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All Journal BALI MEDICAL JOURNAL (BMJ) MNJ (Malang Neurology Journal) The Indonesian Biomedical Journal Nusantara Medical Science Journal Majalah Kedokteran Neurosains MDJ (Makassar Dental Journal) Jurnal Ilmiah Kesehatan (JIKA) Molucca Medica Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) The Journal of Society Medicine (JSOCMED) Neurona Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Andi Kurnia Bintang, Andi Kurnia
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Neurona

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VALIDITAS MICHIGAN NEUROPATHY SCREENING INSTRUMENT VERSI BAHASA INDONESIA DALAM MENDETEKSI POLINEUROPATI DISTAL SIMETRIS DIABETIKA Bintang, Andi Kurnia; Aulina, Susi; Goysal, Yudy; Amran, Muhammad Yunus; Hamid, Firdaus; Setiawan, Denise Dewanto
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 3 (2024): Volume 40, No 3 - Juni 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i3.436

Abstract

Introduction: Distal Symmetric Polyneuropathy (DSPN) is the most common neuropathy subtype found in Diabetes Mellitus (DM) patients. Early screening is important to prevent complications. Michigan Neuropathy Screening Instrument (MNSI) was created in 1994 as an alternative screening tool for diabetic neuropathy. This instrument has not been validated in Indonesia. Aim: Assess validity and reliability of Indonesian version of MNSI in detecting diabetic DSPN. Methods: This cross-sectional study was done in Wahidin Sudirohusodo hospital, Makassar in December 2021-June 2022. Indonesian version of MNSI and Nerve Conduction Studies (NCS) was applied to subjects. Statistics were performed with Statistical Package for the Social Sciences (SPSS) version 25. Study protocol was approved by Health Research Ethics Committee, Faculty of Medicine, Hasanuddin University. Results: 102 subjects were eligible and divided into DM with DSPN (n=60) and DM without DSPN (n=42). Significant differences were found in age, body mass index, duration of DM diagnosis, treatment, HbA1c, Indonesian version of MNSI part B, and all NCS parameters (p<0,05). Area Under Curve (AUC) of part B was bigger than A (0,942 vs 0,606). Cut-off >=2,5 of part B had sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) of 95,0%, 90,5%, 93,4%, and 92,7%, respectively. Discussion: Cut-off >=2,5 for Indonesian version of MNSI part B was considered optimal. EMNG was recommended for DM patients with part B score >=2,5. Conclusion: Indonesian version of MNSI is a valid and reliable instrument to detect DSPN in Indonesian population. Keywords: diabetic neuropathy, DSPN, Indonesia, MNSI
Kadar Homosistein Plasma Berhubungan dengan Derajat Keparahan Stroke Iskemik Akut Bintang, Andi Kurnia
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.237

Abstract

Introduction: Stroke is a major health problem globally, as well as Indonesia. It has high mortality and morbidity rate. Most patients have disability that impacts their quality of life. Recent studies reported the role of homocysteine in neurotoxicity, disruption of the blood-brain barrier, and oxidative stress. However, evidences regarding stroke severity and clinical outcome are still not consistent. Aim: Analyze correlation between serum homocysteine levels and severity index and clinical outcome the acute ischemic stroke. Methods: Subjects in this cross-sectional study were first-attack acute ischemic stroke patients with an onset less than 96 hours were recruited. Venous blood was collected within the first 24 hours of admission for serum homocysteine measurement. Severity index was assessed with National Institute of Health Stroke Scale (NIHSS) score. Clinical outcome was determined using the modified Rankin scale (mRS) score on the 14th day after stroke onset. Spearman’s coefficient was used to analyze correlation. Results: As many as 52 subjects were recruited, with female predominance (n=28, 53,8%). Serum homocysteine levels were higher in males (p=0,006) and had positive correlation with NIHSS score (r=0,029, p=0,036). No correlation was observed with mRS score (r=0,17, p=0,24). Subgroup analysis on homocysteine <15µmol/L showed correlation with stroke severity index (r=0,35, p=0,01). Discussion: This study supports previous ones regarding correlation between serum homocysteine levels and severity index in acute phase of ischemic stroke. No correlation was observed between serum homocysteine level and early clinical outcome. Correlation was found at serum homocysteine levels <15µmol/L. Keywords: acute ischemic stroke, homocysteine, NIHSS
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Muis Amran, Muhammad Yunus Andi Alfian Zainuddin Andi Alfian Zainuddin Andi Asadul Islam Assa, Christantina Pradescha Atiah, Ummu Bahar, Ashari Basri, Muhammad Iqbal Billi Billi, Billi Budi Riyanto Wreksoatmodjo, Budi Riyanto Cahyono Kaelan, Cahyono Carrey, Michael David Gunawan Umbas David Gunawan Umbas Dede Gunawan, Dede Dodik Tugasworo Fakhri M, Faisal Fitriah Handayani Fritz Sumantri Usman, Fritz Sumantri Goysal, Yudy H. Harsono, H. Halim, Wijoyo Hamid, Firdaus Hatta, Mohammad Herpan Syafii Harahap Ilsa Hunaifi, Ilsa IRFAN IDRIS Jimmy Barus, Jimmy Jumraini Tammasse Lotisna, Mimi Madeng, A. Arsidin Mappa Marina Musyawwirina Meryana*, A. Kurnia Bintang**, Muh. Akbar**, Susi Aulina**, Yudy Goysal**, Arifin Limoa*** Minarti, Deri Lidya Mohammad Hasan Machfoed Muhammad Akbar Muhammad Akbar Muhammad Iqbal Basri Paulus Sugianto, Paulus Riza Sulthan, Riza RR. Ella Evrita Hestiandari Rusdi Lamsudin, Rusdi Setiawan, Denise Dewanto Sompa, Andi Weri Soraya, Gita Vita Suseno, Endy Tammasse, Jumraini Tarigan, Ngalasantaru Janstar Wahid, Isra' Walenna, Nirwana Fitriani