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All Journal Jurnal Konseling dan Pendidikan MNJ (Malang Neurology Journal) Biomedical Journal of Indonesia Universa Medicina Paediatrica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Oto Rhino Laryngologica Indonesiana Majalah Patologi Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat CRJIM (Clinical and Research Journal in Internal Medicine) Innovative: Journal Of Social Science Research Media Dermato-Venereologica Indonesiana Jurnal Penyakit Dalam Indonesia Journal of General Procedural Dermatology and Venereology Indonesia
Erial Bahar, Erial
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Higher uric acid serum levels are associated with sarcopenia among elderly in a community health center Farista, A. Deza; Rivianti, Nur; Bahar, Erial; Permata, Mega; Reagan, Muhammad; Indah, Crisnah; Artini, Ika
Universa Medicina Vol. 44 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.335-344

Abstract

BackgroundAs people age, skeletal muscle mass and strength decrease, leading to sarcopenia, diagnosed through calf circumference, muscle mass, strength, and physical performance. Uric acid (UA), with both pro-oxidant and antioxidant properties, is an indicator of oxidative stress and may contribute to sarcopenia. This study aimed to determine the correlation between serum uric acid levels and sarcopenia in elderly in a community health center. MethodsA cross-sectional study was conducted involving 42 subjects aged ≥60 years, consisting of 37 female and 5 male participants. We applied Asian Working Group for Sarcopenia (AWGS) 2019 criteria to define sarcopenia. Muscle mass was measured using skeletal muscle index (SMI) based on bioimpedance analysis (BIA). Handgrip strength (HGS), physical performance, calf circumference, and blood test data were collected. A backward regression analysis was performed to investigate the relationship between UA and SMI, HGS, physical performance, and calf circumference after adjusting for gender, smoking history, upper arm circumference, and body mass index.Results After adjusting for potential confounding variables, uric acid remained significantly associated with muscle strength (β=0.326; p=0.023) and calf circumference (β=0.264; p=0.010), but not with muscle mass (β=0.046; p=0.727) or physical performance (β=–0.171; p=0.279).ConclusionThere is a significant correlation between uric acid levels and muscle strength, physical performance, and calf circumference in sarcopenia among the elderly in the community health center. Higher uric acid serum levels might slow down the progression of sarcopenia.
Correlation between Poly ADP Ribose Polymerase (PARP) expression with Chemotherapy Response in Ovarian Carcinoma Yuniarti, Ria; Wresnindyatsih, Wresnindyatsih; Rusminan, Suly Auline; Bahar, Erial
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.661

Abstract

Background Germline mutations in BRCA1 and BRCA2 are high risk factors for ovarian and breast cancer. The risk of ovarian cancer in BRCA1 mutation carriers is 16-68% and 11-30% in BRCA2 mutation carriers.1,2 The enzyme poly ADP ribose polymerase (PARP) plays an important role in DNA damage repair and genome stability and cancer cells change its regulation as a way for tumor cells to survive cell death due to chemotherapeutic agents.3,4 Positive PARP expression is associated with high-grade tumors. advanced stage and is an indicator of aggressive disease. The aim of this study was to examine the relationship between PARP expression and the response to chemotherapy in ovarian carcinoma. Methods A cross sectional study was conducted using 34 samples of paraffin blocks and slides of ovarian carcinoma from oophorectomy and biopsy of patients registered at the Anatomical Pathology Department Faculty of Medicine Sriwijaya University/Dr. Mohammad Hoesin Hospital Palembang for the period January 2019 to December 2021. Each sample was stained by PARP monoclonal antibody. Qualitative interpretation by assessing semi-quantitatively, namely assessing the area/proportion (P) and intensity (I) of the polished, the score is obtained by multiplying the area by the intensity, the results are grouped into 2, score 0-4 was a weak expression, score 6 was a strong expression. Analysis of the relationship between PARP expression and response to chemotherapy was performed using Chi-square test and Spearmann correlation. Results Chi-square test showed that there was a significant relation PARP expression with chemotherapy response, age, CA 125 levels post chemotherapy and stage with p values were 0.008, 0.005, 0.020 dan 0.006 respectively. There was no relation between PARP expression with histopathology subtype with p values was 0.053. Conclusion There is a significant correlation between PARP expression with chemotherapy response, age, CA 125 levels post chemotherapy and stage in ovarian carcinoma
Co-Authors Abla Ghanie, Abla Achirul Bakri, Achirul Akbar, M Yusuf Arief Anastasia, Monika Anggraini, Ratna Maila Dewi Artini, Ika Aspitriani Asprianto, Muhammad Ayu, Dewi Rosalia Bakrie, Muhammad Bastoni, Ismail Chandra, Riza Citra Dewi Dedianto Dedianto, Dedianto Desmeradd, Soraya Sagita Devi, SNA Ratnasari Dewi, Veni Rosita Dian Puspita Sari Diba, Sarah Dita, Nurul Salmah Alia Eddy Roflin Fahrenheit, Fahrenheit Farista, A. Deza Fitri Octaviana Fitriani Fitriani Garfendo, Grady Handayani, Sri Harun, Yusril Hudari, Harun Husan, Nopriyati Ika Kartika Indah, Crisnah Indrajaya, Taufik Jalili, Melania Kartowigno, Soenarto Kesuma, Imaniar Krisna Murti Lubis, Friska Meutia marisdina, selly Mintardi, Dita Muhammad Hasnawi Haddani Muhammad Reagan Mulya, Adi Myrna Alia, Myrna Nelda Aprilia Salim Nova Lestari Novery, Edy Octyvani, Tiar Marina Permata, Mega Purwoko, Izazi Hari Puspa Zuleika, Puspa Puspitanza, Ika Dian Putra Pratama, Eka Qodir, Nur Radiyati Umi Partan, Radiyati Umi Riani Erna, Riani Rismarini Rismarini, Rismarini Rivianti, Nur Roezin, Shahnaz Fathia Rusminan, Suly Auline Santoso, Ritchie Shahab, Alwi Sri Handayani Suhaimi, Novadian Susanti Budiamal Syahrir, Mediarty Thaha, Mohammad Athuf Toruan, Theresia Lumban Triwibowo, Anang Veny, Veny Wresnindyatsih Wresnindyatsih, Wresnindyatsih Yanti, Lisa Apri Yudianita Kesuma, Yudianita Yuli Kurniawati, Yuli Yulia Farida Yahya Yulianto kusnadi Yuniarti, Ria Yuniza Zen Hafy Zulkhair Ali