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All Journal Jurnal Biometrika dan Kependudukan (Journal of Biometrics and Population) Jurnal Vokasi Jurnal Ilmiah Manusia dan Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Jurnal Malikussaleh Mengabdi Auxilium : Jurnal Pengabdian Kesehatan
Nora Maulina, Nora
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Religion Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Narra J

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Coronary heart disease risk factors among academic workers based on the Jakarta Cardiovascular Score: A cross-sectional study Sawitri, Harvina; Maulina, Nora
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.162

Abstract

Change in lifestyle leads to change in disease patterns from infectious diseases and malnutrition to degenerative diseases, such as coronary heart disease (CHD). The increasing prevalence of cardiovascular diseases among Indonesian workers and the general public will not only burden medical care expenses but also reduce work productivity, leading to more work-related injuries and work-related losses. The aim of this study was to determine the risk factors for CHD (age, sex, blood pressure, smoking, diabetes mellitus, body mass index, and weekly physical activity) and the CHD risk level among university workers. A cross-sectional study was conducted at workers at School of Medicine, Universitas Malikussaleh, Lhokseumawe, Indonesia. The risk level of CHD was calculated using Jakarta Cardiovascular Score and predicting model analyzed with multiple logistic regression model. Our data found that 58.2%, 25.5% and 16.3% of the university workers had low-, medium- and high-risk to have CHD. The final model indicted that the risk of heart disease was determined by gender, age, and the presence of hypertension and diabetes mellitus. Being male had odds ratio (OR) 30.84, aged >41 years old had OR 11.52, having hypertension had OR 4.87 and having diabetes mellitus had OR 13.99 for having high risk of CHD compared to female, those younger than 41 years old, having no hypertension and having no diabetes mellitus, respectively. In conclusion, our data suggests that more than 15% the respondents (university employees) have high risk of CHD and being male and older, and having hypertension and diabetes mellitus are associated with risk of CHD. Implantation of the preventive measures is therefore important to be implemented at the universities.
Effect of black garlic (Allium sativum) on gonadosomatic index, follicle-stimulating hormone level and spermatozoa quality: A study in monosodium glutamate-exposed rat model Bani, Ika I.; Zulkarnain, Zulkarnain; Gholib, Gholib; Syahrizal, Dedy; Nugraha, Taufiq P.; Ramadhan, Akmal; Akmal, Muslim; Maulina, Nora
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.617

Abstract

Infertility rates have risen significantly, one of which is due to monosodium glutamate (MSG) consumption. Recent studies have shown that flavonoids in black garlic (Allium sativum) act as antioxidants. The aim of this study was to assess the effect of black garlic extract (BGE) on gonadosomatic index, follicle-stimulating hormone (FSH) levels, and spermatozoa quality in rats exposed to MSG. Twenty-five healthy rats, aged ten to twelve weeks, were divided equally into five experimental groups: (1) negative control (NC), no intervention; (2) positive control (PC), fed with MSG 8 mg/kg; and (3) fed with MSG + BGE 200 mg/kg; (4) fed with MSG + BGE 400 mg/kg; and (5) fed with MSG + BGE 600 mg/kg. Oral MSG was administered once a day for two weeks before BGE administration was started for two weeks. The measured endpoints were gonadosomatic index, FSH levels, and spermatozoa concentration and quality (spermatozoa motility and abnormality). Analysis of variance (ANOVA) followed by Duncan's post hoc analysis was used to assess the measurement differences. The result suggested that the administration of BGE did not significantly affect the gonadosomatic index (p=0.513). Significant decreases in FSH levels (p=0.005) and spermatozoa concentration were observed in the PC group compared to other groups (p<0.001). Additionally, spermatozoa motility was significantly lower in the PC group compared to NC, BGE200, BGE400, and BGE600 (p<0.001), with higher motility noted in BGE200, BGE400, and BGE600 compared to PC (p<0.001). Furthermore, PC had significantly higher spermatozoa abnormalities compared to NC, BGE200, BGE400, and BGE600 (p<0.001). In conclusion, administration of BGE had a significant effect on the improvement of FSH levels and the quality of spermatozoa in rats exposed to MSG.
Black garlic exhibited hepatoprotective effect against monosodium glutamate-induced hepatotoxicity in animal model Maulina, Nora; Zachreini, Indra; Gholib, Gholib; Suwandi, Abdulhadi; Akmal, Muslim
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.799

Abstract

Monosodium glutamate (MSG) is commonly used as a flavor-enhancing agent in foods, and studies have demonstrated its toxic effects in animal models. Black garlic is known for its antioxidant and anti-inflammatory properties; however, there is a lack of studies on the potential hepatoprotective effect of black garlic ethanol extract (BGE) against MSG-induced hepatotoxicity in rats. The aim of this study was to investigate the hepatoprotective effects of ethanol extract of black garlic against MSG-induced liver damage in animal model. Twenty-five male Wistar rats were randomly assigned to five groups (n=5): negative control, MSG only, and MSG with three different doses of BGE. The MSG only and MSG with BGE groups were orally administered with 8 mg/kg MSG daily. After MSG treatment, the MSG with BGE groups received BGE orally at daily doses of 200, 400, or 600 mg/kg body weight for 16 consecutive days. Subsequently, the levels of serum liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), interferon-gamma (IFN-γ), and cyclooxygenase-2 (COX-2) were measured. Our data indicated that the group treated with 200 mg/kg BGE had significant lower levels of AST and ALT significantly compared to the MSG-only group. The MSG-treated group had higher levels of the inflammatory markers COX-2 and IFN-γ, which were lowered by administration of 200 mg/kg BGE. In contrast, higher doses of BGE led to greater levels of COX-2 and IFN-γ compared to those in the MSG-only group. This study suggested that BGE might have hepatoprotective effects at low dose, potentially mitigating MSG-induced liver damage. However, the higher dose of black garlic extract did not alleviate inflammation, as shown by the higher levels of COX-2 and IFN-γ.
Co-Authors Ahmad Fauzan Al Fadhil, Muhammad Fajar Alia Natasha, Cut Arvinda, Aufa Dery Bani, Ika I. Cut Asmaul Husna, Cut Asmaul Cut Khairunnisa Dedy Syahrizal Divaulhaq, Afiqah Faradilla, Cut Sarah Fawwaza, Nasywa Fitri, Dwi Gholib Gholib, Gholib Habibi, Rojulan Ilham Husna, Hikmatul Iqbal, Teuku Yudi Khaidir Khaidir, Khaidir Khairunnisa Khairunnisa Lestari, Wulan Suci Lubis, Dzakwan Hakim Lubis, Rojulan Ilham Lutfi, T Yocana Maulina, Fury Millizia, Anna Muhammad Kautsar, Muhammad Muhammad, Oktaduta Mulyati Sri Rahayu, Mulyati Mulyati Sri Rahayu, Mulyati Sri Muslim Akmal Muslim, Zahrawanda Ashfarina N. Nazaruddin Nabilla, Ghaitsa Nadhira, Cut Sidrah Nadira, Cut Sidrah Natasha, Cut Alia Nazirah, Jihan Nelvia, Desi Dita Nina Herlina Noviana Zara Nur Sakinah PUTRI EKA SARI, PUTRI EKA Putri Mellaratna, Wizar Putri, Baluqia Iskandar Rahmi Surayya Rahmi, Nita Ramadhan, Akmal Ramadhansyah, Fitriana Rizka, Wulidah Rizki Akbar, Rizki Rizqa, Rizqa Ramadhani Said, Badra Hasana Salsabila, Salsabila Sawitri, Harvina Sawitri3, Harvina Sayuti, Muhammad Sayuti, Muhammad Sidrah Nadira, Cut Sri Wahyuni Susri, Wendy Suwandi, Abdulhadi Syafitri, Laila Syifa, Siti Taufiq P. Nugraha, Taufiq P. Yudhi Iqbal, Teuku Yuziani, Yuziani Zachraeni, Indra Zachreini, Indra Zahara, Ulfa Zakiyya, Najwa Zubir, Zubir Zulkarnain Zulkarnain