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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Molecular and Cellular Biomedical Sciences (MCBS) IRJE (Indonesian Research Journal in Education) Journal of Health Sciences MEDIC MEdical Dedication Jurnal Karya Abdi Masyarakat Journal of Medical Studies Indonesian Journal of Biomedicine and Clinical Sciences Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Anggelia Puspasari
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Journal of Medical Studies

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EFEKTIVITAS ANTIBAKTERI EKSTRAK KULIT KULIT NANAS (Ananas Comosus) N-HEKSANA TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS ATCC 25923 Nadilla Sitepu; Ave Olivia Rahman; Anggelia Puspasari
Journal of Medical Studies Vol. 2 No. 1 (2022): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v2i1.18093

Abstract

ABSTRACT Background: Infectious diseases are generally treated using antibiotics and chloramphenicol is one of the main choice. However, it causes several side effects. Pineapple skin is thought to contain alkaloids, tannins, and terpenoids which are believed to have antibacterial activity. Objectives: This study aims to determine the effect of n-hexane exctract of pineapple peel on antibacterial activity of Staphylococcus aureus. Methods: In this study, we used fresh Pineapple skin that dried, powdered and macerated with n-hexane with ratio 1:10 ml extract were dried by rotary evaporator. A paper disc size 6 mm were soaked in the extract for 15 minutes, then ready to tested. Chloramphenicol as a positive control and n-hexane as a negative control. Antibacterial activity of extract against Staphylococcus aureus were tested by disk-diffussion method. Results: The results of the qualitative phytochemical test of pineapple peel extract of n-hexane showed positive for alkaloids and tannins, and negatif for terpenoid. There were no antibacterial activity of 100% n-hexane extract of pineapple skin against Staphylococcus aureus. While the positive control using chloramphenicol obtained an average clear zone diameter of 22.63 mm which is included in the very strong category. Conclusions: It concluded n-hexane extract of pineapple peel have no antibacterial activity against Staphylococcus aureus. Keywords: pineapple peels extract, Staphylococcus aureus, N-hexane ABSTRAK Latar Belakang: Penyakit infeksi umumnya diobati dengan antibiotik dan kloramfenikol merupakan salah satu pilihan utama. Namun, hal tersebut menyebabkan beberapa efek samping. Kulit nanas diduga mengandung alkaloid, tanin, dan terpenoid yang dipercaya memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak n-heksana kulit nanas terhadap aktivitas antibakteri Staphylococcus aureus. Metode: Pada penelitian ini menggunakan kulit nanas segar yang dikeringkan, diserbukkan dan dimaserasi dengan n-heksana dengan perbandingan ekstrak 1:10 yang dikeringkan dengan rotary evaporator. Kertas cakram ukuran 6 mm direndam dalam ekstrak selama 15 menit, kemudian siap untuk diuji. Menggunakan kloramfenikol sebagai kontrol positif dan n-heksana sebagai kontrol negatif. Aktivitas antibakteri ekstrak terhadap Staphylococcus aureus diuji dengan metode difusi cakram. Hasil: Hasil uji fitokimia kualitatif ekstrak kulit nanas n-heksana menunjukkan positif alkaloid dan tanin, dan negatif untuk terpenoid. Tidak ada aktivitas antibakteri ekstrak n-heksana 100% kulit nanas terhadap Staphylococcus aureus. Sedangkan kontrol positif menggunakan kloramfenikol diperoleh rata-rata diameter zona bening sebesar 22,63 mm yang termasuk dalam kategori sangat kuat. Kesimpulan: Disimpulkan ekstrak n-heksana kulit nanas tidak memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Kata kunci: Ekstrak kulit nanas, Staphylococcus aureus, N-heksana
Effects of Sub-acute Ethanol Extract Toxicity of Karamunting (Rhodomyrtus tomentosa) Leaves on Hematological Profile in Female White Rats Tia Wida Ekaputri; Hana Nurul Qur’ani; Citra Maharani; Anggelia Puspasari; Budi Justitia; Esa Indah Ayudia; Fitriyanti
Journal of Medical Studies Vol. 4 No. 3 (2024): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v4i3.38943

Abstract

ABSTRACT Background: Karamunting leaves (Rhodomyrtus tomentosa) are a medicinal plant widely used in Indonesia for their bioactive compounds, which exhibit anti-inflammatory, antibacterial, antioxidant, antidyslipidemic, and anti-hyperglycemic properties. However, the safe dosage for human use remains undetermined. This study aims to assess the sub-acute toxicity of ethanol extracts of karamunting leaves on the hematological profile of female white rats. Methods: This study used an experimental laboratory design with a post-test control group. Karamunting leaves were extracted by maceration using 70% ethanol as the solvent. The hematological profiles measured included erythrocytes, leukocytes, platelets, and hematocrit levels. Female white rats of the Wistar were randomly divided into six groups. The negative control group received only a 0.5% Na CMC suspension, while the treatment groups received ethanol extracts of karamunting leaves at doses of 200 mg/kg BW, 400 mg/kg BW, 800 mg/kg BW, 1600 mg/kg BW, and 3200 mg/kg BW. Blood samples were collected after 14 days of treatment. Results: The hematological profiles indicated no significant differences among the groups. However, the treatment group that received extracts at a dose of 1600 mg/kg BW showed a poor hematological profile. Conclusion: Generally, the ethanol extract of karamunting leaves did not affect the hematological profiles of the test animals. Keywords: Rhodomyrtus tomentosa; hematological profile; sub-acute toxicity
Hubungan Pemakaian Pampers terhadap Kejadian Infeksi Saluran Kemih (ISK) pada Anak di Bawah 2 Tahun di RSUD H. Abdul Manap Kota Jambi Farrah Balqis; Irawan Anasta; Anggelia Puspasari
Journal of Medical Studies Vol. 4 No. 1 (2024): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v4i1.32087

Abstract

ABSTRACT Background: Urinary tract infections (UTIs) in infants and children have a long-term impact on kidney function, with one of them leading to kidney failure. Wearing diapers is one of the risk factors for suffering UTIs.In This study aims to determine the relationship between the use of diapers and the incidence of UTIs in children under 2 years old at Abdul Manap Hospital, Jambi City. Methods: The research was conducted using Case Control and choosing the subject was taken consequently. The total subjects in this study are 40 children under 2 years old, of which 20 children used diapers and 8 children of them did not. Data collection on the characteristics of the subject used questionnaires and interviews. The diagnosis of UTIs is determined based on the consensus of the Indonesian Medical Association. Urine is collected and tested for nitrites and urinary leukocytes to diagnose a UTI. Bivariate data analysis was used. Results: The results of the study found a meaningful relationship (P <0.05) statistically between the use of diapers, especially the use of diapers > 4 hours as one of the risk factors for the incidence of UTIs. The frequency of subjects who wear diapers and suffer from UTIs of subjects who do not wear diapers (p-value 0.014; OR 10.231; 95% CI: 1.121 – 93.341). The frequency of subjects who wore diapers > 4 hours with a UTI was more than subjects who wore diapers < 4 hours (p-value 0.001; OR 2.421; 95% CI: 0.109 – 2.129). Conclusion: The incidence of UTIs in children under 2 years old is correlated with the use of diapers and the duration of diaper use. Keywords: Diapers, Urinary tract infection, Infant, Children ABSTRAK Latar Belakang: Infeksi saluran kemih (ISK) masa bayi dan anak menimbulkan dampak jangka panjang terhadap fungsi ginjal salah satu dapat mengakibatkan gagal ginjal. Penggunaan pampers merupakan salah satu risiko infeksi saluran kemih (ISK). Penelitian ini bertujuan untuk mengetahui hubungan pemakaian pampers dengan kejadian ISK pada anak di bawah 2 tahun di RSUD H.Abdul Manap Kota Jambi. Metode: Penelitian menggunakan Case Control dan pengambil subjek dilakukan secara konsekutif. Sebanyak 40 anak usia di bawah 2 tahun pada penelitian yang pakai pampers sebanyak 20 anak dan tidak pakai pampers sebanyak 8 orang dilakukan dalam penelitian ini. Pengumpulan data karakteristik subjek dengan kuesioner dan wawancara. Diagnosis Infeksi saluran kemih ditentukan berpedoman pada Konsensus ikatan dokter Indonesia. Urin diambil dengan menggunakan urin collector dan diperiksa nitrit dan leukosit urin untuk membantu diagnosis. Data dianalisis dengan menggunakan bivariat. Hasil: Hasil penelitian didapatkan hubungan bermakna (P <0,05) secara statistik antara pemakaian pampers terutama pemakaian pampers > 4 jam sebagai salah satu faktor risiko. Frekuensi subjek yang memakai pampers dan menderita ISK subjek yang tidak memakai pampers (nilai p 0,014; OR 10,231; 95% CI: 1,121 – 93,341). Frekuensi subjek yang memakai pampers > 4 jam dengan menderita ISK lebih banyak dibandingkan subjek yang memakai pampers < 4 jam (nilai p 0,001 ; OR 2,421 ; 95% CI : 0,109 – 2,529). Kesimpulan: Terdapat hubungan pemakaian pampers dan lama pemakaian pampers terhadap kejadian ISK anak dibawah 2 tahun. Kata Kunci: Pampers, Infeksi saluran kemih, Bayi, Anak
Co-Authors Ahmad Hamim Sadewa Ahmad Syauqy Ahmad Syauqy Alya Dwiva Juhari Amalia, Fenny Amatullah, Afifah Ameli Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Amelia Minarfah Anati Purwakanthi, Anati Annissa Delfira Arif, Cut Wulan Armaidi Darmawan Aryanti, Nindya Asro Hayani Harahap Ave Olivia Rahman Betty Marlina Budi Justitia Charles Apul Simanjuntak Citra Maharani Devy Afriyanti dewi, hasna Dhea Assyifa Effendi, Ian Ekaputri, Tia Wida Elfiani Elfiani Elfiani Erny Kusdiyah Esa Indah Ayu, Esa Indah Fairuz, Fairuz Farrah Balqis Fitriyanti Gading, Patrick Wiliam Hana Nurul Qur’ani Harahap, Asro Hayani Hasmita, Debby Herlambang Herlambang HERLAMBANG HERLAMBANG Herlambang Herlambang Herlambang Herlambang Huntari Harahap Ika Setyawati Irawan Anasta Irlianissa, Mutiara Iskandar, Mirna Marhami Ismi Nurwaqiah Ibnu Khairunnisa, Dhia Fairuz Maharani, Amrina Mus, Rosdiana Nadilla Sitepu Neldi, Vina Nindya Aryanty Nurul Fitriani Nyimas Natasha Ayu Shafira Nys. Natasha Ayu S Pramudji Hastuti Priskila, Loury Rina Nofri Enis Rini Kartika Rita Halim Rita Halim S, Nys. Natasha Ayu Simanjuntak, Charles Apul Suhaimi, Novadian Suprapti Suprapti Susan Tarawifa Suzan, Raihanah Syatria Esa Putra Syukur, Astian Nathaniel Tarawifa, Susan Tarigan, Nadir Putra Indra Tengku Arief Buana Perkasa Tia Wida Ekaputri Utami, Erisca Ayu Virginsia, Sonya Vivekanantharasa, Raveenthiran Wahyu Indah Dewi Aurora Widyawati, Dwi Zulkhair Ali