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All Journal Farmaka Jurnal Sains Materi Indonesia Indonesian Journal of Pharmaceutical Science and Technology JURNAL PHARMASCIENCE CHEMPUBLISH JOURNAL Pharmascience IDJP (Indonesian Journal of Pharmaceutics) Indonesian Food Science and TechnologyJournal JPSCR : Journal of Pharmaceutical Science and Clinical Research Majalah Farmasetika Jurnal Ilmiah Kesehatan Masyarakat Pharmaceutical Sciences and Research (PSR) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Yoga Windhu Wardhana
Department Of Pharmaceutics And Pharmaceutical Technology, Faculty Of Pharmacy, Universitas Padjadjaran, Hegarmanah Road, Jatinangor, West Java, Indonesia, 45363. Study Center On The Development Of Pharmaceutical Preparations, Faculty Of Pharmacy, Un
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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Ophthalmic release of in situ gel Ciprofloxacin HCl based on combination of Hypromellose and HPC Yoga Windhu Wardhana; Wieke Budiati; Rizky Dwi Oktavia; Kalista Tritama Widyanti; Insan Sunan Kurniawansyah; Yedi Herdiana
Indonesian Journal of Pharmaceutics Vol 3, Issue 3, Sept - Dec 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i3.36140

Abstract

The development for ophthalmic delivery was purposed to achieve optimum drug loading for ocular therapeutic benefits. An adequate dose of the drug is needed to absorb in the conjunctival sac to take effect. In situ gel preparation was expected to provide these needs with the polymer aid that makes the droplets suddenly coagulate in the eye area to maintain the drug dose. The in situ gel dosage form is desired to overcome the poor bioavailability of conventional ciprofloxacin HCl eye drops on the market. Thus, this work was studied using two cellulose polymers such as hydroxyl propyl cellulose (HPC) and hydroxypropyl methylcellulose (HMPC) as a gelling forming agent.  The effect of the in situ ophthalmic quality of the gel due to the two individual polymers separately and their combined use was investigated. The in situ gel quality includes the ability of gel-forming under the influence of varying temperature and stirring frequency difference (as a rheological study) was tested together with the drug release model model. Other ophthalmic preparation quality parameters such as clarity, pH measurement, drug content determination, sterility, and antibacterial activity have been evaluated. However, overall in situ gel formulation developed was of better quality compared to the conventional one. Consideration of the choice of cellulose derivative polymer type is seen to affect the quality of controlled release kinetics models.Keywords: Ophthalmic gel, Ciprofloxacin HCl, HPMC, HPC, Drug release kinetics 
Dissolution Behaviours of Acetaminophen and Ibuprofen Tablet Influenced By L–HPC 21, 22, and Sodium Starch Glycolate as Disintegrant Yoga Windhu Wardhana; Dradjad Priambodo
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (970.759 KB) | DOI: 10.24198/idjp.v1i3.23508

Abstract

The dissolution of tablets is one of a drug absorption determinant. Disintegrant agent has play an important role on determining the dissolution of tablets. In this experiment, the dissolution behaviours of Acetaminophen and Ibuprofen Tablet was studied using various disintegrant agent such as Low substituted – Hydroxypropyl Cellulose (L–HPC) 21, L–HPC 22 and Sodium Starch Glycolate (SSG) as comparator. Those disintegrant agents were used at three concentration (6%, 7% and 8%) for every tablets formula. Tablets were made by wet granulation method and pressed using single punch 13 mm flat E. Korsch machine. Evaluation of each tablets quality were conducted include for uniformity of weight and size (diameter and thickness), hardness, friability, disintegration time and dissolution. Physically standards from tablets were in good condition, the standards of the weight and thickness uniformity, hardness and friability met the requirement. The dissolution profile on Acetaminophen Tablets showed that only tablet with 6 % L–HPC 21 did not meet the requirement of FI V (Q = 80%, 30 minutes), but on Ibuprofen Tablets where met the requirement of  FI V (Q = 80%, 60 minutes) only tablet with 8%  L– HPC 21,  7% and 8% SSG. The conclusion of the study was the L–HPC has more disintegrant character at hydrophilic active ingredients. Key words:  Acetaminophen Tablet, Ibuprofen Tablet, SSG, L-HPC 21 and 22, Dissolution Profile
Enhancement of Solubility BCS Class II and IV Pharmaceuticals by Liqusolid Technique: A review Dwi Retno Sari; Yoga Windhu Wardhana; Taofik Rusdiana
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.27297

Abstract

Many techniques can be used to improve drug solubility, which is the development of the liquisolid technique. This technique has a mechanism for increasing the surface area of the drug as well as wetting from the addition of non-volatile solvents resulting in a lower surface tension and contact angle, so the solubility and drug release very increases. Liquisolid tablets show a lower contact angle compared to the conventional tablets. The liquisolid technique approach is also promising because the process is simple in making low production costs and allows the manufacturing industry, including non-volatile solvents, fillers, dryers, and disintegrants. Liquisolid characterized by specific instruments such as powder x-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and scanning electron microscope (SEM). Several liquisolid techniques are described in this review. The liquisolid technique is proven and able to change the physicochemical properties of active pharmaceutical ingredients, especially the solubility, drug release, and stability of the formula so that this technique can be a solution for class II and IV BCS pharmaceutical active drug classes.Keywords: Active Pharmaceutical Ingredients, Contact Angle, Solubility, Drug Release, Stability, Liquisolid Technique
Phase Transitions Among of Valsartan Polymorphs due to Grinding and Humidity Variations Yoga Windhu Wardhana; Risanteni Riskasari; Fikri Alatas
Indonesian Journal of Pharmaceutics Vol 3, Issue 2, May - August, 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i2.35312

Abstract

Phase transition between drugs with polymorphisms needs attention due to unconscious changes in quality. Valsartan (VAL) is a drug model with polymorphic events to be studied here. Two polymorphic forms were obtained from recrystallization with various organic solvents such as acetonitrile and n-butyl acetate.  With untreated materials (from the market) were used as a comparison in this study. The phase transition of each polymorph was studied through grinding and humidity variations (RH 75% and 98%) treatment. The polymorph characterization was observed by microscope light polarization (PLM), Fourier Transform Infrared (FTIR), and Powdered X-ray Diffractometer (PXRD). The transition among polymorphic VAL was monitored by PXRD. There were significant differences in morphology, IR spectra, and diffractograms pattern. Found that the untreated VAL was amorphous, whereas the others were in high crystallinity. The polymorph form from n-butyl acetate was a metastable one that transformed easier into stable crystalline (from acetonitrile) than another polymorph.Keywords : Valsartan, Phase transition, Polymorphism, Recrystallization    
Modifications and Pharmaceutical Applications of Glucomannan as Novel Pharmaceutical Excipient in Indonesia: Review Article Nuur Aanisah; Yoga Windhu Wardhana; Anis Yohana Chaerunisa
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 2 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i2.56076

Abstract

Currently, Indonesia is excessively dependent on imported raw materials, such as pharmaceutical excipients. In this regard, the current pandemic should remind the critical nature of independence in purchasing raw resources to cope with future dynamics. One of the causes of dependence is the lack of raw materials management, specifically from biological sources abundantly available. A significant advantage is directed towards natural excipients because large quantities of more affordable plants ensure sustained availability in nature. Therefore, this study highlighted the possibility of using excipients derived from natural resources that are commonly used yet underutilized in Indonesia, such as glucomannan (GM). Indonesia has the potential to produce GM, considering the high natural resources as its source. However, it has not been applied extensively in pharmaceutical preparations due to diverse uses in several countries' drug, food, and cosmetic industries. This study aimed to discuss the modifications of GM and their use as pharmaceutical excipients with better physical properties. Additionally, the potential of melinjo seeds that have not been widely used was also analyzed. Melinjo seeds can be used as a source of GM due to their fairly large polysaccharide of about 64.11%. This issue will promote national autonomy in developing novel pharmaceutical excipients derived from natural resources that are highly economical and innovative.
REVIEW ARTIKEL: KANDUNGAN METABOLIT SEKUNDER TANAMAN BUNGA TELANG (Clitoria ternatea L.) SEBAGAI TERAPI DIABETES Rachmah, Sinta Aulia; Wardhana, Yoga Windhu
Farmaka Vol 20, No 2 (2022): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i2.34335

Abstract

Diabetes merupakan penyakit tidak menular yang memiliki prevalensi tinggi di seluruh dunia. Indonesia termasuk salah satu negara dengan prevalensi tinggi, yaitu 8,5% pada tahun 2018. Terdapat beberapa cara untuk menanggulangi diabetes, salah satunya penggunaan obat herbal tanaman bunga telang atau Clitoria ternatea. Adapun artikel ini ditujukan untuk mengumpulkan informasi mengenai senyawa metabolit sekunder yang berkontribusi dalam aktivitas antidiabetes Clitoria ternatea. Senyawa fenolik, flavonoid, dan antosianin bertanggung jawab sebagai agen antidiabetes pada bunga telang.Kata Kunci: diabetes, bunga telang, Clitoria ternatea, metabolit sekunder
Pengukuran Nilai Pertukaran Udara pada Sistem Air Handling Unit untuk Pemeriksaan Pra-kualifikasi di Industri Farmasi Azzahra, Salwa Putri; Wardhana, Yoga Windhu
Farmaka Vol 22, No 2 (2024): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i2.53550

Abstract

Dalam menjamin proses produksinya telah sesuai dengan persyaratan pada pedoman Cara Pembuatan Obat yang Baik (CPOB), maka industri farmasi perlu melakukan kualifikasi terhadap sarana penunjang seperti sistem tata udara agar tercapainya ruang bersih. Sebelum kualifikasi dilakukan perlu mempelajari kelayakan sistem melalui pra-kualifikasi. Hasil dari pra-kualifikasi berupa nilai pertukaran udara Air Handling Unit (AHU) untuk memastikan bahwa seluruh AHU beroperasi dengan baik. Metode pra-kualifikasi dilakukan dengan mengukur kecepatan udara pada seluruh Supply Air Grill di gedung produksi sebanyak 2 siklus menggunakan alat anemometer yang sudah terkalibrasi dan data diolah menjadi nilai pertukaran udara. Hasil pemeriksaan dari salah satu industry farmasi menunjukkan bahwa hampir seluruh ruang produksi kelas E memenuhi spesifikasi, kecuali pada 7 ruangan yang tidak memenuhi spesifikasi pertukaran udara yaitu ruang AL3, ALS5, ALS11, ALS12, ALS17, S8, dan S9 dengan nilai pertukaran udara berada pada nilai <6 kali/jam. Faktor-faktor yang mempengaruhi ketidaksesuaian pertukaran udara diantaranya pemilihan filter yang digunakan, pengaturan damper, tekanan ruangan, prosedur pengujian yang kurang tepat dan kondisi alat ukur. Agar ketujuh ruangan memenuhi persyaratan diperlukan perbaikan terlebih dahulu pada sistem AHU, sehingga rentang spesifikasi pertukaran udara sesuai persyaratan CPOB.
PENGUJIAN KEMAMPUAN PRODUK TABIR SURYA MEMPERTAHANKAN KELEMBAPAN KULIT PADA WANITA Salsabila, Esa Balqis; Wardhana, Yoga Windhu
Farmaka Vol 22, No 1 (2024): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i1.53655

Abstract

Kulit yang lembap dan sehat adalah kunci untuk penampilan yang segar dan awet muda. Sayangnya, sinar matahari bisa mengeringkan kulit dan membuatnya tampak kusam. Tabir surya merupakan produk penting untuk melindungi kulit dari kerusakan akibat sinar matahari. tetapi beberapa tabir surya dapat menyebabkan kulit menjadi kering. Studi ini bertujuan untuk menilai kemampuan salah satu produk tabir surya dalam mempertahankan kadar kelembapan kulit pada subjek wanita. Studi ini melibatkan 21 subjek wanita berusia 21-33 tahun dengan jenis kulit normal. Kelompok uji terdiri dari kelompok kontrol dan kelompok sampel pada masing-masing subjek. Subjek diukur kadar kelembaban kulit secara triplo sebelum dan setelah aplikasi produk tabir surya dengan periode pengamatan meliputi t0 (sebelum aplikasi), t15m (setelah 15 menit), t2j (setelah 2 jam), t3j(Setelah 3 jam) dan t5j (setelah 5 jam) menggunakan corneometer CM 825. Kadar kelembapan kulit pada kelompok kontrol pada t15m, t2j, t3j, dan t5j berturut-turut mengalami penurunan dibandingkan t0 yaitu 6,2%, 0,4%, 1,1%, dan 1,1%. Hasil uji ANOVA menunjukan p>0,05 yang berarti tidak terdapat perbedaan kadar kelembapan yang signifikan. Kadar kelembapan kulit pada kelompok sampel mengalami peningkatan dengan dibandingkan t0 yaitu pada t15m, t2j, t3j, dan t5j berturut-turut meningkat sebesar 77,14%, 60,75%,58%, 48%. Hasil uji ANOVA menunjukkan nilai p<0,05 yang berarti terdapat perbedaan kadar kelembapan kulit yang signifikan pada kulit yang diberi tabir surya. Kadar kelembapan mulai menurun setelah 2 jam namun penurunan yang terjadi tidak signifikan dibandingkan dengan t15m (p=0.948). Dapat disimpulkan bahwa tabir surya tersebut mampu mempertahankan kelembapan kulit hingga 5 jam.Kata kunci: kulit, tabir surya, kelembapan, kadar.
Pengujian Kelembapan Produk Pelembap “X” Menggunakan Metode Konduktansi Listrik Dengan Instrumentasi Corneometer CM 825 Rizaldi, Fiqri Taufiq; Wardhana, Yoga Windhu
Majalah Farmasetika Vol 9, No 3 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v9i3.53249

Abstract

Produk pelembap bibir digunakan sehari-hari untuk melindungi serta menjaga kelembapan bibir mulai dari sinar matahari, cuaca buruk hingga suhu ruangan dingin. Sebagai sebuah produk kosmetika pelembap bibir memiliki klaim yang bervariatif, termasuk kemampuan menjaga tingkat hidrasi yang dapat menjadi nilai jual suatu produk. Sebuah metode uji diperlukan untuk mengetahui pengukuran dari perubahan tingkat hidrasi secara signifikan, sehingga dapat menjadi pertimbangan penggunaan produk pelembap salah satunya pelembap bibir. Saat ini tersedia berbagai metode pengukuran tingkat hidrasi dengan berbagai tingkat akurasi serta luaran dari pengujian. Corneometer CM 825 dianggap memiliki tingkat akurasi yang baik karena dapat mengukur secara spesifik pada stratum corneum serta menjadi standar pengujian hidrasi hingga saat ini dibandingkan dengan metode pengukuran lain di pasaran. Pada pengujian kali ini ditujukan untuk mengetahui tingkat hidrasi dari pengaplikasian produk pelembap bibir “X” dengan menggunakan instrumentasi Corneometer CM 825 yang memanfaatkan konduktansi listrik. Dilakukan pengujian produk yang diaplikasikan pada bibir kemudian diamati mulai dari sebelum pemakaian (T0), 15 menit (T15M), 2 jam (T2H), 3 jam(T3H) hingga 5 jam (T5H) setelah pengaplikasian yang dilakukan dengan desain single blind study pada 21 orang subjek wanita rentang usia 21-33 tahun. Digunakan metode statistik One Way Anova dengan tingkat kepercayaan hingga 95%, hasil penelitian menunjukan P<0,05 yang menandakan bahwa secara signifikan pengaplikasian produk pelembap bibir “X” mampu menahan kelembapan bibir hingga 5 jam yang dibandingkan dengan sebelum pemakaian (T0).
Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. Bestari, Muhammad Begawan; Rohmawaty, Enny; Rosdianto, Aziiz Mardanarian; Usman, Hermin A.; Saragih, Winda A. M.; Zuhrotun, Ade; Hendriani, Rini; Wardhana, Yoga Windhu; Ekawardhani, Savira; Wiraswati, Hesti Lina; Agustanti, Nenny; Dewi, Sumartini; Wijaya, Muhammad Palar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023206

Abstract

Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect.Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels.Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels.Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions.
Co-Authors Ade Zuhrotun Aliya Nur Hasanah Anis Khoerunisa Anis Khoerunisa, Anis Anis Yohana Chaerunisa Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa, Anis Yohana Azzahra, Salwa Putri Defertha Ayudia Paramita Dewi, Sumartini DOLIH GOZALI Dradjad Priambodo Dwi Retno Sari Enny Rohmawaty Fajra Dinda Crendhuty Fikri Alatas Ghozali, Dolih HAMMAM HAFIDZURAHMAN SYAHIDAN Hazrina, Aghnia Hesti Lina Wiraswati Hestiary Ratih Insan Sunan Kurniawansyah, Insan Sunan Kalista Tritama Widyanti Kautsar, Angga P. Kurniawan Syah, Insan Sunan M. Ramadhan Saputro Maria Elvina Tresia Butar-Butar Muhaimin Muhaimin Muhammad Begawan Bestari Nasrul Wathoni Nenny Agustanti Nuur Aanisah Patihul Husni Pitriani Priskila O Dwiestri Priskila O Dwiestri, Priskila O Rachmah, Sinta Aulia Rahadianti Khofii Suwanditya Rini Hendriani Risanteni Riskasari Rizaldi, Fiqri Taufiq Rizky Dwi Oktavia Rosdianto, Aziiz Mardanarian Salsabila, Esa Balqis Saragih, Winda A. M. Savira Ekawardhani SHEILA FRIZQIA JELITA Shofa Shofa Shofa Shofa, Shofa Sri Adi Sumiwi Sriwidodo B Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Sudirman Sudirman Taofik Rusdiana Usman, Hermin A. Wieke Budiati Wijaya, Muhammad Palar Wisnu A. Adi Yedi Herdiana