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All Journal Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Penamas Adi Buana Jurnal Analis Farmasi Community Development Journal: Jurnal Pengabdian Masyarakat Medfarm: Jurnal Farmasi dan Kesehatan JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) Jurnal Kesehatan Tambusai J.Abdimas: Community Health Jurnal Pengabdian Teknologi Tepat Guna JAF (Jurnal Analis Farmasi) Farmasis: Jurnal Sains Farmasi Lentera: Multidisciplinary Studies Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Lentera: Multidisciplinary Studies
Nadya Ambarwati
Universitas PGRI Adi Buana Surabaya
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Formulasi dan Uji Karakterisasi Fisikokimia Gel Ekstrak Ranting Patah Tulang (Euphorbia tirucalli) Nadya Ambarwati; Fajar Jamaluddin Sandhori; Annah Hubaedah
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1525

Abstract

Euphorbia tirucalli L. twigs contain various secondary metabolites, including alkaloids, flavonoids, tannins, saponins, and steroids, which have potential antibacterial activity. This study aimed to evaluate the effect of different concentrations of Euphorbia tirucalli twig extract on the physicochemical characteristics of gel formulations. Three gel formulations containing 15% (F1), 20% (F2), and 25% (F3) extract were prepared and evaluated for organoleptic properties, pH, spreadability, adhesiveness, homogeneity, and irritation potential. Quantitative data were analyzed using One-Way ANOVA at a 95% confidence level (α = 0.05). The results showed that all formulations produced homogeneous, semi-solid gels with a soft texture and did not cause skin irritation. The pH values ranged from 5.14 ± 0.193 to 5.67 ± 0.011, which were within the physiological skin pH range. The spreadability values ranged from 5.08 ± 0.310 to 5.19 ± 0.209 cm, meeting the acceptable criteria for topical gel preparations. All formulations exhibited good adhesiveness, with adhesion times exceeding 4 seconds (4.45 ± 1.673 to 4.46 ± 1.075 seconds). Statistical analysis indicated that variations in extract concentration had no significant effect on pH, spreadability, adhesiveness, homogeneity, or irritation parameters, with all p-values greater than 0.05. However, increasing extract concentration resulted in a visually darker gel color. In conclusion, all gel formulations fulfilled the physicochemical requirements for topical preparations, and extract concentrations ranging from 15% to 25% did not significantly affect the physicochemical characteristics of the gel, indicating their potential for further development as a natural topical dosage form.
Co-Authors , Fatmawati Adella Eka Berliyanti Amalia, Sri Hidayati Amanda Safirtri Sinulingga Amanda Safithri Sinulingga Amanda Safitri Sinulingga Annuryanti, Febri Aristina Halawa Asri Wido Mukti Asti Rahayu Asti Rahayu Asti Rahayu Asti Rahayu Astrid Kusuma Putri Corry' Nanda Nabilla Rahmah Danang Prasetya Eka Saputra Desta Ayu Cahya Rosyida Dewi Isadiartuti Dewi Perwito Sari Eka Fitria Ethica Sari Fajar Jamaluddin Sandhori Fatmawati Fatmawati Fikria Marfuatin Nur Fikria Marfuatin Nur Fithri Farchah Frischah Sari Framono, Indra Dwi hamdaniyah, imraatil Hardani, Prisma Trida Hasanah, Ni'matul Hidayah, Fufut Nurul Hubaedah, Annah IAK Pramushinta Indriani , Novamei Intan Ayu Kusuma Pramushinta Ira Purbosari Jamlean, Gloria Silvia Jannah, Ulvatul Kamilia, Abidatul M. Nushron Ali Mukhtar M. Nusron ali Mukhtar Mauliddina, Siska Dwi Maulidiyah, Zahro Al Maulivia Idham Choliq Mufidah, Rofikatul Muhamad Handoyo Sahumena Mukti, Asri Wido Mukti, Ria Andriani Mukti, Ria Andriani Nabillah Zahro, Syarifah Ni Putu Widari Nidom, Reviany Vibrianita Nina Hidayatunnikmah Noor Erma Nasution Nur Rachmawati Pramushinta, IAK Prasetyawan, Hanif Rifqi Prasmita Dian Wijayanti Prasmita Dian Wijayati Purbosari, Ira Rahayu , Asti Rahayu, Asti Rismawati Rizal Adi Saputra Riziq, Khodijah Rizky Anugrah Dirgantara Putra Sambada, Rahmaniyah Wulandari Sandhori, Fajar Jamaluddin Sari, Anita Dwi Prastika Setiana Andarwulan Silvia Triana Pradini Sinulingga, Amanda Safithri Tatang Sopandi Vibrianita Nidom, reviany Wido Mukti, Asri Wisnu Prasetyo Yolanda Camelia Imelda Yurika Sastyarina Zahro Al Maulidiyah