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All Journal Biomedical Journal of Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kreativitas PKM SRIWIJAYA JOURNAL OF MEDICINE Jurnal Biomedika dan Kesehatan Majalah Kesehatan Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine Journal of Community Development Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) AKM: Aksi Kepada Masyarakat International Journal of Islamic and Complementary Medicine Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Denta: Jurnal Kedokteran Gigi Prominentia Medical Journal Science and Technology: Jurnal Pengabdian Masyarakat Journal of Medicine and Health
Syarinta Adenina
Departement Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
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Physical Characterization of Micro-Porosity in Decellularized Gambier Leaf for Potential Use as a Plant-Based Scaffold Adenina, Syarinta; Ar Rahmat, Muhammad Firdzi; Mozartha, Martha; K, Trisnawaty; Tamzil, Nia Savitri; Adnindya, Msy Rulan; Hanifah, Masayu Nabila; Alfajri, Fariz
Denta Journal Kedokteran Gigi Vol 20 No 1 (2026): February
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v20i1.5

Abstract

Background: Scaffolds represent biomaterials designed to provide structural support for cellular adhesion and growth factor sequestration, emulating the extracellular matrix (ECM) to promote tissue regeneration. Plant-based tissues have garnered attention as viable scaffold alternatives owing to their architectural homology with human extracellular structures. Gambier leaves (Uncaria gambir) stand out for their inherent porous, trabecular morphology, where microporosity is pivotal in facilitating cell attachment, proliferation, and differentiation. Objective: This study aims to elucidate the microporous characteristics of decellularized gambier leaves via scanning electron microscopy (SEM). Method: Fresh leaves were meticulously cleaned, cryopreserved at −20°C, and fashioned into five circular discs employing a biopsy punch. Decellularization entailed submersion in 10% sodium dodecyl sulfate (SDS) for five days, succeeded by distilled water lavage. Subsequent cyclic treatment with Tween-20 and NaClO solutions, applied every 24 hours, continued until optical translucency was achieved. Processed tissues underwent thorough washing, overnight fixation, serial ethanol dehydration, hexamethyldisilazane (HMDS) treatment, 50 nm gold sputter-coating, and SEM evaluation across three magnifications. Results: Microscopy revealed surface wrinkling and partial architectural collapse in multiple specimens, likely due to dehydration-induced artifacts. Conversely, a single intact sample exhibited pronounced microporosity, as evidenced by pore diameters of 0.689 µm and 0.5512 µm. Conclusion: These observations affirm the microporous potential of decellularized gambier leaves for cellular anchorage and nutrient permeation, bolstering their candidacy as plant-derived scaffolds in tissue engineering. Nonetheless, inter-sample variability underscores the need for refined decellularization/dehydration methods and expanded quantitative assessments to ensure reproducible structural integrity.
Co-Authors Adnindya, Msy. Adnindya, Rulan Alfajri, Fariz Ananta, Vito Andra Kurnianto Anggun H, Aisyah Aprilio, Muhammad Kevin Ar Rahmat, Muhammad Firdzi Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Atik Diah Mutiara Ningsih Atika Akbari Aulia Rahma Isnaeni Ayeshah A Rosdah Azizah, Aida Nur Bantari Wisynu Kusuma Wardhani Bintang Arroyantri Prananjaya Damarizqa Dara Sjahruddin Debby Handayati Harahap Debby Handayati Harahap Desi Oktariana Dhanty Mukhsina Endratamma, Muhammad Ayun Evi Lusiana F, Angun Kurnia Fadillah, Saniyyah Nur Fatmawati, Fatmawati Ferizon, Ayla Fenezza Hamzah Alfarisi Hanifah, Masayu Hanifah, Masayu Nabila Harahap, Debby Hasbi, Alfian Irinne Karina Putri Islami, Arya Putera Islamia, Medina Putri Jayawarsa, A.A. Ketut Joko Marwoto Julius Anzar Julius Anzar K, Trisnawaty Kamila Alawiyah Komar, Muhammad Hafidh Layal, Kamalia Liniyanti D. Oswari M Rusdi Maharani, Tasya Aulia Malikan, Mohammad Edgar Malikha, Amira Manawan, Efman E.U. Martha Mozartha Medina, Athira Meillisa Carlen Mainassy Mitha Ramadea Moretta Damayanti Mudzakky, Muhammad Yusuf Muhammad, Fadhil Mutiara Budi Azhar Nanda Maharani Saqadifa Nasriyatul Hannak Nia Savitri Tamzil Nita Parisa Nita Parisa Nita Parisa Nurhaura, Nailah Nurul Yuli Permata Sari Oktariana, Desi pariyana, Pariyana Patwa Amani, Patwa Putri , Marsyadilla Putri Maharani Raffi Arrasyid, Muhammad Rafif Shidqi Rafli, Muhammad Ramadhani, Nadhira Tsurayya Renaldy, Melvin Ricky Fajar Adiputra Rizki Andini Nawawi Rizma Adlia Syakurah Rosdah, Ayesha Augusta Rosdah, Ayeshah Sabrina, Nur Nabila Sadakata Sinulingga Salsabillah, Nadya Septi Purnamasari Siti Zahra Syahroni Sitohang, Nadiyah Safitri Sri Nita Sri Rahayu Ningsih Sternatami Liberitera Sutandar, Vivi Swanny Swanny Syarif Husin Syarif Husin Theodorus Theodorus Tri Suciati Valyn Theodra Tantoro Veny Larasaty Vienna Dwinda Putri Wahono, Shafira Wardiansyah Wardiansyah William, Jessica Audrey Zakiyah Zakiyah Ziske Maritska