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All Journal International Journal of Integrated Health Sciences Kreano, Jurnal Matematika Kreatif-Inovatif Teknobuga : Jurnal Teknologi Busana dan Boga AGRIVITA, Journal of Agricultural Science Program Kreativitas Mahasiswa - Penelitian Al Khawarizmi: Jurnal Pendidikan dan Pembelajaran Matematika PRODUCTUM : Jurnal Desain Produk (Pengetahuan dan Perancangan Produk) Jurnal Teknik Pertanian Lampung (Journal of Agricultural Engineering) JURNAL PENDIDIKAN TAMBUSAI IKRA-ITH ABDIMAS International Journal of Economics, Business and Accounting Research (IJEBAR) Jurnal Geuthee Narra J Lughatu Ad-Dhat: Journal of Arabic Languange Education Practice of Fashion and Textile Education Journal BAJU: Journal of Fashion and Textile Design Unesa Journal of Mathematics Science and Computer Education Malacca Pharmaceutics Grimsa Journal of Science Engineering and Technology @-Publik: Jurnal Administrasi Publik Serat Rupa: Journal of Design
Suryawati Suryawati
Balai Penelitian Tanaman Hias
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Rational Use of Proton Pump Inhibitors Among the Early Aging Population: Evidence from a Community Health Center in Indonesia Suryawati, Suryawati; Animalika, Lulu; Narisa, Maghyan; Suardi, Hijra Novia; Aini, Zahratul; Mulia, Vera Dewi; Maghfirah, Desi
Grimsa Journal of Science Engineering and Technology Vol. 4 No. 1 (2026): April 2026
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v4i1.116

Abstract

Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide and are widely used for the management of acid-related disorders, particularly among adults in their early ageing period, where concerns about inappropriate prescribing remain prevalent. This study aimed to evaluate the rational use of PPIs among adults aged ≥46 years at a primary healthcare centre in Banda Aceh, Indonesia. This study focuses on the appropriateness of indications, dosages, and durations, as well as potential drug–drug interactions. Dose appropriateness was assessed using Lexicomp standard adult dosing. Duration and appropriateness of indications were assessed according to the Indonesian Gastroenterology Consensus. A retrospective cross-sectional study was conducted, comprising 1,997 records. A sample of 107 patients who met the predefined inclusion and exclusion criteria was analysed. Most patients were aged 56–65 years and predominantly female, with dyspepsia as the main indication. Omeprazole was prescribed in all cases, commonly at 20 mg twice daily. Nearly half of prescriptions were inappropriate, and appropriate dosing was limited. While treatment duration was generally adequate, some cases were shorter than recommended. Potential drug–drug interactions were identified but were mostly of low clinical significance. Overall, the rational use of PPIs among the patients in this primary healthcare setting remains suboptimal, particularly in terms of indication and dosing. These findings highlight the need to strengthen adherence to clinical guidelines and to implement regular medication reviews to promote safer, more rational PPI use in this population.
Co-Authors Aini, Zahratul Angilia, Ciecielia Animalika, Lulu Annisa Rahmawati, Dinda Anwar, Nadia Aprianto, Revan Arrsyi, Esty Nurbaity Asteriniah, Femi Bintang Zaura Effendi Nawawi, Effendi Ellianti, Ellianti Erni Maidiyah Fajri, Fauzan Farsa, Bianda S. Ferbyan, Sheila Indri Firsty , Velia Harnita, Fahlida Hijra Novia Suardi Husna, Fauzul Khairan Khairan Khairul Umam lestari, mulia Listiani, Sri Lizhen, Chen M Hasbi Maghfirah, Desi Mailizar Mailizar Masra Lena Siregar, Masra Lena Mastura, Ayu Meilasari, Rika Melinda Lasaret, Putri Mohamad Ikbal Riski Danial Muhammad Iqbal Mulia, Vera Dewi Muliana, Devika Narisa, Maghyan Nasrullah Nasrullah Nisa Syahidah, Izzatun Noerharyono, Muchamad Puspita, Nanda Ayu Putri Wahyuni, Sulistia Putri, Vivi Radiona Sofyani Rasydi, Ahmad Rauhillah, Siti Rawiyah Lubis, Harsuyanti Rezki Pebriyana , Tasya Riadhi, Moh Ridho Kurniati Rinaldi Idroes Rosaria Indah Sapitri, Lutfia Ayu Sary, Nirwana L. Sesnawati, Yeni Suci Amalia Suhartati Suhartati Supenti Supenti, Supenti Syafrina, Riska Triana Hertiani Tuti Zubaidah Yasrina, Raisa Yaum Aamruna Yuniarto, Kurnia ZAHRA, E. LUTFIA Zahra, Eneng Lutfia Zakhirah, Haura Zeir, Haya A. Zulham Effendi