Ade Dharmawan
Departemen Mikrobiologi Klinik, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Kristen Krida Wacana, Jakarta, Indonesia

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Journal : Jurnal Biomedika dan Kesehatan

Prevalensi dan Pola Kepekaan Acinetobacter baumannii di Ruang Rawat Intensif RS Swasta di Jakarta Dharmawan, Ade; Devita, Arleen; Gunardi, Wani Devita; Layanto, Nicolas
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.178-185

Abstract

Background Acinetobacter baumannii is one of the bacteria that cause nosocomial infections, especially in the intensive care unit. These bacteria can cause infections, including bacteremia, pneumonia, urinary tract infections, surgical site infections, and meningitis. Most of these bacteria are multi-resistant to various antibiotics, impacting cure rates and length of stay. This study aimed to determine these bacteria's prevalence and antibiotic susceptibility patterns in the intensive care unit. Methods This research is descriptive research with a retrospective approach. The data was taken from the antibiotic susceptibility report in the intensive care unit of a private hospital in Jakarta in the period January 2020 – December 2021. The antibiotic susceptibility report was processed using the WHONET 2018 software. Results From 681 specimens examined in the intensive care unit, the prevalence of Acinetobacter baumannii was 28.7%, 80% of which came from respiratory specimens. In the sensitivity test results, only the antibiotic Colistin has the best sensitivity to this bacteria, which is 100% sensitive, while other antibiotics have poor sensitivity. Conclusions Acinetobacter baumannii is the bacteria that causes infection in the intensive care unit, with almost all of them being multi-drug resistant bacteria.
Pemeriksaan Penunjang Mikrobiologi untuk Diagnosis Infeksi Mycobacterium Other Than Tuberculosis (MOTT) Devita, Arleen; Dharmawan, Ade
Jurnal Biomedika dan Kesehatan Vol 7 No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.251-261

Abstract

Mycobacterium other than tuberculosis (MOTT) is an environmental bacterium that can be an opportunistic pathogen. These bacteria are resistant to various types of disinfectants and antibiotics because they have the characteristics of thick cell wall peptidoglycan that are rich in lipids and mycolic acid. There are now over a hundred MOTT species, some of which are known to infect people with immune system disorders such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), people with a history of tuberculosis (TB), HIV infection, or diabetes mellitus, but can also infect individuals with good immune systems. This type of mycobacterium can also cause nosocomial infections because it can contaminate hospital water as well as medical devices such as bronchoscopes, endoscopes, and dialysis fluids. Infections in humans originate from environmental exposure and spread through ingestion or inhalation. The clinical manifestations of MOTT infection can be pulmonary and extrapulmonary infections, including skin, soft tissue, the gastrointestinal system, bones, and joints, and disseminated with symptoms that are difficult to distinguish from a Mycobacterium tuberculosis infection. Therefore, it is necessary to conduct supporting examinations, in particular microbiological examinations, to detect and identify the species of MOTT and then determine the appropriate therapeutic management. The types of microbiological examination that can be performed are microscopic examination with acid-fast staining, culture, identification with biochemical tests, molecular tests, and immunodiagnostic tests.