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All Journal Farmaka Jurnal Sains Materi Indonesia Indonesian Journal of Pharmaceutical Science and Technology JURNAL PHARMASCIENCE CHEMPUBLISH JOURNAL IDJP (Indonesian Journal of Pharmaceutics) Indonesian Food Science and TechnologyJournal Majalah Farmasetika Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Kesehatan Masyarakat Pharmaceutical Sciences and Research (PSR) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmascience
Yoga Windhu Wardhana
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Pengujian Kelembapan Produk Pelembap “X” Menggunakan Metode Konduktansi Listrik Dengan Instrumentasi Corneometer CM 825 Rizaldi, Fiqri Taufiq; Wardhana, Yoga Windhu
Majalah Farmasetika Vol 9, No 3 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i3.53249

Abstract

Produk pelembap bibir digunakan sehari-hari untuk melindungi serta menjaga kelembapan bibir mulai dari sinar matahari, cuaca buruk hingga suhu ruangan dingin. Sebagai sebuah produk kosmetika pelembap bibir memiliki klaim yang bervariatif, termasuk kemampuan menjaga tingkat hidrasi yang dapat menjadi nilai jual suatu produk. Sebuah metode uji diperlukan untuk mengetahui pengukuran dari perubahan tingkat hidrasi secara signifikan, sehingga dapat menjadi pertimbangan penggunaan produk pelembap salah satunya pelembap bibir. Saat ini tersedia berbagai metode pengukuran tingkat hidrasi dengan berbagai tingkat akurasi serta luaran dari pengujian. Corneometer CM 825 dianggap memiliki tingkat akurasi yang baik karena dapat mengukur secara spesifik pada stratum corneum serta menjadi standar pengujian hidrasi hingga saat ini dibandingkan dengan metode pengukuran lain di pasaran. Pada pengujian kali ini ditujukan untuk mengetahui tingkat hidrasi dari pengaplikasian produk pelembap bibir “X” dengan menggunakan instrumentasi Corneometer CM 825 yang memanfaatkan konduktansi listrik. Dilakukan pengujian produk yang diaplikasikan pada bibir kemudian diamati mulai dari sebelum pemakaian (T0), 15 menit (T15M), 2 jam (T2H), 3 jam(T3H) hingga 5 jam (T5H) setelah pengaplikasian yang dilakukan dengan desain single blind study pada 21 orang subjek wanita rentang usia 21-33 tahun. Digunakan metode statistik One Way Anova dengan tingkat kepercayaan hingga 95%, hasil penelitian menunjukan P<0,05 yang menandakan bahwa secara signifikan pengaplikasian produk pelembap bibir “X” mampu menahan kelembapan bibir hingga 5 jam yang dibandingkan dengan sebelum pemakaian (T0).
Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. Bestari, Muhammad Begawan; Rohmawaty, Enny; Rosdianto, Aziiz Mardanarian; Usman, Hermin A.; Saragih, Winda A. M.; Zuhrotun, Ade; Hendriani, Rini; Wardhana, Yoga Windhu; Ekawardhani, Savira; Wiraswati, Hesti Lina; Agustanti, Nenny; Dewi, Sumartini; Wijaya, Muhammad Palar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023206

Abstract

Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect.Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels.Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels.Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions.
Pengukuran Dan Sosialisasi Terkait Pengetahuan Masyarakat Dalam Penanganan Infeksi Awal Influenza Melalui Media Sosial Windhu Wardhana, Yoga; Ghozali, Dolih; Kautsar, Angga P.; Kurniawansyah, Insan Sunan
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 1 No. 4 (2022): Oktober 2022
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v1i4.763

Abstract

Recently, the world has been hit by a pandemic caused by a virus of the type of influenza that spreads very quickly, called COVID-19. It is named that cause of the disease from this type of influenza virus is relatively new and has not been widely known and began to spread at the end of 2019. Influenza itself is an acute respiratory tract infection (ARTI) caused by an influenza virus from the Orthomyxoviridae family, which can cause mild to severe symptoms. To avoid the occurrence of more severe or recurrent infections requires prevention and proper handling of the influenza disease. But in fact, there are still many Indonesian people who underestimate this and think that the flu is an ordinary disease because this disease actually can heal on its own. To reduce the spread or break the chain of transmission of the influenza virus, the community needs to adequate awareness and knowledge given. Through virtual KKN-PPMD activities, we want to learn the extent of public knowledge about how to prevent and treat early influenza infection. In this activity, an assessment will be given at the beginning and end of providing education related to knowledge for the prevention and handling of early influenza infections. The provision of virtual education was distributed through social media (Youtube, Whatsapp, Instagram, Facebook). The activity results from the category of random respondents in which the majority were women by 73%, with ages ranging from 15-35 years and status as students, it was found that a significant increase in knowledge showed that from each groups as like age group, education level, and type of work, namely 3,495 (sig. 0.062), 5.017 (sig. 0.025), and 1.140 (sig. 0.286).
Solid Dispersion Technology for Improving the Solubility of Antiviral Drugs Butar-Butar, Maria Elvina Tresia; Wathoni, Nasrul; Ratih, Hestiary; Wardhana, Yoga Windhu
Pharmaceutical Sciences and Research Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Most drugs, including antiviral drugs, show low solubility in water, which affects dissolution, bioavailability, and therapeutic effectiveness. Therefore, many antiviral drugs are given in very large doses. One of the efforts to overcome these problems is the application of solid dispersions in which polymers and surfactants can trap drug molecules that are in the amorphous phase. Drugs in a hydrophilic carrier will increase wettability, water absorption capacity, and porosity of particles, so that the drug is released better. This review article will discuss the development of technology in solid-state, how solid dispersion overcomes the lack of solubility and the rate of dissolution of antiviral drugs, and solid dispersion preparation techniques. We also discuss some examples of successful applications of solid dispersion methods to antiviral drugs that have been circulating on the market. Overall, this review article offers information of innovation in the development of antiviral drugs to provide more solid dispersion antiviral drug products.
Increased Toxicity Risk from Nanoparticulate System in Food and Drug Applications Hazrina, Aghnia; Muhaimin, Muhaimin; Chaerunisaa, Anis Yohana; Husni, Patihul; Wardhana, Yoga Windhu
Indonesian Food Science and Technology Journal Vol. 8 No. 2 (2025): Volume 8 Number 2, July 2025 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v8i2.40494

Abstract

Abstract— Nanotechnology involves manipulating matter at the atomic and molecular levels, leading to the creation of new materials for food and drug application with properties that are not always easily anticipated based on existing knowledge. Among the nearly infinite variety of these substances, some are toxic to biological systems, others are generally harmless, and yet others confer health advantages. The biocompatibility and distribution of these materials must be assessed prior to their use in biological and environmental. Consequently, it is essential to comprehend the toxicity of nanomaterials. Mechanisms of cellular uptake and nanoparticles dispersion in biological settings depend on their physicochemical properties. The pathways in which exposure to nanoparticles is harmful to health are through oxidative stress and inflammation. Recent research have indicated that nanoparticles may cause major health impacts when ingested, inhaled, or applied to the skin without precaution. The main sources of toxicity in nanomaterials include their size, shape, concentration, aspect ratio, crystallinity, surface charge, dissolution, and agglomeration. This review article aims to comprehensively summarize the toxicity aspects of nanoparticles for food and drug application, including physiochemical properties, mechanisms of nanoparticle toxicity, and the health risks, so as to provide an overview for future researchers to develop nanoparticulate in a safer way.
Improving Stability and Absorption of Minerals in Pharmaceutical Formulations: A Review of Emerging Strategies Pitriani; Yoga Windhu Wardhana; Chaerunisaa, Anis Yohana
Chempublish Journal Vol. 9 No. 2 (2025): Chempublish Journal (July - December)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i2.46931

Abstract

Minerals are essential for numerous physiological functions. However, their application in pharmaceutical formulations is often limited by hygroscopicity and low bioavailability, which can diminish their therapeutic effectiveness. This article reviewa not only highlights these challenges but also provides an in-depth, up-to-date evaluation of various strategies designed to overcome these limitations, supported by quantitative data from recent literature. This review article emphasizes the role of co-processing with excipients and encapsulation technology, which improve mineral stability by creating an effective moisture barrier, thereby extending product shelf life. Effervescent formulations, through an acid-base reaction, generate gas that significantly enhances mineral solubility and contributes to increased bioavailability. Microencapsulation, using a polymer or protein layer, protects minerals from gastric degradation and allows for controlled release in the intestine, the primary site of absorption. Chelating peptides form stable complexes with mineral ions, improving their transport and uptake in the body. Meanwhile, advanced nanoparticle technologies like Solid Lipid Nanoparticles and liposomes increase the contact surface area, accelerate dissolution, and protect minerals from oxidative degradation. This review article offers a comprehensive overview of strategies that can significantly advance the development of more effective and stable mineral-based pharmaceuticals.
Formulasi dan Evaluasi Tablet Dispersi Padat Kalsium Atorvastatin Dolih Gozali; Yoga Windhu Wardhana; Shofa Shofa
Journal of Pharmascience Vol. 2 No. 2 (2015): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v2i2.5824

Abstract

ABSTRAK Kalsium Atorvastatin  merupakan obat antihiperlipidemia golongan statin.  Berdasarkan Biopharmaceutical Classification System (BCS),   Kalsium Atorvastatin termasuk dalam golongan obat yang memiliki kelarutan rendah. Kelarutan atorvastatin yang rendah dalam air menyebabkan laju disolusi rendah. Salah satu cara untuk meningkatkan disoluisi adalah dengan  dispersi padat. Dispersi padat  yaitu suatu keadaan dimana satu atau lebih bahan aktif terdispersi dalam polimer pembawa pada keadaan padat. Pada penelitian sebelumnya (Lakshmi, 2010), dispersi padat atorvastatain kalsium dengan PEG 6000 (1:3) menunjukkan hasil laju disolusi yang tertinggi. Pada penelitian ini dispersi padat kalsium atorvastatain (ATC) dengan PEG 6000 sebagai pembawa hidrofilik dalam perbandingan 1:3, 1:6, 1:9 Kemudian hasilnya dibuat tablet dengan metode kempa langsung. Uji disolusi dilakukan dengan Spektrofotometri UV-Vis. Hasil disolusi yang dilakukan, menunjukkan bahwa  bahwa adanya peningkatan laju  disolusi dilihat dari persen terdisolusi yang dihasilkan setelah 30 menit yaitu sebesar  formula 1 (ATC tanpa PEG 6000)  25,63%, formula 2  (1:3) 27,90 %), formula 3 (1:6)  31,83 % dan  formula 4  (1:9)   13,61 %. Kata Kunci :  Kalsium Atorvastatin, Dispersi Padat, Disolusi, PEG 6000 ABSTRACTAtorvastatin calcium is anti-hyperlipidemia drugs known as statins. Based on Biopharmaceutical Classification System (BCS), Calcium Atorvastatin belongs to a class of drugs which have low solubility. The low solubility of atorvastatin in water causes low dissolution rate. One way to improve disolution is by solid dispersion. Solid dispersion is a condition which one or more active ingredients dispersed in a polymer carrier in the solid state. In the previous study (Lakshmi, 2010), solid dispersion of calcium atorvastatain with PEG 6000 (1: 3) showed the results of highest dissolution rate. In this study, solid dispersions of calcium atorvastatain (ATC) with a hydrophilic PEG 6000 as a carrier in a ratio of 1: 3, 1: 6, 1: 9 Then the results are made into tablet by direct compress method.  Dissolution rates are tested by UV-Vis spectrophotometry. The dissolution result shows that there is an increase of the  dissolution rate, viewed by percent dissolved after 30 minutes in the amount of formula 1 (ATC without PEG 6000) 25.63%, formula 2 (1: 3) 27.90%), formula 3 (1: 6) 31.83% and the formula 4 (1: 9) 13.61%.Keyword : Atorvastatin calcium, Solid Dispersion, Dissolution, PEG 6000
Co-Authors Ade Zuhrotun Aliya Nur Hasanah Anis Khoerunisa Anis Khoerunisa, Anis Anis Yohana Chaerunisa Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa, Anis Yohana Azzahra, Salwa Putri Camellia Panatarani Cecep Suhandi Defertha Ayudia Paramita Dewi, Sumartini Dolih Gozali Dradjad Priambodo Dwi Retno Sari Enny Rohmawaty Fajra Dinda Crendhuty Fikri Alatas Ghozali, Dolih HAMMAM HAFIDZURAHMAN SYAHIDAN Hazrina, Aghnia Hesti Lina Wiraswati Hestiary Ratih Insan Sunan Kurniawansyah, Insan Sunan Kalista Tritama Widyanti Kautsar, Angga P. Kurniawan Syah, Insan Sunan M. Ramadhan Saputro Maria Elvina Tresia Butar-Butar Meylani Sutoro Muhaimin Muhaimin Muhammad Begawan Bestari Nasrul Wathoni Nenny Agustanti Nuur Aanisah Patihul Husni Pitriani Priskila O Dwiestri Priskila O Dwiestri, Priskila O Rachmah, Sinta Aulia Rahadianti Khofii Suwanditya Rini Hendriani Risanteni Riskasari Rizaldi, Fiqri Taufiq Rizky Dwi Oktavia Rosdianto, Aziiz Mardanarian Salsabila, Esa Balqis Saragih, Winda A. M. Savira Ekawardhani SHEILA FRIZQIA JELITA Shofa Shofa Shofa Shofa, Shofa Sri Adi Sumiwi Sriwidodo Sriwidodo Sudirman Sudirman Taofik Rusdiana Usman, Hermin A. Wieke Budiati Wijaya, Muhammad Palar Wisnu A. Adi Yedi Herdiana, Yedi Zaelani, Diki