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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian UNEJ e-Proceeding The Indonesian Biomedical Journal Jurnal Medik Veteriner Jurnal Masyarakat Madani Indonesia Indonesian Journal of Pharmaceutical Research Jurnal Abdimas Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Martha Ervina
Fakultas Farmasi Universitas Katolik Widya Mandala Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Efek Fraksi Air Daun Salam (Syzygium polyanthum) Terhadap Imunitas Alami Tikus Wistar Jantan Tamayanti, Wahyu Dewi; Soegianto, Lisa; Nurak, Elisabeth; Hadisoewignyo, Lannie; Ervina, Martha
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 2 No. 1 (2015)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v2i1.702

Abstract

Pemberian fraksi air daun salam (Syzygium polyanthum) terhadap jumlah netrofil dan kadar IL-6 tjkus Wistarjantan yang telah diinduksi Staphylococcus aureus telah dilakukan. Tikus Wistar jantan dibagi dalam 3 ckelompok, masing-masing terdiri dari 5 ekor tikus, yaitu kelompok kontrol negatif (perlakuan NaCI 0,9%) kelompok uji (perlakuan fraksi air daun salam 200 mg/kg BB) dan ~elompok kontrol positif (perlakuan suspensi ibuprofen 400 mg/kg BB). Tikus dengan perlakuan dikorbankan satu jam setelah induksi Staphylococcus aureus, dan diambil darahnya. Perhitungan jumlah netrofil darah dilakukan .di bawah mikroskop dan penentuan kadar IL-6 dilakukan dengan metode ELISA. Hasil ana lisa data dengan anava satu arah mengindikasikan bahwa daun salam tidak menurunkan jumlah netrofil darah maupun IL-6 pada tikus Wistar jantan yang terinduksi Staphylococcus aureus.
Karakterisasi dan Uji Aktivitas Antibakteri dari Fungi Endofit Ranting Tanaman Manggis (Garcinia mangostana L.) terhadap Escherichia coli dan Staphylococcus aureus Widjaja, Kevin; Soegianto, Lisa; Ervina, Martha
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 6 No. 1 (2019)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v6i1.2007

Abstract

Resistance is commonly caused by improper usage of antibiotics, so the treatment of the infection always needs a new and more potent compounds. Endophytic microbes are microbes that all or part of its life stay in the tissues of plant, which established a mutually beneficial relationship between them. In this research, isolation of endophytic fungi was conducted by sticking the sterilized twigs of mangosteen to the media Malt Extract Agar obtained three pure endophytic fungi colonies. The antibacterial activity assay with direct inoculation method at media Plate Count Agar which was inoculated with bacteria and showed that the antibacterial activity against Escherichia coli ATCC 8739 was one isolate (ER2) with inhibition average ratio 1.42 and against Staphylococcus aureus ATCC 6538 was three isolates (ER1, ER2, and ER3) with inhibition average ratio 1.66; 1.37; and 1.89. The fungus were observed characteristics of the macroscopic, microscopic and biochemical assay. ER1 and ER3 isolates are suspected as a Penicillium genus with specific characteristics such as the conidiophore, fialid, metulae, and conidiospore. ER2 isolate was suspected as a Rhizoctonia genus because there are nearly right-angled hyphae and monilioid cells.
Penggunaan Carbormer 940 sebagai Gelling Agent dalam Formula Pasta Gigi Ekstrak Buah Apel (Malus sylvestris Mill) dalam Bentuk Gel Wijayanti, Luh Putu Widiasih; Darsono, Farida Lanawati; Ervina, Martha
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 4 No. 1 (2017)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v4i1.2173

Abstract

Teeth are often not protected from several diseases, despite having a hard structure. Dental diseases include dental caries (cavities) and diseases of the tooth supporting tissues. Dental caries is defined as a disease that results in damage to the hard tissue of the tooth structure through the process of demineralization. Streptococcus mutans is known as a major microorganism that plays a role in the process of dental caries. One way to reduce the formation of dental caries is to use toothpaste. Apples (Malus sylvestris Mill) Manalagi variety that has catechins, has efficacy as an anti dental caries. The purpose of this study was to formulate ethanol extract from apples as a gel toothpaste using carbomer 940 as a gelling agent. Apple ethanol extract used in this study was 9.6%, while the carbomer concentration of 940 used was 0.75% (formula I), 1.0% (formula II) and 1.5% (formula III). Evaluation of toothpaste formulas includes physical quality including organoleptic, homogeneity, pH, viscosity, dispersibility. Characteristic evaluation includes ease of release from the tube, adhesion and consistency. The stability evaluation includes room temperature stability, high temperature, and cycling tests. Evaluation of aseptability and evaluation of irritation is done in cow's jaws. Increasing the concentration of Carbomer 940 as a gelling agent has a significant effect on viscosity, dispersion, ease of release from the tube, adhesion and consistency. The test results show formula 3 (1.5% carbomer 940) is the best formula because it has produced physical quality in accordance with specifications, the resulting preparation is stable and very preferred and safe to use.
Perbandingan Aktivitas Antibakteri 4-Metilpiperazin-N-Karbonil Ampisilin dengan Ampisilin Terhadap Micrococcus luteus dan Escherichia coli Pudjianto, Andreyanus Eko; Ervina, Martha; Caroline, Catherine; Soekardjo, Bambang; Foe, Kuncoro
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 1 No. 1 (2013)
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v1i1.2342

Abstract

Piperacillin has antimicrobial action but it is not absorbed from gastrointestinal tract Therefore, it needs structure modification to increase its absorption while keeping its antimicrobial action. The 4-methylpiperazin-N-carbonyl ampicillin was the product of reaction between ampicillin and 4-methylpiperazin-N-carbonyl chloride using Schotten Baumann method. The aim of this research was to compare the antibacterial activity between 4-methylpiperazin-N-carbonyl ampicillin and ampicillin. The comparison test of antibacterial activity was done with Kirby-Bauer disk diffusion susceptibility method on Mueller-Hinton agar which had been inoculated with Micrococcus luteus and Escherichia coli. Based on orientation studies, concentration of 4-methylpiperazin-N-carbonyl ampicillin and ampiCillin were 0.5 ppm against Micrococcus luteus and 500 ppm against Escherichia collin order to get visible zone of inhibition. The results showed that 4-methylpiperazin-Ncarbonyl ampicillin had lower antibacterial activity than ampicillin which was showed by its zone of inhibition which was lower compared to ampicillin in inoculated agar media of Micrococcus luteus and Escherichia coli.
Modified High-Fat High-Sucrose Diet Promotes Obesity and Alters Colonic Cytokines Novita, Bernadette Dian; Wedharga, I Gede Putu Adhi; Tjahjono, Yudy; Wijaya, Hendy; Theodora, Imelda; Ervina, Martha; Wilianto, Yufita Ratnasari; Dewi, Sianty; Parengkuan, Irene Lingkan; Herjunianto, Herjunianto; Ghasani, Sabrina Maria; Limantoro, Michael Christian; Jaya, Ferdinand Wiliam
The Indonesian Biomedical Journal Vol 17, No 5 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i5.3807

Abstract

BACKGROUND: Western dietary patterns are often associated with increasing non-communicable diseases, including inflammatory bowel disease (IBD). In experimental models, a high-fat high-sucrose (HFHS) diet is used to mimic metabolic and inflammatory effects of such diets, however the data regarding colonic inflammation in Indonesia remain limited. Therefore, this study was conducted evaluated the impact of HFHS feeding on colonic interleukin (IL)-6, IL-10 expression, and the IL-6/IL-10 ratio.METHODS: Six weeks old male C57BL/6 mice were randomly assigned to a normal fat diet (NFD) or HFHS diet group and fed ad libitum for 8 weeks. Colonic tissues were collected, and IL-6 and IL-10 expression was analyzed by immunohistochemistry.RESULTS: HFHS-fed mice showed significant increases in body weight (increased by 22.44%, p=0.0047) and caloric intake (increased by 125.17%, p=0.0000), confirming obesity induction. Colitis was also evident, with higher histological colitis scores (p=0.0072). However, colonic IL-6 (increased by 9.12%, p=0.1236), IL-10 (increased by 1.49%, p=0.8013), and the IL-6/IL-10 ratio (increased by 7.38%, p=0.4000) showed no significant differences compared to NFD.CONCLUSION: In C57BL/6 mice, an 8-week modified HFHS diet induced obesity, increased caloric intake, and mucosal injury, but did not significantly alter colonic IL-6, IL-10, or their ratio. This suggests preserved mucosal immune homeostasis consistent with an early compensatory phase rather than overt cytokine-driven inflammation. Longer or more intensive exposure may disrupt this balance, highlighting the need for further studies to define the temporal threshold and clarify immune microbiome interactions in colitis progression.KEYWORDS: high-fat high-sucrose diet, colon inflammation, IL-6, IL-10, obesity mice
In silico study of the essential oil compounds of ginger and thyme on Coronavirus-2 receptors Caroline, Caroline; Ervina, Martha; Pratama, Muhammad Rizki Fadhil; Jessica, Maria Anabella
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.26964

Abstract

Coronavirus-2 (SARS-Cov-2) is a virus that attacks the respiratory system and causes the Covid-19 pandemic. After the pandemic, prevention and appropriate therapy research continue to be carried out to anticipate the emergence of more dangerous viruses. In line with the culture of consuming herbs that has arisen due to the effects of the pandemic, in this study, an insilico screening was carried out for essential oil compounds produced by ginger and thyme herbs which have been widely consumed by the public. The aim of the research was to find the essential oil content that has the most potential as an antiviral against coronavirus-2. The research method was carried out in silico, including ligand preparation, receptor and method validation, and analysis of ligand-receptor binding interactions using the AutoDoc 4.2.6 program. As a comparison, a study was conducted on remdesivir and favipiravir, which have been used as antivirals. The three components that have the most potential based on the calculation of the free energy value, were determined by the ADMET parameters using the Admet lab 2.0 program. The results showed that the three components in the essential oil exhibited better interactions when compared to remdesivir and favipiravir at the 3-Cl protease and spike glycoprotein receptors. The results of the insilico study and ADMET prediction test showed that of the three most potent compounds, lamda-farnesen was the most potent and safe to use
Pelatihan Pembuatan Water Kefir sebagai Minuman Probiotik Caroline, Caroline; Ervina, Martha; Hadinugroho, Wuryanto; Esar, Senny Yesery; Wijaya, Hendy; Tjahjono, Yudi; Handayani, Yuliastuti Ika; Sutedja, Anita Maya
Jurnal Abdimas Kesehatan (JAK) Vol. 6 No. 2 (2024): Juni
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jak.v6i2.620

Abstract

Christ the King of Surabaya Parish through the Socio-Economic Development Section (PSE) in collaboration with Widya Mandala Catholic University Surabaya, was committed to assisting the Indonesian government's program in terms of improving the post-pandemic family economy through training in making health drinks from herbal ingredients, namely water kefir, which has been used as a probiotic drink. The training participants were underprivileged families in the Parish of Christ the King Surabaya. The training was carried out for 1 day with presentation of material by the team, training implementation and training evaluation by filling out pre-tests, post-tests and questionnaires as well as 30 days of assistance for participants who were interested in developing products to improve their economy. The results of the training show high enthusiasm from the participants, an increase in the knowledge of the participants which was marked by an increase in the value of the posttest compared to the pretest and the desire of the participants to produce and market products to improve the family economy
Upaya Pelestarian Lingkungan: Lilin Aromaterapi dari Recycling Minyak Jelantah Prasetyo, Jefri; Caroline, Caroline; Hadinugroho, Wuryanto; Ervina, Martha
Jurnal Masyarakat Madani Indonesia Vol. 3 No. 3 (2024): Agustus
Publisher : Alesha Media Digital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59025/kaycmz23

Abstract

Minyak jelantah merupakan limbah cair hasil dari penggorengan yang umumnya tidak dimanfaatkan lagi, jika dibuang secara langsung dapat menghasilkan pencemaran lingkungan yang serius. Oleh sebab itu, perlu dilakukan sebuah upaya pelestarian lingkungan terhadap limbah minyak jelantah seperti memanfaatkan kembali limbah tersebut menjadi bahan yang lebih bermanfaat dan bernilai lebih tinggi. Pemanfatan kembali limbah minyak jelantah dilakukan dengan masyarakat sekitar kampus bertujuan untuk memberikan edukasi mengenai bahaya minyak jelantah bagi kesehatan dan kelestarian lingkungan serta potensi minyak jelantah sebagai bahan dasar dalam pembuatan lilin aromaterapi yang bernilai ekonomis. Metode yang digunakan terdiri dari beberapa tahapan mulai dari pemetaan permasalahan, persiapan, pelaksanaan, dan evaluasi. Kegiatan berupa pemberian materi, diskusi, dan praktik. Pada pelaksanaan kegiatan, peserta dibagi menjadi kelompok kecil berjumlah 4-5 orang. Berdasarkan hasil evaluasi yang telah dilakukan, dapat disimpulkan bahwa materi kegiatan penyuluhan dan pelatihan telah berhasil diterima dengan baik oleh para peserta yang dibuktikan melalui peningkatan pengetahuan sebesar 30% (berdasarkan nilai pre-test dan post-test) dan sebanyak 70% peserta memperoleh nilai post-test ≥ 80. Dengan kata lain, kegiatan abdimas ini telah berhasil dalam meningkatkan pengetahuan dan wawasan serta menambah ide usaha bagi para peserta agar mampu dalam membuat secara mandiri lilin aromaterapi yang berbahan dasar limbah minyak jelantah.
Penyuluhan dan Pelatihan Pembuatan Minyak Angin Roll On Aromaterapi Prasetyo, Jefri; Caroline, Caroline; Hadinugroho, Wuryanto; Ervina, Martha
Jurnal Masyarakat Madani Indonesia Vol. 4 No. 1 (2025): Februari
Publisher : Alesha Media Digital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59025/6ncskc23

Abstract

Minyak angin aromaterapi menggunakan bahan baku utama yaitu minyak esensial (minyak atsiri) beraroma harum yang di ekstrak dari tanaman menggunakan metode destilasi. Minyak angin aromaterapi digunakan untuk meringankan gejala sakit kepala, masuk angin, menghangatkan dan merilekskan tubuh serta menenangkan pikiran. Kegiatan abdimas ini bertujuan untuk meningkatkan pengetahuan dan ketrampilan peserta terkait manfaat dan cara pembuatan minyak angin roll on aromaterapi. Kegiatan abdimas ini dihadiri oleh 21 peserta yang dibagi menjadi 4 kelompok kecil. Terlebih dahulu dilakukan tahap persiapan yang meliputi penyiapan alat dan bahan hingga penyiapan wadah kemasan menggunakan botol roll on. Selanjutnya, pada tahap pelaksanaan dimulai dengan paparan informasi tentang manfaat minyak angin aromaterapi serta pelatihan cara pembuatannya. Minyak angin aromaterapi yang telah dibuat, dikemas dengan menggunakan botol roll on untuk memudahkan penggunaannya karena dapat langsung di hirup melalui hidung atau dioleskan pada kulit tanpa mengotori tangan penggunanya. Berdasarkan hasil evaluasi, dapat disimpulkan bahwa materi kegiatan abdimas ini berhasil diterima dengan baik oleh para peserta yang dibuktikan melalui peningkatan pengetahuan sebesar 40% dan sebanyak 80% peserta memperoleh nilai post-test ≥ 85 Dengan kata lain, dapat dikatakan bahwa kegiatan ini berhasil meningkatkan wawasan serta menambah ide usaha bagi para peserta agar mampu membuat secara mandiri minyak angin roll on aromaterapi.
Co-Authors Anita Maya Sutedja Caesilia Putri Utami Caesilia Putri Utami, Caesilia Putri Caroline Caroline Caroline Caroline Catherine Caroline Emi Sukarti Emi Sukarti, Emi Esar, Senny Yesery Fandy Susanto Fandy Susanto, Fandy Farida Lanawati Darsono Foe, Kuncoro Ghasani, Sabrina Maria Handayani, Yuliastuti Ika Hendrata, Adi Pramono Henry Kurnia Setiawan Herjunianto Herjunianto Irene Lingkan Parengkuan Jaya, Ferdinand Wiliam Jessica, Maria Anabella Kuncorojakti, Suryo Lannie Hadisoewignyo Lannie Hadisoewignyo Lanny Hartanti Laura Wihanto Limantoro, Michael Christian Lisa Soegianto Maria Anabella Jessica Mohammad Rizki Fadhil Pratama Novita, Bernadette Dian Nurak, Elisabeth Paul L Tahalele Prasetyo, Jefri Pratama, Muhammad Rizki Fadhil Pudjianto, Andreyanus Eko Senny Yesery Esar Sianty Dewi Soediono, Endang Isbandiati Soekardjo, Bambang Stefani Luke Steven, . Sumi WIjaya, Sumi Theodora, Imelda Tjahjono, Yudi Tjahjono, Yudy Wahyu Dewi Tamayanti, Wahyu Dewi Wedharga, I Gede Putu Adhi Widjaja, Kevin Widjaja, Kevin Wijaya, Hendy Wijayanti, Luh Putu Widiasih Wilianto, Yufita Ratnasari Wuryanto Hadinugroho Wuryanto Hadinugroho Yudhikuari Sincihu