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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Majalah Farmaseutik Journal Syifa Sciences and Clinical Research (JSSCR) JURNAL FARMASIMED (JFM) Healthy-Mu Journal Jurnal Kefarmasian AKFARINDO Jurnal Kesmas Asclepius SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Abdimas Bina Bangsa INDRA: Jurnal Pengabdian kepada Masyarakat Sinteza Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Inovasi Masyarakat Indonesia Journal of Food and Pharmaceutical Sciences Indonesian Journal of Cosmetics Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura JPEPT Biodiversitas Journal of Biological Diversity
Baiq Maylinda Gemantari
Universitas Hamzanwadi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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FRAP REDUCING ACTIVITY OF PROTIUM JAVANICUM BURM.FIL LEAVES: A SCREENING ANTIOXIDANT POTENCY OF NATURAL COSMETIC INGREDIENT Sulastri, Novi; Gemantari, Baiq Maylinda; Hayaza, Azzam Hafid; Azim, Muhlisun; Hariadi, Puspawan; Pratiwi, Puspa Dwi
Indonesian Journal of Cosmetics Vol. 3 No. 2 (2025): Indonesian Journal of Cosmetics
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/ijcos.v3i2.2373

Abstract

Tenggulun (Protium javanicum Burm.fil) has been traditionally used to treat various ailments such as cough, stomachache, diarrhea, inflammation and headache. The leaves have therapeutic roles in the treatment and prevention of illnesses acting as antibacterial, antidiabetic and antiinflammation agents. It is also reported that tenggulun leaves can be used for insecticides, cosmetics and food additives. This research aimed to determine antioxidant activity by reducing FRAP of the tenggulun leaves methanol extract using Trolox as the standard solution. The result showed that the tenggulun leaves extract contained secondary metabolites of flavonoid and polyphenolic. The extract showed the FRAP reducing activity at 0,008634±0.00043 μmol TE/g DW. These results indicated the ability of tenggulun methanolic extract to reduce Fe (III) into Fe (II) equivalent to Trolox by the presence of secondary metabolites confirmed.
Formulation and Evaluation of the Physical Properties of Clay Mask Containing Ethanol Extract of Kenikir (Cosmos caudatus) Leaves Puspawan Hariadi; Rina Sri Apriani; Baiq Maylinda Gemantari; Tri Puspita Yuliana; Erma Ewisa Oktresia; Fitriwati Sovia
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 1 No. 2 (2025): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v1i2.19

Abstract

The demand for natural-based cosmetic products continues to increase due to their perceived safety and minimal side effects. Kenikir leaves (Cosmos caudatus Kunth) are known to contain active compounds such as flavonoids, tannins, and phenols, which have antioxidant potential and can be utilized in facial mask preparations. This study aims to formulate a clay mask preparation from the ethanol extract of kenikir leaves and evaluate its physical properties. The extract was obtained through maceration using 96% ethanol, and then formulated into three concentrations: F1 (0.5%), F2 (1%), and F3 (2%). The evaluation of the preparation included organoleptic tests, adhesion test, spreadability test, and pH measurement. The results showed that F1 had a pH of 6, adhesion time of 2 seconds, and spreadability of 5.3 cm. F2 had a pH of 6, adhesion time of 2 seconds, and spreadability of 5.2 cm. F3 had a pH of 6, adhesion time of 4.6 seconds, and spreadability of 5 cm. The evaluation results indicated that all clay mask formulations met the physical quality criteria for clay masks.
POTENSI FRAKSI ETIL ASETAT KULIT BUAH RENGGAK (AMOMUN DEALBATUM ROXB) SEBAGAI AGEN ANTIBAKTERI Puspawan Hariadi; Widia Hidayati; Tri Puspita Yuliana; Baiq Maylinda Gemantari; Erma Ewisa Oktresia; Fitriwati Sovia
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 2 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i2.1

Abstract

Tanaman renggak (Amomun dealbatum Roxb) merupakan tanaman yang tergolong  dalam jenis tumbuhan aromatik yang termasuk dalam suku jahe – jahean, tanaman ini mengandung senyawa metabolit sekunder berupa flavonoid, Tanin, Alkoloid, Saponin, Steroid yang memiliki potensi sebagai antibakteri. Penelitian ini bertujuan untuk mengkaji potensi fraksi kulit buah dari tanaman renggak sebagai antibakteri dengan variasi konsentrasi 10%, 20%, 30%, 40% terhadap bakteri staphylococcus aureus dan pseudomonas aeruginosa. Fraksinasi dilakukan menggunakan metode fraksi cair – cair, dan pengujian aktivitas antibakteri dilakukan menggunakan difusi sumuran. Hasil pengujian fraksi pada bakteri staphyloccoccus aureus pada konsentrasi 10%, 20%, 30% dan 40 % masing masing memilik daya hambat sebesar 11,45 mm, 12,19 mm, 13,62 mm, 15,38 mm dan pada bakteri peudomonas aeruginosa masing masing sebersar 8,24 mm, 9,23 mm, 11,16 mm, 12,63 mm, hal ini menunjukan bahwa tanaman renggak memiliki potensi sebagai antibakteri.
Antibacterial Activity of Tobacco Flower Extract Against Staphylococcus Aureus and Pseudomonas Aeruginosa Puspawan Hariadi; Andhini Yasmina Hukmi; Baiq Maylinda Gemantari
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/x219jd72

Abstract

Background: Tobacco is known contains secondary metabolites such as flavonoids, alkaloids, and phenolic compounds which has pharmacological activity. As a part of the plant, it flowers have not been widely explored but are potentially rich in bioactive compounds that may be utilized as natural antibacterial agents. Aim: this study aimed to determine the antibacterial potential of tobacco flower extract against Gram-positive and Gram-negative bacteria. Methods: The ethanolic extract of tobacco flowers was obtained using a graded maceration method. The experimental groups were divided into six groups, consisting of four treatment groups with extract concentrations of 20%, 30%, 40%, and 50%, as well as one positive control group and one negative control group. Antibacterial activity was evaluated using the disc diffusion method. Result: The results showed that tobacco flower extract at concentrations at 20%, 30%, 40%, and 50% revealed inhibition zone diameters against Staphylococcus aureus as 0.6 mm, 1.5 mm, 1.8 mm, and 3 mm respectively, while were 0.5 mm, 0.6 mm, 0.6 mm, and 2.8 mm, respectively against Pseudomonas aeruginosa the inhibition zones. The positive control exhibited inhibition zone diameters of 18.6 mm against Staphylococcus aureus and 15.8 mm against Pseudomonas aeruginosa, whereas the negative control showed no inhibition zone (0 mm) against both test bacteria. Those activities known related to secondary metabolites compound that could inhibit bacterial growth. Conclusion: Based on those findings, the potency of tobacco flower extract posses inferior in antibacterial activity.
Effect of light exposure on secondary metabolites production of an endophytic fungus Arthrinium rasikravindrae and its antioxidant and anticancer activities Andita Eltivitasari; Rahmawati Rahmawati; Baiq Maylinda Gemantari; Fitra Romadhonsyah; Arief Nurrochmad; Subagus Wahyuono; Puji Astuti
Biodiversitas Journal of Biological Diversity Vol. 22 No. 6 (2021)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d220618

Abstract

Abstract. Eltivitasari A, Rahmawati, Gemantari BM, Romadhonsyah F, Nurrochmad A, Wahyuono S, Astuti P. 2021. Effect of light exposure on secondary metabolites production of an endophytic fungus Arthrinium rasikravindrae and its antioxidant and anticancer activities. Biodiversitas 22: 3156-3163. Endophytic microorganisms are one of the promising sources in producing bioactive compounds, to be developed for new drug candidates. They are found to have the ability to generate the same compounds as their host plant. Metabolite producing capacity of the endophytes is known to be affected by light exposure during fermentation process. This study focused on an endophytic fungus Arthrinium rasikravindrae isolated from Coleus amboinicus stem to reveal out its metabolite profiles due to light exposure as well as its bioactivity consequences. A. rasikravindrae was cultured on potato dextrose broth medium for 14 days and fermented in dark and exposed to natural light. Metabolite profiling was performed using TLC and GC-MS analysis. The activities were observed using DPPH assay for antioxidant and MTT assay for cytotoxicity potential. The results showed that A. rasikravindrae ethyl acetate extract produced during dark and exposed to light fermentation conditions contained different compounds but there was some which showed similarity with their host plant. Methyl octadec-9-enoate was found in all fermentation conditions as well as in C. amboinicus stem extract. Besides methyl octadec-9-enoate, methyl palmitate was also found present in both A. rasikravindrae extract fermented exposed to light and its host plant. The antioxidant activity of extract generated from dark fermentation condition was better as compared to that exposed to light with IC50 value of 66.36±0.53 vs 556.92±34.37 µg/mL. However, cytotoxic activity screening against several cancer cell lines exhibited opposing results in which extract from light-exposed fermentation resulted in better cytotoxic activity (IC50 value of 291.40 ± 2.34 µg/mL on WiDr, 336.80 ± 5.05 µg/mL on T47D, and 404.73 ± 3.46 µg/mL on Hela cell lines). Extract obtained from dark fermentation condition showed IC50 value of more than 500 µg/mL in all tested cancer cell lines. Preliminary examination on cytotoxic activity against WiDR cells suggested that the extract from light-exposed fermentation might induce cell death through mechanisms involving cell cycle arrest.
Fraksinasi Sari Kulit Buah Pisang Kepok (Musa acuminata) Mentah Tua dan Evaluasi Aktivitas Antibakteri terhadap Pertumbuhan Bakteri Propionibacterium acnes Yusron Azhari; Muhlisun Azim; Baiq Maylinda Gemantari
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.11953

Abstract

Acne vulgaris is a skin condition performed the acne due to bacterial activity that infects the skin. Acne problems are often the cause of a person that decrease in self-confidence. One of the most common acne-causing bacteria is Propionibacterium acnes. P.acnes is a gram-positive bacterium with its morphological, shape, properties and composition classified in the group of corynebacteria, but this type of bacteria is not toxigenic or bacteria that does not produce toxic substances (toxic). One of the materials that can be used for acne medication is banana peel. Banana peels are residual waste products from domestic industrial production. The waste of Banana peels have potential as an antibacterial. They contain secondary metabolites such as phenolics, quinones and flavonoids which can act as antibacterials. The purpose of this study was to examine the antibacterial activity of raw kepok banana (Musa acuminata) peel extract against Propionibacterium acne bacteria as a cause of acne. Antibacterial activity test in this study was carried out using the well diffusion method to see how the antibacterial effect of raw kepok banana peel (Musa acuminata) had on the growth of Propionibacterium acnes bacteria. Kepok banana peel extracts were fractionated with hexane, ethyl acetate and water. The results of the antibacterial activity test for the three fractions showed that the water fraction of kepok banana peel extract represented the best inhibition zone of 10.02 ± 0.05 mm, 11.28 ± 0.13 mm, 12.38 ± 0.02 mm and 16.97 ± 0.36 with a strong category at successive concentrations of 20%, 40%, 60% and 80%.
Analisis Kandungan Piroksikam dan Deksametason pada Jamu Pegal Linu yang Beredar di Lombok Timur Ahdiani Hanifa; Yuyun Febriani; Baiq Maylinda Gemantari
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.17436

Abstract

In recent year 2020 and 2021 BPOM discovered aching herbs containing medicinal chemicals such as piroxicam and dexamethasone. The addition of piroxicam and dexamethasone to herbal rheumatic pain can cause dangerous side effects such as myopathy, impaired kidney function, edema, hypertension, and gastrointestinal bleeding. The aim of this study was to determine the presence and levels of piroxicam and dexamethasone in herbal aches and pains circulating in East Lombok. The qualitative and quatittaive analysis of piroxicam and dexamethasone used in this research. The qualitative analysis used test of drug class compounds to determine the presence or absence of piroxicam and dexamethasone with FeCl3 reagent to detect piroxicam and acetic anhydrous and sulfuric acid reagent to detect dexamethasone.  Therefore, using TLC (Thin Layer Chromatography) as confirmation of the presence or absence of piroxicam and dexamethasone also used in this study. Each positive sample in the TLC process has confirmed and searched for levels using UV-Visible Spectrophotometry as quantitave analysis. The data result have analyzed by   SPSS version 16 to show the signification data in each sample. The TLC analysis results showed 6 positive samples containing piroxicam and 5 positive samples containing dexamethasone. According to assay results, the piroxicam levels were 13,71 ppm, 13,74 ppm, 14, 49 ppm, 13,87 ppm, 13, 99 ppm resepectively. The results for dexamethasone levels were 25,20 ppm, 0,45 ppm, 2,20ppm respectively. So, this show that herbal rheumatic pain in east Lombok contained piroxicam and dexamethasone with diffrence level in each sample with signification value p<0,05.
Bahan Tambahan dalam Sediaan Tablet: Review Puspa Dwi Pratiwi; Shesanthi Citrariana; Baiq Maylinda Gemantari
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.17472

Abstract

Tablets are solid pharmaceutical dosage form without or with suitable excipients by press or compression manufacturing process. The excipient chosen can influence the product performance (physical properties and stability) and bioavailability. All excipients must be optimally selected to get the optimal formula of tablet dosage form. This article review aims to overview of excipient in tablet dosage form and their role in formulating tablet dosage form. this review article was written based on literature studies from electronic databases such as PubMed, ScienceDirect, and Google Scholar which contain related information using keyword in Indonesian or English use article published in 2013-2023. excipients in tablet dosage form are fillers or diluents, disintegrants, lubricants, preservatives, flavors, sweeteners, coloring, and coating agents. These excipients added to tablet dosage form to facilitating the process of manufacture tablet dosage form, increasing stability and effectiveness of active pharmaceutical ingredients in tablet. The conclusion of this review, there are many classification of tablet excipients which is different function to get compendial requirements of tablet dosage form.
Telaah Potensi Antivirus Mitraginin terhadap Protease 3CLpro SARS-CoV-2 dengan Pendekatan Molecular Docking Arif Setiawansyah; Gita Susanti; Nurul Hidayati; Baiq Maylinda Gemantari; Reza Alrayan; Ismanurrahman Hadi; Dewi Luthfiana; Nurul Hasanah
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.25634

Abstract

SARS-CoV-2 is a novel coronavirus identified as a major caused of COVID-19. COVID-19 can be prevented and managed by preventing the SARS-CoV-2 infection through inhibition of SARS-CoV-2 main protease. Mitragynine is one of the major compounds found in Mitragyna speciosa leaves that has the potential to be developed as an anti-COVID-19 agent. This research was implemented to evaluate that potential by observing the molecular interaction of mitragynine with the essential amino acid residues of SARS-CoV-2 3CLpro. The study was undertaken by in silico method via molecular docking approach using Autodock 4.2. The potential of mitragynine in inhibiting the SARS-CoV-2 main protease was justified based on its free binding energy and Ki. The result revealed that mitragynine exhibited a lower free binding energy and Ki than remdesivir with the free binding energy and Ki value of -7.80 kcal/mol dan 1.92 µM dan -7.41 kcal/mol dan 3.72 µM, respectively. This concluded that mitragynine has the potential as a SARS-CoV-2 main protease inhibitor with the affinity was better than remdesivir. However, further in vitro research must be carried out to prove this potential. 
Co-Authors Agustin, Indri Aulia Ahdiani Hanifa Andhini Yasmina Hukmi Andini, Kamila Alfi Andita Eltivitasari Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arif Setiawansyah Baiq Risma Fatmayanti Citrariana, Shesanthi Dewi Luthfiana Erma Ewisa Oktresia Ewisa Oktresia Fitra Romadhonsyah Fitra Romadhonsyah Fitriwati Sovia Gita Susanti Hadi, Ismanurrahman Hartini Haritani Hasnawi, Muhammad Lutfi Hasratul Kusuma Hayaza, Azzam Hafid Hidayati, Kartika Jeli Marlita Juniarti, Irma Laili Hidayati Leny Ramadhan Minawati Minawati Minawati Minawati, Minawati Mufidah, Syarifatul Muhlisun Azim Novitasari, Putri Rachma Nurlaili, Mustika Nurul Hasanah Nurul Hidayati Prita Anggraini Kartika Sari Puji Astuti Puji Astuti Puji Astuti Puspa Dwi Pratiwi Puspa Dwi Pratiwi Puspawan Hariadi Rahmatullah, Lalu Abdul Roqib Rahmawati Rahmawati Reza Alrayan Rina Sri Apriani Risma Hayatun Nufus Romadhonsyah, Fitra Siti Nurhaliza Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sulastri, Novi Tri Puspita Yuliana Widia Hidayati Yusron Azhari Yuyun Febriani Zulfiana, Salina