Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Jurnal Veteriner

Aktivitas Hipolipidemik dan Indeks Aterogenik yang Rendah Ekstrak Air Daun Tapak Dara pada Tikus Hiperkolesterolemia (HYPOLIPIDEMIC ACTIVITY AND LOW ATHEROGENIC INDEX OF AQUEOUS LEAF EXTRACTS OF CATHARANTHUS ROSEUS IN HYPERCHOLESTEROLEMIC RATS) I Nyoman Suarsana; Iwan Harjono Utama; I Made Kardena; I Gusti Ayu Agung Suartini; Ni Luh Watiniasih
Jurnal Veteriner Vol 16 No 4 (2015)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.36 KB)

Abstract

Catharanthus roseus is one plant recognized as medical potential which can decrease cholesterol. Thepresent study was carried out to evaluate the effect of aqueous leaf extracts of C. roseus on plasma lipidprofil levels in rats cholesterol rich diet and atherogenic index. This study was carried out on 15 SpraqueDawley male rats randomly distributed into five groups (n=3). Rats hypercholesterolemic wereadministrated cholesterol rich diet containing 1% (w/w). Normal control group with normal diet whitoutextracts (K1), positive control hypercholesterolemic group (K2) with cholesterol rich diet whitout extracts,and others three groups (K3-K5) were feed high cholesterol and 1 mL of aqueous leaf extracts of C. roseuswith a dose of 20% (w/v), 40% (w/v) and 80% (w/v) respectively, administered twice daily 1 mL orally.Treatment was given for 28 days. After treatment, the plasma lipids profile such cholesterol total, highdensity lipoprotein (HDL), low density lipoprotein (LDL), triglyceride (TGA) level were measured. Theresults showed that during the period of treatment with cholesterol rich diet have produced under condition hypercholesterolemic of rats with average cholesterol levels of 124.33 ± 4.04 mg/dL (K2 group). Treatmentwith extract dose of 80% showed the best results among the other doses in reducing levels of total cholesterol,triglycerides, LDL and raise HDL levels. Extract treatment dose of 80% up to four weeks resulted incholesterol total (79.33±3.51 mg/dL), TGA (72.33±6.65 mg/dL), HDL (55.00±3.60 mg/dL), and LDL(9.87±5.34mg/dL). In addition, value ratio of cholesterol:HDL was 1.4: 1 and atherogenic index value was0.44. These results suggest that extracts of leaf C. roseus optimum doses 80% (w/v) has hipolipidemicactivity in hypercholesterolemic rats and it has low atherogenic index value.
Co-Authors Abdi Jana Guna Agnevia, Rizkita Dimar Agung Mahayoni Aksari Akbar Akbar Aksari, Agung Mahayoni Alfi Hermawati Waskita Sari Anak Agung Gde Raka Dalem Anak Agung Sagung Alit Sukmaningsih Ari Isnen Sobari Arie Setiadi Moerwanto Arliza Cynthia Razali Ayu Putu Wiweka Krisna Dewi Ayu Saka Laksmita W Ayu Wulan Trisna Aziz, Alifya Ibnu Beny Mustofa Chandra Yowani Dahlia Sandewi Deny Suhermawan Yusup Dewa Adi Putra Dewa Ayu Angga Pebriani Dhira Alfiah R. Pettalolo Dwikasari, Ida Ayu Indira ENIEK KRISWIYANTI Eyang Sriyani Toineno Fathur Rochman Felicia Augustine Florentina Gultom FX. Sudaryanto Husnayaen Husnayaen I Gede Hendrawan I Gusti Agung Ayu Suartini I Gusti Ayu Putu Intan Udayani I Gusti Ngurah Kade Mahardika I K. Putra Juliantara I Kadek Teguh Indra Dewantara I Ketut Ginantra I Ketut Junitha I KETUT MUKSIN I Komang Andika Putra I Made Gatot Wija Damara I Made Kardena I Made Merdana I Nengah Nuyana I Nyoman Suarsana I Nyoman Suartha I Putu Candra Noviarta I Putu Gede Bayu Ade Wianta I PUTU NARKA EKA PRATAMA I W BUDIARSA SUYASA I Wayan Arthana I Wayan Arthana I Wayan Kasa I Wayan Suardana I. G. A. PRADANA PUTRA Ida Bagus Made Suaskara Iwan Harjono Utama Juan Aldo Jaya Pradipta Sitepu Julian Tambunan Juniartini, Nyoman Sweet Kadek Bayu Prabha Mahesswara Kadek Wiwik Widaswari Kartika, I Wayan Darya Komang Gede Wahyu Saputra Kompyang Bagus Suyoga LUH Puru ESWARYANTI KUSUMA YUNI M Windhu Made Ayu Pratiwi MADE PHARMAWATI Mahendra Duwi Astutik Mufadilatur Rohmah Mutiara Yuliana Dewi Ni Gusti Made Yuliari Ni Kadek Febri Yanti Ni Ketut Suwiti Ni Luh Putu Ria Puspitha ni luh wayan hanny prabandari Ni Made Ernawati, Ni Made Ni Made Sekarmini Ni Made Suartini Ni Pande Putu Suji Dian Antari Ni Putu Adriani Astiti Ni Putu Dian Pertiwi Ni Putu Kiki Mahayuni Ni Putu Putri Wijayanti Ni Putu Sintha Maharani Ni Putu Sri Ayuni Ni Wayan Sudatri Niko Susanto Putra Odjastira Vidyastari Pramurdya, Yesika Nanda Putu Ade Hinduari Putra Putu Angga Wiradana Putu Ayu Parwati Putu Ayu Wiwin Vitrayanthi Putu Frissa Anasthasya Widhiandari Putu Laksmi Candra Dewi Resti Ayu NengTias Retno Kawuri Reza Yunita Sari Romlah Setiawati Roni Adi Samba Sari, Alfi Herawati Waskita Suprabadevi Ayumayasari Saraswati Suprabadevi Ayumayasari Saraswati WIDIASTUTI - Widiastuti Widiastuti Yesi Breanita Yulia Kartika