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All Journal Biomedical Journal of Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kreativitas PKM SRIWIJAYA JOURNAL OF MEDICINE Jurnal Biomedika dan Kesehatan Majalah Kesehatan Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine Journal of Community Development Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) AKM: Aksi Kepada Masyarakat International Journal of Islamic and Complementary Medicine Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Denta: Jurnal Kedokteran Gigi Prominentia Medical Journal Science and Technology: Jurnal Pengabdian Masyarakat Journal of Medicine and Health
Syarinta Adenina
Departement Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
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Salbutamol Usage Pattern in Asthma Patients at Merdeka Public Health Center Palembang for the Period of January 1 – December 31, 2023 Mudzakky, Muhammad Yusuf; Adenina, Syarinta; Harahap, Debby Handayati
Sriwijaya Journal of Medicine Vol. 8 No. 1 (2025): Vol 8, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i1.305

Abstract

Salbutamol is a bronchodilator commonly used in the management of asthma, both in acute and chronic cases. As part of the Short-Acting Beta-2 Agonist (SABA) class, salbutamol is effective in relieving bronchospasms. The purpose of this study was to determine the rationality of drug use at the Merdeka Community Health Center Palembang. A drug utilization study was conducted at Merdeka Public Health Center Palembang in 2024. 96 patients meeting inclusion criteria. Drug use patterns were evaluated for dose rationalization, duration, frequency, contraindications, and interactions. Data analysis was performed using univariate methods. Sociodemographic characteristics showed that women were more prevalent than men (58.3%), with the most common age groups being pre-elderly and elderly (each 36.5%). All salbutamol doses (2–4 mg per administration) were appropriate (100%), with a duration of ≤3 days for all patients. The frequency of salbutamol administration of 3–4 times daily was found in 51% of cases, in line with recommendations. A total of 74% of patients received salbutamol with appropriate consideration of contraindications, while 26% received it despite contraindications, such as hypertension or hypertensive heart disease. Drug interactions were absent in 67.7% of cases, while antagonistic interactions, primarily with amlodipine, occurred in 17.3% of cases. The use of salbutamol at Merdeka Public Health Center Palembang mostly rational to drug use guidelines. However, attention is needed for contraindications and antagonistic interactions, especially with antihypertensive drugs. These findings can serve as a reference for improving asthma management and patient safety.
Efektifitas Ekstrak Daun Sirsak (Annona muricata L) Dalam Terapi Kanker Payudara Pada Jalur Apoptosis Ramadhani, Nadhira Tsurayya; Maharani, Putri; Wahono, Shafira; Maharani, Tasya Aulia; Adenina, Masayu Syarinta
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.79-86

Abstract

Breast cancer is one of the leading causes of cancer-related mortality in Indonesia. The number of new breast cancer cases has reached 68,858 cases (16.6%) out of a total of 396,914 new cancer cases. Conventional approaches to cancer therapy include surgery, radiation, and chemotherapy. However, these treatments are often expensive and associated with significant side effects. As a result, various preventive and therapeutic efforts have been developed, including the use of herbal plants with potential anticancer properties such as Annona muricata L. Therefore, a more in-depth review of this compound is needed. This article is based on data retrieved from databases such as PubMed, ScienceDirect, ClinicalKey, and Google Scholar using the keywords: “Annona muricata L.”, “breast cancer”, “acetogenin”, “apoptosis”, and “oxidative stress”. Articles in English or Indonesian within the last 10 years were included. The literature review revealed that Annona muricata L. contains active compounds, primarily acetogenins, which exhibit cytotoxic activity through the induction of apoptosis. Acetogenins act by inhibiting mitochondrial complex I (NADH dehydrogenase), resulting in decreased adenosine triphosphate (ATP) production, energy stress, and subsequently, apoptosis induction. In addition, acetogenins affect the intrinsic apoptotic pathway by downregulating anti-apoptotic proteins such as Bcl-2 and Bcl-xL, while upregulating p53 gene expression, which plays a key role in activating the extrinsic apoptosis pathway. Another mechanism is its ability to reduce oxidative stress by enhancing the activity of antioxidant enzymes, thereby protecting normal cells from free radical-induced damage. However, to date, studies of Annona muricata L. as an adjuvant therapy for breast cancer remain limited—especially regarding its long-term use and effects on normal cells. Therefore, Annona muricata L. holds potential as an adjunct therapy in the treatment of breast cancer. Further research is needed to determine the appropriate dosage, long-term effectiveness, and potential side effects, particularly in breast cancer patients.
Comparative Histopathological Effects of Several Non-Selective NSAIDs on Gastric Mucosa in Wistar Rats Adenina, Syarinta; Amani, Patwa; Layal, Kamalia
Journal of Medicine and Health Vol 7 No 2 (2025)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v7i2.9540

Abstract

Non-selective NSAIDs are widely used for their anti-inflammatory effects. However, their use is limited by significant gastrointestinal side effects. Little is known about which NSAIDs cause more damage to the gastrointestinal. This study aims to compare the mucosal damage induced by various non-selective NSAIDs. Adult male Wistar rats were divided into six groups and administered different NSAIDs: mefenamic acid, diclofenac sodium, piroxicam, ibuprofen, aspirin, and a control group with distilled water. After five days of treatment, the rats were sacrificed, and their gastric tissues were examined both macroscopically and microscopically for signs of damage, including hemorrhagic injury, mucosal edema, epithelial cell loss, and inflammatory cell infiltration. All NSAID-treated groups exhibited significant gastric damage compared to the control group. Diclofenac sodium and piroxicam groups showed the most pronounced hemorrhagic injury, while piroxicam induced the most severe mucosal edema. Ibuprofen caused the highest level of inflammatory cell infiltration. Aspirin resulted in the least gastric histopathological damage score among the tested drugs. Among the tested NSAIDs, aspirin exhibited the least histopathological damage, suggesting a lower risk of gastric injury in this model
Profile of Nutritional Status Based on Chemotherapy Regimen and Cycle in Colorectal Cancer Patients at Dr. Mohammad Hoesin Hospital Palembang Muhammad, Fadhil; Manawan, Efman E.U.; Kurniati, Ardesy Melizah; Komar, Muhammad Hafidh; Lusiana, Evi; Adenina, Syarinta
Sriwijaya Journal of Medicine Vol. 8 No. 2 (2025): Vol 8, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i2.228

Abstract

A cancerous growth that develops from the colon's or rectum's epithelial tissue is called colorectal cancer.  Chemotherapy is one of the interdisciplinary approaches used to treat colorectal cancer.  Chemotherapy is administered in cycles of one to eight.  One of the many adverse consequences of chemotherapy is a decline in nutritional status.  In this study, colon cancer patients receiving chemotherapy at Dr. Mohammad Hoesin Hospital Palembang will have their nutritional status described using BMI.  It was a descriptive investigation. The most recent medical records of colorectal cancer patients who visited Dr. Mohammad Hoesin Hospital Palembang for chemotherapy were used to gather data. Of the 44 patients, the majority were equally male and female (50%), middle-aged (52.3%), had colon cancer (50%), were in stage IV (75%), had undergone chemotherapy cycle 2 (34.1%), were on the FOLFOX 6 regimen (27.3%), and were well-nourished (50%). The majority of the study's patients were normoweight individuals, undergoing chemotherapy cycle 2, and were on the FOLFOX 6 regimen.
Association of Wrist Ratio, Body Mass Index, and Hand Grip Strength with Boston Carpal Tunnel Questionnaire Scores among Online Motorcycle Drivers Rulan Adnindya; Syarinta Adenina; Tri Suciati
Majalah Kesehatan Indonesia Vol. 7 No. 2 (2026)
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/makein.2026300

Abstract

Carpal tunnel syndrome (CTS) is a common work-related musculoskeletal disorder associated with repetitive hand activities. Online motorcycle drivers are at increased risk due to prolonged gripping and repetitive wrist movements. Anthropometric factors and hand strength have been suggested as potential contributors to CTS, but evidence remains inconsistent, particularly in informal occupational groups. This study aimed to analyze the association between wrist ratio, body mass index (BMI), and hand grip strength with CTS symptoms based on the Boston Carpal Tunnel Questionnaire (BCTQ). An observational cross-sectional study was conducted involving 80 online motorcycle drivers selected using consecutive sampling. Wrist ratio, BMI, and hand grip strength were measured, while CTS symptoms were assessed using the BCTQ. Data was analyzed using univariate and bivariate statistical tests. CTS symptoms were identified in 48.8% of participants. A substantial proportion of participants were classified as overweight or obese (approximately 44%). Statistical analysis showed no significant association between wrist ratio, BMI, or hand grip strength and CTS symptoms (p > 0.05). Wrist ratio, BMI, and hand grip strength were not significantly associated with CTS symptoms among online motorcycle drivers. These findings suggest that CTS is a multifactorial condition influenced by factors beyond basic anthropometric and strength measurements.
Physical Characterization of Micro-Porosity in Decellularized Gambier Leaf for Potential Use as a Plant-Based Scaffold Adenina, Syarinta; Ar Rahmat, Muhammad Firdzi; Mozartha, Martha; K, Trisnawaty; Tamzil, Nia Savitri; Adnindya, Msy Rulan; Hanifah, Masayu Nabila; Alfajri, Fariz
Denta Journal Kedokteran Gigi Vol 20 No 1 (2026): February
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v20i1.5

Abstract

Background: Scaffolds represent biomaterials designed to provide structural support for cellular adhesion and growth factor sequestration, emulating the extracellular matrix (ECM) to promote tissue regeneration. Plant-based tissues have garnered attention as viable scaffold alternatives owing to their architectural homology with human extracellular structures. Gambier leaves (Uncaria gambir) stand out for their inherent porous, trabecular morphology, where microporosity is pivotal in facilitating cell attachment, proliferation, and differentiation. Objective: This study aims to elucidate the microporous characteristics of decellularized gambier leaves via scanning electron microscopy (SEM). Method: Fresh leaves were meticulously cleaned, cryopreserved at −20°C, and fashioned into five circular discs employing a biopsy punch. Decellularization entailed submersion in 10% sodium dodecyl sulfate (SDS) for five days, succeeded by distilled water lavage. Subsequent cyclic treatment with Tween-20 and NaClO solutions, applied every 24 hours, continued until optical translucency was achieved. Processed tissues underwent thorough washing, overnight fixation, serial ethanol dehydration, hexamethyldisilazane (HMDS) treatment, 50 nm gold sputter-coating, and SEM evaluation across three magnifications. Results: Microscopy revealed surface wrinkling and partial architectural collapse in multiple specimens, likely due to dehydration-induced artifacts. Conversely, a single intact sample exhibited pronounced microporosity, as evidenced by pore diameters of 0.689 µm and 0.5512 µm. Conclusion: These observations affirm the microporous potential of decellularized gambier leaves for cellular anchorage and nutrient permeation, bolstering their candidacy as plant-derived scaffolds in tissue engineering. Nonetheless, inter-sample variability underscores the need for refined decellularization/dehydration methods and expanded quantitative assessments to ensure reproducible structural integrity.
Pendampingan pemanfaatan tanaman herbal pada pasien hipertensi dan diabetes melitus sebagai upaya pencegahan penyakit gagal ginjal di Puskesmas Gandus Palembang Evi Lusiana; Ardesy Melizah Kurniati; Debby Handayati Harahap; Nia Savitri Tamzil; Nita Parisa;  Masayu Syarinta Adenina; Ayesha Augusta Rosdah; Desi Oktariana; Pariyana Pariyana; Aida Nur Azizah; Arya Putera Islami
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 5 No 1 (2024): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V5I1.138

Abstract

Hypertension and diabetes mellitus are risk factors for chronic kidney disease. A person diagnosed with hypertension and diabetes mellitus is required to regularly take medication for life, which can lead to side effects of drugs (ESO). This triggers the search for more effective and safer drugs, so many people start to turn to traditional medicine. The main objective of this community service is to increase community knowledge and skills through assistance in cultivating herbal plants such as Sambiloto, Celery, and Ginger. The method of service carried out in this activity is by giving questionnaires before and after the delivery of material with the community in the working area of the Gandus Palembang Health Center. The targets of community service activities are hypertension and diabetes mellitus patients and the community registered in the working area of the Gandus Palembang Health Center as many as 30 participants. The results of the counseling showed that there was an increase in the results of participants who fell into the good category, according to the variables of knowledge, attitude and action respectively 56.7%, 23.3% and 40%.
LITERATURE REVIEW OF EMBRYONIC DEVELOPMENT EPIGENETICS: CHROMATIN MODIFICATION AND CELL PROGRAMMING Kamila Alawiyah; Rizki Andini Nawawi; Meillisa Carlen Mainassy; Syarinta Adenina; Hamzah Alfarisi; Sternatami Liberitera
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 5 No. 6 (2025): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.18492220

Abstract

This study aims to comprehensively examine epigenetic mechanisms in embryonic development, focusing on the role of chromatin modification and cell programming as regulators of gene expression without changes in DNA sequence. The type of study used was qualitative , with a descriptive approach through literature review, which examined scientific literature from reputable international journals such as Nature, Trends in Genetics, and The FEBS Journal published between 2015 and 2025. Data were collected through systematic searches of scientific articles using thematic and inductive analysis techniques, including theme identification, data reduction, and concept categorization. The results of the study show that DNA methylation, acetylation, and histone methylation are key factors in regulating gene expression during the zygotic genome activation (ZGA) phase and the formation of cell lineages. This process demonstrates the complex interaction between epigenetic and transcriptional factors that determine the direction of cell differentiation. In addition, similarities in epigenetic regulation principles between mammals and plants were found, indicating the conservation of biological mechanisms across species. The implications of the study " " include the development of regenerative therapies, increased effectiveness of assisted reproductive technologies, and innovations in agricultural biotechnology. In conclusion, this study confirms that epigenetics is an important layer of regulation in developmental biology that enriches our understanding of the mechanisms of life formation from the earliest stages.
Deteksi dini kanker payudara dengan pemeriksaan sadari dan pemanfaatan tanaman obat keluarga Syarinta Adenina; Rulan Adnindya; Nia Savitri Tamzil; Angun Kurnia F; Saniyyah Nur Fadillah; Amira Malikha; Melvin Renaldy; Mohammad Edgar Malikan; Muhammad Ayun Endratamma; Athira Medina; Muhammad Kevin Aprilio
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 7 No 1 (2026): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V7I1.227

Abstract

The high incidence of breast cancer remains a significant public health problem in Indonesia. Breast cancer management is challenging because the disease is generally detected at an advanced stage. In fact, breast self-examination (BSE) is a simple and inexpensive method for the early detection of breast cancer. Early detection and management of breast cancer are expected to reduce mortality rates associated with the disease. A preliminary survey revealed that nearly all members of the FKMT Sukarami women’s study group were unaware of breast self-examination and the use of family medicinal plants (ginger) for breast cancer prevention. Based on these findings, this community service activity aimed to enhance public knowledge and skills in performing breast self-examination and utilizing family medicinal plants. The activities included lectures, discussions, and demonstrations. Evaluation was carried out by measuring knowledge levels before and after the program. The analysis showed an increase in knowledge regarding breast cancer, breast self-examination, and the use of family medicinal plants (ginger) following the educational session.
THE POTENTIAL OF GINGEROL ACTIVE COMPOUNDS IN ZINGIBER OFFICINALE AS ANTI-CANCER AGENTS Kamalia Layal; Aisyah Anggun H; Nadya Salsabillah; Syarinta Adenina
International Journal of Islamic and Complementary Medicine Vol. 5 No. 2 (2024): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/ijicm.v5i2.83

Abstract

Cancer is a type of chronic disease which is the main cause of death in the world with 19.3 million new cases in 2020. Current cancer treatment includes surgery, chemotherapy, radiotherapy, hormone therapy, antiangiogenesis inhibitors, stem cell therapy, and others. Long-term cancer treatment can cause other health problems, so alternative anti-cancer therapy with the fewest side effects is needed. One natural ingredient that is known to prevent and act as anti-cancer therapy is Zingiber officinale. Zingiber officinale contains gingerol which functions as an anti-oxidant, anti-inflammatory, anti-bacterial, anti-cancer, anti-tumor and anti-mutagenic. The anticancer effects of gingerol are known to be effective in cancers of the liver, stomach, mouth, prostate, breast and ovaries. This literature aims to delve deeper into the role of gingerol as an anti-cancer compound. The strategy employed in the article search involved using electronic databases such as Google Scholar and PubMed. Keywords utilized included "cancer," "red ginger," "gingerol," "Zingiber officinale," and "anticancer." The articles selected were those published within the last 10 years. The study results indicate that gingerol is beneficial in oral, breast, lung, colorectal, cervical, and prostate cancers. The mechanism of action of gingerol involves pathways such as the PI3K/AKT, JAK/STAT, apoptosis, and ROS proliferation pathways. Gingerol is known to be effective as an anti-cancer agent and has the potential to become one of the alternative anti-cancer treatments.
Co-Authors Adnindya, Rulan Aida Nur Azizah Aisyah Anggun H Alfajri Alfajri, Fariz Alfian Hasbi Amira Malikha Ananta, Vito Andra Kurnianto Angun Kurnia F Ar Rahmat, Muhammad Firdzi Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Arya Putera Islami Athira Medina Atik Diah Mutiara Ningsih Atika Akbari Aulia Rahma Isnaeni Aura Salsabilla Putri Ayesha Augusta Rosdah Ayeshah A Rosdah Ayeshah Rosdah Bantari Wisynu Kusuma Wardhani Bintang Arroyantri Prananjaya Damarizqa Dara Sjahruddin Debby Handayati Harahap Debby Handayati Harahap Debby Handayati Harahap Debby Harahap Desi Oktariana Desi Oktariana Dhanty Mukhsina Evi Lusiana Fatmawati, Fatmawati Ferizon, Ayla Fenezza Hamzah Alfarisi Hanifah, Masayu Nabila Irinne Karina Putri Islamia, Medina Putri Joko Marwoto Julius Anzar Julius Anzar K, Trisnawaty Kamalia Layal Kamila Alawiyah Komar, Muhammad Hafidh Layal, Kamalia Liniyanti D. Oswari M Rusdi Maharani, Tasya Aulia Manawan, Efman E.U. Marsyadilla Putri Martha Mozartha Masayu Hanifah Meillisa Carlen Mainassy Melvin Renaldy Mitha Ramadea Mohammad Edgar Malikan Moretta Damayanti Msy. Adnindya Mudzakky, Muhammad Yusuf Muhammad Ayun Endratamma Muhammad Kevin Aprilio Muhammad, Fadhil Mutiara Budi Azhar Nadira Rifda Utami Nadya Salsabillah Nailah Nurhaura Nanda Maharani Saqadifa Nasriyatul Hannak Nia Savitri Tamzil Nia Savitri Tamzil Nia Savitri Tamzil Nita Parisa Nita Parisa Nita Parisa Nurul Yuli Permata Sari Nyiayu Fauziah Kurniawati Pariyana Pariyana Patwa Amani, Patwa Putri Maharani Raffi Arrasyid, Muhammad Rafif Shidqi Rafli, Muhammad Ramadhani, Nadhira Tsurayya Ricky Fajar Adiputra Rizki Andini Nawawi Rizma Adlia Syakurah Rulan Adnindya Sabrina, Nur Nabila Sadakata Sinulingga Saniyyah Nur Fadillah Septi Purnamasari Siti Zahra Syahroni Sitohang, Nadiyah Safitri Sri Nita Sri Rahayu Ningsih Sternatami Liberitera Swanny Swanny Syarif Husin Syarif Husin Theodorus Theodorus Theodorus Theodorus Tri Suciati Valyn Theodra Tantoro Veny Larasaty Vienna Dwinda Putri Vivi Sutandar Wahono, Shafira Wardiansyah Wardiansyah William, Jessica Audrey Zakiyah Zakiyah Ziske Maritska