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All Journal PHARMACON Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN Jurnal Teknosains Interest : Jurnal Ilmu Kesehatan Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional As-syifaa Jurnal Farmasi JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) JURNAL PENGABDI Media Farmasi Al-Khidmah PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Riset Kefarmasian Indonesia Media Farmasi Indonesia Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Journal Pharmacy of Tanjungpura
Isnindar Isnindar
Bagian Biologi Farmasi Fakultas Kedokteran Universitas Tanjungpura Pontianak
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Economics, Econometrics & Finance Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Patterns of Antihypertensive Drug Prescribing and Refill Adherence Among BPJS Referral-Back Patients: A Study at Pharmacy “X”, Pontianak Isnindar Isnindar; Shahiroh Haulaini Shahiroh Haulaini; Hestiva Hestiva; Berlian Rizky Putra
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.902

Abstract

High blood pressure often develops without obvious symptoms, causing many individuals to remain unaware of the condition until organ damage has already occurred. The absence of noticeable signs makes hypertension a major contributor to the increasing incidence of complications within the cardiovascular system. It has become a government priority to control hypertension through the National Health Insurance Program (JKN) BPJS, particularly the Referral Back Program (Program Rujuk Balik/PRB). This study aims to describe medication refill adherence and prescribing patterns of antihypertensive drugs among BPJS Kesehatan participants at “X” Pharmacy, Pontianak. This research employed a descriptive observational design with retrospective data from prescriptions and the Pharmacy–BPJS application for the period of October 2025. The analyzed data included sex, age, and the types of antihypertensive therapy used. Adherence was asessed using the Medication Possession Ratio (MPR) method. The results showed that medication refill adherence among PRB patients at Pharmacy “X” was predominantly in the adherent category. The most frequently prescribed antihypertensive drug was candesartan, an angiotensin receptor blocker (ARB), with a tendency toward combination therapy. Most patients were within the 60–75 age group and were predominantly female. In conclusion, medication refill adherence among PRB antihypertensive patients was generally good, supporting long-term therapeutic effectiveness. The prescribing patterns observed were largely consistent with clinical practice guidelines for hypertension management. Continuous education and monitoring are recommended to further improve adherence and therapeutic outcomes.  
Pharmaceutical Preparation Formulation and Innovation in Active Substance Delivery Technology of Premna serratifolia: Literature Review isnindar isnindar; rise desnita
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.110

Abstract

Background: The Premna serratifolia L. plant is a botanical resource rich in potential secondary metabolites for development into modern pharmaceutical preparations. Over the last decade (2016-2026), research has progressed rapidly from conventional topical formulations to more sophisticated drug delivery systems to overcome the stability issues of active substances. Objective: To systematically review various pharmaceutical formulations of Premna serratifolia leaves and evaluate their biological efficacy based on the latest original studies. Methods: Over the previous 10 years, original scientific literature from reliable databases like Science Direct and Google Scholar was reviewed. Results: Various preparations have been successfully optimized, including a peel-off gel mask with antioxidant activity reaching 77.20%, a sunscreen lotion with an ultra SPF value of up to 34.60, and an anti-inflammatory cream combined with sappanwood. Recent delivery technology innovations include Ethocel/Eudragit polymer-based microparticles with a size of 1.024-1.662 µm, and excellent antibacterial potential is demonstrated by biosynthesized silver nanoparticles (AgNPs). Conclusion: P. serratifolia exhibits high formulation flexibility for cosmetic and therapeutic applications, although standardization of marker compounds and validation through human clinical trials remain major challenges for future development.
Effect of maceration and mae (microwave assisted extraction) on antioxidant activity of methanol Extract of simpur air leaves (dillenia suffruticosa (griff.) martelli) Isnindar Isnindar; Siti Nurhayati; Sri Luliana; Meri Ropiqa
Jurnal Teknosains Vol 15, No 1 (2025): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.106535

Abstract

The simpur air plant (Dillenia suffruticosa) is one of the plants used in traditional medicine to treat various diseases and has potential as an antioxidant. Antioxidants are compounds that inhibit, prevent, and reduce oxidative damage to target molecules. The effectiveness of extracting active compounds depends on the extraction method used. Maceration requires a relatively long duration, so faster and more efficient alternatives, such as MAE, are needed. However, heat-sensitive compounds may degrade if the power is too high or the extraction time is prolonged. Therefore, a comparison between maceration and MAE methods is necessary. This study aims to determine the effect of maceration and MAE on the antioxidant activity of the methanol extract from the simpur air leaves. Samples were then analyzed using TLC with a mobile phase of toluene, ethyl acetate, and formic acid (3:5:1 v/v/v). Antioxidant activity was assessed using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, and data were analyzed with SPSS. TLC results confirmed the presence of flavonoids indicated by a yellow color after spraying with AlCl3, with IC50 values supporting their antioxidant potential. The Rf values of extracts obtained by maceration and MAE with the rutin standard (0.22) and quercetin standard (0.8). The MAE method produced higher antioxidant activity than maceration, with IC₅₀ values of 5.942 ± 0.345 μg/mL and 10.498 ± 0.213 μg/mL, respectively, both classified as strong antioxidants (IC50 < 50). Independent sample t-test analysis yielded a p-value of less than 0.05, indicating a significant difference between the two methods. The methanol extract of simpur air leaves extracted by the MAE method produces better antioxidant activity than the maceration method.
Pharmaceutical Preparation Formulation and Innovation in Active Substance Delivery Technology of Premna serratifolia: Literature Review isnindar isnindar; rise desnita
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 4 No. 1 (2026): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v4i1.110

Abstract

Background: The Premna serratifolia L. plant is a botanical resource rich in potential secondary metabolites for development into modern pharmaceutical preparations. Over the last decade (2016-2026), research has progressed rapidly from conventional topical formulations to more sophisticated drug delivery systems to overcome the stability issues of active substances. Objective: To systematically review various pharmaceutical formulations of Premna serratifolia leaves and evaluate their biological efficacy based on the latest original studies. Methods: Over the previous 10 years, original scientific literature from reliable databases like Science Direct and Google Scholar was reviewed. Results: Various preparations have been successfully optimized, including a peel-off gel mask with antioxidant activity reaching 77.20%, a sunscreen lotion with an ultra SPF value of up to 34.60, and an anti-inflammatory cream combined with sappanwood. Recent delivery technology innovations include Ethocel/Eudragit polymer-based microparticles with a size of 1.024-1.662 µm, and excellent antibacterial potential is demonstrated by biosynthesized silver nanoparticles (AgNPs). Conclusion: P. serratifolia exhibits high formulation flexibility for cosmetic and therapeutic applications, although standardization of marker compounds and validation through human clinical trials remain major challenges for future development.
Co-Authors Adahane, Euistya Febrianti Putri Amaria, Egita Feby Ananda, Elcie Anastasia, Desy Siska Azizzah Dwi Rahmawati Azura, Dhea Nur Badaria, Lailatul Bambang WIJIANTO Berlian Rizky Putra Cristin, Bella Darin Iftinan Dina Pratiwi, Dina Erna Prawita Setyowati Erna Prawita Setyowati Erna Prawita Setyowati Hadi Kurniawan, Hadi Hariyanto IH Hervianto, Willy Hestiva Hestiva Ilham Saputra Kamil, Insan Liza Pratiwi Luliana, Sri Maulidia, Yuninta Meri Ropiqa Nadine, Shahira Audia Nasution, Nuraini Nur Atikah Putri, Dinda Marlinda Rafika Sari Rahmi Septiani Ricky Midi Candra Rise Desnita, Rise Rissa Febriyanto Robiyanto Robiyanto, Robiyanto Robiyanto, Robiyanto Ropiqa, Meri Saputra, Ilham Shahiroh Haulaini Shahiroh Haulaini Sitarina Widyarini Sitarina Widyarini Siti Nani Nurbaeti Siti Nurhayati Sri Wahdaningsih Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Syalsabila, Regitha Rianda Tara Kamita Riduana Tarung, Albianus Febri Uray Cindy Hafinur Willy Hervianto Wintari Taurina Yuswanto Yuswanto Yuswanto Yuswanto Yuswar, Muhammad Akib Zahid, Muhammad