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All Journal Biomedical Journal of Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Kreativitas PKM SRIWIJAYA JOURNAL OF MEDICINE Jurnal Biomedika dan Kesehatan Jurnal Pengabdian Masyarakat: Humanity and Medicine AKM: Aksi Kepada Masyarakat International Journal of Islamic and Complementary Medicine Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Prominentia Medical Journal Science and Technology: Jurnal Pengabdian Masyarakat Journal of Medicine and Health
Syarinta Adenina
Departement Of Pharmacology, Faculty Of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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THE POTENTIAL OF GINGEROL ACTIVE COMPOUNDS IN ZINGIBER OFFICINALE AS ANTI-CANCER AGENTS Layal, Kamalia; Anggun H, Aisyah; Salsabillah, Nadya; Adenina, Syarinta
International Journal of Islamic and Complementary Medicine Vol. 5 No. 2 (2024): International Journal of Islamic and Complementary Medicine
Publisher : International Islamic Medicine Forum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55116/IJICM.V5I2.83

Abstract

Cancer is a type of chronic disease which is the main cause of death in the world with 19.3 million new cases in 2020. Current cancer treatment includes surgery, chemotherapy, radiotherapy, hormone therapy, antiangiogenesis inhibitors, stem cell therapy, and others. Long-term cancer treatment can cause other health problems, so alternative anti-cancer therapy with the fewest side effects is needed. One natural ingredient that is known to prevent and act as anti-cancer therapy is Zingiber officinale. Zingiber officinale contains gingerol which functions as an anti-oxidant, anti-inflammatory, anti-bacterial, anti-cancer, anti-tumor and anti-mutagenic. The anticancer effects of gingerol are known to be effective in cancers of the liver, stomach, mouth, prostate, breast and ovaries. This literature aims to delve deeper into the role of gingerol as an anti-cancer compound. The strategy employed in the article search involved using electronic databases such as Google Scholar and PubMed. Keywords utilized included "cancer," "red ginger," "gingerol," "Zingiber officinale," and "anticancer." The articles selected were those published within the last 10 years. The study results indicate that gingerol is beneficial in oral, breast, lung, colorectal, cervical, and prostate cancers. The mechanism of action of gingerol involves pathways such as the PI3K/AKT, JAK/STAT, apoptosis, and ROS proliferation pathways. Gingerol is known to be effective as an anti-cancer agent and has the potential to become one of the alternative anti-cancer treatments.
Pemberdayaan Ibu-Ibu Majelis Taklim Al Kahfi: Deteksi Asam Urat dan Edukasi Sindrom Terowongan Karpal Adnindya, Msy Rulan; Adenina, Syarinta; Harahap, Debby Handayati; Tamzil, Nia Savitri; Kurniati, Ardesy Melizah; Islamia, Medina Putri; Rafli, Muhammad
Science and Technology: Jurnal Pengabdian Masyarakat Vol. 1 No. 3 (2024): September
Publisher : CV. Science Tech Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69930/scitech.v1i3.53

Abstract

Masalah kesehatan sendi, khususnya sindrom terowongan karpal (CTS), sering dialami oleh ibu-ibu rumah tangga yang melakukan gerakan repetitif. Berdasarkan wawancara dengan ketua pengajian Majelis Taklim Al Kahfi, nyeri pada persendian tangan merupakan salah satu keluhan utama yang dirasakan oleh anggota ibu pengajian. Selain itu, tingkat pengetahuan mereka mengenai CTS masih rendah. Fokus pengabdian ini adalah memberdayakan ibu-ibu pengajian dalam pengelolaan kesehatan melalui deteksi dini kadar asam urat dan edukasi pencegahan CTS. Tujuan dari pengabdian ini adalah meningkatkan pengetahuan ibu-ibu tentang CTS, melakukan deteksi dini kesehatan melalui pemeriksaan kadar asam urat, dan memberikan informasi terkait CTS. Metode yang digunakan meliputi penyuluhan dengan alat bantu presentasi dan flyer, diskusi, skrining kesehatan menggunakan alat strip asam urat, serta evaluasi melalui pretest dan posttest. Hasil pengabdian diharapkan dapat meningkatkan pemahaman ibu-ibu pengajian tentang CTS, serta kemampuan mereka dalam mencegah dan menangani masalah kesehatan sendi. Evaluasi menunjukkan peningkatan pengetahuan dan kesadaran kesehatan di kalangan peserta. Program ini juga memfasilitasi pembentukan kelompok pendukung di media sosial untuk pendampingan berkelanjutan.
The Relationship of Fat Intake and Body Fat Percentage in Medical Students Nurul Yuli Permata Sari; Ardesy Melizah Kurniati; Julius Anzar; Liniyanti D. Oswari; Sri Nita; Syarinta Adenina
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.201

Abstract

Introduction. Obesity is an excessive fat accumulation in the body, now the prevalence is increasing in the group aged>18 years based on Body Mass Index (BMI). Nowadays body fat percentage has been declared to assess the risk factor of disease-related body weight better than BMI, people with proportioned weight had excessive body fat percentage evenly. Excessive fat intake is one of the important factors for obesity. The objective of this study was to analyze the association between fat intake with body fat percentage. Methods. This study was conducted with a cross-sectional design on 275 medical faculty students of Sriwijaya University, starting from August until December 2017 by collecting primary data through completing forms, food records, questionnaires, and physical examinations. Results. The results were analyzed statistically using chi-square. 67.3% of subjects had excessive body fat percentage and 50.2% with excessive fat intake. Results by the chi-square test indicate a negative association between fat intake with body fat percentage (p value=0.184). Conclusion. Fat intake with body fat percentage was negatively associated.
Knowledge And Perceptions of Nutrition and Weight Among First-Year Medical Students at Sriwijaya University Mitha Ramadea; Ardesy Melizah Kurniati; Joko Marwoto; Syarif Husin; Wardiansyah Wardiansyah; Syarinta Adenina
Biomedical Journal of Indonesia Vol. 10 No. 3 (2024): Vol 10, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v10i3.202

Abstract

Introduction. Medical students of Sriwijaya University batch 2019 are new students who don’t have much knowledge about nutrition. In addition, new students also don’t know how to calculate Body Mass Index (BMI) through body height and weight. This study aimed to know the level of nutritional knowledge and the suitability of weight perception among the medical students of Sriwijaya University batch 2019. Methods. Descriptive research with a cross-sectional research design was conducted in Health Clinic UPT of Sriwijaya University and the Faculty of Medicine of Sriwijaya University in September 2019. The sample of this study was all medical students from Sriwijaya University batch 2019 who met the inclusion and exclusion criteria. The data was obtained through direct measurement and filling M-GNKQ questionnaire and weight perception questionnaire online. Results. In this study, 222 students met the inclusion and exclusion criteria, with 74 male students and 148 female students. As many as 70.7% of students have normal nutritional status. The average value of nutrition knowledge is 18.21 (45.5%) with the lowest value 0 and the highest value 32. Of all of the students, only 52.3% can perceive body weight correctly. The rest, as much as 33.3% is exaggerating perception and 14.4% is reducing perception. Conclusion. The knowledge of nutrition among the medical students of Sriwijaya University batch 2019 is still quite low and there are still many students who mistakenly perceive their weight.
The Role of Mtor Inhibitors in Endocrine Resistance Therapy of Breast Cancer Type ER+ Syarinta Adenina; Bantari Wisynu Kusuma Wardhani
Sriwijaya Journal of Medicine Vol. 6 No. 1 (2023): Vol 6, No. 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i1.146

Abstract

Breast cancer is the leading cause of death in women. Although hormonal therapy has produced positive results in HR+ breast cancer, resistance to this therapy remains a challenge in the treatment of breast cancer. Various mechanisms have been proposed as an explanation of resistance in breast cancer, one of which is the activation of the PI3K/AKT/mTOR pathway. The PI3K/AKT/mTOR pathway is a transduction pathway that regulates many important aspects in both normal cells and cancer cells, including cell proliferation, apoptosis, cell morphology and migration, protein synthesis, and integrase metabolism. Preclinical dan clinical data show inhibition of this pathway can improve survival, especially in resistant hormonal therapy models. The use of mTOR inhibitors (everolismus) has been approved by the FDA as a combination therapy with exemestane for postmenopausal women with HR+/HER2-breast cancer.
Management of Breast Cancer with Curcumae Rhizoma: A Therapeutic Approach Atik Diah Mutiara Ningsih; Rafif Shidqi; Syarinta Adenina
Sriwijaya Journal of Medicine Vol. 6 No. 2 (2023): Vol 6, No. 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v6i2.203

Abstract

Breast cancer has the highest incidence in women, covering 2.3 million new cases per year and a mortality rate of 23%. Therapeutic strategies applied in breast cancer treatment include surgery, chemotherapy, endocrine therapy, and radiation. All of these therapies have relatively high side effects, so alternative therapies are needed that are more effective with minimal side effects. One of the herbs known to be effective in treating breast cancer is Curcumae Rhizoma from Curcumae longa extract. The essential components of this drug are Curcumol and Curcumin. Literature searches were obtained from various online portals such as Pubmed, Google Scholar and Science Direct using the keywords "breast cancer", "Curcumae", "Curcuma Rhizoma" and "herbal medicine". Curcuma Rhizomae can inhibit the formation and spread of cancer cells by utilizing anti-angiogenic effects, disrupting the cell proliferation cycle, and inducing apoptosis. In Indonesia, Curcumae or turmeric is commonly used as a spice ingredient. Its anti-cancer potential can be used as a breast cancer therapy in Indonesia.
The Relationship of Knowledge and Attitude to The Behavior of Using Celery as An Antihypercholesterolemia at The Gandus Health Center in Palembang Nia Savitri Tamzil; Debby Handayati Harahap; Evi Lusiana; Nita Parisa; Ayeshah Augusta Rosdah; Syarinta Adenina; Desi Oktariana
Sriwijaya Journal of Medicine Vol. 7 No. 2 (2024): Vol 7, No 2, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i2.230

Abstract

Efforts to lower cholesterol levels can be made using traditional medicine. The better a person's knowledge and attitude towards traditional medicine will influence his actions in choosing medicine. This study aims to determine the relationship between knowledge and attitudes regarding traditional medicine on the behavior/actions of choosing celery to treat hypercholesterolemia in the community around the Gandus Health Center, Palembang. Analytical observational research with a cross-sectional design has been carried out at the Gandus Palembang Health Center from 13 to 20 September 2023. 30 respondents met the inclusion criteria. There are still many (43.3%) respondents who have poor knowledge about the use of herbs as anti-hypercholesterolemia, especially celery, while 30% of respondents with a negative attitude towards choosing traditional medicine were found. Based on statistical analysis, the results showed that there was an insignificant relationship between knowledge and behavior (PR = 1.500 (IK95% 0.325 – 6.918); p = 0.896). However, there is a significant relationship between attitudes and behavior (PR = 21.00 (95% CI 2.868 – 153.754); p = 0.002). A person's attitude towards traditional medicine is related to their behavior/actions in choosing celery for the treatment of hypercholesterolemia.
The Relationship between Knowledge and Self-Medication Practices for Dysmenorrhea among Female Students of SMK Negeri 2 Palembang Kamalia Layal; Syarinta Adenina; Septi Purnamasari; Ayeshah Augusta Rosdah; Msy Rulan Adnindya
Sriwijaya Journal of Medicine Vol. 7 No. 3 (2024): Vol 7, No 3, 2024
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v7i3.236

Abstract

Dysmenorrhea is a common occurrence in most women. The pain arising from dysmenorrhea ranges from mild to moderate and can disrupt daily activities and performance. Many women practice self-medication to alleviate this pain. This self-medication practice is influenced by several factors, one of which is the level of knowledge. This study aims to explore the relationship between the level of knowledge among female students and self-medication behavior in dysmenorrhea. This study used a cross-sectional design with a random sampling of female students from SMK Negeri 2 Palembang. The total sample involved 41 students. Data were collected and analyzed using chi-square and Mann-Whitney U tests. The majority of students experienced dysmenorrhea (87.8%) with an average Visual Analog Scale (VAS) score of 4.6. The duration of pain varied, with most experiencing pain for 2-3 days after menstruation. Almost all students (97.6%) had good or sufficient knowledge about dysmenorrhea. However, only a few students practiced self-medication (11.1%), with paracetamol being the most commonly used medication. The analysis showed a significant relationship between knowledge level and self-medication behavior (p=0.002, OR: 12.681). The level of knowledge among female students is significantly associated with self-medication behavior in dysmenorrhea. Better health education on dysmenorrhea management and the use of safe medication needs to be strengthened to reduce the risk of side effects and improve the well-being of students.
Efek Polimorfisme Terhadap Kerentanan dan Tatalaksana Tuberkulosis Paru Rusdi, M.; Adenina, Syarinta
Bahasa Indonesia Vol 5 No 2 (2024): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v5i2.4776

Abstract

Pulmonary tuberculosis (TB) remains the second leading cause of death from a single infectious agent. The number of people with pulmonary TB in the world still increased, and TB treatment success percentage in Indonesia has not reached the target until now. Genetic polymorphisms are defined as DNA variations seen in ≥1% of the population. The study of genetic polymorphisms can help identify disease risk, predict drug efficacy and safety, and determine the right chemotherapeutic agent with a dose that suits each patient. Various genetic polymorphisms associated with pulmonary TB susceptibility have been found, including polymorphisms of the NRAMP1, HLA-DRB1, vitamin D receptor, TNF-α, and IFN-γ genes. In addition, several genetic polymorphisms associated with TB treatment were also found, such as SLCO1B1, NAT2, SLC2A9, and ABCB1 genes. Detection of genetic polymorphisms in each individual can help predicts TB risk and improve TB treatment success and reduce side effects that may occur due to TB treatment.
The Role of TNF- α Inhibitors in The Management of Gout Arthritis and Its Comparison with Other Modalities Nita Parisa; Valyn Theodra Tantoro; Masayu Syarinta Adenina; Bintang Arroyantri Prananjaya
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 2 (2024): September 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i2.3730

Abstract

Background: Gout arthritis is caused by the deposition of monosodium urate crystals in the joints, which can cause significant pain, swelling, and recurring inflammation, particularly in the big toe. Inflammatory mediators are critical to the beginning and duration of the inflammatory response in gout arthritis. Gout is mediated by TNF-α, ILs, and the NLRP3 inflammasome, which promotes macrophages, monocytes, and neutrophils, leading to inflammatory reactions. TNF-α acts as a potent inflammatory mediator by stimulating the expression of other inflammatory cytokines, adhesion molecules, and matrix metalloproteinases (MMPs). TNF-α interacts with particular receptors and activates intracellular signaling pathways, leading to leukocyte recruitment, NLRP3 inflammasome activation, and the release of other inflammatory mediators. Objective: This article is a review article in which the researchers examine the current state of understanding regarding the role of TNF-α as a major inflammatory mediator in gout arthritis, deepen the understanding of TNF-α in gout inflammation, and explore its potential as a therapeutic target. Method: It involvedsystematically searching relevant databases, selecting studies based on inclusion criteria, and synthesizing findings to identify trends, gaps, and the current state of knowledge on the topic. Result: The results of this review article indicated that TNF-α plays a crucial role in joint inflammation by triggering the release of pro-inflammatory cytokines and stimulating neutrophil infiltration into the joints. Conclusion: Thus, Inhibiting TNF-α can reduce inflammation and improve symptoms in people with gout arthritis.
Co-Authors Adnindya, Msy Rulan Ananta, Vito Andra Kurnianto Anggun H, Aisyah Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Ardesy Melizah Kurniati Atik Diah Mutiara Ningsih Atika Akbari Aulia Rahma Isnaeni Ayeshah A Rosdah Ayeshah Augusta Rosdah Ayeshah Augusta Rosdah Azizah, Aida Nur Bantari Wisynu Kusuma Wardhani Bintang Arroyantri Prananjaya Damarizqa Dara Sjahruddin Debby Handayati Harahap Debby Handayati Harahap Desi Oktariana Dhanty Mukhsina Evi Lusiana Fatmawati, Fatmawati Ferizon, Ayla Fenezza Irinne Karina Putri Islami, Arya Putera Islamia, Medina Putri Jayawarsa, A.A. Ketut Joko Marwoto Julius Anzar Julius Anzar Komar, Muhammad Hafidh Layal, Kamalia Liniyanti D. Oswari M Rusdi Maharani, Tasya Aulia Manawan, Efman E.U. Mitha Ramadea Moretta Damayanti Mudzakky, Muhammad Yusuf Muhammad, Fadhil Mutiara Budi Azhar Nanda Maharani Saqadifa Nasriyatul Hannak Nia Savitri Tamzil Nita Parisa Nita Parisa Nita Parisa Nurul Yuli Permata Sari Oktariana, Desi pariyana, Pariyana Patwa Amani, Patwa Putri Maharani Raffi Arrasyid, Muhammad Rafif Shidqi Rafli, Muhammad Ramadhani, Nadhira Tsurayya Ricky Fajar Adiputra Rizma Adlia Syakurah Rosdah, Ayesha Augusta Rulan Adnindya Sabrina, Nur Nabila Sadakata Sinulingga Salsabillah, Nadya Septi Purnamasari Siti Zahra Syahroni Sitohang, Nadiyah Safitri Sri Nita Sri Rahayu Ningsih Swanny Swanny Syarif Husin Syarif Husin Theodorus Theodorus Valyn Theodra Tantoro Veny Larasaty Vienna Dwinda Putri Wahono, Shafira Wardiansyah Wardiansyah William, Jessica Audrey Zakiyah Zakiyah Ziske Maritska