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All Journal Biomedical Journal of Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kreativitas PKM SRIWIJAYA JOURNAL OF MEDICINE Jurnal Biomedika dan Kesehatan Jurnal Pengabdian Masyarakat: Humanity and Medicine Journal of Community Development AKM: Aksi Kepada Masyarakat International Journal of Islamic and Complementary Medicine Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Denta: Jurnal Kedokteran Gigi Prominentia Medical Journal Science and Technology: Jurnal Pengabdian Masyarakat Journal of Medicine and Health
Syarinta Adenina
Departement Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Edukasi swamedikasi obat herbal yang rasional pada kelompok ibu rumah tangga di Kelurahan Karya Baru Rosdah, Ayeshah Augusta; Adenina, Masayu Syarinta; Parisa, Nita; Harahap, Debby Handayati; Lusiana, Evi; Fatmawati, Fatmawati
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V6I1.169

Abstract

Indonesian Health Survey reported that more than half of the population in South Sumatera utilizes herbal medicine to alleviate disease symptoms. The survey also indicated that factors such as lower-middle income levels and the female gender are relatively more likely to utilize medicinal plants compared to higher-income levels and the male gender. The findings from this health survey strongly support the characteristics of the target audience for this community service, specifically the residents of Karya Baru Village represented by the women in Majelis Taklim Al-Kahfi. Initial interviews with several members of this group revealed a tendency to self-treat sick family members, particularly using herbal remedies, as they are perceived to have no side effects compared to modern medications (synthetic drugs). These findings indicate a potential irrational use of herbal medicine in self-medication practices. Self-medication refers to the efforts made by individuals to determine treatments for their disease symptoms. For self-medication practices to be safe and effective, it is essential for the community to be equipped with adequate knowledge about the rational use of herbal medicines. Therefore, a community service initiative is necessary to enhance public knowledge regarding the types of herbal medicines and promote rational behaviors on self-medication practice of herbal medicines within the community.
MOMORDICA CHARANTIA L. (PARE) SEBAGAI AGEN HIPOGLIKEMIK DALAM MANAJEMEN DIABETES MELITUS TIPE 2 William, Jessica Audrey; Ananta, Vito; Adiputra, Ricky Fajar; Adenina, Syarinta
Bahasa Indonesia Vol 6 No 1 (2025): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v6i1.5489

Abstract

Background: Diabetes Mellitus is a condition characterized by consistently high blood glucose levels due to a chronic metabolic disorder. Type 2 diabetes mellitus accounts for 90% of all cases. According to the 10th edition of the International Diabetes Federation report, Indonesia ranks fifth in the world for the number of type 2 diabetes patients, with 19.5 million affected individuals. Efforts to address the rise in type 2 diabetes cases require effective management to maintain normal blood glucose levels. Currently, oral hypoglycemic drugs are the preferred treatment for type 2 diabetes. However, potential side effects can raise concerns among patients. As a result, alternative approaches, such as herbal therapy, may help reduce the prevalence of type 2 diabetes. Momordica charantia L. is known for its hypoglycemic properties. Methods: The literature search is conducted in PubMed, ScienceDirect, and ClinicalKey databases. The articles used were those published in the last 10 years, and the keywords included "type 2 diabetes," "Momordica charantia L.," "bitter melon," and "blood glucose." Results: Momordica charantia L. contains many compounds with antidiabetic properties. These compounds include polysaccharides, peptides, terpenoids, saponins, alkaloids, flavonoids, and others. Momordica charantia L. contains the insulin-mimetic compound mclRBP-19, which is associated with a decrease in FBG and HbA1c levels. Triterpenoids have been found to stimulate GLUT-4 translocation in muscle and fat cells, as well as inhibit PTP1B activity. Additionally, charantin is known to inhibit DPP4 activity. Conclusion: Momordica charantia L. has the potential to lower blood glucose levels in type 2 diabetes patients through its bioactive components.
Salbutamol Usage Pattern in Asthma Patients at Merdeka Public Health Center Palembang for the Period of January 1 – December 31, 2023 Mudzakky, Muhammad Yusuf; Adenina, Syarinta; Harahap, Debby Handayati
Sriwijaya Journal of Medicine Vol. 8 No. 1 (2025): Vol 8, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i1.305

Abstract

Salbutamol is a bronchodilator commonly used in the management of asthma, both in acute and chronic cases. As part of the Short-Acting Beta-2 Agonist (SABA) class, salbutamol is effective in relieving bronchospasms. The purpose of this study was to determine the rationality of drug use at the Merdeka Community Health Center Palembang. A drug utilization study was conducted at Merdeka Public Health Center Palembang in 2024. 96 patients meeting inclusion criteria. Drug use patterns were evaluated for dose rationalization, duration, frequency, contraindications, and interactions. Data analysis was performed using univariate methods. Sociodemographic characteristics showed that women were more prevalent than men (58.3%), with the most common age groups being pre-elderly and elderly (each 36.5%). All salbutamol doses (2–4 mg per administration) were appropriate (100%), with a duration of ≤3 days for all patients. The frequency of salbutamol administration of 3–4 times daily was found in 51% of cases, in line with recommendations. A total of 74% of patients received salbutamol with appropriate consideration of contraindications, while 26% received it despite contraindications, such as hypertension or hypertensive heart disease. Drug interactions were absent in 67.7% of cases, while antagonistic interactions, primarily with amlodipine, occurred in 17.3% of cases. The use of salbutamol at Merdeka Public Health Center Palembang mostly rational to drug use guidelines. However, attention is needed for contraindications and antagonistic interactions, especially with antihypertensive drugs. These findings can serve as a reference for improving asthma management and patient safety.
Efektifitas Ekstrak Daun Sirsak (Annona muricata L) Dalam Terapi Kanker Payudara Pada Jalur Apoptosis Ramadhani, Nadhira Tsurayya; Maharani, Putri; Wahono, Shafira; Maharani, Tasya Aulia; Adenina, Masayu Syarinta
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.79-86

Abstract

Breast cancer is one of the leading causes of cancer-related mortality in Indonesia. The number of new breast cancer cases has reached 68,858 cases (16.6%) out of a total of 396,914 new cancer cases. Conventional approaches to cancer therapy include surgery, radiation, and chemotherapy. However, these treatments are often expensive and associated with significant side effects. As a result, various preventive and therapeutic efforts have been developed, including the use of herbal plants with potential anticancer properties such as Annona muricata L. Therefore, a more in-depth review of this compound is needed. This article is based on data retrieved from databases such as PubMed, ScienceDirect, ClinicalKey, and Google Scholar using the keywords: “Annona muricata L.”, “breast cancer”, “acetogenin”, “apoptosis”, and “oxidative stress”. Articles in English or Indonesian within the last 10 years were included. The literature review revealed that Annona muricata L. contains active compounds, primarily acetogenins, which exhibit cytotoxic activity through the induction of apoptosis. Acetogenins act by inhibiting mitochondrial complex I (NADH dehydrogenase), resulting in decreased adenosine triphosphate (ATP) production, energy stress, and subsequently, apoptosis induction. In addition, acetogenins affect the intrinsic apoptotic pathway by downregulating anti-apoptotic proteins such as Bcl-2 and Bcl-xL, while upregulating p53 gene expression, which plays a key role in activating the extrinsic apoptosis pathway. Another mechanism is its ability to reduce oxidative stress by enhancing the activity of antioxidant enzymes, thereby protecting normal cells from free radical-induced damage. However, to date, studies of Annona muricata L. as an adjuvant therapy for breast cancer remain limited—especially regarding its long-term use and effects on normal cells. Therefore, Annona muricata L. holds potential as an adjunct therapy in the treatment of breast cancer. Further research is needed to determine the appropriate dosage, long-term effectiveness, and potential side effects, particularly in breast cancer patients.
Comparative Histopathological Effects of Several Non-Selective NSAIDs on Gastric Mucosa in Wistar Rats Adenina, Syarinta; Amani, Patwa; Layal, Kamalia
Journal of Medicine and Health Vol 7 No 2 (2025)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v7i2.9540

Abstract

Non-selective NSAIDs are widely used for their anti-inflammatory effects. However, their use is limited by significant gastrointestinal side effects. Little is known about which NSAIDs cause more damage to the gastrointestinal. This study aims to compare the mucosal damage induced by various non-selective NSAIDs. Adult male Wistar rats were divided into six groups and administered different NSAIDs: mefenamic acid, diclofenac sodium, piroxicam, ibuprofen, aspirin, and a control group with distilled water. After five days of treatment, the rats were sacrificed, and their gastric tissues were examined both macroscopically and microscopically for signs of damage, including hemorrhagic injury, mucosal edema, epithelial cell loss, and inflammatory cell infiltration. All NSAID-treated groups exhibited significant gastric damage compared to the control group. Diclofenac sodium and piroxicam groups showed the most pronounced hemorrhagic injury, while piroxicam induced the most severe mucosal edema. Ibuprofen caused the highest level of inflammatory cell infiltration. Aspirin resulted in the least gastric histopathological damage score among the tested drugs. Among the tested NSAIDs, aspirin exhibited the least histopathological damage, suggesting a lower risk of gastric injury in this model
Profile of Nutritional Status Based on Chemotherapy Regimen and Cycle in Colorectal Cancer Patients at Dr. Mohammad Hoesin Hospital Palembang Muhammad, Fadhil; Manawan, Efman E.U.; Kurniati, Ardesy Melizah; Komar, Muhammad Hafidh; Lusiana, Evi; Adenina, Syarinta
Sriwijaya Journal of Medicine Vol. 8 No. 2 (2025): Vol 8, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i2.228

Abstract

A cancerous growth that develops from the colon's or rectum's epithelial tissue is called colorectal cancer.  Chemotherapy is one of the interdisciplinary approaches used to treat colorectal cancer.  Chemotherapy is administered in cycles of one to eight.  One of the many adverse consequences of chemotherapy is a decline in nutritional status.  In this study, colon cancer patients receiving chemotherapy at Dr. Mohammad Hoesin Hospital Palembang will have their nutritional status described using BMI.  It was a descriptive investigation. The most recent medical records of colorectal cancer patients who visited Dr. Mohammad Hoesin Hospital Palembang for chemotherapy were used to gather data. Of the 44 patients, the majority were equally male and female (50%), middle-aged (52.3%), had colon cancer (50%), were in stage IV (75%), had undergone chemotherapy cycle 2 (34.1%), were on the FOLFOX 6 regimen (27.3%), and were well-nourished (50%). The majority of the study's patients were normoweight individuals, undergoing chemotherapy cycle 2, and were on the FOLFOX 6 regimen.
Deteksi Dini Penyakit Asam Urat dan Inovasi Pembuatan Teh Dari Tanaman Obat Keluarga untuk Mengatasi Penyakit Asam Urat Pada Guru dan Tendik SDN 149 Palembang Adenina, Syarinta; Adnindya, Msy.; Harahap, Debby; Sutandar, Vivi; Parisa, Nita; Rosdah, Ayeshah; Hasbi, Alfian; Hanifah, Masayu; Nurhaura, Nailah; Putri , Marsyadilla
Journal of Community Development Vol. 6 No. 2 (2025): Desember
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v6i2.1809

Abstract

Kadar asam urat yang tinggi merupakan salah satu masalah kesehatan yang sering terjadi pada usia produktif, termasuk guru dan tenaga kependidikan (tendik) dengan beban kerja tinggi dan aktivitas fisik rendah. Deteksi dini diperlukan untuk mencegah komplikasi metabolik. Selain itu, edukasi mengenai pemanfaatan Tanaman Obat Keluarga (TOGA) melalui inovasi teh herbal, dapat menjadi alternatif pengelolaan mandiri asam urat. Kegiatan pengabdian masyarakat ini bertujuan untuk melakukan skrining kadar asam urat dan tekanan darah pada guru dan tendik SDN 149 Palembang, serta memperkenalkan teh herbal dari TOGA. Metode pelaksanaan program dilakukan dengan pendekatan partisipatif yang mengedepankan keterlibatan aktif warga sekolah sejak perencanaan, pelaksanaan, hingga evaluasi kegiatan sebagai subjek utama dalam proses pembelajaran. Program meliputi penyuluhan, demonstrasi pembuatan teh herbal, pemeriksaan kesehatan, dan penyerahan bibit TOGA. Hasil menunjukkan rerata usia peserta 47,9 tahun. Hasil evaluasi pre dan posttest penyuluhan menunjukkan pengetahuan peserta meningkat signifikan setelah edukasi. Hasil skrining menunjukkan sebanyak 68,7% memiliki kadar asam urat tinggi, sedangkan tekanan darah terbagi menjadi 15,6% normal, 31,3% prahipertensi, 31,3% hipertensi derajat 1, dan 21,8% hipertensi derajat 2. Kegiatan ini terbukti efektif dalam meningkatkan pemahaman mengenai pencegahan hiperurisemia berbasis TOGA. Pembagian bibit TOGA diharapkan menjadi langkah berkelanjutan untuk mendukung gaya hidup di lingkungan sekolah.
Physical Characterization of Micro-Porosity in Decellularized Gambier Leaf for Potential Use as a Plant-Based Scaffold Adenina, Syarinta; Ar Rahmat, Muhammad Firdzi; Mozartha, Martha; K, Trisnawaty; Tamzil, Nia Savitri; Adnindya, Msy Rulan; Hanifah, Masayu Nabila; Alfajri, Fariz
Denta Journal Kedokteran Gigi Vol 20 No 1 (2026): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v20i1.5

Abstract

Background: Scaffolds represent biomaterials designed to provide structural support for cellular adhesion and growth factor sequestration, emulating the extracellular matrix (ECM) to promote tissue regeneration. Plant-based tissues have garnered attention as viable scaffold alternatives owing to their architectural homology with human extracellular structures. Gambier leaves (Uncaria gambir) stand out for their inherent porous, trabecular morphology, where microporosity is pivotal in facilitating cell attachment, proliferation, and differentiation. Objective: This study aims to elucidate the microporous characteristics of decellularized gambier leaves via scanning electron microscopy (SEM). Method: Fresh leaves were meticulously cleaned, cryopreserved at −20°C, and fashioned into five circular discs employing a biopsy punch. Decellularization entailed submersion in 10% sodium dodecyl sulfate (SDS) for five days, succeeded by distilled water lavage. Subsequent cyclic treatment with Tween-20 and NaClO solutions, applied every 24 hours, continued until optical translucency was achieved. Processed tissues underwent thorough washing, overnight fixation, serial ethanol dehydration, hexamethyldisilazane (HMDS) treatment, 50 nm gold sputter-coating, and SEM evaluation across three magnifications. Results: Microscopy revealed surface wrinkling and partial architectural collapse in multiple specimens, likely due to dehydration-induced artifacts. Conversely, a single intact sample exhibited pronounced microporosity, as evidenced by pore diameters of 0.689 µm and 0.5512 µm. Conclusion: These observations affirm the microporous potential of decellularized gambier leaves for cellular anchorage and nutrient permeation, bolstering their candidacy as plant-derived scaffolds in tissue engineering. Nonetheless, inter-sample variability underscores the need for refined decellularization/dehydration methods and expanded quantitative assessments to ensure reproducible structural integrity.
Deteksi dini kanker payudara dengan pemeriksaan sadari dan pemanfaatan tanaman obat keluarga Adenina, Syarinta; Adnindya, Rulan; Tamzil, Nia Savitri; F, Angun Kurnia; Fadillah, Saniyyah Nur; Malikha, Amira; Renaldy, Melvin; Malikan, Mohammad Edgar; Endratamma, Muhammad Ayun; Medina, Athira; Aprilio, Muhammad Kevin
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 7 No 1 (2026): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V7I1.227

Abstract

The high incidence of breast cancer remains a significant public health problem in Indonesia. Breast cancer management is challenging because the disease is generally detected at an advanced stage. In fact, breast self-examination (BSE) is a simple and inexpensive method for the early detection of breast cancer. Early detection and management of breast cancer are expected to reduce mortality rates associated with the disease. A preliminary survey revealed that nearly all members of the FKMT Sukarami women’s study group were unaware of breast self-examination and the use of family medicinal plants (ginger) for breast cancer prevention. Based on these findings, this community service activity aimed to enhance public knowledge and skills in performing breast self-examination and utilizing family medicinal plants. The activities included lectures, discussions, and demonstrations. Evaluation was carried out by measuring knowledge levels before and after the program. The analysis showed an increase in knowledge regarding breast cancer, breast self-examination, and the use of family medicinal plants (ginger) following the educational session.
Co-Authors Adnindya, Msy Rulan Adnindya, Msy. Adnindya, Rulan Alfajri, Fariz Ananta, Vito Andra Kurnianto Anggun H, Aisyah Aprilio, Muhammad Kevin Ar Rahmat, Muhammad Firdzi Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Atik Diah Mutiara Ningsih Atika Akbari Aulia Rahma Isnaeni Ayeshah A Rosdah Azizah, Aida Nur Bantari Wisynu Kusuma Wardhani Bintang Arroyantri Prananjaya Damarizqa Dara Sjahruddin Debby Handayati Harahap Debby Handayati Harahap Desi Oktariana Dhanty Mukhsina Endratamma, Muhammad Ayun Evi Lusiana F, Angun Kurnia Fadillah, Saniyyah Nur Fatmawati, Fatmawati Ferizon, Ayla Fenezza Hanifah, Masayu Hanifah, Masayu Nabila Harahap, Debby Hasbi, Alfian Irinne Karina Putri Islami, Arya Putera Islamia, Medina Putri Jayawarsa, A.A. Ketut Joko Marwoto Julius Anzar Julius Anzar K, Trisnawaty Komar, Muhammad Hafidh Layal, Kamalia Liniyanti D. Oswari M Rusdi Maharani, Tasya Aulia Malikan, Mohammad Edgar Malikha, Amira Manawan, Efman E.U. Martha Mozartha Medina, Athira Mitha Ramadea Moretta Damayanti Mudzakky, Muhammad Yusuf Muhammad, Fadhil Mutiara Budi Azhar Nanda Maharani Saqadifa Nasriyatul Hannak Nia Savitri Tamzil Nita Parisa Nita Parisa Nita Parisa Nurhaura, Nailah Nurul Yuli Permata Sari Oktariana, Desi pariyana, Pariyana Patwa Amani, Patwa Putri , Marsyadilla Putri Maharani Raffi Arrasyid, Muhammad Rafif Shidqi Rafli, Muhammad Ramadhani, Nadhira Tsurayya Renaldy, Melvin Ricky Fajar Adiputra Rizma Adlia Syakurah Rosdah, Ayesha Augusta Rosdah, Ayeshah Rulan Adnindya Sabrina, Nur Nabila Sadakata Sinulingga Salsabillah, Nadya Septi Purnamasari Siti Zahra Syahroni Sitohang, Nadiyah Safitri Sri Nita Sri Rahayu Ningsih Sutandar, Vivi Swanny Swanny Syarif Husin Syarif Husin Theodorus Theodorus Valyn Theodra Tantoro Veny Larasaty Vienna Dwinda Putri Wahono, Shafira Wardiansyah Wardiansyah William, Jessica Audrey Zakiyah Zakiyah Ziske Maritska