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All Journal e-CliniC Jurnal Kedokteran Molecular and Cellular Biomedical Sciences (MCBS) JOURNAL OF HEALTH SCIENCE (JURNAL ILMU KESEHATAN) Amerta Nutrition Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Medica Hospitalia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Ilmiah Kesehatan Ar-Rum Salatiga World Nutrition Journal Respiratory Science Narra J Cermin Dunia Kedokteran Journal Of World Science MEDICINUS Strada Jurnal Ilmiah Kesehatan (SJIK)
Fariz, Nurwidya
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Indonesia – Persahabatan Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Respiratory Syncytial Virus (RSV): Virologi, Patogenesis, Respon Imun, dan Vaksin Pada Dewasa Resti H. Lestari; Fariz Nurwidya; Anis Karuniawati
MEDICINUS Vol. 38 No. 7 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/n0vpzd50

Abstract

Respiratory syncytial virus (RSV) is classified within the Pneumoviridae family, genus Orthopneumovirus. RSV is a single-stranded, negative-sense RNA virus and has two genotypes, A and B. It is primarily associated with lower respiratory tract infections, including bronchiolitis and bronchopneumonia, and is a common cause of hospitalization in infants, elderly individuals, and immunocompromised patients. RSV also has the potential to become systemic infection. Symptoms of RSV infection, such as fever, cough, sore throat, and runny nose, are usually mild in adults. However, in some cases, especially for specific high-risk individuals, the infection can become severe enough to require hospitalization, and complications may lead to death. Understanding the pathogenesis and immune response to RSV are crucial for recognizing the virus’s effects and potential risks. This literature review covers the virology, pathogenesis, immune response, and recent advancements in RSV vaccine development in adult populations. Comprehensive knowledge of RSV is essential for developing effective prevention and treatment strategies.
Immunopathogenesis of Pneumocystis Pneumonia (PCP) and Its Clinical Implications Malik, Andi Sri Suryani; Agustin, Heidy; Nurwidya, Fariz; Rozaliyani, Anna
Respiratory Science Vol. 5 No. 3 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i3.172

Abstract

Pneumocystis pneumonia (PCP) is a serious lung infection caused by Pneumocystis jirovecii, primarily affecting immunocompromised individuals. It remains a major health concern, especially in HIV/AIDS patients and those undergoing immunosuppressive therapy. This review discusses how the immune system responds to P. jirovecii and why immunocompromised individuals are more vulnerable. In healthy individuals, CD4+ T cells, B cells, and macrophages help control the infection. However, in immunocompromised individuals, a weakened immune response allows fungal overgrowth, leading to severe lung damage. The review also covers symptoms, diagnosis, and treatment options. TMP-SMX is the preferred treatment, while alternative drugs are available for those who cannot tolerate it. Understanding the immune response to PCP can help improve treatment and patient care.
Relationship between age and vas appetite score among patients with post-tuberculosis lung disease at Persahabatan National Respiratory Referral Hospital, Jakarta Mahardika, Linda; Nurwidya, Fariz; Singal, Anna Maurina
World Nutrition Journal Vol. 9 No. S1 (2025): Vol. 9 No. S1 (2025): Selected conference proceedings of the Nutri Symposium 2
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V09.S1.0022

Abstract

Background: Post-tuberculosis lung disease (PTLD) is a form of progressive lung tissue damage following tuberculosis (TB) infection. In addition to clinical symptoms, patients with PTLD often experience nutritional problems. Appetite plays a crucial role in determining adequate nutrient intake, which can affect nutritional status, the recovery process, and overall quality of life. One factor that may influence appetite is age. Although age is known to affect appetite, the relationship between the two has not been studied, particularly in patients with PTLD at Persahabatan Hospital, National Respiratory Centre.
Zinc Intake and Appetite in Patients with Post-Tuberculosis Lung Disease at Persahabatan National Respiratory Referral Hospital, Jakarta Mahardhika, Linda; Nurwidya, Fariz; Singal, Anna Maurina; Sutanto, Krisadelfa; Imaniar, Rania; Syam, Shaogi
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.232-240

Abstract

Introduction: After completion of pulmonary tuberculosis (TB) treatment, some people may continue to experience respiratory issues that can progress into post-TB lung disease (PTLD). Individuals with PTLD exhibit suboptimal nutritional status. The loss of appetite is a significant factor influencing nutritional status. Zinc plays a role in hunger control.  Lack of zinc reduces taste sensitivity and food intake. This study examined the relationship between zinc intake and appetite in patients with PTLD at Persahabatan National Respiratory Referral Hospital, Jakarta. Methods: This cross-sectional study was conducted at Persahabatan National Respiratory Referral Hospital, Jakarta, from November 2024 to March 2025. Eighty-five adult patients with PTLD were included. Zinc intake was assessed by a semi-quantitative food frequency questionnaire (SQ-FFQ) and analyzed by NutriSurvey software. Appetite was measured using the visual analog scale (VAS) for appetite. Results: A total of 85 subjects participated in the study, comprising 78.8% males and 21.2% females. The average daily zinc intake was 4.4 mg/day, and 92.9% of the subjects had zinc intake below the recommended dietary allowance (RDA). The average VAS appetite score was 70 mm. A significant positive correlation was found between zinc intake and appetite, indicating that a decrease in zinc intake might result in a reduced appetite (r=0.266, p=0.014). Conclusion: Zinc intake is positively associated with appetite in patients with PTLD. Therefore, zinc intake monitoring is essential for supporting nutritional recovery and lung function in PTLD.
Peran Bromhexine dalam Tata Laksana Gangguan Pernapasan: Mekanisme dan Efektivitas Klinis Fariz Nurwidya
MEDICINUS Vol. 38 No. 11 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/zb6m9p23

Abstract

Bromhexine hydrochloride is a mucoactive agent that has been used for more than five decades. Although primarily known as a mucolytic agent, recent evidence indicates a more complex mechanism of action as well as broader potentialtherapeutic applications. This literature review aims to synthesize the latest scientific evidence regarding the mechanism of action, clinical efficacy, and safety of bromhexine in the management of various respiratory tract diseases. A literaturesearch was conducted using the PubMed and Scopus databases with the keywords “bromhexine”, “bromhexin”, “mucolytic”, “COPD”, “bronchitis”, “respiratory tract infection”, and “COVID-19”. Selected articles included clinical trials,in vitro/in vivo studies, reviews, and metaanalysis published up to 2025. The review found that bromhexine acts through several mechanisms, including mucin depolymerisation via disulfide bonds cleavage, stimulation of alveolar type II cellssurfactant production, enhancement of ciliary system activity, as well as anti-inflammatory and antioxidant activities. Bromhexine has demonstrated effectiveness as an adjuvant therapy in acute and chronic bronchitis, chronic obstructivepulmonary disease (COPD), asthma, and bronchiectasis, by reducing sputum viscosity and improving productive cough symptoms. In conclusion, bromhexine shows good efficacy and safety for the management of mucus production and transport disorders in various pulmonary diseases, owing to its mucolytic and surfactant-stimulating properties. These mechanisms remain relevant in the modern era of respiratory disease management.
ANTI INTERLEUKIN-1 PADA COVID-19 Nurwidya, Fariz; Zulfiyah, Itsna Arifatuz
Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Vol 9, No 1 (2024)
Publisher : STIKES Ar-Rum Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36409/jika.v9i1.242

Abstract

Pada coronavirus infectious disease (COVID-19) terjadi invasi virus SARS-COV2 pada epitel alveolar. Sel epitel alveolar yang terinfeksi akan mengekpresikan antigen virus pada permukaan sel yang kemudian memicu respon rekognisi oleh makrofag. Sel makrofag ini kemudian mensekresikan interleukin-1 (IL-1) untuk aktivasi respon seluler. Metode, dilakukan penelusuran bukti ilmiah menggunakan kata kunci IL-1, Covid-1 dan inhibitor IL-1 pada database ilmiah PubMed dan Google Scholar. Hasil, pasien COVID-19 memiliki peningkatan kadar IL-1 pada darah dan berhubungan dengan severitas penyakit. Penggunaan zat biologik yang mentarget secara spesifik jalur yang mengalami hiperaktivasi pada pasien COVID-19 adalah salah satu strategi untuk mengatasi hiperinflamasi. Beberapa penelitian uji klinis telah dilakukan menggunakan IL-1 inhibitor pada pasien COVID-19 derajat berat dan mengancam jiwa. Kesimpulan, tinjauan pustaka ini menemukan bahwa IL-1 berperan pada kaskade inflamasi pasien COVID-19 dan inhibisi IL-1 sebagai salah satu cara untuk mengatasi proses inflamasi pada pasien COVID-19 derajat berat.
STEROID PADA COVID-19 Nurwidya, Fariz; Zulfiyah, Itsna Arifatuz
Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Vol 8, No 2 (2024)
Publisher : STIKES Ar-Rum Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36409/jika.v8i2.144

Abstract

Pada pasien Corona virus infection disease (COVID)-19 dengan gejala berat ditemukan kadar sitokin proinflamasi yang tinggi dibandingkan dengan pasien bergejala ringan hingga sedang. Agen imunomodulator utama yang telah diketahui memiliki berbagai manfaat sekaligus efek samping adalah kortikosteroid. Tujuan artikel tinjauan pustaka ini adalah untuk mengelaborasi penggunaan kortikosteroid pada pasien COVID-19. Metode penulisan ini adalah deskripsi naratif berdasarkan panduan Organisasi Kesehatan Dunia, Perhimpunan Dokter Paru Indonesia dan berbagai penelitian uji klinis pada pasien COVID-19. Hasil penelusuran bukti ilmiah menunjukkan bahwa kortikosteroid telah diindikasikan untuk berbagai macam penyakit, yang secara umum dapat dibagi menjadi penyakit infeksi dan inflamasi, penyakit alergi dan autoimun. Kortikosteroid bekerja dengan mekanisme yang kompleks, yang terdiri dari mekanisme genomik dan nongenomik. Pada COVID-19, kortikosteroid digunakan secara sistemik dan dapat diberikan melalui rute oral atau injeksi. Berdasarkan berbagai bukti ilmiah dari uji pra-klinis dan uji klinis yang meneliti aspek indikasi, mekanisme kerja, efek samping, interaksi obat, dan penggunaan pada kelompok khusus, disimpulkan bahwa steroid efektif dan aman digunakan pada pasien COVID-19 membutuhkan suplementasi oksigen pada perawatan di rumah sakit.
Sarcoidosis: Epidemiology, Etiology, Pathogenesis, and Diagnosis Setiawan, Fachri; Nurwidya, Fariz
Journal of World Science Vol. 3 No. 2 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i2.544

Abstract

Interstitial lung disease is a lung condition with wide variations. There are over 200 disorders classified under interstitial lung disease, including sarcoidosis. Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas involving the lungs, lymphatic system, skin, and eyes. Clinical manifestations of sarcoidosis vary greatly, ranging from asymptomatic to severe symptoms with uncertain prognosis. The cause of sarcoidosis remains unknown, though several hypotheses suggest its association with genetic, environmental, infectious, and autoimmune factors. The main pathogenesis involves the formation of non-caseating granulomas involving various types of innate and adaptive immune cells. Based on its clinical presentation, sarcoidosis is classified into two types: Lofgren syndrome and non-Lofgren syndrome. Diagnosis of this disease can be established through clinical examination, radiological imaging, and biopsy revealing non-caseating granulomas. Corticosteroid therapy remains the primary treatment option, alongside immunosuppressive and biological therapies for advanced-stage sarcoidosis.
Nutritional Status and Lung Cavity in Pulmonary Tuberculosis Patient Hanafi, Christi Giovani Anggasta; Nurwidya, Fariz; Lestari, Wiji; Agustin, Heidy; Syam, Shaogi
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.6-14

Abstract

Introduction: As one of the leading causes of death worldwide, pulmonary tuberculosis (PTB) is an infectious disease that continues to pose a serious threat to public health. The presence of cavities in radiological imaging of patients with PTB is associated with malnutrition, age, gender, and other comorbidities, including diabetes mellitus. This study aimed to find the association between nutritional status and lung cavity in PTB patients. Methods: This was an analytical observational study with a cross-sectional design that involved 134 adult patients who were diagnosed with PTB at Persahabatan National Respiratory Referral Hospital, Jakarta. All patients were interviewed using a questionnaire for sociodemographic and anthropometric data, the nutritional status was assessed using the subjective global assessment (SGA), and the lung cavity was determined using a chest X-ray interpreted by radiologists. The Chi-square test was performed using the Statistical Package for the Social Sciences (SPSS) version 25 for Windows. Results: Of 134 PTB patients, 61.9% were males, and 92.5% were from the 18-59 years old age group. Based on the SGA score, 77 (57.5%) were grouped as mild-moderate malnutrition/SGA B and 22 (16.4%) as severe malnutrition/SGA C. Lung cavity was found in 42 (31.3%) patients. The analysis showed that malnutrition was statistically significantly associated with lung cavity with OR=6.933 (95%CI 1.986-24.205; p=0.002) and the adjusted OR were 7.303 (95%CI 2.060-25.890; p=0.002) after controlling for age, sex, smoking, education, and comorbidities. Conclusion: This study found that malnutrition was associated with lung cavities in PTB patients. These findings might indicate how malnutrition impaired the immune function in PTB patients.
Penyakit Paru Interstisial pada Sindrom Sjogren Primer Kemas Rakhmat Notariza; Fariz Nurwidya
Majalah Kedokteran Indonesia Vol 74 No 6 (2024): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.74.6-2024-1705

Abstract

Interstitial lung disease (ILD) is the most common extraglandular manifestation in primary Sjogren’s syndrome (pSS), the second most prevalent autoimmune rheumatic disease. This literature review aimed to discuss about ILD in pSS (pSS-ILD), beginning from aspect of epidemiology, classification criteria, monitoring of disease activity, pathogenesis, diagnostic approaches, to management. The 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for pSS are useful for establishing a diagnosis of pSS. The level of disease activity can be assessed by using the EULAR Sjogren’s Syndrome Disease Activity Index (ESSDAI). Development of autoimmunity to epithelial cells is the pathogenesis mechanism of pSS not only in exocrine glands but also extraglandular, including the lungs. The main diagnostic modalities recommended in the screening and monitoring of ILD in pSS are pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) of thorax. Systemic therapy options for pSS-ILD include glucocorticoids, immunosuppressive agents and biological drugs.
Co-Authors Aditya Wirawan Adityo Wibowo Agustin, Heidy Ahmad Hudoyo Amien, Bagus Radityo Ammar Abdurrahman Hasyim Andarini, Sita Andayani, Diyah Eka Andika Chandra Putra Andrijono Anis Karuniawati Anna Rozaliyani Anwar Jusuf Aprilia Katarina Baskoro, Hario Bies, Asri Liqditta Budi Rahayu Chandra, Dian Novita Christi Giovani Anggasta Hanafi Dewi Krisna Yunda Dharmawan, Ibrahim N.I.P. Diana Sunardi Elisna Syahruddin Ercia Maria da Conçeição Sequeira Fachri Setiawan Faisal Yunus Faiza Hatim Fattrias Handayani Jayaatmaja Fiastuti Witjaksono Fiastuti Witjaksono Hanafi, Christi Giovani Anggasta Harinda, Fadlika Hendra Wahyuni Ibrahim Nur Insan Putra Dharmawan Inge Permadhi Isabela Andhika Paramita Isbaniah, Fathiyah Itsna Arifatuz Zulfiyah Itsna Arifatuz Zulfiyah Johan Nathan Judhiastuty Februhartanty Kemas Rakhmat Notariza Khoirun Nisa Alfitri Krisadelfa Sutanto Linda Mahardhika Mahardika, Linda Malik, Andi Sri Suryani marques lafo, merita Merita Marques Lafo Miraz Radhea Bagaskoro Mitrasari, Surya Moelamsyah, Yandi Noer Mohamad Yusup Mohammad N. Uddin Moulid Hidayat Muhammad Ryan Adi Putra Muliawan, Hary Sakti Nabila Fawzia Neni Sawitri Nurul Ratna Manikam Nurul Ratna Mutu Manikam Patricia S. Sinuraya Rabbani, Hadiati Rania Imaniar Resti H. Lestari Rina Diana Nurfitri Santri Dwizamzami Faridahanum Santri Dwizamzami Faridahanum Sequiera, Ercia Maria da Conceicao Singal, Anna Maurina Syam, Shaogi Wiji Lestari Wiji Lestari Wiji Lestari Wira Winardi Wira Winardi, Wira Yohannessa Wulandari Zaini, Jamal Zulfiyah, Itsna Arifatuz