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All Journal Biomedical Journal of Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kreativitas PKM SRIWIJAYA JOURNAL OF MEDICINE Jurnal Biomedika dan Kesehatan Jurnal Pengabdian Masyarakat: Humanity and Medicine Journal of Community Development AKM: Aksi Kepada Masyarakat International Journal of Islamic and Complementary Medicine Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Denta: Jurnal Kedokteran Gigi Prominentia Medical Journal Science and Technology: Jurnal Pengabdian Masyarakat Journal of Medicine and Health
Syarinta Adenina
Departement Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Prominentia Medical Journal

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Efek Polimorfisme Terhadap Kerentanan dan Tatalaksana Tuberkulosis Paru Rusdi, M.; Adenina, Syarinta
Bahasa Indonesia Vol 5 No 2 (2024): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v5i2.4776

Abstract

Pulmonary tuberculosis (TB) remains the second leading cause of death from a single infectious agent. The number of people with pulmonary TB in the world still increased, and TB treatment success percentage in Indonesia has not reached the target until now. Genetic polymorphisms are defined as DNA variations seen in ≥1% of the population. The study of genetic polymorphisms can help identify disease risk, predict drug efficacy and safety, and determine the right chemotherapeutic agent with a dose that suits each patient. Various genetic polymorphisms associated with pulmonary TB susceptibility have been found, including polymorphisms of the NRAMP1, HLA-DRB1, vitamin D receptor, TNF-α, and IFN-γ genes. In addition, several genetic polymorphisms associated with TB treatment were also found, such as SLCO1B1, NAT2, SLC2A9, and ABCB1 genes. Detection of genetic polymorphisms in each individual can help predicts TB risk and improve TB treatment success and reduce side effects that may occur due to TB treatment.
MOMORDICA CHARANTIA L. (PARE) SEBAGAI AGEN HIPOGLIKEMIK DALAM MANAJEMEN DIABETES MELITUS TIPE 2 William, Jessica Audrey; Ananta, Vito; Adiputra, Ricky Fajar; Adenina, Syarinta
Bahasa Indonesia Vol 6 No 1 (2025): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v6i1.5489

Abstract

Background: Diabetes Mellitus is a condition characterized by consistently high blood glucose levels due to a chronic metabolic disorder. Type 2 diabetes mellitus accounts for 90% of all cases. According to the 10th edition of the International Diabetes Federation report, Indonesia ranks fifth in the world for the number of type 2 diabetes patients, with 19.5 million affected individuals. Efforts to address the rise in type 2 diabetes cases require effective management to maintain normal blood glucose levels. Currently, oral hypoglycemic drugs are the preferred treatment for type 2 diabetes. However, potential side effects can raise concerns among patients. As a result, alternative approaches, such as herbal therapy, may help reduce the prevalence of type 2 diabetes. Momordica charantia L. is known for its hypoglycemic properties. Methods: The literature search is conducted in PubMed, ScienceDirect, and ClinicalKey databases. The articles used were those published in the last 10 years, and the keywords included "type 2 diabetes," "Momordica charantia L.," "bitter melon," and "blood glucose." Results: Momordica charantia L. contains many compounds with antidiabetic properties. These compounds include polysaccharides, peptides, terpenoids, saponins, alkaloids, flavonoids, and others. Momordica charantia L. contains the insulin-mimetic compound mclRBP-19, which is associated with a decrease in FBG and HbA1c levels. Triterpenoids have been found to stimulate GLUT-4 translocation in muscle and fat cells, as well as inhibit PTP1B activity. Additionally, charantin is known to inhibit DPP4 activity. Conclusion: Momordica charantia L. has the potential to lower blood glucose levels in type 2 diabetes patients through its bioactive components.
Co-Authors Adnindya, Msy Rulan Adnindya, Msy. Alfajri, Fariz Ananta, Vito Andra Kurnianto Anggun H, Aisyah Ar Rahmat, Muhammad Firdzi Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Atik Diah Mutiara Ningsih Atika Akbari Aulia Rahma Isnaeni Ayeshah A Rosdah Azizah, Aida Nur Bantari Wisynu Kusuma Wardhani Bintang Arroyantri Prananjaya Damarizqa Dara Sjahruddin Debby Handayati Harahap Debby Handayati Harahap Desi Oktariana Dhanty Mukhsina Evi Lusiana Fatmawati, Fatmawati Ferizon, Ayla Fenezza Hanifah, Masayu Hanifah, Masayu Nabila Harahap, Debby Hasbi, Alfian Irinne Karina Putri Islami, Arya Putera Islamia, Medina Putri Jayawarsa, A.A. Ketut Joko Marwoto Julius Anzar Julius Anzar K, Trisnawaty Komar, Muhammad Hafidh Layal, Kamalia Liniyanti D. Oswari M Rusdi Maharani, Tasya Aulia Manawan, Efman E.U. Martha Mozartha Mitha Ramadea Moretta Damayanti Mudzakky, Muhammad Yusuf Muhammad, Fadhil Mutiara Budi Azhar Nanda Maharani Saqadifa Nasriyatul Hannak Nia Savitri Tamzil Nita Parisa Nita Parisa Nita Parisa Nurhaura, Nailah Nurul Yuli Permata Sari Oktariana, Desi pariyana, Pariyana Patwa Amani, Patwa Putri , Marsyadilla Putri Maharani Raffi Arrasyid, Muhammad Rafif Shidqi Rafli, Muhammad Ramadhani, Nadhira Tsurayya Ricky Fajar Adiputra Rizma Adlia Syakurah Rosdah, Ayesha Augusta Rosdah, Ayeshah Rulan Adnindya Sabrina, Nur Nabila Sadakata Sinulingga Salsabillah, Nadya Septi Purnamasari Siti Zahra Syahroni Sitohang, Nadiyah Safitri Sri Nita Sri Rahayu Ningsih Sutandar, Vivi Swanny Swanny Syarif Husin Syarif Husin Theodorus Theodorus Valyn Theodra Tantoro Veny Larasaty Vienna Dwinda Putri Wahono, Shafira Wardiansyah Wardiansyah William, Jessica Audrey Zakiyah Zakiyah Ziske Maritska