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All Journal Jurnal Kedokteran Molecular and Cellular Biomedical Sciences (MCBS) JOURNAL OF HEALTH SCIENCE (JURNAL ILMU KESEHATAN) Amerta Nutrition Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Ilmiah Kesehatan Ar-Rum Salatiga World Nutrition Journal Respiratory Science Narra J Cermin Dunia Kedokteran Journal Of World Science Strada Jurnal Ilmiah Kesehatan (SJIK)
Fariz, Nurwidya
Departemen Pulmonologi Dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Indonesia-RSUP Persahabatan, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Relationship between age and vas appetite score among patients with post-tuberculosis lung disease at Persahabatan National Respiratory Referral Hospital, Jakarta Mahardika, Linda; Nurwidya, Fariz; Singal, Anna Maurina
World Nutrition Journal Vol. 9 No. S1 (2025): Vol. 9 No. S1 (2025): Selected conference proceedings of the Nutri Symposium 2
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V09.S1.0022

Abstract

Background: Post-tuberculosis lung disease (PTLD) is a form of progressive lung tissue damage following tuberculosis (TB) infection. In addition to clinical symptoms, patients with PTLD often experience nutritional problems. Appetite plays a crucial role in determining adequate nutrient intake, which can affect nutritional status, the recovery process, and overall quality of life. One factor that may influence appetite is age. Although age is known to affect appetite, the relationship between the two has not been studied, particularly in patients with PTLD at Persahabatan Hospital, National Respiratory Centre.
Zinc Intake and Appetite in Patients with Post-Tuberculosis Lung Disease at Persahabatan National Respiratory Referral Hospital, Jakarta Mahardhika, Linda; Nurwidya, Fariz; Singal, Anna Maurina; Sutanto, Krisadelfa; Imaniar, Rania; Syam, Shaogi
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.232-240

Abstract

Introduction: After completion of pulmonary tuberculosis (TB) treatment, some people may continue to experience respiratory issues that can progress into post-TB lung disease (PTLD). Individuals with PTLD exhibit suboptimal nutritional status. The loss of appetite is a significant factor influencing nutritional status. Zinc plays a role in hunger control.  Lack of zinc reduces taste sensitivity and food intake. This study examined the relationship between zinc intake and appetite in patients with PTLD at Persahabatan National Respiratory Referral Hospital, Jakarta. Methods: This cross-sectional study was conducted at Persahabatan National Respiratory Referral Hospital, Jakarta, from November 2024 to March 2025. Eighty-five adult patients with PTLD were included. Zinc intake was assessed by a semi-quantitative food frequency questionnaire (SQ-FFQ) and analyzed by NutriSurvey software. Appetite was measured using the visual analog scale (VAS) for appetite. Results: A total of 85 subjects participated in the study, comprising 78.8% males and 21.2% females. The average daily zinc intake was 4.4 mg/day, and 92.9% of the subjects had zinc intake below the recommended dietary allowance (RDA). The average VAS appetite score was 70 mm. A significant positive correlation was found between zinc intake and appetite, indicating that a decrease in zinc intake might result in a reduced appetite (r=0.266, p=0.014). Conclusion: Zinc intake is positively associated with appetite in patients with PTLD. Therefore, zinc intake monitoring is essential for supporting nutritional recovery and lung function in PTLD.
Pneumonia Eosinofilik: Patofisiologi, Diagnosis Dan Tata Laksana Terkini Bagaskoro, Miraz Radhea; Nurwidya, Fariz
Majalah Kedokteran Indonesia Vol 75 No 4 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.4-2025-1933

Abstract

Eosinophilic pneumonia is a rare and heterogeneous group of lung diseases, comprising two main subtypes: acute eosinophilic pneumonia (AEP) and chronic eosinophilic pneumonia (CEP). Both are marked by eosinophilic infiltration into lung tissue and alveolar spaces, sharing similar pathophysiology but differing in clinical presentation and etiology. AEP is often linked to recent smoking or relapse in former smokers, while CEP commonly occurs in individuals with a history of atopy, such as asthma or allergic rhinitis. Diagnosis involves imaging and confirmation through bronchoscopy with bronchoalveolar lavage. Corticosteroids are the primary treatment, though relapses may occur, requiring long-term therapy. Biologic agents, particularly monoclonal antibodies, are being explored as alternative therapies. This review aims to summarize current knowledge on the clinical features, pathophysiology, diagnosis, and management of eosinophilic pneumonia.
ANTI INTERLEUKIN-1 PADA COVID-19 Nurwidya, Fariz; Zulfiyah, Itsna Arifatuz
Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Vol 9, No 1 (2024)
Publisher : STIKES Ar-Rum Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36409/jika.v9i1.242

Abstract

Pada coronavirus infectious disease (COVID-19) terjadi invasi virus SARS-COV2 pada epitel alveolar. Sel epitel alveolar yang terinfeksi akan mengekpresikan antigen virus pada permukaan sel yang kemudian memicu respon rekognisi oleh makrofag. Sel makrofag ini kemudian mensekresikan interleukin-1 (IL-1) untuk aktivasi respon seluler. Metode, dilakukan penelusuran bukti ilmiah menggunakan kata kunci IL-1, Covid-1 dan inhibitor IL-1 pada database ilmiah PubMed dan Google Scholar. Hasil, pasien COVID-19 memiliki peningkatan kadar IL-1 pada darah dan berhubungan dengan severitas penyakit. Penggunaan zat biologik yang mentarget secara spesifik jalur yang mengalami hiperaktivasi pada pasien COVID-19 adalah salah satu strategi untuk mengatasi hiperinflamasi. Beberapa penelitian uji klinis telah dilakukan menggunakan IL-1 inhibitor pada pasien COVID-19 derajat berat dan mengancam jiwa. Kesimpulan, tinjauan pustaka ini menemukan bahwa IL-1 berperan pada kaskade inflamasi pasien COVID-19 dan inhibisi IL-1 sebagai salah satu cara untuk mengatasi proses inflamasi pada pasien COVID-19 derajat berat.
STEROID PADA COVID-19 Nurwidya, Fariz; Zulfiyah, Itsna Arifatuz
Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Vol 8, No 2 (2024)
Publisher : STIKES Ar-Rum Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36409/jika.v8i2.144

Abstract

Pada pasien Corona virus infection disease (COVID)-19 dengan gejala berat ditemukan kadar sitokin proinflamasi yang tinggi dibandingkan dengan pasien bergejala ringan hingga sedang. Agen imunomodulator utama yang telah diketahui memiliki berbagai manfaat sekaligus efek samping adalah kortikosteroid. Tujuan artikel tinjauan pustaka ini adalah untuk mengelaborasi penggunaan kortikosteroid pada pasien COVID-19. Metode penulisan ini adalah deskripsi naratif berdasarkan panduan Organisasi Kesehatan Dunia, Perhimpunan Dokter Paru Indonesia dan berbagai penelitian uji klinis pada pasien COVID-19. Hasil penelusuran bukti ilmiah menunjukkan bahwa kortikosteroid telah diindikasikan untuk berbagai macam penyakit, yang secara umum dapat dibagi menjadi penyakit infeksi dan inflamasi, penyakit alergi dan autoimun. Kortikosteroid bekerja dengan mekanisme yang kompleks, yang terdiri dari mekanisme genomik dan nongenomik. Pada COVID-19, kortikosteroid digunakan secara sistemik dan dapat diberikan melalui rute oral atau injeksi. Berdasarkan berbagai bukti ilmiah dari uji pra-klinis dan uji klinis yang meneliti aspek indikasi, mekanisme kerja, efek samping, interaksi obat, dan penggunaan pada kelompok khusus, disimpulkan bahwa steroid efektif dan aman digunakan pada pasien COVID-19 membutuhkan suplementasi oksigen pada perawatan di rumah sakit.
Sarcoidosis: Epidemiology, Etiology, Pathogenesis, and Diagnosis Setiawan, Fachri; Nurwidya, Fariz
Journal of World Science Vol. 3 No. 2 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i2.544

Abstract

Interstitial lung disease is a lung condition with wide variations. There are over 200 disorders classified under interstitial lung disease, including sarcoidosis. Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas involving the lungs, lymphatic system, skin, and eyes. Clinical manifestations of sarcoidosis vary greatly, ranging from asymptomatic to severe symptoms with uncertain prognosis. The cause of sarcoidosis remains unknown, though several hypotheses suggest its association with genetic, environmental, infectious, and autoimmune factors. The main pathogenesis involves the formation of non-caseating granulomas involving various types of innate and adaptive immune cells. Based on its clinical presentation, sarcoidosis is classified into two types: Lofgren syndrome and non-Lofgren syndrome. Diagnosis of this disease can be established through clinical examination, radiological imaging, and biopsy revealing non-caseating granulomas. Corticosteroid therapy remains the primary treatment option, alongside immunosuppressive and biological therapies for advanced-stage sarcoidosis.
Nutritional Status and Lung Cavity in Pulmonary Tuberculosis Patient Hanafi, Christi Giovani Anggasta; Nurwidya, Fariz; Lestari, Wiji; Agustin, Heidy; Syam, Shaogi
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.6-14

Abstract

Introduction: As one of the leading causes of death worldwide, pulmonary tuberculosis (PTB) is an infectious disease that continues to pose a serious threat to public health. The presence of cavities in radiological imaging of patients with PTB is associated with malnutrition, age, gender, and other comorbidities, including diabetes mellitus. This study aimed to find the association between nutritional status and lung cavity in PTB patients. Methods: This was an analytical observational study with a cross-sectional design that involved 134 adult patients who were diagnosed with PTB at Persahabatan National Respiratory Referral Hospital, Jakarta. All patients were interviewed using a questionnaire for sociodemographic and anthropometric data, the nutritional status was assessed using the subjective global assessment (SGA), and the lung cavity was determined using a chest X-ray interpreted by radiologists. The Chi-square test was performed using the Statistical Package for the Social Sciences (SPSS) version 25 for Windows. Results: Of 134 PTB patients, 61.9% were males, and 92.5% were from the 18-59 years old age group. Based on the SGA score, 77 (57.5%) were grouped as mild-moderate malnutrition/SGA B and 22 (16.4%) as severe malnutrition/SGA C. Lung cavity was found in 42 (31.3%) patients. The analysis showed that malnutrition was statistically significantly associated with lung cavity with OR=6.933 (95%CI 1.986-24.205; p=0.002) and the adjusted OR were 7.303 (95%CI 2.060-25.890; p=0.002) after controlling for age, sex, smoking, education, and comorbidities. Conclusion: This study found that malnutrition was associated with lung cavities in PTB patients. These findings might indicate how malnutrition impaired the immune function in PTB patients.
Clinical, Immunological, and Microbiological Aspects of Nontuberculous Mycobacterium (NTM) Nurfitri, Rina Diana; Isbaniah, Fathiyah; Nurwidya, Fariz; Imaniar, Rania; Hatim, Faiza; Dharmawan, Ibrahim Nur Insan Putra
Jurnal Respirologi Indonesia Vol 46 No 1 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v46i1.1084

Abstract

Nontuberculous mycobacteria (NTM) refer to all mycobacterial species except Mycobacterium tuberculosis (M. tuberculosis) complex and M. leprae complex. These bacteria are acid-fast. The bacteria are environmental bacteria that act opportunistically in humans. The infection can lead to disease, primarily affecting the lungs in susceptible hosts. Risk factors for NTM infection include defects in the body's defence mechanisms, changes in lung structure, and immune system abnormalities, which can be congenital or acquired. The bacteria possess pathogen-associated molecular patterns (PAMPs) and cell wall components that differ from those of M. tuberculosis, one of which is the glycopeptidolipid (GPL) component. Different species have distinct cell wall components, enabling them to modulate the immune system in various ways by interacting with multiple pathogen recognition receptors, including toll-like receptors and fibronectin. The cell-mediated immune response plays a role in the response to NTM infection. Alveolar macrophages, as the first line of defence, release interleukin (IL)-12, activating the T-helper-1 (Th1) axis and natural killer (NK) cells, followed by the release of tumour necrosis factor- α (TNF-α), interferon (IFN)-γ, and IL-17. The clinical symptoms of NTM lung disease (NTM-LD) are similar to those of M. tuberculosis. Two radiological findings are commonly observed: fibro-cavitary lesions and nodular bronchiectasis. Diagnosis must meet clinical, radiological, and microbiological criteria. The decision to start therapy should consider host factors, clinical conditions, and species type. The treatment approach involves multi-drug therapy and long-term administration, depending on species, disease extent, drug susceptibility testing results, and comorbidities.
Co-Authors Aditya Wirawan Adityo Wibowo Agustin, Heidy Ahmad Hudoyo Amien, Bagus Radityo Ammar Abdurrahman Hasyim Andarini, Sita Andayani, Diyah Eka Anna Rozaliyani Anwar Jusuf Bagaskoro, Miraz Radhea Baskoro, Hario Bies, Asri Liqditta Budi Rahayu Chandra, Dian Novita Christi Giovani Anggasta Hanafi Dewi Krisna Yunda Dharmawan, Ibrahim N.I.P. Dharmawan, Ibrahim Nur Insan Putra Elisna Syahruddin Fachri Setiawan Faisal Yunus Fattrias Handayani Jayaatmaja Fiastuti Witjaksono Hanafi, Christi Giovani Anggasta Harinda, Fadlika Hatim, Faiza Hendra Wahyuni Hidayat, Moulid Imaniar, Rania Inge Permadhi Isbaniah, Fathiyah Itsna Arifatuz Zulfiyah Judhiastuty Februhartanty Khoirun Nisa Alfitri Mahardhika, Linda Mahardika, Linda Malik, Andi Sri Suryani marques lafo, merita Moelamsyah, Yandi Noer Mohamad Yusup Mohammad N. Uddin Moulid Hidayat Muliawan, Hary Sakti Nabila Fawzia Neni Sawitri Notariza, Kemas Rakhmat Nurfitri, Rina Diana Nurul Ratna Mutu Manikam Putra, Andika Chandra Rabbani, Hadiati Santri Dwizamzami Faridahanum Santri Dwizamzami Faridahanum Sequeira, Ercia Maria da Conçeição Sequiera, Ercia Maria da Conceicao Singal, Anna Maurina Sutanto, Krisadelfa Syam, Shaogi Wiji Lestari Wiji Lestari Wiji Lestari Wira Winardi Wira Winardi, Wira Yohannessa Wulandari Zaini, Jamal Zulfiyah, Itsna Arifatuz