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All Journal Journal of Indonesian Tourism and Development Studies Wacana, Jurnal Sosial dan Humaniora Indonesian Green Technology Journal Jurnal Pembangunan dan Alam Lestari ECSOFiM (Economic and Social of Fisheries and Marine Journal) Habitat AGRIVITA, Journal of Agricultural Science IJEMS (Indonesian Journal of Environmental Management and Sustainability) TEKNOLOGI PANGAN : Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Soemarno Soemarno
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Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Energy Engineering Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Efficacy and Safety of In-Asia-manufactured Interferon alpha-2b in Combination with Ribavirin for Therapy of Naïve Chronic Hepatitis C Patients: A Multicenter, Prospective, Open-Label Trial Nurul Akbar; Ali Sulaiman; Rino Alvani Gani; Irsan Hasan; Laurentius Lesmana; Andri Sanityoso; Sjaifoellah Noer; FX Pridady; Soemarno Soemarno
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 10, ISSUE 1, April 2009
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/10120097-13

Abstract

Background: An open-label, multi center and non-comparative study was conducted to evaluate the efficacy and safety of a more affordable in-Asia-manufactured interferon á-2b product in combination with ribavirin to treat naïve chronic hepatitis C patients. Method: Thirty chronic naïve hepatitis C patients were treated with in-Asia-manufactured interferon   a-2b subcutaneously 3 MIU thrice weekly and ribavirin 800-1,200 mg daily for 48 weeks. Follow-up was done until 24 weeks after the end of treatment. Efficacy was assessed by examining serologic and biochemical parameters at pre and post-treatment. Safety was assessed by evaluating clinical symptoms and laboratory parameters. Results: The virological response and sustained virological response rates of all Hepatitis C Virus (HCV) genotypes were 83.3% and 76.7% respectively. Post-treatment, 80% patients had significant alanine transaminase (ALT) decreased into normal level and remained normal in 76.7% patients at 24th week follow up period. At that time, the ALT level and sustained virological response were lower in HCV genotypes 1 and 4 than in non-1 and non-4 genotypes. The most frequent adverse event was flu-like syndrome. Conclusion: The efficacy and safety study on combination therapy of in-Asia-manufactured interferon a-2b and ribavirin has shown a good result based on the current standard of interferon alpha and ribavirin combination therapy. Keywords: interferons, combination drug therapy, chronic hepatitis C, treatment efficacy, safety
Pengaruh Livelihood Asset terhadap Livelihood Strategies Masyarakat Tepi Hutan di UB Forest Desa Tawangargo Kecamatan Karangploso Kabupaten Malang Hary Wahyu Wijayanto; Aminudin Affandi; Soemarno Soemarno
HABITAT Vol. 30 No. 2 (2019): August
Publisher : Department of Social Economy, Faculty of Agriculture , University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.habitat.2019.030.2.7

Abstract

Perubahan lingkungan hutan berdampak terhadap kondisi aset penghidupan maysarakat dan menyebabkan beragamnya strategi penghidupan masyarakat sekitar hutan. Penelitian ini bertujuan untuk menganalisis pengaruh aset penghidupan (livelihood asset) masyarakat sekitar hutan terhadap strategi penghidupan (livelihood straregy) yang mereka lakukan. Penelitian ini dilakukan di UB Forest Desa Tawangargo Kabupaten Malang. Responden penelitian ini adalah masyarakat sekitar UB forest dengan jumlah sampel sebanyak 105 responden. Metode yang digunakan adalah Structure Equation Modelling (SEM). Hasil penelitian menunjukkan bahwa aset memiliki positif terhadap strategi penghidupan. Sementara itu, demografi memiliki pengaruh negatif terhadap strategi penghidupan masyarakat sekitar hutan. Akan tetapi demografi akan memiliki pengaruh positif terhadap strategi penghidupan ketika masyarakat memiliki aset penghidupan. Hal ini menyiratkan bahwa perlu adanya peningkatan kepemilikan asset masyarakat tepi hutan untuk mempertahankan bahkan meningkatkan penghidupan mereka.
Co-Authors Agus Suman Ali Sulaiman Aminudin Afandhi Aminudin Affandi Andri Sanityoso Anes Putri Octasari Anita Qur'ania Anthon Efani Azwar Ali Bagyo Yanuwiadi Bobby Polii Budi Prasetya Djumilah Hadiwidjojo Eko Naryono Ellis Nihayati Endang Bidayani Endhay Kusnendar FX Pridady Happy Nursyam Hary Wahyu Wijayanto Hendro Prasetyo Herianto Kurniawan Ieke Wulan Ayu Ika Saputri Wulandari Imam Hanafi Irsan Hasan Jamhari Jamhari Jeany Mandang Koderi Laurentius Lesmana Lily Agustina M Muslich Mustadjab Mangku Purnomo Marsoedi Marsoedi Maulana Zulkarnain Melkhianus Hendrik Pentury Mimit Primyastanto Moch Sasmito Djati Mochammad Munir Muhammad Syamsidi Muniah Muniah Nuddin Harahab Nuddin Harahap Nunuk Hariyani Nurul Akbar Purwoko, Agus Regina R. Butarbutar Retno Suntari Rino Alvani Gani Rurini Retnowati Sahri Muhammad Sjaifoellah Noer Sri Muljaningsih Sri Sudaryanti Steefra Mangkay Sugeng Prijono Syamsul Akbar Tatik Wardiyati Treesye I Turang Yudhi Ahmad Nazari Yuli Prayitno