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GAMBARAN PERILAKU KESEHATAN GIGI ANAK SEKOLAH DASAR DI DESA BANGSALSARI KABUPATEN JEMBER Nadie Fatimatuzzahro; Rendra Chriestedy Prasetya; Winda Amilia
Jurnal Ilmu Kesehatan Masyarakat Vol 12 No 2 (2016)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

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Abstract

Pendahuluan: Karies gigi merupakan penyakit dengan prevalensi tertinggi selainpenyakit periodontal. Penyakit ini menjadi masalah nasional di beberapa Negaraberkembang terutama di Indonesia.Tujuan Penelitian: Etiologi utama karies pada anak adalah pola makan. Kelompok usiasekolah dasar mempunyai kebiasan jajan yang lebih tinggi dari kelompok usia lainkhususnya makanan manis, sehingga menyebabkan meningkatnya indeks karies gigi.Kegiatan ini didanai oleh Kemenristekdikti, yang dilakukan pada 2 SD yaitu SDN 03 danSDN 04 Bangsalsari. Metode Penelitian: Jumlah responden adalah siswa kelas 3 sebanyak 70 orang di SDN 03Bangsalsari dan 51 orang di SDN 04 Bangsalsari yang diperoleh dengan menggunakanmetode total sampling. Penyuluhan dan praktek gosok gigi bersama dilakukan kepadapara siswa untuk memberi pengetahuan serta memperbaiki perilaku mengenai kesehatanrongga mulut.Hasil Penelitian: Hasil pemeriksaan menunjukkan indeks DMF-T rata-rata untuk siswaSDN 03 Bangsalsari yaitu 6,1, sedangkan rerata indeks DMF-T untuk siswa SDN 04Bangsalsari yaitu 5. Indeks gigi yang karies (D) lebih dominan yaitu sekitar 67%dibanding gigi yang telah dicabut (M) sebanyak 2% dan gigi yang telah ditambal(F) hanya 1%. Masih tinggi nya gigi yang karies (D) dibandingkan gigi yang sudahditambal (F) menunjukkan masih rendahnya pengetahuan dan kesadaran siswa SDserta orang tua dalam menjaga kesehatan rongga mulutnya. Status karies gigi padasiswa SDN 03 dan 04 Bangsalsari berada pada kategori Tinggi berdasarkan kriteriaWHO. Kata kunci : Karies gigi, Perilaku, Siswa SD, Indeks DMF-T
Respon inflamasi pulpa gigi tikus Sprague Dawley setelah aplikasi bahan etsa ethylene diamine tetraacetic acid 19% dan asam fosfat 37% Nadie Fatimatuzzahro; Tetiana Haniastuti; Juni Handajani
Dental Journal (Majalah Kedokteran Gigi) Vol. 46 No. 4 (2013): December 2013
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (887.331 KB) | DOI: 10.20473/j.djmkg.v46.i4.p190-195

Abstract

Background: Etching agents such as ethylene diamine tetraacetic acid (EDTA) and phosphoric acid which are widely used in adhesive restoration system, are aimed to increase retention of restorative materials; however, these agents may induce inflammation of dental pulp. The major function of the inflammatory response is to remove invading pathogens or damaged tissue/ cells and therefore, initiate repair. Neutrophils and macrophages are motile phagocytes that constitute the body's first line of defense. Purpose: The purpose of the present research was to study the effect of 19% EDTA and 37% phosphoric acid for etching application agents on the inflammatory response of the dental pulp. Methods: Forty-five male Sprague Dawley rats were divided into 3 groups. Cavity preparation was made on the occlusal surface of maxillary first molar using a round diamond bur. Nineteen percent of EDTA, 37% phosphoric acid, and distilled water were applied on the surface of the cavity of the teeth in group I, II and III respectively. The rats were sacrified at 1, 3, 5, 7, and 14 days after the application (n=3 for each day). The specimens were then processed histologically and stained with hematoxylin eosin. Results: ANOVA showed a significant difference (p<0.05) among treatment groups, indicating that etching agents application induced neutrophils, macrophages and lymphocytes infiltration in the dental pulp. Tuckey HSD test showed that application of 37% phosphoric acid increased higher number of neutrophils, macrophages and lymphocytes significantly than 19% EDTA (p<0.05). Conclusion: The study suggested that 37% phosphoric acid induced higher number of the inflammatory cells than 19% EDTA.Latar belakang: Penggunaan bahan etsa seperti ethylene diamine tetraacetic acid (EDTA) dan asam fosfat pada sistem restorasi adhesif bertujuan untuk meningkatkan retensi bagi bahan restorasi, namun penggunaan bahan-bahan tersebut dapat menginduksi inflamasi pada pulpa. Respon inflamasi berfungsi untuk menghilangkan patogen, sel-sel atau jaringan yang rusak dan menginisiasi perbaikan. Netrofil dan makrofag adalah sel fagosit yang merupakan garis pertama pertahanan tubuh. Tujuan: Penelitian ini bertujuan untuk meneliti efek EDTA 19% dan asam fosfat 37% sebagai bahan etsa terhadap respon inflamasi pada pulpa gigi. Metode: Empat puluh lima ekor tikus Sprague Dawley jantan dibagi menjadi 3 kelompok. Permukaan oklusal gigi molar satu rahang atas dipreparasi menggunakan diamond round bur. Pada kelompok I kavitas diaplikasikan EDTA 19%, kelompok II diaplikasikan asam fosfat 37% dan kelompok III diaplikasikan akuades. Hewan coba dikorbankan pada hari ke-1, 3, 5, 7 dan 14 setelah aplikasi bahan etsa (n=3). Spesimen diproses secara histologis dan dicat dengan hematoksilin eosin. Hasil: Hasil ANOVA menunjukkan perbedaan yang bermakna (p<0,05) antar kelompok perlakuan, mengindikasikan bahwa aplikasi bahan etsa menyebabkan infiltrasi sel inflamasi pada pulpa, baik netrofil, makrofag dan limfosit. Hasil uji Tuckey HSD menunjukkan bahwa asam fosfat 37% menstimulasi infiltrasi sel netrofil, makrofag dan limfosit signifikan (p<0,05) lebih banyak dibanding EDTA 19%. Simpulan: Penelitian ini menunjukkan bahwa asam fosfat 37% menyebabkan infiltrasi sel inflamasi yang lebih banyak dibanding EDTA 19%.
Potential of 5% tamarind extract gel as an etching agent: tensile strength and scanning electron microscope (SEM) evaluation Erawati Wulandari; Faiqatin Cahya Ramadhani; Nadie Fatimatuzzahro
Dental Journal (Majalah Kedokteran Gigi) Vol. 53 No. 1 (2020): March 2020
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v53.i1.p16-19

Abstract

Background: Acid etching is a stage in obtaining bonds between composites and enamel. The application of acid to the enamel surface, however, can cause dissolution of hydroxyapatite and demineralisation of the enamel surface. Phosphoric acid, a strong acid, is an etching material that can reduce enamel hardness. Excessively reducing hardness can interfere with attachment to the restorative material. One medicinal plant that can be used as an alternative material in acid etching is tamarind. Purpose: This study aims to determine the effect of 5% tamarind extract gel on the tensile strength of composite resins. Methods: This is an experimental research study with a post-test-only control-group design. The study used 14 mandibular incisors. The labial part of the incisor was prepared using a diamond fissure bur with a diameter of 4 mm and a depth of 2 mm. The control group was then etched with 37% phosphoric acid gel, while the experimental group was etched with 5% tamarind extract gel. Bonding resins and micro-hybrid composite resins were applied, based on the manufacturers’ instructions. Next, a tensile strength test and seeing formation resin tags by scanning electron microscope (SEM) were performed. Data were analysed using an independent t-test (p < 0.05). Results: The average tensile strength of composite resins in the group etched with 5% tamarind extract gel was the same as in the 37% phosphoric acid group (p > 0.05). SEM images also show that enamel etched with 5% tamarind extract gel produced a tag similar to that etched with 37% phosphoric acid gel. Conclusion: 5% tamarind extract as an etching material can generate tensile strength of composite resin and trigger formation of resin tags in the same way as 37% phosphoric acid.
Addition of gourami (Osphronemus goramy) fish scale powder on porosity of glass ionomer cement Erawati Wulandari; Farah Rachmah Aulia Wardani; Nadie Fatimattuzahro; I Dewa Ayu Ratna Dewanti
Dental Journal (Majalah Kedokteran Gigi) Vol. 55 No. 1 (2022): March 2022
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v55.i1.p33-37

Abstract

Background: Porosity is one of the disadvantages of glass ionomer cement (GIC) restorative materials, as it causes a reduction in strength and durability; the greater the porosity, the lower the strength of the restorative material and vice versa. As gourami fish scales contain calcium and phosphate, they have the potential to reduce the porosity of GIC. Purpose: This study aimed to analyse the effect of adding gourami fish scale powder (GFSP) on the pore size and porosity level of the GIC. Methods: This experimental research included a post-test-only control. The GFSP was fabricated using the freeze-drying method. Sixteen Fuji IX Extra sample cylinders with a diameter of 5 mm and a height of 3 mm were divided into four groups: K0, which comprised GIC without the addition of GFSP; K1, which contained GIC powder + 2.5% GFSP (by weight); K2, which comprised GIC powder + 5% GFSP (by weight), and K3, which contained GIC powder + 10% GFSP (by weight). The samples were observed using scanning electron microscopy and measured using ImageJ software. Data were analysed using a one-way analysis of variance (ANOVA) test. Results: The addition of 2.5% GFSP (by weight) produced the smallest pore size and lowest porosity, while the one-way ANOVA test results were significant among all groups at p = 0.000. There was no significant difference in pore sizes between K0 and K1 (p = 0.359), but a significant difference was found in the level of porosity (p = 0.024). Conclusion: The addition of GFSP affected the porosity of the GIC; the pore size and porosity level of the GIC were reduced by the addition of 2.5% GFSP.
Potensi gel ekstrak cocoon laba-laba Argiope modesta 5% terhadap jumlah sel fibroblas dan kepadatan kolagen pada penyembuhan luka gingivaPotential of 5% Argiope modesta spiders cocoon extract gel on the fibroblasts number and collagen density in gingival wound healing Nadie Fatimatuzzahro; Peni Pujiastuti; Renda Shania Alicia
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 33, No 3 (2021): Desember 2021
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v33i3.34401

Abstract

Pendahuluan: Sutra cocoon laba-laba merupakan bahan alternatif yang diketahui sering digunakan oleh masyarakat tradisional untuk menghentikan pendarahan dan menutup luka. Cocoon laba-laba terdiri dari asam amino glisin dan alanin yang berkontribusi pada adhesi dan proliferasi sel. Tujuan penelitan ini adalah menganalisis potensi gel ekstrak sutra cocoon laba-laba Argiope modesta 5% terhadap jumlah sel fibroblas dan kepadatan kolagen pada penyembuhan luka gingiva. Metode: Penelitian experimental laboratories dengan the post- test only control group design. Sampel yang digunakan sebanyak 35 ekor tikus wistar jantan, dibagi secara acak menjadi 3 kelompok yaitu (a) kelompok kontrol negatif, diaplikasikan gel plasebo; (b) kelompok perlakuan, diberi gel ekstrak cocoon laba-laba 5%; (c) kelompok sehat, tidak diberi perlukaan maupun terapi. Lima belas ekor tikus kelompok kontrol negatif dan 15 ekor tikus kelompok perlakuan dibagi menjadi 3 sub kelompok hari pengamatan, yaitu hari ke-3, ke-5 dan hari ke-7 yang terdiri dari 5 ekor tikus setiap sub kelompok. Kelompok tikus sehat terdiri dari 5 ekor tikus. Perlukaan dibuat pada mukosa gingiva M1 kiri rahang bawah, kemudian dilakukan aplikasi gel. Hewan coba di euthanasia untuk selanjutnya dibuat sediaan histologi dan dilakukan pengamatan sel fibroblas dan kolagen. Hasil: Terdapat perbedaan yang signifikan (p=0,01) rerata jumlah fibroblas kelompok perlakuan (18,67±0,72) dibanding kelompok kontrol negatif (12,08±0,32) dan kelompok sehat (9,17±0,43) pada hari ke-7. Rerata kolagen berbeda signifikan (p=0,01) pada kelompok perlakuan (245,12±1,07) dibanding kelompok kontrol negatif (231,53±0,90) dan kelompok sehat (248,75±1,27) pada hari ke-7. Simpulan: Aplikasi gel ekstrak cocoon laba-laba (Argiope modesta) 5% terbukti meningkatakan jumlah sel fibroblas dan kepadatan kolagen.Kata kunci: cocoon; laba-laba; glisin; alanin; fibroblast; kolagen ABSTRACTIntroduction: Spider cocoon silk is an alternative material that traditional people often use to stop bleeding and close wounds. Spider cocoon is composed of glycine and alanine amino acids which con-tribute to cell adhesion and proliferation. This study aimed to analyze the potency of the 5% Argiope modesta spider silk extract gel on the number of fibroblasts and collagen density on gingival wound healing. Methods: Experimental laboratory research with the post-test only control group design. The samples used were 35 male Wistar rats, randomly divided into three groups, namely (a) negative control group, placebo gel was applied; (b) the treatment group was given 5% spider cocoon extract gel; (c) healthy group, not given any injury or therapy. Fifteen rats in the negative control group and 15 rats in the treatment group were divided into three subgroups on the day of observation, namely, on the third, fifth and seventh days, which consisted of five rats in each subgroup. The healthy rat group consisted of five rats. An injury was made on the mandibular left M1 gingival mucosa, and then the gel was applied. Experimental animals were euthanized for further histology preparation, and observations of fibroblasts and collagen cells were carried out. Results: There was a significant difference (p=0.01) in the mean number of fibroblasts in the treatment group (18.67±0.72) compared to the negative control group (12.08±0.32) and the healthy group (9.17±0, 43) on the seventh day. The mean collagen was sig-nificantly different (p=0.01) in the treatment group (245.12±1.07) compared to the negative control group (231.53±0.90) and the healthy group (248.75±1.27) on the day of seventh. Conclusions: The application of spider cocoon extract gel (Argiope modesta) 5% increases the number of fibroblasts and collagen density.Keywords: cocoon; spider; glycine; alanine; fibroblasts; collagen
Perubahan Histologis Jaringan Pulpa sebagai Respon terhadap Aplikasi Bahan Etsa Nadie Fatimatuzzahro
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 12 No 1 (2015)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Etching agents which are widely used in adhesive restoration aimed to increase retention of restorative materials, may act a chemical irritant that induce inflammation of dental pulp. Odontoblasts which are located at the periphery of the pulp, are the first cells encountered by irritant and infectious agents. This research aimed to elucidate the responses of dental pulp to 37% phosphoric acid and 19% EDTA application as an etching agents. Forty-five male Sprague Dawley rats were divided into 3 groups. Cavity preparation was made on the occlusal surface of maxillary first molar. 37% phosphoric acid, 19% EDTA and distilled water were applied on the surface of the cavity of the teeth in group I, II, and III subsequently. The cavities were filled by glass ionomer cements. The rats were sacrified at 1, 3, 5, 7 and 14 days after the treatment (n=3 for each day). The specimens were then processed histologically, stained with Hematoxylin Eosin. In intact teeth showed histological features of normal pulp tissue with no inflammation, odontoblast layer were aligned along the pulp chamber with normal morphology of cells. Severe inflammation was observed after 37% phosphoric acid application, odontoblast layer could not be observed in the areas below the cavity. Slight to moderate inflammation and disorganization of odontoblast layer were seen after application of 19% EDTA. In conclusion, application of 37% phosphoric acid induces severe inflammation and disorganization of pulp tissue than 19% EDTA.
Seduhan Bubuk Kopi Robusta Spray Dryed Meningkatkan Viabilitas Monosit yang Dipapar Eksotoksin Streptococcus mutans (In Vitro) Fiftiani Syarah; I Dewa Ayu Susilawati; Nadie Fatimatuzzahro
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 16 No 1 (2019)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v16i1.19956

Abstract

Monocytes response against bacterial exotoxins can cause cell damage, due to the production of antimicrobial compounds such as oxidants and free radicals. Spray dryed robusta coffee brewed contained antioxidants that was alleged to be able counteract oxidants and free radicals leading to prevent cell damage. This research aimed to prove the effect of spray dryed robusta coffee brew (SDRCB) to increase monocytes viability after being exposed by exotoxins of Streptococcus mutans (in vitro). This in vitro experimental study used the post test only control group design. The object of study was human peripheral blood monocytes, isolated by means of gradient centrifugation method. Monocyte viability was analyzed by trypan blue assay. The parameter was the percentage viable monocytes. Data were analyzed using Anova and LSD. Monocytes incubated with SDRCB showed a significant (p<05) higher viability (96.95%) than monocytes without SDRCB (94,27%). Spray dryed robusta coffee brew proved to be able increase viability of monocytes after S.mutans exposure (in vitro).
37% Phosphoric Acid Induced Stronger Matrix Metalloproteinase-8 Expression of the Dental Pulp than 19% Ethylene Diamine Tetraacetic Acid Nadie Fatimatuzzahro; Tetiana Haniastuti; Juni Handajani
Journal of Tropical Life Science Vol. 4 No. 3 (2014)
Publisher : Journal of Tropical Life Science

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Abstract

Etching agents such as ethylene diamine tetraacetic acid (EDTA) and phosphoric acid which are widely used in adhesive restoration system aimed to increase for retention of restorative materials, may act a chemical irritant that induce inflammation of dental pulp. Inflammation is a body response against irritant and infectious agents. Matrix metalloproteinase-8, the major collagenolytic enzyme, degrades collagen type 1. This enzyme is expressed in low level in normal condition, however, the expression will increase during inflammation. The purpose of the present research was to study the effect of 19% EDTA and 37% phosphoric acid application as an etching agents on the MMP-8 expression of dental pulp. Forty-five male Sprague Dawley rats were divided into 3 groups. Cavity preparation was made on the occlusal surface of maxillary first molar using a round diamond bur. 19% EDTA, 37% phosphoric acid, and distilled water were applied on the surface of the cavity of the teeth in group I, II, and III subsequently. The cavity then filed by glass ionomer cements. The rats were sacrified at 1, 3, 5, 7, and 14 days after the treatment (n=3 for each day). The specimens were then processed histologically. Immunohistochemical (IHC) analysis was performed using rabbit anti rat MMP-8 polyclonal antibody to examine MMP-8 expression and HE (Hematoxylen Eosin) staining to observe the number of macrophages. The results showed 37% phos­phoric acid application induced stronger expression of MMP-8 and higher number of macrophages than 19% EDTA. The strongest expression of MMP-8 seems on 5 days after the treatment where the highest number of macrophages were also found.
Tingkat kesesuaian pembacaan struktur normal maksila pada radiografi panoramik: Studi Observasional Nadie Fatimatuzzahro; Supriyadi Supriyadi; Aulia Vanadia
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 35, No 2 (2023): Agustus 2023
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v35i2.47848

Abstract

ABSTRAKPendahuluan: Radiografi panoramik merupakan salah satu radiograf yang banyak digunakan pada praktek kedokteran gigi. Radiografi panoramik menampilkan struktur anatomi yang kompleks sehingga memiliki tantangan tersendiri dalam menginterpretasi khususnya pada gambaran radiografi maksila. Interpretasi atau pembacaan struktur anatomi normal pada radiografi sangat penting dalam ketepatan diagnosis penyakit. Struktur anatomi daerah maksila dekat dengan ruang fasial memiliki kompleksitas tersendiri secara deskriptif. Penelitian ini bertujuan untuk mengetahui kesesuaian pembacaan struktur normal maksila pada radiografi panoramik. Metode: Penelitian observasional deskriptif dengan pendekatan cross-sectional ini melibatkan 77 mahasiswa profesi semester 3 dan 27 mahasiswa profesi semester 4 Fakultas Kedokteran Gigi Universitas Jember. Penelitian dilakukan dengan cara menyebar kuesioner terbuka berupa sebuah radiograf panoramik berisikan struktur normal rongga mulut disertai tanda panah dan nomor pada struktur yang ditentukan untuk disebutkani jawaban yang benar. Data yang diperoleh dianalisis secara deskriptif. Hasil: Kesesuaian pembacaan pada struktur sinus maksila sangat baik sebesar 100%. Kesesuaian pada struktur maksila lainnya dikatakan baik dengan persentase palatum sebesar 80%, cavum nasi sebesar 84%, spina nasalis anterior sebesar 84%, foramen insisif sebesar 82%, dan septum nasal sebesar 83%. Simpulan: Tingkat kesesuaian pembacaan struktur maksila yang paling tinggi ialah sinus maksila dan yang terendah ialah palatum. Struktur yang memiliki variasi jawaban tertinggi adalah foramen insisif dan cavum nasi.Kata kunciinterpretasi, rongga mulut, maksila, radiografi panoramik Conformity level of maxillary normal structure reading on panoramic radiographs: Observational studyABSTRACTIntroduction: Panoramic radiography is a widely utilized imaging technique in dental practice. It presents a comprehensive view of complex anatomical structures, which presents challenges in interpretation, particularly in the context of maxillary radiographic images. Accurately interpreting typical anatomical structures on radiographs is crucial for precise disease diagnosis. The intricate anatomical features in the maxillary region adjacent to the facial space add to the complexity of the description. This study assesses the accuracy of interpreting typical maxillary anatomical structures on panoramic radiographs. Methods: This descriptive observational study employed a cross-sectional approach. It included 77 third-semester professional students and 27 fourth-semester professional students from the Faculty of Dentistry at the University of Jember. The study involved the distribution of open-ended questionnaires, presenting panoramic radiographs depicting typical oral cavity structures, each marked with arrows and corresponding numbers. The obtained data were subject to descriptive analysis. Results: The accuracy of interpreting maxillary sinus structures was excellent at 100%. The interpretation accuracy of other maxillary structures was rated as good, with percentages as follows: palate 80%, nasal cavity 84%, anterior nasal spine 84%, incisive foramen 82%, and nasal septum 83%. In conclusion, the reading accuracy was highest for maxillary sinus structures and lowest for the palate. The incisive foramen and cavum nasi displayed the highest variation in answers among the structures. Keywordsreading, oral cavity, maxilla, panoramic radiography
Potensi Ekstrak Daun Asam Jawa (Tamarindus indica L) dalam Menghambat Pertumbuhan Bakteri Streptococcus mutans pada Resin Akrilik Heat-cured Raissa Salma Hardiani; Achmad Gunadi; Depi Praharani; Rahardyan Parnaadji; Nadie Fatimatuzzahro
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 20 No 2 (2023)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v20i2.44012

Abstract

Heat-cured acrylic resin is a material that is often used as a denture base. However, heat-cured acrylic resin is porous which can be a site for plaque accumulation. Streptococcus mutans is a microorganism that initiates plaque formation. Therefore, the cleanliness of the denture must always be maintained, one of which is by immersing the denture in 0.5% NaOCl solution. However, NaOCl can fade the color of acrylic resin and is corrosive. Alternative materials that can be used are materials derived from nature. Tamarind leaves are known to contain bioactive compounds that have antibacterial activity. The purpose of this study is to determine the potential of tamarind leaf extract at several concentrations that could inhibit the growth of S. mutans on heat-cured acrylic resin and the concentration that had the greatest ability to inhibit the growth of S. mutans on heat-cured acrylic resin. This type of research is a laboratory experimental study with a post-test-only control group design. Each acrylic resin plate will be contaminated with S. mutans for 24 hours and then immersed in the tamarind leaves extract concentration of 3.125%; 6.25%; 12.5%; 25%, positive control (NaOCl 0,5%), and negative control. The measurement of the number of S. mutans was carried out using a spectrophotometer. . The results showed that tamarind leaf extract was able to inhibit the growth of S. mutans on heat-cured acrylic resin and the highest concentrations in inhibiting the growth of S. mutans on heat-cured acrylic resin were 12.5% and 25%.