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Journal : Paediatrica Indonesiana

Short term memory, physical fitness, and serum brain-derived neurotrophic factor in obese adolescents Rini Rossanti; Dida Akhmad Gurnida; Eddy Fadlyana
Paediatrica Indonesiana Vol 55 No 5 (2015): September 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.121 KB) | DOI: 10.14238/pi55.5.2015.277-81

Abstract

Background Obesity in adolescents is a major health problem and has been associated with low academic achievement. Brainderived neurotrophic factor (BDNF), a neurotrophin, plays a role in appetite suppression and memory, and its secretion is enhanced by physical activity. This neurotrophin may be associated with academic achievement in obese. Objective To compare physical fitness and serum BDNF levels to short term memory levels in obese adolescents aged 10–14 years. Methods This comparative, cross-sectional, analytic study was carried out on 40 elementary and high school students in Bandung, West Java, who were recruited by stratified random sampling. Short term memory was assessed by a psychologist using the Wechsler Intelligence Scale for Children-III Digit Span test (WISC-III Digit Span). Physical fitness was assessed by a clinical exercise physiologist using the Asian Committee on the Standardization of Physical Fitness Test (ACSPFT). Serum BDNF levels were measured by ELISA test in a certified laboratory. ANOVA test was used to assess for a correlation between serum BDNF concentration and short term memory, as well as between physical fitness level and short term memory. Pearson’s correlation test was used to analyze for a correlation between serum BDNF and physical fitness levels. Results The majority of subjects were in the physical fitness categories of moderate or poor. Subjects had a mean BDNF level of 44,227.8 (SD 10,359) pg/mL. There was no statistically significant difference in physical fitness with either serum BDNF or with short term memory levels (P=0.139 and P=0.383, respectively). Also, no correlation was determined between serum BDNF and physical fitness levels (r=0.222; P=0.169). Conclusion In obese adolescents, short term memory levels are not significantly different between physical fitness levels nor between serum BDNF levels.
Serum interleukin-6 and mean platelet volume in pediatric pneumonia Melisa Lilisari; Heda Melinda Nataprawira; Dida Akhmad Gurnida
Paediatrica Indonesiana Vol 56 No 1 (2016): January 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.186 KB) | DOI: 10.14238/pi56.1.2016.57-61

Abstract

Background In pneumonia, interleukin (IL)-6 is released in response to inflammation. Interleukin-6 stimulates megakaryocyte maturation, leading to larger platelets being released into the circulation. Platelet size is measured as mean platelet volume (MPV). The MPV may also be affected by nutritional status and smoking.Objective To assess for a possible relationship between serum IL-6 concentration and MPV, including smoking and nutritional status as confounding factors, in children with pneumonia.Methods An analytic, observational study with cross-sectional design and consecutive sampling of children aged 2 to 59 months with a clinical diagnosis of pneumonia was conducted from November 2013 to March 2014 in Dr. Hasan Sadikin General Hospital and two network hospitals. All patients underwent routine complete blood counts including MPV and measurement of serum IL-6 concentration using an enzyme-linked immunosorbent assay (ELISA) technique. Regression linear analysis was used to assess the relationship between MPV and IL-6, passive smoking, and nutritional status.Results There were 67 patients enrolled in the study. Subjects’ mean serum IL-6 concentration was 49.3 (SD 78.3) pg/mL, and mean MPV was 9.2 (SD 0.9) fL. The regression model for MPV was 7.531 + 0.662 (passive smoking) + 0.276 (weight per age) + 0.009 (IL-6).Conclusion There was a relationship between IL-6 serum concentration and MPV in children with pneumonia.
Relationship between ionized calcium and serum albumin level in children with idiopathic nephrotic syndrome Viiola Irene Winata; Dida Akhmad Gurnida; Nanan Sekarwana
Paediatrica Indonesiana Vol 50 No 6 (2010): November 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.59 KB) | DOI: 10.14238/pi50.6.2010.361-4

Abstract

Background Nephrotic syndrome (NS) patients frequently have abnormalities in calcium metabolism that manifest as hypocalcemia and reduced intestinal absorption of calcium. Hypocalcemia is initially attributed to hypoalbuminemia but it may also relate to a low level of ionized calcium. The ionized calcium level depends on the severity and duration of proteinuria.Objective To assess the rel ationship between ionized calcium and serum albumin level in idiopathic NS children.Methods An analytical study with cross-sectional design was applied to NS and healthy children between 1-14 years old in the Child Health Department of Hasan Sadikin Hospital, Bandung from December 2009 to April 2010. Ionized calcium was examined by Ca2 + analyzer AVL 980 with ion-selective electrodes (ISE) methods.Results A total of34 subjects were recruited, consist of 17 NS and 17 healthy children. The mean ionized calcium and serum albumin level in NS children was 4.56 (SD 0.23) mg/dLand 1.45 (SD 0.24) g/dL, respectively. Statistical difference between ionized calcium level in NS and in healthy children was significant (P<0.05). Pearson correlation test between ionized calcium and serum albumin was significant (P<0.05) with correlation coefficient (r) 0.53. We found the following equation to estimate ionized calcium (y) based on the serum albumin level (x): y=3.84+0.49x.Conclusion There is a moderately positive linear relationship between ionized calcium and serum albumin level in NS children.
Co-Authors Abdullah Ichsan Adhi Pribadi Akhmad Yogi Pramatirta, Akhmad Yogi Alamsyah Aziz Alex Chairulfatah Anas Subarnas Anggraini Alam Ari indra Susanti Aris Primadi Aziz, Muhammad Alamsyah Carla Pusparani Chin Annrie Eidwina Chin Annrie Eidwina, Chin Annrie Damayani, Ayi Diah Dany Hilmanto Dedi Rachmadi Deni Kurniadi Sunjaya Dewi Marhaeni Diah Herawati Dewi Marheini Diah Herawati Dicky Santosa Dwi Agustian Dzulfikar Djalil Lukmanul Hakim Dzulfikar Djalil Lukmanul Hakim Eddy Fadlyana Elsa Pudji Setiawati Erliana Ulfah Erwina Sumartini Febrianda, Rilda Dwi Fitria Nurwulansari Fransisca Sri Susilaningsih Fransisca Sri Susilaningsih Gaga Irawan Nugraha Galuhafiar Puratmaja Geraldo Laurus Giyawati Yulilania Okinarum Hadi - Susiarno Hadyana Sukandar Hadyana Sukandar Hakim, Dzulfikar Djalil Lukamnul Hani Hilda Kartika Heda Melinda Nataprawira Herri S. Sastramihardja Herry Garna Herry Herman Ichsan, Abdullah Ieva Baniasih Akbar Iis Rosita Insi Farisa Desy Arya Irna Sufiawati Irvan Afriandi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Kusnandi Rusmil Kusteja, Nadya Fauzia Larasati, Putri Argi Laurus, Geraldo Lelani Reniarti Lia Faridah Lina Ferryana Melisa Lilisari Melsa Sagita Imaniar Mercy Amelia Mustika Hana Harahap Nanan Nur&#039;aeny Nanan Nur&#039;aeny Nanan Nur'aeny Nanan Sekarwana Novina Novina Nur Eva Aristina Nur'aeny, Nanan Nurfandi, Wendi Nurihsan, Achmad Juntika Nurul Auliya Kamila Nurwulansari, Fitria Oki Suwarsa Primadevi, Inggit Putria Rayani Apandi, Putria Rayani Rahmat Budi Kuswiyanto, Rahmat Budi Reni Ghrahani Rini Rossanti Ruswana Anwar Sembiring, Gaipyana Setyorini Irianti Siska Wiramihardja Siska Wiramihardja, Siska Siti - Damayanti Siti Aisyah Siti Nur Fatimah Siti Nur Fatimah Sri Endah Rahayuningsih Sri Endah Rahayuningsih Susiarno, Hadi Syarifah Prita Yulianty Syifa Rahma Septiani Tetty - Yuniati Tika - Lubis Tisnasari Hafsah, Tisnasari Tono Djuwantono Uni Gamayani Viiola Irene Winata Yesi Herawati Yudith Setiati Ermaya Zulmansyah , Zulmansyah