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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Majalah Farmaseutik Journal Syifa Sciences and Clinical Research (JSSCR) Healthy-Mu Journal Jurnal Kefarmasian AKFARINDO Jurnal Kesmas Asclepius SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Abdimas Bina Bangsa INDRA: Jurnal Pengabdian kepada Masyarakat Sinteza Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Inovasi Masyarakat Indonesia Journal of Food and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Journal Pharmacy of Tanjungpura
Baiq Maylinda Gemantari
Universitas Hamzanwadi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Fraksinasi Sari Kulit Buah Pisang Kepok (Musa acuminata) Mentah Tua dan Evaluasi Aktivitas Antibakteri terhadap Pertumbuhan Bakteri Propionibacterium acnes Azhari, Yusron; Azim, Muhlisun; Gemantari, Baiq Maylinda
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.11953

Abstract

Acne vulgaris is a skin condition performed the acne due to bacterial activity that infects the skin. Acne problems are often the cause of a person that decrease in self-confidence. One of the most common acne-causing bacteria is Propionibacterium acnes. P.acnes is a gram-positive bacterium with its morphological, shape, properties and composition classified in the group of corynebacteria, but this type of bacteria is not toxigenic or bacteria that does not produce toxic substances (toxic). One of the materials that can be used for acne medication is banana peel. Banana peels are residual waste products from domestic industrial production. The waste of Banana peels have potential as an antibacterial. They contain secondary metabolites such as phenolics, quinones and flavonoids which can act as antibacterials. The purpose of this study was to examine the antibacterial activity of raw kepok banana (Musa acuminata) peel extract against Propionibacterium acne bacteria as a cause of acne. Antibacterial activity test in this study was carried out using the well diffusion method to see how the antibacterial effect of raw kepok banana peel (Musa acuminata) had on the growth of Propionibacterium acnes bacteria. Kepok banana peel extracts were fractionated with hexane, ethyl acetate and water. The results of the antibacterial activity test for the three fractions showed that the water fraction of kepok banana peel extract represented the best inhibition zone of 10.02 ± 0.05 mm, 11.28 ± 0.13 mm, 12.38 ± 0.02 mm and 16.97 ± 0.36 with a strong category at successive concentrations of 20%, 40%, 60% and 80%.
Analisis Kandungan Piroksikam dan Deksametason pada Jamu Pegal Linu yang Beredar di Lombok Timur Hanifa, Ahdiani; Febriani, Yuyun; Gemantari, Baiq Maylinda
Sinteza Vol. 4 No. 1 (2024): February
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i1.17436

Abstract

In recent year 2020 and 2021 BPOM discovered aching herbs containing medicinal chemicals such as piroxicam and dexamethasone. The addition of piroxicam and dexamethasone to herbal rheumatic pain can cause dangerous side effects such as myopathy, impaired kidney function, edema, hypertension, and gastrointestinal bleeding. The aim of this study was to determine the presence and levels of piroxicam and dexamethasone in herbal aches and pains circulating in East Lombok. The qualitative and quatittaive analysis of piroxicam and dexamethasone used in this research. The qualitative analysis used test of drug class compounds to determine the presence or absence of piroxicam and dexamethasone with FeCl3 reagent to detect piroxicam and acetic anhydrous and sulfuric acid reagent to detect dexamethasone.  Therefore, using TLC (Thin Layer Chromatography) as confirmation of the presence or absence of piroxicam and dexamethasone also used in this study. Each positive sample in the TLC process has confirmed and searched for levels using UV-Visible Spectrophotometry as quantitave analysis. The data result have analyzed by   SPSS version 16 to show the signification data in each sample. The TLC analysis results showed 6 positive samples containing piroxicam and 5 positive samples containing dexamethasone. According to assay results, the piroxicam levels were 13,71 ppm, 13,74 ppm, 14, 49 ppm, 13,87 ppm, 13, 99 ppm resepectively. The results for dexamethasone levels were 25,20 ppm, 0,45 ppm, 2,20ppm respectively. So, this show that herbal rheumatic pain in east Lombok contained piroxicam and dexamethasone with diffrence level in each sample with signification value p<0,05.
Bahan Tambahan dalam Sediaan Tablet: Review Pratiwi, Puspa Dwi; Citrariana, Shesanthi; Gemantari, Baiq Maylinda
Sinteza Vol. 3 No. 2 (2023): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v3i2.17472

Abstract

Tablets are solid pharmaceutical dosage form without or with suitable excipients by press or compression manufacturing process. The excipient chosen can influence the product performance (physical properties and stability) and bioavailability. All excipients must be optimally selected to get the optimal formula of tablet dosage form. This article review aims to overview of excipient in tablet dosage form and their role in formulating tablet dosage form. this review article was written based on literature studies from electronic databases such as PubMed, ScienceDirect, and Google Scholar which contain related information using keyword in Indonesian or English use article published in 2013-2023. excipients in tablet dosage form are fillers or diluents, disintegrants, lubricants, preservatives, flavors, sweeteners, coloring, and coating agents. These excipients added to tablet dosage form to facilitating the process of manufacture tablet dosage form, increasing stability and effectiveness of active pharmaceutical ingredients in tablet. The conclusion of this review, there are many classification of tablet excipients which is different function to get compendial requirements of tablet dosage form.
Telaah Potensi Antivirus Mitraginin terhadap Protease 3CLpro SARS-CoV-2 dengan Pendekatan Molecular Docking Setiawansyah, Arif; Susanti, Gita; Hidayati, Nurul; Gemantari, Baiq Maylinda; Alrayan, Reza; Hadi, Ismanurrahman; Luthfiana, Dewi; Hasanah, Nurul
Sinteza Vol. 4 No. 2 (2024): August
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/sinteza.v4i2.25634

Abstract

SARS-CoV-2 is a novel coronavirus identified as a major caused of COVID-19. COVID-19 can be prevented and managed by preventing the SARS-CoV-2 infection through inhibition of SARS-CoV-2 main protease. Mitragynine is one of the major compounds found in Mitragyna speciosa leaves that has the potential to be developed as an anti-COVID-19 agent. This research was implemented to evaluate that potential by observing the molecular interaction of mitragynine with the essential amino acid residues of SARS-CoV-2 3CLpro. The study was undertaken by in silico method via molecular docking approach using Autodock 4.2. The potential of mitragynine in inhibiting the SARS-CoV-2 main protease was justified based on its free binding energy and Ki. The result revealed that mitragynine exhibited a lower free binding energy and Ki than remdesivir with the free binding energy and Ki value of -7.80 kcal/mol dan 1.92 µM dan -7.41 kcal/mol dan 3.72 µM, respectively. This concluded that mitragynine has the potential as a SARS-CoV-2 main protease inhibitor with the affinity was better than remdesivir. However, further in vitro research must be carried out to prove this potential. 
Co-Authors Agustin, Indri Aulia Alrayan, Reza Andini, Kamila Alfi Arief Nurrochmad Arief Nurrochmad Arif Setiawansyah Azhari, Yusron Baiq Risma Fatmayanti Citrariana, Shesanthi Erma Ewisa Oktresia Ewisa Oktresia Fitra Romadhonsyah Fitriwati Sovia Gita Susanti, Gita Hadi, Ismanurrahman Hanifa, Ahdiani Hartini Haritani Hasnawi, Muhammad Lutfi Hasratul Kusuma Hidayati, Kartika Jeli Marlita Juniarti, Irma Laili Hidayati Leny Ramadhan Luthfiana, Dewi Minawati Minawati Minawati Minawati, Minawati Mufidah, Syarifatul Muhlisun Azim Novitasari, Putri Rachma Nurlaili, Mustika Nurul Hasanah Nurul Hidayati Prita Anggraini Kartika Sari Puji Astuti Puji Astuti Puspa Dwi Pratiwi Puspawan Hariadi Rahmatullah, Lalu Abdul Roqib Risma Hayatun Nufus Romadhonsyah, Fitra Siti Nurhaliza Subagus Wahyuono Subagus Wahyuono Tri Puspita Yuliana Yuyun Febriani Zulfiana, Salina