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Journal : Hang Tuah Medical Journal

Pengaruh Pencemaran Logam Berat Timbal (Pb) dan Ekskresi Iodium Urine (EIU) Terhadap Kejadian Stunting Pada Anak di Surabaya LEONI; WIENTA DIARSVITRI; VERNA BIUTIFASARI
HANG TUAH MEDICAL JOURNAL Vol 18 No 2 (2021): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract

ABSTRACT Background : The existence of children, living in the coastal area with such risk of suffering from lead (Pb) intoxication, is still considered high. This pollutant plays a role in children’s growth and development. Lead (Pb), existing in our body, would directly reduce the amount of iodine that is absorbed by our body and in the end, would reduce the number of hormones affecting both physical growth and mental development for instance Growth Hormone, Thyroid Hormone, and Insulin-like Growth Factor (IGF-1). Other than Lead (Pb), growth is affected by another factor such as heredity, nutrition, and physical activity. This study serves the purpose of determining the effect of lead (Pb) pollution and Urinary Iodine Concentration (UIC) on the occurrence of stunting in children at the age of 25-60 months old at the urban village of Kedung Cowek Surabaya. Methods : observational analytic study a cross-sectional study design, by using a quantitative method which was used on 27 mothers whose children are 25-60 months old at Posyandu RW 2 and RW 3 urban village of Kedung Cowek Surabaya. The sample was chosen using a purposive sampling method. Data was collected through weight and height measurement, age, KMS (Card Towards Health), KIA (Kartu Ibu dan Anak), and questionnaires done by interviewing. Bivariate analysis was performed using Kruskal-Wallis. Results : Based on the laboratory test, it is shown that there’s no lead (Pb) pollution detected in seawater with the final result of 0,00035 mg/L (polluted > 0,008 mg/L). Based on Kruskal-Wallis, Urinary Iodine Concentration (UIC) doesn’t influence the occurrence of stunting based on deviation standard and nutritional status from the Ministry of Health (p = 0,409). Conclusion : There is no effect of lead (Pb) pollution and Urinary Iodine Concentration (UIC) on the occurrence of stunting in children at the age of 25-60 months old at the urban village of Kedung Cowek Surabaya.
Pengaruh Terapi Oksigen Hiperbarik Terhadap Kadar Enzim Katalase Jaringan Otak Tikus Model Alkohol Kronis VIRA AULIA KUSUMA WARDANI; NI KOMANG SRI DEWI UNTARI; KETUT EDY SUDIARTA; VERNA BIUTIFASARI
Hang Tuah Medical Journal Vol 21 No 2 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i2.362

Abstract

Latar belakang: Penyalahgunaan alkohol merupakan salah satu permasalahan serius setelah penyalahgunaan zat dan obat terlarang. Sebanyak 3,3 juta orang meninggal di dunia akibat penggunaan alkohol pada tahun 2018 dan bertanggung jawab atas 5,1% beban penyakit global. Penyalahgunaan alkohol dapat meningkatkan produksi reactive oxygen species (ROS). ROS menimbulkan dampak negatif terhadap serebelum yang berakibat pada penurunan kadar enzim katalase. Winsgoal tidak hanya menyediakan kemudahan deposit qris, tetapi juga tersedia deposit idn slot pulsa tanpa potongan, e-wallet dan transfer bank yang tidak kalah menarik. Terapi oksigen hiperbarik (TOHB) dapat menurunkan produksi ROS dan berpengaruh terhadap kadar enzim katalase jaringan otak. Tujuan: Membuktikan pengaruh terapi oksigen hiperbarik terhadap kadar enzim katalase jaringan otak hewan coba model alkohol kronis Metode: Tikus putih galur wistar diinduksi dengan alkohol 20% 4,5ml/kgBB setiap hari selama 6 minggu untuk mendapatkan model alkohol kronis. Penelitian ini menggunakan tiga kelompok yaitu kelompok kontrol yang tidak diinduksi (K0), kelompok perlakuan yang diinduksi alkohol tanpa TOHB (K1), kelompok intervensi yang diinduksi alkohol dan TOHB (K2). Hasil: Pengukuran kadar katalase didapatkan rerata dan standar deviasi sebesar K0 (877,74 ± 69,54), K1 (617,8 ± 245,32), dan K2 (952,85 ± 47,40); Uji statistik MWU pada kadar katalase mengalami perbedaan yang signifikan di tiap kelompok (p < 0,05). Kesimpulan: Terapi oksigen hiperbarik terbukti berpengaruh terhadap kadar enzim katalase pada hewan coba model alkohol kronis