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All Journal Farmaka Interest : Jurnal Ilmu Kesehatan Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) The Indonesian Biomedical Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kedokteran dan Kesehatan JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Bioscientia Medicina : Journal of Biomedicine and Translational Research Kumawula: Jurnal Pengabdian Kepada Masyarakat Jurnal Kefarmasian AKFARINDO Journal of Fundamental and Applied Pharmaceutical Science Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Biological Pharmacy Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Eli Halimah, Eli
Fakultas Farmasi Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : The Indonesian Biomedical Journal

 1 
Relationship between Circulating Protein p53 and High Sensitivity C-Reactive Protein in Central Obesity Men with Inflammaging Rina Triana; Anna Meiliana; Eli Halimah; Andi Wijaya
The Indonesian Biomedical Journal Vol 11, No 1 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i1.436

Abstract

BACKGROUND: The mechanism of aging goes along with age, one of which is characterized by cellular senescent, which occurs mostly in adipose tissue. Adipose tissue is the site of accumulation of large cell senescent, in the regulation of obesity and aging. Proteins p53 is marker for cell senescent, which are also known to induce inflammation. This study was aimed to determine the relationship between circulating protein p53 and high sensitivity C-reactive protein (hsCRP) in central obese men with inflammaging.METHODS: The study design is an observational study with cross-sectional approach. The subjects were 75 central obese men (waist circumference/WC > 90 cm), aged ≥ 45 years old. Subjects were divided into 2 age groups, those are middle age group: 45-59 years old (50.7%) and elderly group: ≥ 60 years old (49.3%). Examination of circulating p53 was done using enzyme-linked immunosorbent assay (ELISA) method, and the hsCRP examination was done by chemiluminescent method.RESULTS: It was found that there was a correlation between circulating p53 and hsCRP in elderly (r=-0.414; p<0.05) but not in middle age (r=-0.127; p=0.449).CONCLUSION: From this study, it is assumed that more senescence cells in elderly are resulting in increased chronic inflammation.KEYWORDS: aging, senescent, inflammaging, protein p53, hsCRP
Co-Authors Abdul Kholik Tasib Abdul Mutalib Abdul Mutalib Ade Zuhrotun Aep W Irwan Aep W Irwan, Aep W Ahmad Muhtadi Ahmad Muhtadi ALFIA NURSETIANI ALIFIA SYIFA PEBRIANTI Ami Tjitraresmi, Ami Aminah Nurhadiyah Anas Subarnas Andi Wijaya Anna Meiliana Arifah, Gina As&#039;ari Nawawi Aulia, Gina Barliana, Melisa I. Barliana, Melisa I. Budhi Prihartanto California, Salma H. Chaeriadi, Venice Chintami Nurkholbiah Desianti Khoiriyah, Shahnaz Destiani, Dika P. Dika P. Destiani DONI DERMAWAN Dwi Prasetyo Dwi Prasetyo Ellin Febrina Erwin Sasmita Evy Liswati Evy Liswati, Evy Faizatun Maulida Gatera, Vesara A. Gina Arifah Gina Aulia Herawati, Irma E. Irma M. Puspitasari, Irma M. Irma Melyani Puspitasari Irma Pratiwi Ivan S. Pradipta Jajan Solahudin Jajan Solahudin, Jajan Julisiana Sanggelorang Jutti Levita Keri Lestari Lina Nafisah Lutfi Sulaiman Mally G. Sholih Mardhiani, Yanni Dhiani Marline Abdassah Marline Abdassah, Marline MEGANTARA, SANDRA Melisa I. Barliana Melisa I. Barliana Miski A. Khairinisa Muchtaridi Muchtaridi Mutakin Mutakin Naja, Syahrul Nasrul Wathoni Nawawi, Asari Ni Made Susilawati Nia Kurniasih Noviani, Tatat NUR AZIZAH ALI Nurhadiyah, Aminah Nurul Annisa NURUL ANNISA Nyi M. Saptarini Oktarina, Dewi Ria Pani, Sarini Pani, Sarini Peppi Z. Yuzaqi Pradipta, Ivan S. Pratiwi, Irma Puspitadewi, Nurhanifah Putri, Aulia Nur Assyifa Rano K. Sinuraya Rano K. Sinuraya Ratnawati, Rani Rena Choerunisa Rina Triana Rini Hendriani RISDA RAHMI ISLAMIATY Riyadi Adrizain Rizkita Nur Ainun Rizky Abdulah Rumaseuw, Ellen Stephanie Rusdianto, Aziiz M. Ruterlin, Valen Sadli, Nurul Kamilah Salma H. California Saptarini, Nyi M. Sarini Pani Sarini Pani Sasmita, Erwin Sholih, Mally G. Sinuraya, Rano K. Sinuraya, Rano K. SITI SAIDAH Slamet Ibrahim - Sri A Sumiwi Sri A Sumiwi, Sri A Sri A. Sumiwi Sri Adi Sumiwi Sri Hartini Sri Hartini Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Suhendi, Cece Sumiwi, Sri A. Sumiwi, Sri A. Suseno Amin Suseno Amin, Suseno Syahrul Naja Tania R. Amalia Taofik Rusdiana Tatat Noviani TRAJU NINGTIAS DWI UTARI Valen Ruterlin Venice Chaeriadi Vesara A. Gatera Wahyuni, Indah S. Widyatmoko, Leonardus Winarni, Rina Wiwik Rositawati Wiwik Rositawati, Wiwik Yasmiwar Susilawati Yoppi Iskandar Yuzaqi, Peppi Z. Zahra, Citra Aulia