I Gusti Agung Trisna Windiani
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Udayana, Denpasar, Bali

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Fatty Liver and Liver Malondialdehyde Expression in Severe Malnourished Wistar Rats that given Virgin Coconut oil Compared to Corn Oil in World Health Organization Formula I Gusti Ayu Putu Eka Pratiwi; Soetjiningsih .; I N. Mantik Astawa; I Gusti Ayu Trisna Windiani; I Gede Ngurah Harry Wijaya Surya
Journal of Global Pharma Technology Vol. 9 Issue 7 : 2017
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: There is a lack of antioxidant in severe malnutrition, and it may lead to increase oxidative stress. Fatty liver is one of severe malnutrition (SM) cardinal features. Virgin coconut oil (VCO) contains high antioxidant capacity and medium chain triglyceride. It is supposed to improve those problems. Methods: Posttest only control group design study was done to observe whether VCO could decrease fatty liver and liver malondialdehyde (MDA) expression in 38 male wistar rat with SM. The rats were divided into two group which were VCO Group (Group A) and Control Group (corn oil (Group B)). They were given feeding World Health Organization (WHO) Formula for SM (Formula 75 and Formula 100) that contained VCO or corn oil. After being SM, this formula was fed until 28 days. In the 29th day, they were sacrificed, and liver samples were obtained for fatty liver analysis and MDA expression. Results: Fatty liver was less in Group A (mean 13.74 cell in 5 view field (SD 1.32) than Group B (mean 20.74 cell in 5 view field (SD 2.01), and it was statistically significant (p=0.000). Cut off point for determining low and high liver MDA expression based on o ROC curve were <2.9% (low) and ≥2.9% (high). Low MDA expression (<2.9%) was higher in Group A than Group B (p <0.05). Conclusions: This study found less fatty liver and low liver MDA expression in severe malnourished rat given VCO than corn oil.  Keywords: Virgin coconut oil, Fatty liver, Malondialdehyde, Severe malnutrition.
HUBUNGAN OVERWEIGHT-OBESITAS DENGAN NILAI AKADEMIS SISWA SEKOLAH MENENGAH ATAS (SMA) NEGERI 1 TABANAN, BALI Dewi, Ni Nyoman Gita Kharisma; Arimbawa, I Made; Putra, I Gusti Ngurah Sanjaya; Windiani, I Gusti Ayu Trisna
E-Jurnal Medika Udayana Vol 11 No 8 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i8.P05

Abstract

Overweight-obesity is a condition that results from the accumulation of excess body fat and can affect cognitive function in adolescents, thus having an impact on academic achievement. The aim of this study was to see the relationship between overweight-obesity and academic achievement of student at SMA N 1 Tabanan. The research design of this study was analytic observational cross-sectional. The data were taken by consecutive sampling method through distributing questionnaires in the form of google form. The subject of this study were students of class XI of SMA N 1 Tabanan. Bivariate and multivariate tests were used to analyze the data in this study. The results of the bivariate analysis, the relationship between academic achievement with nutritional status (p = 0.018), gender (p = < 0.001), socioeconomic status (p = 0.005), screen time (p = 0.001), breakfast habits (p = 0.133), and physical activity (p = 0.516). The results of the multivariate analysis, the relationship between academic achievement with nutritional status (OR 4.343; CI 95% 1.050-17.964), socioeconomic status (OR 4.614; CI95% 1.775-11.993), breakfast habits (OR 2.605; CI95% 1.003-6.767), screen time (OR 0.245; CI95% 0.092-0.651), and gender (OR 2.567; CI95% 0.979–6.733).The conclusion is that the overweight-obesity nutritional status has a significant relationship with academic achievement that is less than the average. The habit of not frequent/never having breakfast and less socioeconomic status were also shown to have a significant relationship with academic achievement that is less than the average. Key word : overweight-obesity, academic achievement, school age students.
The efficacy of audiovisual distraction as an anxiety-minimizing technique during echocardiography in preschool children Yantie, Ni Putu Veny Kartika; Gunawijaya, Eka; Windiani, I Gusti Ayu Trisna; Maharini, Kadek
Paediatrica Indonesiana Vol 63 No 5 (2023): September 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.5.2023.328-34

Abstract

Background Echocardiography procedures can cause fear and anxiety in children, especially at preschool age. Audiovisual distraction is a simple, harmless, and low-cost technique that does not interfere with the procedure. Objective To assess the effect of audiovisual distraction on the anxiety levels of children aged 2-5 years during echocardiography. Methods This quasi-experimental study included children aged 2-5 years who were admitted for echocardiography. Patients with hearing or visual impairment, Down syndrome, autism, or attention-deficit/hyperactivity disorder were excluded. We administered anxiety-reducing intervention in the form of cartoon audiovisual media shown on a ceiling-mounted television during the echocardiography procedure. Anxiety levels were assessed using the Visual Analogue Scale - Anxiety (VAS-A) before and after the intervention was given. We compared the subjects’ pre- and post-procedure VAS-A scores and heart rates. Results Of the 43 subjects who underwent echocardiography during the study period, the mean age was 3.2 (SD 0.9) years, with an equal sex distribution. Most subjects had a history of repeated echocardiography procedures and hospitalizations. Thirty-nine (90.6%) of subjects demonstrated anxiety during the echocardiography procedure. There was a significant mean difference of 11.9 (SD 13.2) bpm (95%CI 7.8 to 15.9 bpm, p<0.001) in heart rate pre- vs. post-intervention. Median pre- and post-intervention VAS-A scores were 5 (range 0-10) and 1 (range 0-4), respectively (P=0.001). Post-intervention, almost all (97.7%) subjects had no or mild anxiety. Conclusion Audiovisual content presented on television serves as an effective distraction method to reduce children's anxiety during echocardiography.
Hair zinc level and autism spectrum disorder in children Windiani, I Gusti Ayu Trisna; Adnyana, I Gusti Agung Ngurah Sugitha; Pratiwi, Ni Luh Putu Sukma; Hapsari, Ida Ayu Nyoman Dian Permana
Paediatrica Indonesiana Vol 64 No 3 (2024): May 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.3.2024.227-32

Abstract

Background Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders. In children with ASD, the neurodevelopmental and behavioral disorders are characterized by impaired quality of interaction, communication, and social imagination, with limited interest and repetitive behavior. Various studies have found that the mean zinc level is lower in children with ASD than in children without ASD, especially in the low functioning autism. Objective To compare hair zinc level in children with and without ASD. Methods This case-control study included children with ASD and controls without ASD. Subjects were children under 5 years old who came to Prof I.G.N.G. Ngoerah Hospital and Masadini Clinic in Denpasar. Hair zinc cut-off level was determined by the area under curve (AUC) based on the receiver operating characteristic (ROC) curve. Results A total of 128 subjects consisted of 64 cases and 64 controls, with a mean age of 4 (SD 0.8) years. Most subjects were male (76%); 82.3% were well-nourished. The mean maternal age at delivery was 28.82 (SD 3.2) years. Subjects’ mean hair zinc level was 87.9 (SD 231.1) ?g/g. Bivariate analysis with Chi-square test revealed that children with hair zinc concentration of <33.88 ?g/g were 22.19 times more likely to have ASD than those with higher zinc levels (OR 22.19; 95%CI 8.02 to 42.09; P<0.001). Conclusion Low hair zinc level is more likely to occur in children with ASD than in children without ASD.
COGNITIVE BEHAVIOUR THERAPY PADA REMAJA DENGAN PERCOBAAN BUNUH DIRI SUWANDI, NYOMAN DEFRIYANA; ARDANI, I GUSTI AYU INDAH; ADNYANA, I GUSTI AGUNG NGURAH SUGITHA; WINDIANI, I GUSTI AYU TRISNA
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 3 No. 2 (2024)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v3i2.3153

Abstract

Cognitive Behavioral Therapy (CBT) is a therapeutic approach that has been proven effective in treating various mental health problems, including suicide attempts in adolescents. The World Health Organization states that suicide is the second leading cause of death in the 15-29 year age group. In adolescents with suicide attempts, CBT can be used to help identify negative thoughts that drive suicidal thoughts and develop healthier coping strategies. It is important to note that CBT is not the only solution, but can be combined with other interventions, such as family support, psychoeducational education, and group therapy. This is a qualitative study using a case study approach combining observational studies and biographical studies. A 15-year-old girl, domiciled in Denpasar, junior high school education, unmarried, unemployed. The patient was diagnosed with a Major Depressive Episode without Psychotic Symptoms complaining of sadness since 1 month ago and felt even sadder when she had to go home. The patient felt more sensitive and felt that no one loved and understood her condition. The stressors felt were getting worse since she was suspended from school for not paying school fees and was reprimanded for dating. There are thoughts of drinking bleach and suddenly thinking about drinking the liquid. The patient also feels a loss of interest and joy, gets tired easily, and has difficulty concentrating. The patient is a stubborn and unruly child. When corrected, the patient will get angry and run away from home. Children with more severe depressive symptoms are more likely to benefit from antidepressants. The patient needs to be given pharmacotherapy and non-pharmacotherapy. Pharmacotherapy in this case is fluoxetine 5 milligrams intraorally every 24 hours (morning). Non-pharmacotherapy can be given supportive psychotherapy, CBT, and psychoeducation. Conflict management is not only done to the patient but also to the patient's family. Family conflict and parenting patterns can be one of the factors that aggravate the patient's current condition. ABSTRAKTerapi Perilaku Kognitif (CBT) merupakan pendekatan terapeutik yang telah terbukti efektif dalam mengatasi berbagai masalah kesehatan mental, termasuk percobaan bunuh diri pada remaja. Organisasi Kesehatan Dunia mengungkapkan bunuh diri menjadi penyebab kematian terbanyak kedua pada kelompok usia 15-29 tahun. Pada remaja dengan percobaan bunuh diri, CBT dapat digunakan untuk membantu dalam identifikasi pemikiran negatif yang mendorong keinginan untuk bunuh diri serta mengembangkan strategi koping yang lebih sehat. Penting untuk dicatat bahwa CBT bukan menjadi solusi tunggal, namun dapat dikombinasikan dengan intervensi lain, seperti dukungan keluarga, pendidikan psikoedukatif, dan terapi kelompok. Merupakan penelitian kualitatif melalui pendekatan studi kasus menggabungkan antara studi observasi dan studi biografi. Seorang anak perempuan 15 Tahun, domisili Denpasar, Pendidikan SMP, belum menikah, belum bekerja. Pasien didiagnosa dengan Episode Depresif Berat tanpa Gejala Psikotik mengeluh sedih sejak 1 bulan yang lalu dan makin merasa sedih saat harus pulang ke rumah. Pasien merasa lebih sensitif serta merasa tidak ada yang menyayangi dan memahami kondisinya. Stressor yang dirasakan semakin memberat sejak mendapatkan skorsing dari sekolah karena belum membayar uang sekolah dan ditegur karena berpacaran. Terdapat pikiran terlintas untuk minum pemutih pakaian dan secara tiba-tiba berpikir untuk meminum cairan tersebut. Pasien juga merasa kehilangan minat dan kegembiraan, mudah lelah, dan sulit untuk konsentrasi. Pasien merupakan anak yang keras kepala dan sulit diatur. Bila dikoreksi, pasien akan marah dan kabur dari rumah. Anak-anak dengan gejala depresi yang lebih parah kemungkinan besar mendapatkan manfaat dari pemberian antidepresan. Pada pasien perlu untuk diberikan farmakoterapi dan nonfarmakoterapi. Farmakoterapi pada kasus ini berupa fluoxetine 5 miligram intraoral tiap 24 jam (pagi). Nonfarmakoterapi dapat diberikan psikoterapi supportif, CBT, serta psikoedukasi. Penanganan konflik tidak hanya dilakukan kepada pasien saja namun juga kepada keluarga pasien. Konflik keluarga dan pola asuh orang tua bisa menjadi salah satu factor yang memperberat kondisi pasien saat ini.
GANGGUAN MOOD PADA ANAK DENGAN IBU KEPRIBADIAN AMBANG: LAPORAN KASUS NEGARA, NI WAYAN WIRAYANTI PUTRI; ARDANI, I GUSTI AYU INDAH; WINDIANI, I GUSTI AYU TRISNA; ADNYANA, I GUSTI AGUNG NGURAH SUGITHA
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 4 No. 1 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v3i4.4355

Abstract

ABSTRACT Childhood is an important phase in personality formation, but it is often accompanied by psychological problems that affect child development. Child development is greatly influenced by various factors, including parenting patterns. Data in this case study were obtained through in-depth interviews, medical records and psychometric examinations and projection tests aimed at seeing how mood disorders in children who have mothers with borderline personality. The patient is a 9-year-old boy who shows symptoms of aggression, hallucinations, unstable moods, and feelings of emptiness and loneliness. The child in this case shows problems with emotional dysregulation due to inconsistent parenting and environmental stress. The patient's mother has a borderline personality characterized by difficulty controlling emotions, extreme mood swings, and unstable behavior, which negatively affects parenting patterns. Studies show that mothers with borderline personality tend to create unstable environments, increase the risk of insecure attachment in children, and affect their emotional regulation. This case study highlights the importance of understanding the relationship between parental personality disorders and parenting, and their impact on child development. Interventions in parenting and support for families at risk of psychopathology can be preventive steps to reduce the incidence of mood disorders in children. ABSTRAKMasa kanak-kanak adalah fase penting dalam pembentukan kepribadian, namun sering disertai masalah psikologis yang memengaruhi perkembangan anak. Perkembangan anak sangat dipengaruhi oleh berbagai faktor, diantaranya pola asuh orangtua. Data dalam studi kasus ini diperoleh melalui wawancara mendalam, catatan rekam medis dan pemeriksaan psikometri dan tes proyeksi yang bertujuan untuk melihat bagaimana gangguan mood pada anak yang memiliki ibu dengan kepribadian ambang. Pasien adalah anak laki-laki 9 tahun yang menunjukkan gejala agresivitas, halusinasi, mood yang tidak stabil, serta rasa hampa dan kesepian. Anak dalam kasus ini menunjukkan masalah disregulasi emosi akibat pola asuh yang tidak konsisten dan tekanan lingkungan. Ibu pasien memiliki kepribadian ambang yang ditandai dengan kesulitan mengendalikan emosi, perubahan suasana hati yang ekstrem, dan perilaku tidak stabil, yang memengaruhi pola pengasuhan secara negatif. Studi menunjukkan bahwa ibu dengan kepribadian ambang cenderung menciptakan lingkungan yang tidak stabil, meningkatkan risiko kelekatan yang tidak aman pada anak, dan memengaruhi regulasi emosinya. Studi kasus ini menyoroti pentingnya memahami hubungan antara gangguan kepribadian orang tua dan pengasuhan, serta dampaknya pada perkembangan anak. Intervensi pada pola asuh dan dukungan bagi keluarga dengan risiko psikopatologi dapat menjadi langkah preventif untuk menurunkan kejadian gangguan mood pada anak.
SINDROM AMNESTIK ORGANIK PADA ANAK DENGAN EPILEPSI Tulus, Angelina; Ayu Trisna Windiani, I Gusti; Agung Ngurah Sugitha Adnyana, I Gusti; Ayu Indah Ardani, I Gusti
PAEDAGOGY : Jurnal Ilmu Pendidikan dan Psikologi Vol. 5 No. 2 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia (P4I)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/paedagogy.v5i2.6708

Abstract

Epilepsy is a chronic neurological disorder that can affect physical, cognitive, psychological, and social aspects in children. One of the prominent impacts is memory impairment, which in severe cases may develop into organic amnestic syndrome, particularly when accompanied by structural abnormalities such as hippocampal sclerosis. This article aims to report a case of organic amnestic syndrome in an adolescent with epilepsy and bilateral mesial temporal sclerosis, and to emphasize the importance of early detection and multidisciplinary management. The patient was a 15-year-old female adolescent with a history of generalized tonic-clonic epilepsy for the past two years and persistent memory complaints for six months. Cognitive assessment using the Indonesian version of the MoCA (MoCA-INA) showed a score of 19/30, and emotional evaluation using the CDI yielded a score of 19. Brain MRI revealed bilateral hippocampal atrophy, while EEG showed bilateral temporal epileptiform activity. The diagnosis was established based on clinical, neuropsychological, and radiological findings. The patient received combination therapy consisting of fluoxetine 10 mg/day, carbamazepine 300 mg twice daily, and supportive psychotherapy. The findings revealed a close association between epilepsy, hippocampal damage, memory impairment, and depressive symptoms. This case highlights the importance of structured memory screening and multidisciplinary intervention to minimize the cognitive and psychosocial impact of epilepsy in children and adolescents. ABSTRAK Epilepsi merupakan gangguan neurologis kronis yang dapat berdampak pada aspek fisik, kognitif, psikologis, dan sosial anak. Salah satu dampak yang menonjol adalah gangguan memori, yang pada kasus berat dapat berkembang menjadi sindrom amnestik organik, khususnya jika disertai kelainan struktural seperti sklerosis hipokampus. Artikel ini bertujuan melaporkan kasus sindrom amnestik organik pada remaja dengan epilepsi dan sklerosis mesial temporal bilateral, serta menekankan pentingnya deteksi dini dan manajemen multidisipliner. Pasien adalah remaja perempuan usia 15 tahun dengan riwayat epilepsi tonik-klonik umum sejak dua tahun terakhir dan keluhan gangguan memori menetap selama enam bulan. Pemeriksaan kognitif menggunakan MoCA-INA menunjukkan skor 19/30, dan penilaian emosional menggunakan CDI menghasilkan skor 19. MRI otak menunjukkan atrofi hipokampus bilateral, sementara EEG memperlihatkan aktivitas epileptiform di area temporal bilateral Diagnosis ditegakkan berdasarkan data klinis, neuropsikologis, dan radiologis. Pasien menerima terapi kombinasi berupa fluoxetine 10 mg/hari, carbamazepine 300 mg dua kali sehari, serta psikoterapi suportif. Temuan menunjukkan adanya hubungan erat antara epilepsi, kerusakan hipokampus, gangguan memori, dan gejala depresi. Kasus ini menggarisbawahi pentingnya skrining memori terstruktur dan intervensi multidisipliner untuk meminimalkan dampak kognitif dan psikososial epilepsi pada anak dan remaja.
Co-Authors Abadi, Dewa Ayu Ketut Sri Adnyana, I Gusti Agung Ngurah Sugitha Agung Ngurah Sugitha Adnyana, I Gusti Anak Agung Ayu Windi Antari and R. Kusnandi Ardani, I Gusti Ayu Indah Ayu Indah Ardani, I Gusti Ayu Setyorini Mestika Mayangsari Budi Santoso Adji Desak Putu Gayatri Saraswati Seputra Desak Putu Kunti Wedayanti Desak Putu Yulita Kurniati Dewa Ayu Dini Primashanti Dewa Ayu Ketut Sri Abadi Dewa Nyoman Wirawan Dewa Nyoman Wirawan, Dewa Nyoman Dewi, Ni Nyoman Gita Kharisma Djauhar Ismail Dyah Ekowati Eka Gunawijaya Ekawaty Lutfia Haksari Ekowati, Dyah Gusti Ayu Teja Devi Megapuspita Hapsari, Ida Ayu Nyoman Dian Permana Hendra Salim Hendrikus Gede Surya Adhi Putra I Gde Raka Widiana I Gede Ngurah Harry Wijaya Surya I Gusti Agung Ngurah Sugitha Adnyana I Gusti Ayu Endah Ardjana I Gusti Ayu Putu Eka Pratiwi I Gusti Istri Agung Widnyani I Gusti Lanang Sidiartha I Gusti Ngurah Sanjaya Putra I Made Arimbawa I Nyoman Budi Hartawan I NYOMAN MANTIK ASTAWA I Wayan Gede Artawan Eka Putra I Wayan Gede Artawan Eka Putra, I Wayan Gede Artawan Eka I Wayan Gustawan Ida Bagus Putu Alit Ida Bagus Subanda Julitasari S Kadek Apik Lestari, Kadek Apik Khrispina Owa Khrispina Owa Komang Ayu Kartika Sari Kurniasih Widayati Lie Affendi Kartikahadi Luh Gede Ayu Putri Vebriany Widiaskara Luh Kadek Pande Ary Susilawati Luh Putu Rihayani Budi Luh Seri Ani Made Ardinata Made Supartha Maharini, Kadek Mei Neni Sitaresmi Muhammad Reza Muhammad Reza Muliawati, Ni Kadek NEGARA, NI WAYAN WIRAYANTI PUTRI Ni Kadek Muliawati Ni Nyoman Ayuk Widiani Ni Nyoman Sukarti Ni Putu Anggun Laksmi Ni Putu Siadi Purniti Ni Putu Veny Kartika Yantie, Ni Putu Veny Kartika Ni Rai Sintarini Novilia Sjafri Bachtiar PITIKA ASPR Pratiwi, Ni Luh Putu Sukma Putu Anindia Sekarningrum Putu Dian Savitri Irawan Putu Junara Putra Putu Vivi Paryati Ricky Theddy Rini Mulia Sari S. Soetjiningsih, S. S. Sotjiningsih SAK Indriyani Sawitri, Anak Agung Sagung Soetjiningsih - Soetjiningsih - Soetjiningsih - Soetjiningsih Soetjiningsih . Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Soetjiningsih Sri Maya Suwandi, Nyoman Defriyana Tristina Wardani TULUS, ANGELINA Widayati, Kurniasih Widiani, Ni Nyoman Ayuk Wiradharma Wiradharma Yuliani Yuliani Yuliani