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All Journal Jurnal MIPA PHARMACON CHEMISTRY PROGRESS Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ The Studies of Social Sciences Jurnal Farmasi Malacca Pharmaceutics Grimsa Journal of Science Engineering and Technology Borneo Journal of Pharmacy Jurnal Lentera: Penelitian dan Pengabdian Masyarakat
Elly Suoth
Pharmacy Study Program, Faculty Of Mathematics And Natural Sciences, Sam Ratulangi University, Manado, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Efek Pemberian Ekstrak Buah Salak (Salacca zalacca) dalam menurunkan kadar glukosa darah pada tikus model Diabetes melitus Olvie Syenni Datu; Julianri Sari Lebang; Elly Juliana Suoth
Jurnal MIPA Vol. 12 No. 1 (2023)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v12i1.44267

Abstract

Diabetes Mellitus is a chronic disease characterized by elevated blood glucose levels. Diabetes Mellitus is a global disease that affects 536.6 million people in the world and is predicted to increase to 643 million people in 2030 and 783.2 million people in 2045. Snake fruit is one of the fruits in North Sulawesi that has the potential to be developed. be an alternative to treatment. The aims of this study is was to examine the effect of snake fruit extract in rats with diabetes mellitus model. The study used 5 groups, negative control group was given NaCMC solution, the positive control group was given metformin and the treatment group was given snake fruit extract with concentrations of 10%, 20% and 40%. The parameters observed in this study were body weight and blood glucose profile. The study showed that the administration of snake fruit extract had a significant effect on blood glucose profiles and body weight with p < 0.05 and there were significant differences between each treatment group both in the glucose profile parameters and body weight of rats.
Uji Aktivitas Antioksidan Ekstrak dan Fraksi Spons Stylissa carteri yang diperoleh dari Pulau Manado Tua Fenezia Yosevina Lumempow; Adithya Yudistira; Elly Juliana Suoth
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 6 No. 1 (2023): Vol 6 No 1
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v6i1.43086

Abstract

FENEZIA YOSEVINA LUMEMPOW. Aktivitas Antioksidan Ekstrak dan Fraksi Spons Stylissa carteri yang diperoleh dari Pulau Manado Tua. Di bawah bimbingan ADITHYA YUDISTIRA sebagai ketua dan ELLY JULIANA SUOTH sebagai anggota.Tubuh dapat menghasilkan antioksidan dari metabolisme sel tubuh namun dengan meningkatnya jumlah radikal bebas, tubuh perlu didukung oleh asupan antioksidan. Spons Stylissa carteri dapat menghasilkan metabolit sekunder dari proses metabolisme dalam sel yang ada pada tubuhnya, karena ekstrak dari spons dipercaya memiliki senyawa bioaktif yang mempunyai sifat sitotoksin, anti tumor, antivirus, dan anti inflamasi. Spons Stylissa carteri terdapat di bawah laut dan spons ini mengandung senyawa aktif yang persentase keaktifannya lebih besar dibandingkan dengan senyawa- senyawa yang dihasilkan oleh tumbuhan darat. Tujuan dari penelitian ini yaitu untuk mengetahui adanya aktivitas antioksidan dari ekstrak dan fraksi spons laut (Stylissa carteri). Pengujian antioksidan ini dilakukan dengan menggunakan metode DPPH (1,1-difenil-2-pikrilhidrazil) yang diukur menggunakan alat uji Spektrofotometer UV-Vis dengan konsentrasi 100 ppm. Hasil penelitian menunjukkan bahwa spons Stylissa carteri memiliki aktivitas senyawa antioksidan yang tinggi disetiap pengujian, terlihat hasil tertinggi terdapat pada ektrak kasar dengan rata-rata nilai inhibisi 95,7%.
ULTRASOUND-ASSISTED EXTRACTION SENYAWA ANTIOKSIDAN DARI LIMBAH BIJI PEMBUATAN MINYAK BUAH MERAH (Pandanus conoideus) Frenly Wehantouw; Risma Situngkir; Elly Suoth
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 6 No. 1 (2023): Vol 6 No 1
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v6i1.47723

Abstract

The aim of this research was to obtain antioxidant active component from Papuan red fruit oil waste using Ultrasound-assisted extraction. The research was done started from the making of Papuan red fruit oil, extraction and bioactive component analysis (total tocopherol and betacaroten) using spectrophotometry. The result shows that waste from Papuan red fruit oil process contains high amount of yield at 20 minutes extraction time with total carotenoid 20, 23 ppm and tocopherol absorbance 1.04. Ultrasound assisted extraction method significantly increase carotenoid content aw well as tocopherol (p<0.05).
FINGERPRINT ANALYSIS OF BETEL (Piper betle L.) AS RAW MATERIALS OF TRADITIONAL MEDICINE USING FTIR SPECTROSCOPE Vibrila Berliana Djanas; Fatimawali; Elly Suoth
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.40599

Abstract

Betel (Piper betle L.) is a plant that has long been used as a traditional medicine due to its nutritious chemical components in it. These components can be analyzed using the FTIR (Fourier Transform Infra-Red) spectroscopy method which can describe the chemical structure based on the fingerprint spectrum. The purpose of this study was to analyze the fingerprints of betel nut originating from Manado, North Minahasa, Minahasa, and Bitung using the FTIR spectroscopic method. Betel fruit samples were measured in the mid-IR region (4000-650 Cm-1) and obtained 4 FTIR spectra which were relatively the same, then the functional groups were determined for each main peak. The results showed that there were 10 functional groups in 17 absorbance bands for each betel fruit spectrum obtained. Fingerprint analysis of betel fruit with FTIR spectroscopic method can provide an overview of the chemical structure contained in 4 types of betel fruit based on geographically different growing areas.
Evaluation of Antibacterial Properties from Endophytic Fungi of Chrysanthemum indicum (L.) Flowers against Escherichia coli and Staphylococcus aureus Titah Amelia Ratte; Fatimawali Fatimawali; Trina Ekawati Tallei; Elly Juliana Suoth; Irma Antasionasti; Paulina Yamlean
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.15

Abstract

Uncovering the therapeutic potential of secondary metabolites produced by plants, animals, and microbes constitutes the foundation for the development of novel medications. The objective of this investigation is to discern the classes of secondary metabolites and assess the antibacterial properties of endophytic fungal extracts obtained from Chrysanthemum indicum L. flowers. Through the isolation process, five isolates designated as JEC1, JEC2, JEC3, JEC4, and JEC5 were identified. The cultivation of endophytic fungal isolates spanned a three-week period before undergoing extraction with ethyl acetate. The phytochemical tests revealed the presence of alkaloids, flavonoids, steroids, terpenoids, saponins, and tannins in the ethyl acetate extract. Antibacterial activity was determined using the agar well diffusion method, with ciprofloxacin serving as a positive control. Notably, all ethyl acetate extracts from endophytic fungi exhibited antibacterial activity. The most substantial inhibitory diameter against Staphylococcus aureus was recorded as 19.1±0.8 mm for the JEC3 endophytic fungi, while Escherichia coli exhibited an inhibitory diameter of 16±1.1 mm for the JEC2 endophytic fungi.
PENGGUNAAN PATI SAGU (Metroxylon sp.) SEBAGAI GELLING AGENT TERHADAP KESTABILAN FISIK GEL ASAM SALISILAT Mansauda, Karlah Lifie Riani; Suoth, Elly Juliana; Rumondor, Erladys M.
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 6 No. 2 (2023): Vol. 6, No.2, 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v6i2.51703

Abstract

ABSTRACT The gelling agent component is a critical factor that can affect gel’s physical characteristics, such as organoleptic properties, homogeneity, pH, adhesion, and viscosity. Starch is widely use as a filler and binder. The aim of the research was to analyze the effect of the formulation of salicylic acid gel using sago starch as a gelling agent on the physical characteristics of the gel. The research began with the extraction of sago starch, and gel formulations were prepared using starch as the gelling agent with variations in sago starch with F1 (6%), F2 (8%), and F3 (10%). The gels were evaluated for their physical properties, including organoleptic, homogeneity, pH, adhesion, and spreadability testing over a period of 12 weeks at a temperature of 28ºC±2ºC. The research showed that all gel formulations did not undergo changes in organoleptic and homogeneity. In the pH test, all preparations met the requirements. The spreadability test results indicated that all gels did not meet the requirements, while only gel F1 did not meet the adhesion test requirements. Keywords Gelling agent, Sago Starch (Metroxylon sp.), Physical Stability, Gel
Penentuan nilai IC50 Karang Lunak Lobophytum sp. dan Sarcophyton sp. dari Perairan Pantai Parentek Kabupaten Minahasa Rumondor, Erladys Melindah; Yudistira, Adithya; Wewengkang, Defny Silvia; Suoth, Elly Juliana; Rotinsulu, Henki; Tumundo, Berlian Tasya; Kindangen, Eunike Elizabeth
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v7i2.58117

Abstract

Karang lunak bertahan hidup dengan mengeluarkan metabolit sekunder sebagai respon terhadap lingkungan. Metabolit sekunder ini diketahui memiliki aktivitas farmakologi salah satunya antioksidan. Senyawa antioksidan berperan melengkapi elektron radikal bebas. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari ekstrak etanol Lobophytum sp. dan Sarcophyton sp.. Jenis penelitan ini merupakan eksperimental laboratorium dengan pengujian terhadap ekstrak etanol karang lunak Lobophytum sp. dan Sarcophyton sp. menggunakan metode DPPH (1-1-diphenyl-2-picrylhidrazyl). Aktivitas antioksidan ditentukan dengan nilai IC50. Dari hasil perhitungan IC50, didapatkan ekstrak karang lunak Lobophytum sp. 14.5732 mg/L dan Sarcopyhton sp. 24,3527 mg/L dan. Nilai IC50 dari Sarcophyton sp maupun Lobophytum sp. yang diperoleh dari Perairan Pantai Parentek Kabupaten Minahasa masuk kategori sangat kuat dengan nilai dibawah 50 mg/L.
Evaluation of Antibacterial Properties from Endophytic Fungi of Chrysanthemum indicum (L.) Flowers against Escherichia coli and Staphylococcus aureus Ratte, Titah Amelia; Fatimawali, Fatimawali; Tallei, Trina Ekawati; Suoth, Elly Juliana; Antasionasti, Irma; Yamlean, Paulina
Grimsa Journal of Science Engineering and Technology Vol. 1 No. 2 (2023): December 2023
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v1i2.15

Abstract

Uncovering the therapeutic potential of secondary metabolites produced by plants, animals, and microbes constitutes the foundation for the development of novel medications. The objective of this investigation is to discern the classes of secondary metabolites and assess the antibacterial properties of endophytic fungal extracts obtained from Chrysanthemum indicum L. flowers. Through the isolation process, five isolates designated as JEC1, JEC2, JEC3, JEC4, and JEC5 were identified. The cultivation of endophytic fungal isolates spanned a three-week period before undergoing extraction with ethyl acetate. The phytochemical tests revealed the presence of alkaloids, flavonoids, steroids, terpenoids, saponins, and tannins in the ethyl acetate extract. Antibacterial activity was determined using the agar well diffusion method, with ciprofloxacin serving as a positive control. Notably, all ethyl acetate extracts from endophytic fungi exhibited antibacterial activity. The most substantial inhibitory diameter against Staphylococcus aureus was recorded as 19.1±0.8 mm for the JEC3 endophytic fungi, while Escherichia coli exhibited an inhibitory diameter of 16±1.1 mm for the JEC2 endophytic fungi.
ANALISIS GAS CHROMATOGRAPHY-MASS SPECTROMETRY EKSTRAK N-HEKSAN DARI DAUN GEDI HIJAU (Abelmoschus manihot (L.) Medik) Siboantua Broolin Simanjuntak; Elly Suoth; Fatimawali Fatimawali
PHARMACON Vol. 10 No. 4 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.37407

Abstract

ABSTRACT Green Gedi Leaf (Abelmoschus manihot (L.) Medik) is an herb often used by the people of Sulawesi as food and traditional medicine, among others, for the treatment of cholesterol, kidney disease, high blood pressure, and diabetes. This study aims to analyze the phytochemical compounds contained in the Green Gedi leaves. The method used is the extraction of dry powder of Green Gedi leaves through maceration using n-hexane solvent, then analyzed using gas chromatography-mass spectrometry (GC-MS). The results showed that there were 56 possible compounds contained in the n-hexane extract of Green Gedi leaves. The analysis results also showed three possible compounds at the highest peak of the chromatogram: Ethyl 9,12,15-octadecatrienoate; 9,12,15-Octadecatrienoic acid, ethyl ester, (Z,Z,Z)- and Methyl 8,11,14-heptadecatrienoate. Keywords: Abelmoschus manihot (L.) Medik, Green Gedi Leaf, GC-MS    ABSTRAK Daun Gedi Hijau Abelmoschus manihot (L.) Medik merupakan herbal yang dimanfaatkan oleh masyarakat Sulawesi sebagai pangan dan obat tradisional antara lain untuk pengobatan kolestrol, sakit ginjal, tekanan darah tinggi, dan diabetes. Penelitian ini berujuan untuk menganalisis senyawa fitokimia yang terkandung dalam daun Gedi Hijau. Metode yang digunakan yaitu ekstraksi serbuk kering daun Gedi Hijau melalui maserasi menggunakan pelarut n-heksan, kemudian dianalisis menggunakan kromatografi gas–spektrometri massa (GC-MS). Hasil penelitian menunjukkan bahwa terdapat 56 kemungkinan senyawa yang terkandung dalam ekstrak n-heksan daun Gedi Hijau. Hasil analisis juga menunjukkan bahwa terdapat tiga kemungkinan senyawa pada puncak tertinggi kromatogram: Ethyl 9,12,15-octadecatrienoate; 9,12,15-Octadecatrienoic acid, ethyl ester, (Z,Z,Z)- dan Methyl 8,11,14-heptadecatrienoate. Kata kunci: Abelmoschus manihot (L.) Medik, Daun Gedi Hijau, GC-MS
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL SPONS Aaptos aaptos DARI TELUK MANADO SULAWESI UTARA Fitriawati Tongkali; Adithya Yudistira; Elly Suoth
PHARMACON Vol. 11 No. 1 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.39138

Abstract

ABSTRACTThe Aaptos aaptos sponge is found under the sea and this sponge contains active compounds whose percentage of activity is greater than the compounds produced by land plants. This study aimed to examine the antioxidant activity of Aaptos aaptos. This research is a laboratory experiment by testing the ethanolic extract of the sponge Aaptos aaptos using the DPPH (1,1-diphenyl-2-picrihydrazil) method to test the antioxidant activity measured using a UV-Vis Spectrophotometer with various concentrations of 10,15,20 and 25. Sponge Aaptos aaptos was obtained by maceration using 95% ethanol as solvent. The results of the average % inhibition value obtained were 77.8% (10mg/L); 81.1% (15mg/L); 84% (20mg/L); and 85.4% (25mg/L). The highest antioxidant activity was found at a concentration of 25mg/L with an average % inhibition value of 85.4%. This indicates that the ethanolic extract of the Aaptos aaptos sponge has high antioxidant activity.Keywords: Antioxidant, DPPH, Sponge Aaptos aapto, Manado Bay.ABSTRAKSpons Aaptos aaptos terdapat dibawah laut dan spons ini mengandung senyawa aktif yang persentase keaktifannya lebih besar dibandingkan dengan senyawa yang dihasilkan oleh tumbuhan darat. Penelitian ini bertujuan untuk menguji aktivitas antioksidan dari Aaptos aaptos. Penelitian ini merupakan ekperimental laboratorium dengan pengujian terhadap ekstrak etanol spons Aaptos aaptos dengan metode DPPH (1,1- diphenil-2-pikrihidrazil) untuk menguji aktivitas antioksidan yang diukur menggunakan spektrofotometer UV-Vis dengan variasi konsentrasi 10,15,20 dan 25. Ekstrak spons Aaptos aaptos diperoleh dengan cara maserasi menggunakan pelarut etanol 95%. Hasil nilai % inhibisi rata-rata yang didapat yaitu 77,8% (10mg/L); 81,1% (15mg/L); 84% (20mg/L); dan 85,4% (25mg/L). Aktivitas antioksidan tertinggi terdapat pada konsentrasi 25mg/L dengan nilai % inhibisi rata-rata 85,4%. Hal ini menunjukkan bahwa ekstrak etanol spons Aaptos aaptos memiliki aktivitas antioksidan yang tinggi.Kata kunci: Antioksidan, DPPH, Spons Aaptos aaptos, Teluk Manado
Co-Authors AA Sudharmawan, AA Abdullah, Fatamorgana Abdullah, Rezky Putri Indarwati Abdullah, Surya Sumantri Adikila, Gregorius Giani Adithya Yudistira Adithya Yudistira Angellia Grace Yetto Antasionasti, Irma Aryani Tampi Astrid Maulani Runtukahu Axl Laurens Lukas Windah Billy Johnson Kepe Datu, Olvie Syenni Datu, Ronald Joy DEBY AFRIANI MPILA Defny S. Wewengkang Defny S. Wewengkang, Defny S. Defny Wewengkang Dolongtelide, Jeclin Inebel Edwin de Queljoe ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Fatimawali Fatimawali . Fatimawali Fatimwali Fenezia Yosevina Lumempow Fitriawati Tongkali Frenly Wehantouw Frenly Wehantouw Gabriel Tikulembang Gosal, Angel T. Gultom, Minar N. S. Hariyanto, Yuanita Amalia Henki Rotinsulu, Henki Herni E.I Simbala Herny E.I. Simbala Hindang Kaempe Hosea J. Edy, Hosea J. Hosea Jaya Edy Hotmian, Ellen Irma Antasionasti Irma Antasionasti Irma Antasionasti Irma Febrianti Wahongan Josua, Endro Julianri Sari Lebang Julianri Sari Lebang, Julianri Sari Kalalo, Marko Jeremia Karlah L. R. Mansauda Kindangen, Eunike Elizabeth Lomboan, Evander Roliand Manik, Grace Dien Manopo, Chintia M. Mansauda, Karlah Lifie Margaretha, Putri Maria Immaculata Tangkau Marko Jeremia Kalalo Meilani Jayanti Nikita Thalia Ayu Jati Nursafitri Syahrudin Olvi Datu Pamudji, Gunawan Paulina yamlean Paulina Yamlean Pehino, Albrita Pendong, Christa Hana Angle Purwoko, Agus Ratte, Titah Amelia Risma Situngkir Rumondor, Erladis Rumondor, Erladys M. Rundengan, Gerald Saerang, Missyeling Siboantua Broolin Simanjuntak Sitti Juliah Nurhamidin Sri Sudewi Sri Sudewi, Sri Tania, Adinda Dwi Tifani, Tifani Titah Amelia Ratte TRINA EKAWATI TALLEI Trina Ekawati Tallei Trina Tallei Trina Tallei Tumundo, Berlian Tasya Vibrila Berliana Djanas Wewengkang, Defny Silvia Widdhi Bodhi Widya Astuty Lolo