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Journal : Biomedical Journal of Indonesia

Side Stream Cigarette Smoke and Its Role in Inducing Oxidative Stress in Rat Cerebral Tissue Farindra, Irmawan; Rakhmawati, Annisa; Rusdi, Warda Elmaida; Benge, Wilhemus Dionysius Mario Randy; Farmananda, Irsandi Rizki; Rusdi, Muhammad Salsabeela
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.253

Abstract

Introduction. Smoking behavior can affect not only the individual smoker but also those around them. Individuals exposed to secondhand smoke are at risk of developing similar health problems as those faced by individuals who actively smoke. Secondhand smoke causes an imbalance of systemic oxidants and antioxidants characterized by the presence of a lipid peroxidation product, namely Malondialdehyde (MDA). The main objective of this study was to assess how exposure to sidestream cigarette smoke affects MDA levels in rat cerebral tissue Methods. A true experimental study was conducted using 30 male Wistar rats with a post-test only control group design. All rats were randomly divided into 5 groups, namely 1 control group and 4 treatment groups. A total of 270 cigarettes were used as exposure sources. A spectrophotometer at a wavelength (λmax) of 533 nm was used to measure MDA levels. The MDA level data were then analyzed. ANOVA and Kruskall Wallis tests were performed after evaluating the results of the Normality and Homogeneity tests. A p value <0.05 indicates significant data. Results. The results indicate that the group exposed to cigarette smoke using 4 cigarettes for 30 days (P4) exhibited elevated MDA levels compared to the control group. Statistical analysis showed a significant correlation between secondhand smoke and increased MDA levels (p < 0.05). Conclusion. This study results suggest that exposure to SSCS contributes to increased MDA levels in the brain tissue of Wistar rats, which indicates oxidative stress.
Co-Authors -, Marinda Dwi Affrita, Tia Maya Agus Aan Adriansyah Alfaridzi, Aditya Rizky Algristian, Hafid Almah, Bunga An Nur Rahmillah Anggarsari, Yasi Annisa Rakhmawati, Annisa Aqilah, Nahwa Shofiyul Artanti, Widyana Beta Artyuga, Ahmad Hero Aufar Zimamuz Zaman Al Hajiri Ayu Aisyah Alya Hamida Benge, Wilhemus D.M.R Benge, Wilhemus Dionysius Mario Randy Benge, Wilhemus Dionysius Mario Randy Dewi Masithah Dewi Masithah, Dewi Dwijayanti, ira Fahira, Aulia Farakhin, Noer Farmananda, Irsandi Rizki Farmananda, Irsandi Rizki Fitria Dwi Anggraini Galih Wicaksono Irmawan Farindra Irsandi Rizky Farmananda Kombih, Muhammad Fifin Krismawati, Amelia Laila Hanum Lailiyah, Hikmatul M. Fifin Kombih M. Shodiq Maizoniarta, Ayrton Putra Masithah, Dewi Muhammad Salsabeela Rusdi Muhammad, Akbar Reza Nailuvar, Revani Yuni Nihazzatuzzain N Nuari, Nuzlan Nur Masruroh Nur Sophia Matin Nur Zuwariah Putri, Salsabil Nabila Wigayana Putri, Winawati Eka Ramadhany, Rahmat Rizal Rhomadhoni, Muslikhah Nourma Rima Isna Rahmawati Rima Putri Permata Sari Rizkina, Marosa Nabila Roosyidah R Rusdi, Muhammad Salsabeela Rusdi, Muhammad Salsabeela Sabania Hari Raharjeng Saffanah, Vena Saksia Prima Saputra, M. Kevin Bintang Setiawan, Muhammad Devabrata Shinta Maulydiyah Basuki Siti Nur Hasina Syahrul Gusnaldi Prawidya Tirthaningsih, Ni Wajan Viskasari P. Kalanjati Wibowo, Novan Kurnia Wilada, Hajar Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Wiwik Winarningsih Yuniati, Dyah Zuwariyah, Nur