johan Qalaba Kade Yudi Saspriyana Kade Yudi Saspriyana Ketut Suwiyoga Kevin Agastya Duarsa Lazarosony, Nicholas Renata Made Ayu Prabawaty Indraswari Made Bagus Dwi Aryana Made Yudha Ganesa Wikantyas Widia Maria Septiana Parmonang Aroean Mirani Ulfa Yusrika Musa Taufiq Musa Taufiq Ngakan Ketut Darmawan Ni Luh Wita Astari Widhusadi Ni Wayan Armerinayanti Nicholas Renata Lazarosony Nicholas Renata Lazarosony Nyoman Bayu Mahendra Ongko, Eric Gradiyanto Pande Kadek Aditya Prayudi Pande Kadek Aditya Prayudi Pande Made Suwanpramana Paskarani, Putu Erika Piere Emanuel Yoltuwu Piers Andreas Noak Pradnyana, I Wayan Agus Surya Putu Bagus Darmayasa Putu Doster Mahayasa Putu Harrista Indra Pramana Rayvany Uil Ryan Saktika Mulyana Sitohang, Elisa Laura Oktrinita Sucitawati, Putu Devita Tjokorda Gde Agung Suwardewa Wibawa, I Gusti Ngurah Agung Satria William Alexander Setiawan Yuliantini, Sang Ayu Putu