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All Journal Jurnal Gizi dan Pangan SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Indonesian Journal of Cardiology Amerta Nutrition Indonesian Journal of Pharmacology and Therapy
Astika Widy Utomo, Astika Widy
Department Of Pharmacology And Therapeutic, Faculty Of Medicine Diponegoro University, Semarang, Indonesia
Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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The effect of red cabbage extract to serum MDA levels in rats after maximum physical activity Haris, Nadia Husna; Nugroho, Trilaksana; Utomo, Astika Widy; Yora Nindita
Indonesian Journal of Pharmacology and Therapy Vol 2 No 3 (2021)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.1117

Abstract

The maximum physical activity led to generate of free radical levels in the human body called oxidative stress. Red cabbage is well known as the vegetable containing highest anthocyanin among various other head cabbage plants. Anthocyanin is an antioxidant which is proven can prevent oxidative stress through reduction of MDA levels. The study aimed to investigate the effect of red cabbage extract (RCE) on MDA levels in rat after doing maximum physical activity. It was a true experimental study with post-test only control group design. Twenty-four male albino Wistar rats were used in this study. The rats were randomly divided into four groups i.e. the rats receiving maximum physical activity without and with RCE administration at dose of 86 mg/kg BW for eight days and the rats not receiving maximum physical activity without and with RCE administration. A swim test was used for maximum physical activity intervention. Serum MDA levels were measured using TBARS method. Data were analysed using one-way Anova followed by post-hoc LSD. A p value <0.005 was considered to be significant. The results showed that the rats treated with RCE both receiving maximum physical activity or not showed significant MDA reduction compared to rats without treated RCE (p=0.011 and p=0.027, respectively). Meanwhile, there was no significant difference in serum MDA levels between rats treated with RCE receiving maximum physical activity and rats not treated with RCE and not receiving maximum physical activity (p=0.540). Supplementation of RCE can reduce serum MDA levels in rats with and without maximum physical activity. Further study to investigate effective dose of RCE is recommended.
Effect of arum manis mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats Saputra, Taufik; Naufal, Haidar Satya; Utomo, Astika Widy; Widyastiti, Nyoman Suci; Kurniawan, Muhammad Farhan; Azizah, Arfianty Nur
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.236960

Abstract

BACKGROUND Dyslipidemia is characterized by an increase in low-density lipoprotein (LDL) and triglyceride (TG) levels and a decrease in high-density lipoprotein (HDL). Cholestyramine as an antidyslipidemia has several side effects, so an alternative is needed. Pectin is a natural substance with a mechanism of action similar to that of cholestyramine. Mango peel is one of the sources of pectin, containing 10–15% of this substance. This study aimed to prove the effect of arum manis mango (Mangifera indica L.) peel extract on LDL, HDL, and TG levels in dyslipidemic Sprague-Dawley rats. METHODS 25 Sprague-Dawley rats were divided into 5 groups. All groups were given high-fat diet for the first 18 days, followed by standard feed (negative control group), cholestyramine (Sequest®) 80 mg/200 g body weight (standard treatment group), and mango peel extract (M-90 [90 mg/day], M-180 [180 mg/day], and M-360 [360 mg/day] groups) for the next 15 days. LDL and HDL levels were analyzed using the cholesterol oxidase-phenyl aminopyrazolone method and TG level using the glycerol-3-phosphate-oxidase-phenol-aminophenazone method. RESULTS The M-360 group reduced the LDL level (p = 0.015), while the standard treatment group increased the HDL level (p = 0.042). Although significant TG level changes were found in the negative control, standard treatment, and M-360 groups (p = 0.042), the mean differences of LDL, HDL, and TG levels between groups were not significantly different (p = 0.245, 0.328, and 0.454, respectively). CONCLUSIONS M. indica peel extract reduced LDL and TG levels at 360 mg/day.
Association of Anthropometric Profiles with Triglyceide/High-Density Lipoprotein Ratios in Adult Islamic Boarding School Students Batubara, Astriana Marta; Tsani, A. Fahmy Arif; Utomo, Astika Widy; Syauqy, Ahmad
Jurnal Gizi dan Pangan Vol. 18 No. Supp.1 (2023)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2023.18.Supp.1.96-98

Abstract

The aim of this study was to analyze the relationship between anthropometric profiles and Triglyceide/High-Density Lipoprotein (TG/HDL-C) ratio in adult Islamic boarding school students. A cross-sectional study was conducted on 83 Islamic boarding school students, aged 19 to 23 years, selected using a consecutive sampling design. Anthropometric measurements consisted of Waist Circumference (WC), Waist-to-Hip Ratio (WHR), and Skinfold Thickness (SFT). There were 45.8% students who had high TG/HDL-C ratio, WC (p<0.001; r=0.379) and WHR (p<0,001; r=0.455). The respondents' waist circumference and waist-to-hip ratio were positively associated with TG/HDL-C ratio.
Pengaruh Kefir Susu Kambing Terfortifikasi Vitamin D3 terhadap Kadar hs-CRP Tikus Rattus Norvegicus DM Tipe 2: Studi Eksperimental: The Effect of Vitamin D3-Fortified Goat Milk Kefir on hs-CRP Levels of Type 2 Diabetic Rattus Norvegicus Rats: An Experimental Study Zulfa, Fairuz; Utomo, Astika Widy; Ardiaria, Martha; Syauqy, Ahmad; Purwanti, Rachma; Ernalia, Yanti; Masha, Tania; Maharani, Mutiara Irma; Faradina, Amelia; Panunggal, Binar
Amerta Nutrition Vol. 9 No. 4 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i4.2025.667-678

Abstract

Background: Insulin resistance and chronic hyperglycemia in diabetes are linked to the synthesis of the inflammatory biomarker hs-CRP. Goat milk kefir and vitamin D have anti-diabetic and anti-inflammatory properties. Objectives: Aimed to evaluate the impact of goat milk kefir fortified with vitamin D3 on hs-CRP levels of diabetic rats. Methods: Twenty-one male Rattus norvegicus rats were randomly divided into four groups for a 35-day study: Control (C), Diabetes Mellitus (DM), unfortified goat milk kefir treatment (P1), and vitamin D3-enriched goat milk kefir treatment (P2). Diabetes was induced via intraperitoneal injection of streptozotocin (STZ) at 65 mg/kg BW and nicotinamide (NA) at 230 mg/kg BW. Goat milk kefir was administered orally at 2 mL/200 g BW/day, with the fortified version containing 600 IU of vitamin D3 per 100 mL. Fasting blood glucose levels and serum hs-CRP were measured pre- and post-intervention using the GOD-PAP and ELISA methods, respectively. Data were analyzed using bivariate and multivariate methods in GraphPad Prism 8. Results: There was a statistically insignificant decrease in hs-CRP levels in the P2 group (p-value=0.21) and in the P1 group (p-value=0.63), suggesting limited impact on inflammation. However, there was a statistically significant drop in blood glucose levels in the P2 group (∆FBG -65.50±35.44 mg/dL, p-value=0.03) and in the P1 group (∆FBG -81.63±50.07 mg/dL, p-value=0.05). Conclusions: The reduction in hs-CRP levels indicates that vitamin D3-fortified kefir may help modulate low-grade inflammation and shows promise in managing diabetes. Future research should examine dose, duration, and sample size for better efficacy assessment.
Co-Authors Ahmad Syauqy Ainun Rahmasari Gumay, Ainun Rahmasari Antari, Arlita Leniseptaria Azizah, Arfianty Nur Batubara, Astriana Marta Binar Panunggal Cecilia Noviyanti Salim Defie, Rhory Desy Armalina Dwi Aris Agung Nugrahaningsih Ekawati, Nuraini Eva Annisaa Faradina, Amelia Haris, Nadia Husna Indah Saraswati Iwan Dwiprahasto Kurniasari, Teny Kurniawan, Muhammad Farhan Maharani, Mutiara Irma MARTHA ARDIARIA Martin Adhitya Subagio Masha, Tania Matondang, Asri Rizqi Nadia Husna Haris Nani Maharani Naufal, Haidar Satya Neni Susilaningsih Novi Kusumaningrum Nugroho, Trilaksana Nyoman Suci Widyastiti Qorina Putri Srisantoso Rachma Purwanti Retnoningrum, Dwi Saekhol Bakri, Saekhol Santoso Jaeri Saputra, Taufik Sihombing, Maria Anna Siringoringo, Ester Theresia Tarigan, Clara Vica Rudangta Trilaksana Nugroho Tsani, A. Fahmy Arif Wafi Banadzir Resya Widyastuti, Esti Yanti Ernalia Yora Nindita Yora Nindita Zulfa, Fairuz