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All Journal Jurnal Kedokteran Brawijaya Medical Journal of Indonesia Journal of Environmental Engineering and Sustainable Technology Indonesian Journal of Human Nutrition Majalah Kesehatan FKUB Medical Laboratory Technology Journal Molecular and Cellular Biomedical Sciences (MCBS) Meditory : The Journal of Medical Laboratory Oto Rhino Laryngologica Indonesiana Majalah Patologi Indonesia Journal of Issues in Midwifery Medika Teknika : Jurnal Teknik Elektromedik Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Prosiding Seminar Nasional Unimus Jurnal Info Kesehatan
Kenty Wantri Anita, Kenty Wantri
Fakultas Kedokteran Universitas Brawijaya, Malang.
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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The Effect Flavonoids Phaleria macrocarpa Fruit Extract on Thickness of Trabeculae, Cortex Ratio Femoral Bone and Aortic Intima-Media in Mice Menopause Model Fadilah, R. A. Rahmawati Nurul; Khoirinda, Ani; Sutrisno, Sutrisno; Irwanto, Yahya; Anita, Kenty Wantri; Dewi, R. A. Rose Khasana
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1553

Abstract

A deficiency of the hormone estrogen at menopause can lead to an increased rate of the destruction of the bone tissue that leads to bone loss, which can lead to osteoporosis and impaired fat metabolism, which increases the risk of atherosclerosis. Phytoestrogens from flavonoid extract P. Macrocarpa, having effects similar to endogenous estrogens themselves, prevent osteoporosis and atherosclerosis in menopausal women. The purpose of this research is to assess the influence of flavonoids from P. Macrocarpa fruit extract on trabeculae cortex thickness, ratio of femoral bone, and aortic IMT (A-IMT) in a menopausal mouse model. The study was conducted in a true experimental-posttest-only control group design. Using 32 mice; namely KN (normal mice with no treatment), KP (OVX with no treatment), P1(OVX and given flavonoid 3.75 mg/mice/day), P2 (OVX and given flavonoid 7.5 mg/mice/day), P3(OVX and given flavonoid 11.25 mg/mice/day), P4 (OVX and given flavonoid 15 mg/mice/day), the treatment given within 14 days. Then the thickness of the trabeculae, cortex, and intima-media aorta with Hematoxylin-Eosin (HE) staining. In the trabeculae, cortex thickness ratio obtained KN results meaningfully dissimilar to the KP group and the P3 and P4 groups were meaningfully dissimilar from the KP. The A-BMI in KP is meaningfully dissimilar to P1, P2, P3 and P4. The conclusion of the study is flavonoid fruit extract P. Macrocarpa can increase the thickness ratio of trabeculae, and cortex femoral bone of mice menopausal model in groups P3, P4 and can decrease A-IMT starting in groups P1 to P4.              
Effect of selective androgen receptor modulator RAD140 on prostate and testosterone levels in Wistar strain rats with bilateral orchidectomy Budaya, Taufiq Nur; Nurhadi, Pradana; Anita, Kenty Wantri; Nugroho, Prasetyo; Dhani, Fauzan Kurniawan
Medical Journal of Indonesia Vol. 33 No. 2 (2024): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247289

Abstract

BACKGROUND Selective androgen receptor modulators (SARMs) have been investigated as a potential treatment for hypogonadism, a condition characterized by low testosterone levels in men. The idea is to provide therapeutic benefits similar to traditional testosterone replacement therapy. However, research in this area is still in its early stages, and more extensive studies are needed to establish the efficacy of SARM. This study aimed to determine the impact of SARM RAD140 on testosterone levels, fibromuscular stroma, and prostate mass in rats undergoing bilateral orchidectomy. METHODS This was an in vivo study using posttest-only control group design in rats (Rattus norvegicus). The positive and negative control groups consisted of rats with and without bilateral orchidectomy, respectively. The treatment groups were rats given SARM RAD140 with and without orchidectomy. Testosterone levels, histopathology, and prostate mass were examined at the end of week 6, and the quantitative data were analyzed using one-way ANOVA. RESULTS This study found no difference in prostate mass (0.598 [0.05] g versus 0.590 [0.07] g, p = 0.984), fibromuscular stroma ratio (0.483 [0.094] versus 0.463 [0.057], p = 0.984), and testosterone level (0.006 [0.005] ng/dl versus 0.014 [0.004] ng/dl, p = 0.098) compared to positive control with orchidectomy and SARM RAD140 administration 6 weeks after treatment. CONCLUSIONS There were no differences in testosterone levels, prostate mass, or the ratio of fibromuscular stroma to epithelium area in rats undergoing bilateral orchidectomy and placebo surgery with the administration of SARM RAD140.
Ekspresi EBER pada Berbagai Tipe Histopatologi Karsinoma Nasofaring Anita, Kenty Wantri; Putranto, Bambang Endro; Prasetyo, Awal; Paramita, Dewi Kartikawati
Majalah Patologi Indonesia Vol. 24 No. 1, Januari 2015
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

ABSTRAK Latar belakang Etiologi kanker nasofaring (KNF) sudah terbukti merupakan interaksi dari infeksi Epstein-Barr Virus (EBV), paparan lingkungan dan kerentanan genetik. Infeksi EBV mendominasi etiopatogenesis KNF terutama untuk tipe WHO-3. Di Indonesia, saat ini belum ada publikasi tentang ekspresi Epstein-Barr-virus-encoded small nuclear RNA (EBER) yang dikaitkan dengan klasifikasi histopatologi KNF. Tujuan penelitian ini menganalisis ekspresi EBER pada berbagai tipe histopatologi KNF untuk menambah informasi dalam diagnosis etiologi KNF, sehingga bermanfaat dalam strategi terapi. Metode Penelitian dengan desain cross sectional ini menggunakan sampel biopsi nasofaring yang didiagnosis sebagai KNF antara tahun 2009 sampai 2012 di Laboratorium Patologi Anatomik Fakultas Kedokteran Universitas Diponegoro/RSUP. Dr. Kariadi dan RS. St. Elisabeth Semarang. Sediaan dievaluasi ulang dan dilakukan in situ hybridization dengan probe fluorescein-conjugated peptide nucleic acid (PNA) pada jaringan blok parafin. Hasil Sebanyak 29 dari 31 kasus (93,5%) KNF tipe WHO-3 mengeskpresikan EBER positif dan terdapat perbedaaan bermakna (p=0,024) dengan KNF tipe WHO-1 dan 2. Uji korelasi antara ekspresi EBER dengan tipe histopatologi KNF positif kuat (koefisien korelasi Lambda = 0,667, p=0,034). Kesimpulan Ekspresi EBER terdapat lebih banyak pada KNF WHO tipe 3 yang berarti EBV lebih sering ditemukan pada KNF WHO tipe 3. Kata kunci: EBER, hibridisasi in situ, karsinoma nasofaring, virus Epstein-Barr. ABSTRACT Background The factors contributing nasopharingeal carcinoma (NPC) has been proven to be the interaction of viral, environmental and genetic factors. Etiopathogenesis of NPC is dominated by Epstein-Barr virus (EBV) infection, especially for WHO type 3. In Indonesia, there has been no publication about the expression of Epstein-Barr-virus-encoded small nuclear RNA (EBER) associated with histopathological classification. The aim of this study is to analyze the expression of EBER in various histopathological types of NPC and provide information onetiological diagnosis ofNPC that can be useful for therapeutic strategies. Methods This study was an descriptive designed as cross sectional study. Nasopharyngeal biopsies that were diagnosed as nasopharyngeal carcinoma, between the year 2009 and 2012, in Dr. Kariadi Hospital and St. Elisabeth Hospital Semarang were reevaluated. In situ hybridization with fluorescein-conjugated peptide nucleic acid (PNA) probe was performed on paraffin embedded tissue sections. Results This study found that 29 of 31 (93.5%) WHO-3 type NPC cases were EBER positif that significantly differed from WHO-1 and WHO-2 type NPC (p=0.024). There were strong positive correlation between histopathological types of NPC and expression of EBER (Lambda coefficient correlation=0.667, p=0.034). Conclusion EBER expressions found more in NPC WHO type 3 which mean EBV is often found in NPC WHO type 3. Key words: EBER, Epstein-Barr- virus, in situ hybridization, nasopharyngeal carcinoma.
Co-Authors - Suprapto A.A. Ketut Agung Cahyawan W AA Sudharmawan, AA Aina Angelina Anandasari , Noni Fidya Ayu Anandasari, Noni Fidya Ayu Angelica, Aina Annisa' Wigati Rozifa Aris Rosidah Awal Prasetyo Bambang Endro Putranto Barasabha, Thareq Christiawan Purba, Andreas Putra Dewi Kartikawati Paramita Dewi Kartikawati Paramita Dewi, Rose Khasana Dhani, Fauzan Kurniawan Diah Ayuningtyas Diputra, Ariyanta Dafa Dwi Hadi Sulistyarini Dwi Wulandari, Recavery Ekaputra, Aditya Airlangga Eviana Norahmawati Fabrianta, Dio Mafazi Fadilah, R. A. Rahmawati Nurul Fitria Mayasari Harun Al Rasyid Harun Al Rasyid Hendy Setyo Yudhanto Husnul Khotimah Ihda Dian Kusuma Irawan, Dwi Dianita Kaspirayanthi, Ni Ketut Devy Khoirinda, Ani Kridayanti, Novalia Kurnia Penta Seputra Lukmantya Lukmantya Moch Mundir Arif Nurasih, Amelinda Natania Nurdiana Nurdiana Nurhadi, Pradana Pinahayu, Griesinta Trianty Andria Prasetyo Adi Prasetyo Nugroho Pratiwi, Made Dinda Purwitasari, Alief Ayu Putra Yudha, Muhammad Agung Putranto, Bambang Endro Rachmad Sarwo Bekti Retnani, Diah Prabawati Retty Ratnawati Rofifa, Amira Fithri Rus Suheryanto Soeprapto Soeprapto Subandi Subandi Susilo, Hery Sutrisno, Sutrisno Syifa Mustika Tatit Nurseta Taufiq Nur Budaya Tri Yudani MR Ulfaningtyas, Kiki Wijaya, Dyah Ayu Septika Wijayanti Saputri, Nur Estu Yahya Irwanto Yudhanto, Hendy Setyo