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All Journal PHARMACON Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Jurnal Teknosains Interest : Jurnal Ilmu Kesehatan Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA As-syifaa Jurnal Farmasi JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JURNAL PENGABDI Media Farmasi Al-Khidmah JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Media Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura
Isnindar Isnindar
Bagian Biologi Farmasi Fakultas Kedokteran Universitas Tanjungpura Pontianak
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Isolasi Dan Identifikasi Terpenoid Fraksi Heksan Daun Premna serratifolia L. Menggunakan GC-MS Ricky Midi Candra; Isnindar Isnindar; Sri Luliana
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.15311

Abstract

Buas-buas (Premna serratifolia L.) is a plant that belongs to the Verbenaceae family. Terpenoid compounds that exist in buas-buas plants have bioactivity as medicine. Terpenoid compounds are soluble compounds in n-hexane. The purpose of this study was to isolate and identify the terpenoid compounds contained in the n-hexane fraction of buas-buas leaves using the GC-MS method. The buas-buas leaves were macerated with 96% ethanol solvent and then fractionated using a separating funnel with n-hexane as solvent. The n-hexane fraction of buas-buas leaves was isolated using column chromatography with a gradient mobile phase combination of n-hexane and ethyl acetate, then identified using the GC-MS instrument. The terpenoid compounds found in the n-hexane fraction of buas-buas leaves are estimated to be neophytadiene; 3,7,11,15-tetramethyl-2-hexadecen-1-ol; and 2 hydroxy-4a,5-dimethyl-3-(prop-1-en-2-yl) octahydronaphthalen-1-(2H)-one.
FORMULASI GRANUL INSTAN EKSTRAK MENIRAN, KUNYIT, DAN DAUN KELOR DENGAN PENGISI MALTODEKSTRIN DAN LAKTOSA: FORMULATION OF INSTANT GRANULE CONTAINING MENIRAN, TURMERIC, AND MORINGA LEAF EXTRACTS WITH MALTODEXTRIN AND LACTOSE AS DILUENTS Azizzah Dwi Rahmawati; Sri Luliana; Isnindar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.429

Abstract

Pengembangan sediaan farmasi dalam bentuk granul instan kombinasi ekstrak meniran (Phyllantus niruri L.), kunyit (Curcuma longa L.), dan daun kelor (Moringa oleifera L.) dapat mempermudah masyarakat dalam mengonsumsi dan berkhasiat meningkatkan sistem imun tubuh. Penelitian ini bertujuan untuk mengevaluasi karakteristik fisik granul instan kombinasi ekstrak meniran, kunyit, dan daun kelor dengan bahan pengisi maltodekstrin dan laktosa. Metode pembuatan granul instan menggunakan metode granulasi basah. Granul instan dibuat dalam 3 formula dengan konsentrasi maltodekstrin dan laktosa yaitu, F1 (94% : 0%), F2 (0% : 94%), dan F3 (47% : 47%). Evaluasi yang dilakukan meliputi pengamatan organoleptik, kandungan lembab, waktu alir, sudut istirahat, waktu larut, dan pH. Berdasarkan evaluasi yang didapatkan, karakteristik fisik granul instan seluruh formula memenuhi persyaratan. Hasil analisis SPSS menunjukkan adanya pengaruh yang signifikan pada uji kelembaban (F1 terhadap F2; F2 terhadap F3), waktu alir (F1 terhadap F2 dan F3), sudut istirahat (F1 terhadap F2 dan F3), dan disolusi (F1 terhadap F2 dan F3; F2 terhadap F1 dan F3; F3 terhadap F1 dan F2).
Comparing Antioxidant Activity of Extracts and Gel Preparations Combination of Buas-buas Leaves (Premna serratifolia l.) and Secang Wood (Caesalpinia sappan) Tarung, Albianus Febri; Cristin, Bella; Maulidia, Yuninta; Kamil, Insan; Syalsabila, Regitha Rianda; Isnindar, Isnindar
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.77740

Abstract

Indonesia is a tropical country that has exposure to ultraviolet rays from the sun throughout the year. This causes susceptibility to skin problems for the Indonesian population, including the vulnerability to aging of the skin due to exposure to ultraviolet rays for a long time. In the prevention of degenerative diseases and aging, antioxidants play an important role. Buas-buas and secang, which are plants from the West Kalimantan region, have very high antioxidant activity. Gel preparations are typically formulated as moisturizers with the aim of increasing water content in the stratum corneum, thus hydrating and maintaining skin pH. Hence, this study aimed to create a gel preparation combining buas-buas leaf extract and secang, effective as a moisturizing and anti-aging gel. The results of measuring the antioxidant activity of the combination of crude ethanol extracts of buas-buas leaves and secang wood with the results of the three formulas have very strong antioxidant activity, namely F1 at 0.0329 mg/ml, F2 at 0.0246 mg/ml, and F2 at 0.0246 mg/ml. F3 of 0.2282 mg/ml, and IC50 results for gel preparations for F1 3,8677 mg/ml, F2 4,3953 mg/ml, F3 4,396 mg/ml. The gel preparations produced in this study have the appearance and fulfill the evaluation requirements, except for the evaluation of spreadability.
Formulation and Sunscreen Activity Test of Lotion of Buas-Buas (Premna Serratifolia Linn.) Leaf Extract Adahane, Euistya Febrianti Putri; Isnindar, Isnindar; Luliana, Sri
Majalah Obat Tradisional Vol 29, No 1 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.86919

Abstract

Excessive UV exposure can cause various skin disorders, so protection from UV rays is needed by using sunscreen. One of the plants that have the potential as a sunscreen is buas-buas leaf (Premna serratifolia Linn.) which contains flavonoid compounds. Sunscreen formulated in lotion form is the most common preparation found in the market. The purpose of this study was to evaluate the physical characteristics of lotion preparations and to determine the potential of lotion of buas-buas leaf extract as a sunscreen. Buas-buas leaf extract was obtained through maceration extraction with 96% ethanol solvent. Lotion with the active substance of buas-buas leaf extract was made with concentration variations of 1, 2, and 3%. Evaluation of the physical characteristics of the lotion was tested with organoleptic observation parameters, homogeneity, pH, spreadability, and adhesion. Then, it was tested for sunscreen potential using UV-Vis spectrophotometry. Data were analyzed with SPSS Statistics 22 software, namely the One Way ANOVA (Analysis of Variance) test. The results of the study were the three lotion formulas of buas-buas leaf extract met all the requirements of the physical characteristics evaluation test. The SPF value of F1 (1%) is 7.12 (extra protection), F2 (2%) is 9.54 (maximum protection) and F3 (3%) is 15.68 (ultra protection). Based on the results of the study, it can be concluded that the lotion of buas-buas leaf extract meets the requirements of evaluating the physical characteristics of lotions and has activity as a sunscreen.
The Effect of Cocamide Dea on the Characteristics of Ginger and Celery Extract Shampoo Preparations Anastasia, Desy Siska; Septiani, Rahmi; Isnindar, Isnindar
Majalah Obat Tradisional Vol 29, No 3 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.88466

Abstract

Ginger and celery extracts are recognized anti-dandruff agents. Managing dandruff can be accomplished by creating a cleanser formulation. Shampoo contains an essential cleansing ingredient known as surfactant. SLS enables good foams, but at >10% concentration, it irritates skin. Adding a nonionic surfactant like cocamide DEA reduces irritation. This study examined how cocamide DEA concentrations affected the physical qualities and hedonic evaluation of a shampoo containing ginger and celery extracts. The shampoo was produced in three formulas with differing cocamide DEA concentrations: F1 (6%), F2 (8%), and F3 (10%). The formulation is evaluated using organoleptic, homogeneity, viscosity, pH, bulk density, foam height, foam stability, cycling, hedonic, and irritant studies. The result of this study revealed that shampoo had a brownish-orange color, a ginger-mint scent, and different looks. All three formulations were homogeneous, did not separate during cycling, and had significant viscosity variances, pH, bulk density, foam height, and foam stability. The formula with an 8% cocamide DEA concentration was the most popular and did not produce irritation. In conclusion, varying cocamide DEA concentrations affect the physical properties and preferences of panelists in a shampoo formulation that includes ginger and celery extracts.
Penyuluhan dan Pendampingan Pembuatan Jamu Serbuk Instan Imunostimulan di Desa Tebang Kacang IH, Hariyanto; Isnindar, Isnindar; Nurbaeti, Siti Nani; Luliana, Sri; Yuswar, Muhammad Akib; Kurniawan, Hadi; Ropiqa, Meri
Jurnal Pengabdi Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/jplp2km.v7i2.72379

Abstract

Abstrak: Masyarakat indonesia telah lama menggunakan tanaman obat keluarga (TOGA) sebagai upaya pencegahan timbulnya penyakit dan menjaga kesehatannya. Salah satunya adalah meniran (Phillanthus niruri L.) dan jahe (Zingiber Officinale) dimana kombinasi tanaman tersebut telah terbukti dapat meningkatkan daya tahan tubuh. Namun dalam pegolahannya masih dalam bentuk yang sederhana, oleh karena itu diperlukan edukasi dan pendampingan pemanfaatan TOGA menjadi bentuk yang lebih praktis, mudah dan memiliki nilai ekonomi yang tinggi seperti serbuk instan. Oleh karena itu tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan edukasi dan pendampingan pembuatan meniran dan jahe menjadi serbuk instan sebagai imunostimulan di desa tebang kacang. Sasaran dari kegiatan PKM ini adalah ibu-ibu kader PKK yang ada di Desa Tebang Kacang. Metode dari PKM ini adalah penyuluhan dan workshop dengan tahapan kegiatan yaitu persiapan kegiatan, pelaksanaan kegiatan (penyuluhan dan workshop atau pendampingan pembuatan jamu serbuk instan), serta evaluasi kegiatan. Hasil kegiatan menunjukkan  adanya peningkatan pengetahuan peserta yang ditunjukkan dari nilai post-test rata-rata peserta, yaitu 65, jika dibandingkan terhadap nilai rata-rata pre-test, yaitu sebesar 53,33. Evaluasi kepuasan peserta dari kuesioner juga menunjukkan bahwa, materi yang disampaikan mudah dipahami, bermanfaat, menambah keterampilan, produk yang dihasilkan memiliki rasa yang enak dan dapat meningkatkan perekonomian desa.  Kata Kunci:  Serbuk Instan, Imunostimulan , Meniran, Jahe dan Desa Tebang Kacang  Abstract: Indonesians have long used family medicinal plants (TOGA) to prevent disease and maintain health. A few of them are meniran (Phillanthus niruri L.) and ginger (Zingiber Officinale). Their combination has been proven to increase the body's immune system. However, their processing was still in a simple form; therefore, education and assistance are needed to use TOGA in a more practical, easier, and highly economical value, such as instant powder. Therefore, this community service activity aims to educate and assist in making meniran and ginger into instant powder as an immunostimulant in the Tebang Kacang village. The targets of this program are PKK cadre mothers in Tebang Kacang Village. The method of this PKM is counseling and workshops with activity stages, namely preparation of activities, implementation of activities (counseling and workshops or assistance in making instant powdered herbal medicine), and evaluation of activities. The activity results showed an increase in participants' knowledge as indicated by the participants' average post-test score, which was 65%, compared to the average pre-test score, which was 53.33.% Evaluation of participant satisfaction from the questionnaire also shows that the material presented is easy to understand, valuable, increases skills, the product produced has a good taste, and can improve the village economy.  Keywords: Instant Powder, Immunostimulant, Meniran, Ginger and Tebang Kacang Village.  
An Effectiveness Test Combination of Ethanol Extracts of Buas-buas Leaves (Premna serratifolia L.) and Sappan Wood (Caesalpinia sappan L.) as Topical Antiinflammatory Agent in Male White Rats (Rattus novergicus) Isnindar; Purnamaputra, Alfred; Luliana , Sri
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 3 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i32024.356-365

Abstract

Background: Inflammation is the reaction of the immune system to tissue damage resulting from physical injury, harmful chemicals, or microbial agents. Steroid and non-steroid drugs are commonly used to treat inflammation, but long-term use can result in side effects, such as hormonal disorders and gastric ulcers. Buas-buas leaves and sappan wood has potential as traditional medicines, and based on empirical evidence, they utilize both plants as anti-inflammatory, antibacterial, antioxidant, antiallergic, and antiarthritic agents, as well as for the treatment of cardiovascular disorders, cough, and leprosy. Objective: This study aimed to evaluate the effect of combining 96% ethanol extracts from buas-buas leaves and sappan wood to deliver topical anti-inflammatory benefits. Methods: This research was experimental, using thirty male rats divided into six treatment groups: a negative control group with 2% carrageenan, Biocream® control group, a positive control group with Hydrocortisone Acetate, and three treatment groups receiving a combination of ethanol extracts from buas-buas leaves and sappan wood at concentrations of 1.67%, 2.5%, and 3.75%. The test compounds were administered after carrageenan injection. Measurement of skinfold thickness on the backs of the rats was conducted every hour for 6 h using digital calipers, and the difference in skinfold thickness of each rat, AUC value, and percentage of inflammation inhibition was calculated. Data analysis involved the Kolmogorov-Smirnov test and Levene's test to assess normality and homogeneity, respectively, and was subsequently followed by One-way ANOVA and a post-hoc test. Conclusion: The combination of ethanol extracts of Buas-Buas leaves and sappan wood can provide a topical anti-inflammatory effect, with the most effective concentration being 3.75% and an inflammation inhibition percentage of 32.77%.
Effect of extraction, ratio, and solvent concentration on total flavonoid content and antioxidant activit of singkel (premna serratifolia linn.) using dpph method Isnindar, Isnindar; Luliana, Sri; Zahid, Muhammad
Jurnal Teknosains Vol 14, No 2 (2025): June
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.100099

Abstract

Singkel (Premna serratifolia Linn.) is a medicinal plant commonly found in tropical regions, including Indonesia, which contains flavonoids, alkaloids, polyphenols, and triterpenoids. Flavonoids in singkel leaves act as antioxidants that can prevent oxidative stress, which is a causative factor of degenerative and chronic diseases such as cancer, arthritis, and cardiovascular diseases. This study aims to determine the effects of total flavonoid content and IC50 values in singkel leaves based on extraction methods, solvent concentration, and the ratio of extract to solvent. The methods used include maceration, soxhlet extraction, and Microwave-Assisted Extraction (MAE), with ethanol solvent concentrations of 60%, 70%, 80%, and 96%, and extract-to-solvent ratios of 1:10, 1:20, and 1:30. Antioxidant activity was measured using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with UV-Vis spectrophotometry. The results showed that the soxhlet extraction method yielded the highest total flavonoid content of 24.56±1.81 mgQE/g with an IC50 value of 20.31±1.58 μg/mL. The 96% solvent concentration provided the best results with a total flavonoid content of 26.12±0.06 mgQE/g and an IC50 value of 15.51±2.17 μg/mL. In the solvent ratio testing, the 1:20 ratio showed the highest total flavonoid content of 19.37±0.5 mgQE/g, while the 1:10 ratio provided the best IC50 value of 11.99±1.02 μg/mL. In conclusion, the extraction method, solvent concentration, and solvent ratio significantly affect the flavonoid content and antioxidant activity of singkel leaves.
Evaluasi Penggunaan Antibiotik Bangsal Penyakit Dalam di Rumah Sakit Umum Daerah dengan Metode ATC/DDD Periode Januari-Maret 2025: Evaluation of Antibiotic Use in Internal Medicine Wards at Regional General Hospitals Using the ATC/DDD Method for the Period January-March 2025 Badaria, Lailatul; Nasution, Nuraini; Azura, Dhea Nur; Nadine, Shahira Audia; Ananda, Elcie; Wijianto, Bambang; Isnindar, Isnindar
Jurnal Sains dan Kesehatan Vol. 7 No. 5 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i5.2551

Abstract

Resistance can occur in several types of microorganisms with high prevalence that threaten human health. To reduce the occurrence of antibiotic resistance, an evaluation of antibiotic use is needed to determine the rational use of drugs using a quantitative method, namely the ATC/DDD method. The purpose of this study was to determine the use of antibiotics and an overview of antibiotic use patterns in inpatients in the internal medicine ward at the Regional General Hospital for the period January-March 2025 using the ATC/DDD method. This study is a descriptive study with data collection carried out retrospectively through a review of medical record documents available in the SIMRS application, manual prescriptions, and electronic prescriptions at the Regional General Hospital for the period January-March 2025. The results obtained from this study showed that the most widely used antibiotic was ceftriaxone with a figure of 59.47 DDD/100 patient days. The majority of patients were male and over 60 years old, with the three most common diagnoses being diarrhea, typhoid fever, and chronic kidney disease, and with a length of hospitalization of 3-6 days so that the use of antibiotics at the Regional General Hospital was rational in accordance with the line therapy according to the most common disease. Keywords:          Antibiotic Use Evaluation, ATC/DDD Method   Abstrak Resistensi dapat terjadi pada beberapa jenis mikroorganisme dengan prevalensi tinggi yang mengancam kesehatan manusia. Untuk mengurangi terjadinya resistensi antibiotik diperlukan evaluasi penggunaan antibiotik untuk menentukan penggunaan obat secara rasional dengan menggunakan metode kuantitatif yaitu metode ATC/DDD. Tujuan penelitian yaitu mengetahui penggunaan antibiotik dan gambaran pola penggunaan antibiotik pada pasien rawat inap di bangsal penyakit dalam di Rumah Sakit Umum Daerah Periode Januari-Maret 2025 menggunakan metode ATC/DDD. Penelitian ini merupakan studi deskriptif kuantitatif dengan pengumpulan data yang dilakukan secara retrospektif melalui peninjauan dokumen rekam medis yang tersedia di aplikasi SIMRS, resep manual, dan resep elektronik di Rumah Sakit Umum Daerah periode Januari-Maret 2025. Hasil yang didapatkan dari penelitian ini bahwa bahwa antibiotik yang paling banyak digunakan adalah ceftriaxone dengan angka 59,47 DDD/100 patient days. Mayoritas pasien berjenis kelamin laki-laki dan berusia lebih dari 60 tahun, dengan tiga diagnosis terbanyak yaitu diare, demam tifoid, dan penyakit ginjal kronik, serta dengan lama rawat inap selama 3-6 hari sehingga penggunaan antibiotik di Rumah Sakit Umum Daerah sudah rasional sesuai dengan lini terapi sesuai penyakit terbanyak. Kata Kunci:         Evaluasi Penggunaan Antibiotik, Metode ATC/DDD
FORMULATION AND EVALUATION OF FUNCTIONAL BEVERAGES INSTANT POWDER COMBINATION OF THE BUAS-BUAS LEAVES (Premna serratifolia L.), SECANG WOOD (Caesalpina sappan L.) AND GINGER Rhizome (Zingiber officinale R.) Putri, Dinda Marlinda; Isnindar, Isnindar; Luliana, Sri
Journal Pharmacy Of Tanjungpura Vol 1, No 1 (2023): Oktober
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

BACKGROUND: The use of buas-buas leaves (Premna serratifolia L.), sappanwood (Caesalpina sappan L.) and ginger rhizomes (Zingiber officinale R.) as raw materials for instant powder drink is to make it easier to serve and has health benefits. OBJECTIVE: This study aims to determine the physical characteristics and the level of public preference for instant powder drinks. METHOD: This research is an experimental study with sugar crystallization as a method of making instant powder made in 4 different formulas. Data collection was carried out to respondents through questionnaires with a total of 20 respondents. Data analysis was performed using Oneway ANOVA on the SPSS program. RESULTS: The results showed that the resulting powder had a yellow to orange color with a distinctive aroma of wild leaves, the powder had a smooth and dry texture. CONCLUSION: The four formulas met the physical properties requirements of instant powder and F2 became the most preferred formula.Keywords: buas-buas leaves, sappan, ginger, instant powder
Co-Authors Adahane, Euistya Febrianti Putri Amaria, Egita Feby Ananda, Elcie Anastasia, Desy Siska Azizzah Dwi Rahmawati Azura, Dhea Nur Badaria, Lailatul Bambang WIJIANTO Cristin, Bella Dina Pratiwi, Dina Erna Prawita Setyowati Erna Prawita Setyowati Erna Prawita Setyowati Hadi Kurniawan, Hadi Hariyanto IH Hervianto, Willy Ilham Saputra Kamil, Insan Liza Pratiwi Luliana , Sri Luliana, Sri Maulidia, Yuninta Nadine, Shahira Audia Nasution, Nuraini Nur Atikah Purnamaputra, Alfred Putri, Dinda Marlinda Rafika Sari Rahmi Septiani Ricky Midi Candra Rise Desnita, Rise Rissa Febriyanto Robiyanto Robiyanto, Robiyanto Robiyanto, Robiyanto Ropiqa, Meri Saputra, Ilham Sitarina Widyarini Sitarina Widyarini Siti Nani Nurbaeti Sri Wahdaningsih Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Syalsabila, Regitha Rianda Tara Kamita Riduana Tarung, Albianus Febri Uray Cindy Hafinur Willy Hervianto Wintari Taurina Yuswanto Yuswanto Yuswanto Yuswanto Yuswar, Muhammad Akib Zahid, Muhammad