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All Journal Farmaka Jurnal Sains Materi Indonesia Indonesian Journal of Pharmaceutical Science and Technology JURNAL PHARMASCIENCE CHEMPUBLISH JOURNAL Pharmascience IDJP (Indonesian Journal of Pharmaceutics) Indonesian Food Science and TechnologyJournal JPSCR : Journal of Pharmaceutical Science and Clinical Research Majalah Farmasetika Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Kesehatan Masyarakat Pharmaceutical Sciences and Research (PSR) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Medical Sains : Jurnal Ilmiah Kefarmasian
Yoga Windhu Wardhana
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Ophthalmic release of in situ gel Ciprofloxacin HCl based on combination of Hypromellose and HPC Yoga Windhu Wardhana; Wieke Budiati; Rizky Dwi Oktavia; Kalista Tritama Widyanti; Insan Sunan Kurniawansyah; Yedi Herdiana
Indonesian Journal of Pharmaceutics Vol 3, Issue 3, Sept - Dec 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i3.36140

Abstract

The development for ophthalmic delivery was purposed to achieve optimum drug loading for ocular therapeutic benefits. An adequate dose of the drug is needed to absorb in the conjunctival sac to take effect. In situ gel preparation was expected to provide these needs with the polymer aid that makes the droplets suddenly coagulate in the eye area to maintain the drug dose. The in situ gel dosage form is desired to overcome the poor bioavailability of conventional ciprofloxacin HCl eye drops on the market. Thus, this work was studied using two cellulose polymers such as hydroxyl propyl cellulose (HPC) and hydroxypropyl methylcellulose (HMPC) as a gelling forming agent.  The effect of the in situ ophthalmic quality of the gel due to the two individual polymers separately and their combined use was investigated. The in situ gel quality includes the ability of gel-forming under the influence of varying temperature and stirring frequency difference (as a rheological study) was tested together with the drug release model model. Other ophthalmic preparation quality parameters such as clarity, pH measurement, drug content determination, sterility, and antibacterial activity have been evaluated. However, overall in situ gel formulation developed was of better quality compared to the conventional one. Consideration of the choice of cellulose derivative polymer type is seen to affect the quality of controlled release kinetics models.Keywords: Ophthalmic gel, Ciprofloxacin HCl, HPMC, HPC, Drug release kinetics 
Dissolution Behaviours of Acetaminophen and Ibuprofen Tablet Influenced By L–HPC 21, 22, and Sodium Starch Glycolate as Disintegrant Yoga Windhu Wardhana; Dradjad Priambodo
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (970.759 KB) | DOI: 10.24198/idjp.v1i3.23508

Abstract

The dissolution of tablets is one of a drug absorption determinant. Disintegrant agent has play an important role on determining the dissolution of tablets. In this experiment, the dissolution behaviours of Acetaminophen and Ibuprofen Tablet was studied using various disintegrant agent such as Low substituted – Hydroxypropyl Cellulose (L–HPC) 21, L–HPC 22 and Sodium Starch Glycolate (SSG) as comparator. Those disintegrant agents were used at three concentration (6%, 7% and 8%) for every tablets formula. Tablets were made by wet granulation method and pressed using single punch 13 mm flat E. Korsch machine. Evaluation of each tablets quality were conducted include for uniformity of weight and size (diameter and thickness), hardness, friability, disintegration time and dissolution. Physically standards from tablets were in good condition, the standards of the weight and thickness uniformity, hardness and friability met the requirement. The dissolution profile on Acetaminophen Tablets showed that only tablet with 6 % L–HPC 21 did not meet the requirement of FI V (Q = 80%, 30 minutes), but on Ibuprofen Tablets where met the requirement of  FI V (Q = 80%, 60 minutes) only tablet with 8%  L– HPC 21,  7% and 8% SSG. The conclusion of the study was the L–HPC has more disintegrant character at hydrophilic active ingredients. Key words:  Acetaminophen Tablet, Ibuprofen Tablet, SSG, L-HPC 21 and 22, Dissolution Profile
Enhancement of Solubility BCS Class II and IV Pharmaceuticals by Liqusolid Technique: A review Dwi Retno Sari; Yoga Windhu Wardhana; Taofik Rusdiana
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.27297

Abstract

Many techniques can be used to improve drug solubility, which is the development of the liquisolid technique. This technique has a mechanism for increasing the surface area of the drug as well as wetting from the addition of non-volatile solvents resulting in a lower surface tension and contact angle, so the solubility and drug release very increases. Liquisolid tablets show a lower contact angle compared to the conventional tablets. The liquisolid technique approach is also promising because the process is simple in making low production costs and allows the manufacturing industry, including non-volatile solvents, fillers, dryers, and disintegrants. Liquisolid characterized by specific instruments such as powder x-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and scanning electron microscope (SEM). Several liquisolid techniques are described in this review. The liquisolid technique is proven and able to change the physicochemical properties of active pharmaceutical ingredients, especially the solubility, drug release, and stability of the formula so that this technique can be a solution for class II and IV BCS pharmaceutical active drug classes.Keywords: Active Pharmaceutical Ingredients, Contact Angle, Solubility, Drug Release, Stability, Liquisolid Technique
Phase Transitions Among of Valsartan Polymorphs due to Grinding and Humidity Variations Yoga Windhu Wardhana; Risanteni Riskasari; Fikri Alatas
Indonesian Journal of Pharmaceutics Vol 3, Issue 2, May - August, 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i2.35312

Abstract

Phase transition between drugs with polymorphisms needs attention due to unconscious changes in quality. Valsartan (VAL) is a drug model with polymorphic events to be studied here. Two polymorphic forms were obtained from recrystallization with various organic solvents such as acetonitrile and n-butyl acetate.  With untreated materials (from the market) were used as a comparison in this study. The phase transition of each polymorph was studied through grinding and humidity variations (RH 75% and 98%) treatment. The polymorph characterization was observed by microscope light polarization (PLM), Fourier Transform Infrared (FTIR), and Powdered X-ray Diffractometer (PXRD). The transition among polymorphic VAL was monitored by PXRD. There were significant differences in morphology, IR spectra, and diffractograms pattern. Found that the untreated VAL was amorphous, whereas the others were in high crystallinity. The polymorph form from n-butyl acetate was a metastable one that transformed easier into stable crystalline (from acetonitrile) than another polymorph.Keywords : Valsartan, Phase transition, Polymorphism, Recrystallization    
Modifications and Pharmaceutical Applications of Glucomannan as Novel Pharmaceutical Excipient in Indonesia: Review Article Nuur Aanisah; Yoga Windhu Wardhana; Anis Yohana Chaerunisa
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 2 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i2.56076

Abstract

Currently, Indonesia is excessively dependent on imported raw materials, such as pharmaceutical excipients. In this regard, the current pandemic should remind the critical nature of independence in purchasing raw resources to cope with future dynamics. One of the causes of dependence is the lack of raw materials management, specifically from biological sources abundantly available. A significant advantage is directed towards natural excipients because large quantities of more affordable plants ensure sustained availability in nature. Therefore, this study highlighted the possibility of using excipients derived from natural resources that are commonly used yet underutilized in Indonesia, such as glucomannan (GM). Indonesia has the potential to produce GM, considering the high natural resources as its source. However, it has not been applied extensively in pharmaceutical preparations due to diverse uses in several countries' drug, food, and cosmetic industries. This study aimed to discuss the modifications of GM and their use as pharmaceutical excipients with better physical properties. Additionally, the potential of melinjo seeds that have not been widely used was also analyzed. Melinjo seeds can be used as a source of GM due to their fairly large polysaccharide of about 64.11%. This issue will promote national autonomy in developing novel pharmaceutical excipients derived from natural resources that are highly economical and innovative.
Pertimbangan Penggunaan Polimer Responsif perubahan pH dan Suhu pada Formulasi Sediaan Topikal Cecep Suhandi; Yoga Windhu Wardhana
Majalah Farmasetika Vol 8, No 4 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v8i4.46653

Abstract

Berbagai metode dan strategi modifikasi untuk pengembangan sediaan topikal telah banyak diterapkan, diantaranya pemanfaatan polimer pintar atau polimer yang responsif terhadap rangsangan menjadi alternatif solusi yang menjanjikan. Kontrol pelepasan terjadi akibat rangsangan lingkungan, yaitu pH dan suhu yang menjadi faktor utama pada pengahantaran sediaan secara topikal. Tinjauan pustaka ini disusun dengan tujuan untuk mengetahui perkembangan terkini dari berbagai polimer responsif pada perubahan suhu dan pH dalam penghantaran sediaan obat secara topikal. Sebanyak 63 artikel yang diperoleh melalui pencarian pada databasis Scopus, PubMed, dan Google Scholar memenuhi kriteria sebagai literatur dalam menyusun artikel tinjauan pustaka ini. Hasil tinjauan mengindikasikan bahwa berbagai polimer yang dapat mengalami perubahan struktural terhadap perubahan suhu dan pH telah berhasil diaplikasikan dalam penghantaran berbagai sediaan zat aktif secara topikal. Suksesnya tujuan pengendalian ini diperoleh dari pertimbangan pemilihan polimer yang sesuai pada kemampuan transformasi polimer pada perubahan pH dan suhu spesifik dimana kondisi patologis kulit berlangsung.
REVIEW: PROCESS OF FLUID BED GRANULATOR PARAMETERS AT THE TIME OF SCALE UP IN GRANUL PRODUCTION Diki Zaelani; Yoga Windhu Wardhana; Anis Yohana Chaerunisaa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.836

Abstract

Scaling up is one of the difficulties faced by the production process of the pharmaceutical industry. We must manufacture in higher quantities than a laboratory size with set requirements as we scale up. Understanding the crucial variables that affect the final product's specifications will aid in choosing appropriate upgrade settings. Fluidized-bed granulation is one of the most frequently used techniques to increase the scale of the pharmaceutical industry. The complex fluidized bed granulation process is influenced by several factors. The most important process variables were the intake air temperature and humidity, concentration of the binder solution, spray rate, atomizing air pressure, and air flow rate. Numerous investigations have examined the effects of large-scale fluid bed granulation. An improved fluid bed granulation technology was employed based on the relative droplet size and moisture content of the powder in the bed after the spraying cycle. These values are comparable, demonstrating that the granulation procedure can be enhanced by considering only the moisture content of the powder and relative droplet size. Keywords: fluid bed granulation, process parameters, scale up
Peningkatan Disolusi dan Stabilitas Efavirenz Menggunakan Beberapa Metode Dispersi Padat Meylani Sutoro; Yoga Windhu Wardhana; Camellia Panatarani
Majalah Farmasetika Vol 8, No 5 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v8i5.40510

Abstract

Efavirenz merupakan obat terapi AIDS yang memiliki beberapa bentuk polimorf. Beberapa bentuk polimorf akan memiliki perbedaan dalam disolusi dan stabiltasnya. Dispersi padat merupakan dispersi bahan aktif farmasi kedalam pembawa yang hidrofilik, yang bertujuan untuk meningkatkan disolusi dan stabilitasnya. Beberapa metode dispersi padat efavirenz pada penelitian sebelumnya yang berpotensi dalam meningkatkan kelarutan, disolusi, dan stabilitas efavirenz diantaranya hot melt extrusion, penguapan pelarut, pengeringan semprot, pengeringan beku, dan pengadukan (kneading). Diantara kelima metode dispersi padat yang dapat dirujuk diantara metode lainnya dalam meningkatkan kelarutan, disolusi, dan stabilitas adalah hot melt extrusion karena telah dilakukan uji kelarutan dan disolusi dengan peningkatan kelarutan rentang hingga 5,45 kali dan peningkatan disolusi hingga 9 kali dibandingkan efavirenz murni, serta pengujian stabilitas tetap stabil setelah dilakukan selama 1-6 bulan. Namun metode lainnya terkecuali penguapan pelarut (karena tidak meningkatkan profil disolusi meskipun stabil dalam penyimpanan 1 bulan), seperti pengeringan semprot, pengeringan beku, dan pengadukan (kneading) dapat dijadikan rujukan untuk pengembangan dispersi padat untuk meningkatkan kelarutan, disolusi, dan stabilitas efavirenz. Peningkatan stabilitas setelah penyimpanan salah satunya ditandai dengan stabil dalam bentuk amorf, stabil atau serupa dalam kelarutan, profil pelepasan dan kandungannya. Perbaikan stabilitas penyimpanan dispersi padat perlu disesuaikan antara parameter metode dispersi padat (terutama suhu dan perilaku mekanis) dengan sifat pembawa dan atau eksipien lain yang akan digunakan (seperti pelarut, plastizer dsb.).
REVIEW: PROCESS OF FLUID BED GRANULATOR PARAMETERS AT THE TIME OF SCALE UP IN GRANUL PRODUCTION Diki Zaelani; Yoga Windhu Wardhana; Anis Yohana Chaerunisaa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.836

Abstract

Scaling up is one of the difficulties faced by the production process of the pharmaceutical industry. We must manufacture in higher quantities than a laboratory size with set requirements as we scale up. Understanding the crucial variables that affect the final product's specifications will aid in choosing appropriate upgrade settings. Fluidized-bed granulation is one of the most frequently used techniques to increase the scale of the pharmaceutical industry. The complex fluidized bed granulation process is influenced by several factors. The most important process variables were the intake air temperature and humidity, concentration of the binder solution, spray rate, atomizing air pressure, and air flow rate. Numerous investigations have examined the effects of large-scale fluid bed granulation. An improved fluid bed granulation technology was employed based on the relative droplet size and moisture content of the powder in the bed after the spraying cycle. These values are comparable, demonstrating that the granulation procedure can be enhanced by considering only the moisture content of the powder and relative droplet size. Keywords: fluid bed granulation, process parameters, scale up
REVIEW ARTIKEL: KANDUNGAN METABOLIT SEKUNDER TANAMAN BUNGA TELANG (Clitoria ternatea L.) SEBAGAI TERAPI DIABETES Rachmah, Sinta Aulia; Wardhana, Yoga Windhu
Farmaka Vol 20, No 2 (2022): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i2.34335

Abstract

Diabetes merupakan penyakit tidak menular yang memiliki prevalensi tinggi di seluruh dunia. Indonesia termasuk salah satu negara dengan prevalensi tinggi, yaitu 8,5% pada tahun 2018. Terdapat beberapa cara untuk menanggulangi diabetes, salah satunya penggunaan obat herbal tanaman bunga telang atau Clitoria ternatea. Adapun artikel ini ditujukan untuk mengumpulkan informasi mengenai senyawa metabolit sekunder yang berkontribusi dalam aktivitas antidiabetes Clitoria ternatea. Senyawa fenolik, flavonoid, dan antosianin bertanggung jawab sebagai agen antidiabetes pada bunga telang.Kata Kunci: diabetes, bunga telang, Clitoria ternatea, metabolit sekunder
Co-Authors Ade Zuhrotun Aliya Nur Hasanah Anis Khoerunisa Anis Khoerunisa, Anis Anis Yohana Chaerunisa Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa, Anis Yohana Azzahra, Salwa Putri Camellia Panatarani Cecep Suhandi Defertha Ayudia Paramita Dewi, Sumartini Dolih Gozali Dradjad Priambodo Dwi Retno Sari Enny Rohmawaty Fajra Dinda Crendhuty Fikri Alatas Ghozali, Dolih HAMMAM HAFIDZURAHMAN SYAHIDAN Hazrina, Aghnia Hesti Lina Wiraswati Hestiary Ratih Insan Sunan Kurniawansyah, Insan Sunan Kalista Tritama Widyanti Kautsar, Angga P. Kurniawan Syah, Insan Sunan M. Ramadhan Saputro Maria Elvina Tresia Butar-Butar Meylani Sutoro Muhaimin Muhaimin Muhammad Begawan Bestari Nasrul Wathoni Nenny Agustanti Nuur Aanisah Patihul Husni Pitriani Priskila O Dwiestri Priskila O Dwiestri, Priskila O Rachmah, Sinta Aulia Rahadianti Khofii Suwanditya Rini Hendriani Risanteni Riskasari Rizaldi, Fiqri Taufiq Rizky Dwi Oktavia Rosdianto, Aziiz Mardanarian Salsabila, Esa Balqis Saragih, Winda A. M. Savira Ekawardhani SHEILA FRIZQIA JELITA Shofa Shofa Shofa Shofa, Shofa Sri Adi Sumiwi Sriwidodo B Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Sudirman Sudirman Taofik Rusdiana Usman, Hermin A. Wieke Budiati Wijaya, Muhammad Palar Wisnu A. Adi Yedi Herdiana, Yedi Zaelani, Diki