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Fariz, Nurwidya
Departemen Pulmonologi Dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Indonesia-RSUP Persahabatan, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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ANTI INTERLEUKIN-1 PADA COVID-19 Nurwidya, Fariz; Zulfiyah, Itsna Arifatuz
Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Vol 9, No 1 (2024)
Publisher : STIKES Ar-Rum Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36409/jika.v9i1.242

Abstract

Pada coronavirus infectious disease (COVID-19) terjadi invasi virus SARS-COV2 pada epitel alveolar. Sel epitel alveolar yang terinfeksi akan mengekpresikan antigen virus pada permukaan sel yang kemudian memicu respon rekognisi oleh makrofag. Sel makrofag ini kemudian mensekresikan interleukin-1 (IL-1) untuk aktivasi respon seluler. Metode, dilakukan penelusuran bukti ilmiah menggunakan kata kunci IL-1, Covid-1 dan inhibitor IL-1 pada database ilmiah PubMed dan Google Scholar. Hasil, pasien COVID-19 memiliki peningkatan kadar IL-1 pada darah dan berhubungan dengan severitas penyakit. Penggunaan zat biologik yang mentarget secara spesifik jalur yang mengalami hiperaktivasi pada pasien COVID-19 adalah salah satu strategi untuk mengatasi hiperinflamasi. Beberapa penelitian uji klinis telah dilakukan menggunakan IL-1 inhibitor pada pasien COVID-19 derajat berat dan mengancam jiwa. Kesimpulan, tinjauan pustaka ini menemukan bahwa IL-1 berperan pada kaskade inflamasi pasien COVID-19 dan inhibisi IL-1 sebagai salah satu cara untuk mengatasi proses inflamasi pada pasien COVID-19 derajat berat.
STEROID PADA COVID-19 Nurwidya, Fariz; Zulfiyah, Itsna Arifatuz
Jurnal Ilmiah Kesehatan Ar-Rum Salatiga Vol 8, No 2 (2024)
Publisher : STIKES Ar-Rum Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36409/jika.v8i2.144

Abstract

Pada pasien Corona virus infection disease (COVID)-19 dengan gejala berat ditemukan kadar sitokin proinflamasi yang tinggi dibandingkan dengan pasien bergejala ringan hingga sedang. Agen imunomodulator utama yang telah diketahui memiliki berbagai manfaat sekaligus efek samping adalah kortikosteroid. Tujuan artikel tinjauan pustaka ini adalah untuk mengelaborasi penggunaan kortikosteroid pada pasien COVID-19. Metode penulisan ini adalah deskripsi naratif berdasarkan panduan Organisasi Kesehatan Dunia, Perhimpunan Dokter Paru Indonesia dan berbagai penelitian uji klinis pada pasien COVID-19. Hasil penelusuran bukti ilmiah menunjukkan bahwa kortikosteroid telah diindikasikan untuk berbagai macam penyakit, yang secara umum dapat dibagi menjadi penyakit infeksi dan inflamasi, penyakit alergi dan autoimun. Kortikosteroid bekerja dengan mekanisme yang kompleks, yang terdiri dari mekanisme genomik dan nongenomik. Pada COVID-19, kortikosteroid digunakan secara sistemik dan dapat diberikan melalui rute oral atau injeksi. Berdasarkan berbagai bukti ilmiah dari uji pra-klinis dan uji klinis yang meneliti aspek indikasi, mekanisme kerja, efek samping, interaksi obat, dan penggunaan pada kelompok khusus, disimpulkan bahwa steroid efektif dan aman digunakan pada pasien COVID-19 membutuhkan suplementasi oksigen pada perawatan di rumah sakit.
Sarcoidosis: Epidemiology, Etiology, Pathogenesis, and Diagnosis Setiawan, Fachri; Nurwidya, Fariz
Journal of World Science Vol. 3 No. 2 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i2.544

Abstract

Interstitial lung disease is a lung condition with wide variations. There are over 200 disorders classified under interstitial lung disease, including sarcoidosis. Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas involving the lungs, lymphatic system, skin, and eyes. Clinical manifestations of sarcoidosis vary greatly, ranging from asymptomatic to severe symptoms with uncertain prognosis. The cause of sarcoidosis remains unknown, though several hypotheses suggest its association with genetic, environmental, infectious, and autoimmune factors. The main pathogenesis involves the formation of non-caseating granulomas involving various types of innate and adaptive immune cells. Based on its clinical presentation, sarcoidosis is classified into two types: Lofgren syndrome and non-Lofgren syndrome. Diagnosis of this disease can be established through clinical examination, radiological imaging, and biopsy revealing non-caseating granulomas. Corticosteroid therapy remains the primary treatment option, alongside immunosuppressive and biological therapies for advanced-stage sarcoidosis.
Nutritional Status and Lung Cavity in Pulmonary Tuberculosis Patient Hanafi, Christi Giovani Anggasta; Nurwidya, Fariz; Lestari, Wiji; Agustin, Heidy; Syam, Shaogi
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.6-14

Abstract

Introduction: As one of the leading causes of death worldwide, pulmonary tuberculosis (PTB) is an infectious disease that continues to pose a serious threat to public health. The presence of cavities in radiological imaging of patients with PTB is associated with malnutrition, age, gender, and other comorbidities, including diabetes mellitus. This study aimed to find the association between nutritional status and lung cavity in PTB patients. Methods: This was an analytical observational study with a cross-sectional design that involved 134 adult patients who were diagnosed with PTB at Persahabatan National Respiratory Referral Hospital, Jakarta. All patients were interviewed using a questionnaire for sociodemographic and anthropometric data, the nutritional status was assessed using the subjective global assessment (SGA), and the lung cavity was determined using a chest X-ray interpreted by radiologists. The Chi-square test was performed using the Statistical Package for the Social Sciences (SPSS) version 25 for Windows. Results: Of 134 PTB patients, 61.9% were males, and 92.5% were from the 18-59 years old age group. Based on the SGA score, 77 (57.5%) were grouped as mild-moderate malnutrition/SGA B and 22 (16.4%) as severe malnutrition/SGA C. Lung cavity was found in 42 (31.3%) patients. The analysis showed that malnutrition was statistically significantly associated with lung cavity with OR=6.933 (95%CI 1.986-24.205; p=0.002) and the adjusted OR were 7.303 (95%CI 2.060-25.890; p=0.002) after controlling for age, sex, smoking, education, and comorbidities. Conclusion: This study found that malnutrition was associated with lung cavities in PTB patients. These findings might indicate how malnutrition impaired the immune function in PTB patients.
Hubungan Antara Asupan Vitamin A dan Seng dengan Penanda Inflamasi pada Pasien Tuberkulosis Paru di Rumah Sakit Umum Pusat Persahabatan Mitrasari, Surya; Nurwidya, Fariz; Wulandari, Yohannessa; Agustin, Heidy
Medica Hospitalia : Journal of Clinical Medicine Vol. 13 No. 1 (2026): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v13i1.1222

Abstract

BACKGROUND: Indonesia has the second highest burden of tuberculosis (TB) worldwide, with an incidence of 354 per 100,000 population and approximately 969,000 cases reported in 2021. Micronutrients such as vitamin A and zinc play important roles in immune function and may influence inflammatory responses in TB. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are potential markers of systemic inflammation; however, evidence regarding their association with dietary micronutrient intake in pulmonary TB patients remains limited, particularly in Indonesia. AIMS: To examine the association between vitamin A and zinc intake and inflammatory markers in pulmonary TB patients. METHODS: A cross-sectional study was conducted among 133 pulmonary TB patients recruited consecutively from March to April 2024 at Persahabatan Hospital. Vitamin A and zinc intake were assessed using a semi-quantitative food frequency questionnaire (SQ-FFQ), while NLR and PLR values were obtained from medical records. Data normality was tested using the Kolmogorov–Smirnov test, and correlations were analyzed using Spearman’s test. The median vitamin A intake was 105.47 RE/day and zinc intake was 7.38 mg/day, with median NLR and PLR of 2.91 and 202.08, respectively. RESULTS: No significant correlations were found between vitamin A or zinc intake and NLR or PLR (p > 0.05). CONCLUSION: In conclusion, vitamin A and zinc intake were not associated with inflammatory markers in pulmonary TB patients, although host-related factors may contribute to the inflammatory response.
Co-Authors Aditya Wirawan Adityo Wibowo Agustin, Heidy Ahmad Hudoyo Amien, Bagus Radityo Ammar Abdurrahman Hasyim Andarini, Sita Andayani, Diyah Eka Anna Rozaliyani Anwar Jusuf Baskoro, Hario Bies, Asri Liqditta Budi Rahayu Chandra, Dian Novita Christi Giovani Anggasta Hanafi Dewi Krisna Yunda Dharmawan, Ibrahim N.I.P. Elisna Syahruddin Fachri Setiawan Faisal Yunus Fattrias Handayani Jayaatmaja Fiastuti Witjaksono Hanafi, Christi Giovani Anggasta Harinda, Fadlika Heidy Agustin Hendra Wahyuni Imaniar, Rania Inge Permadhi Itsna Arifatuz Zulfiyah Judhiastuty Februhartanty Khoirun Nisa Alfitri Mahardhika, Linda Mahardika, Linda Malik, Andi Sri Suryani marques lafo, merita Mitrasari, Surya Moelamsyah, Yandi Noer Mohamad Yusup Mohammad N. Uddin Moulid Hidayat Muliawan, Hary Sakti Nabila Fawzia Neni Sawitri Nurul Ratna Mutu Manikam Putra, Andika Chandra Rabbani, Hadiati Santri Dwizamzami Faridahanum Santri Dwizamzami Faridahanum Sequiera, Ercia Maria da Conceicao Singal, Anna Maurina Sutanto, Krisadelfa Syam, Shaogi Wiji Lestari Wiji Lestari Wiji Lestari Wira Winardi Wira Winardi, Wira Wulandari, Yohannessa Yohannessa Wulandari Zaini, Jamal Zulfiyah, Itsna Arifatuz