Article Per Year (5 Year)
p-Index From 2021 - 2026
3.018
P-Index
This Author published in this journals
All Journal Medical Journal of Indonesia Sari Pediatri Paediatrica Indonesiana JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Amerta Nutrition Oto Rhino Laryngologica Indonesiana World Nutrition Journal Cermin Dunia Kedokteran
Bernie Endyarni Medise
Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Indonesia Rumah Sakit Dr. Cipto Mangunkusumo, Jakarta
Education Health Professions Medicine & Pharmacology Nursing Public Health Other

Published : 34 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 34 Documents
Search

 1   2   3   4 
Prediksi Kompleksitas Mutasi Virus Influenza dalam Pengembangan Vaksin yang Efektif untuk Anak: Analisis Priscilla, Birgitta; Benedictus; Medise, Bernie Endyarni
Cermin Dunia Kedokteran Vol 52 No 6 (2025): Kesehatan Jiwa
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i6.1659

Abstract

Influenza virus infection is common in populations of all ages. Vaccination is the most effective measure to prevent infection. However, influenza viruses are prone to antigenic drift, causing the virus to mutate within a few months. Predicting influenza virus evolution plays a crucial role in ensuring the protective effect of vaccines, allowing for the selection of the appropriate vaccine type. Stacking models, convolutional neural network (CNN) models, Gaussian processes vector autoregressive models, and susceptible-exposed-infectious-removed (SEIR) models can predict influenza virus antigenic variants. Various modern models and approaches, such as influenza antigenic variants (IAV)-CNN models, sequence-based antigenic distance approach (SBA), and ensemble of nonlinear regression models, have been used to improve the efficacy and relevance of vaccination strategies.
The Role of Iron for Supporting Children’s Growth and Development Medise, Bernie Endyarni
World Nutrition Journal Vol. 5 No. S1 (2021): Special Issue : The role and importance of iron
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.S1.0003

Abstract

According to the World Health Organization (WHO), Iron Deficiency (ID) affects around 2 billion people worldwide. Early childhood ID has been associated with permanent cognitive deficits associated with CNS structural, metabolic impairment, growth retardation, impaired immune response, psychological abnormalities, and behavioral delays. This literature review will focus on the important role of iron in child growth and development. Iron is necessary for various cellular processes in the growing brain especially when it comes to memory and learning. Children with early ID show cognitive deficits that persist; however, prompt iron treatment soothes the problem. A chronic ID group reported substantially lower scores of vocabularies, ambient sound perception, and motor measurements in a recent study relative to infants with normal nutritional iron status at 6 months and 14-18 months. Children's iron requirement differentiates based on individual age. The daily iron requirement for one- to three-year-old children is 7 mg. Some risk factors of infants and toddlers in developing ID are insufficient food intake, poor bioavailability, reduced absorption, increase demand, increase losses, cow’s milk enteropathy hookworm infection, and maternal gestation. Iron plays an important role in promoting children's growth and development. Physical health and nutrition are important in the first two years of life. Children who are unable to achieve iron adequacy will possibly show permanent cognitive deficit and impaired motor growth. Thus, iron supplementation may only be successful in early prescription after diagnosing iron deficiency.
Social-emotional development in early life: what happens and how to optimize it Medise, Bernie Endyarni; Wiguna, Tjhin; Dharma Asih, Ni Ketut Susila
World Nutrition Journal Vol. 5 No. S2 (2022): Special Issue : critical aspects of early life nutrition, gut health, and deve
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V05.S2.0002

Abstract

The Physical, metabolic, emotional, cognitive, and social development all begin to develop during early years of childhood.. Social and emotional competencies are increasingly recognized as critical for children's success, in school and in later phases of life into adulthood. According to new research, changes in the gastrointestinal tract's development during the early postnatal period can affect brain development and vice versa., collectively called the gut-brain axis. The gut microbiota has an impact on a variety of mental processes and phenomena, as well as being involved in the pathophysiology of a variety of mental and neurological diseases.. Insights in this area can be targeted through dietary treatments to improve cognitive outcomes in newborns by optimizing the link between the gastrointestinal system and the brain. Further, having a healthy and happy human life could be ensured by acquiring adequate and balance microbiota
Therapeutic reassessment of first-line antiepileptic drugs in pediatric patients unresponsive to second-line agents: a randomized trial in Jakarta Perdani, Roro Rukmi Windi; Arozal, Wawaimuli; Mangunatmadja, Irawan; Kaswandani, Nastiti; Handryastuti, Setyo; Medise, Bernie Endyarni; Wardani, Amanda Saphira; Thandavarayan, Rajarajan Amirthalingam; Oswari, Hanifah; Lee, Hee Jae
Paediatrica Indonesiana Vol. 65 No. 6 (2025): November 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Epilepsy has a significant incidence in children, with 20-25% resistance to standard antiepileptic drugs (AEDs). Drug-resistant epilepsy (DRE) refers as the failure of two or more AEDs, either as monotherapies or in combination, to achieve seizure freedom, which includes the absence of all seizure types, even auras. Treatment algorithms for children with epilepsy range from starting with the lowest effective dose to using add-on or substitution therapy of AEDs. It usually started from using first-line AEDs (valproic acid, phenytoin, phenobarbital, carbamazepine) with titrated dose based on the patient condition, if seizure persist, another first-line AEDs may be added or substituted. Second-line AEDs (topiramate, levetiracetam, oxcarbazepine) are introduced when seizure persist despite optimal doses of first-line drugs with good compliance. Epilepsy treatment response is a dynamic process, not a fixed state. In some cases, repeating the medication cycle remains an option, as patient may initially appear drug-resistant but later respond to treatment. Thus, first-line AEDs may also serve as substitution therapy in children unresponsive to second-line agents as studies show comparable effectiveness between the two regimens. Objective To evaluate the efficacy and safety of first-line AEDs as substitution therapy (intentional replacement of patient’s current medication) in children resistant to second-line AEDs. Methods This 12-week, open-label, multicenter, randomized controlled trial was conducted in 91 epileptic children. Children aged 1 – 18 years with DRE, were randomized into the intervention (patients who received substitution therapy:  one AEDs was changed to first-line of AEDs) and control (patients who got standard therapy: one AEDs was changed to second-line of AEDs) groups. The primary outcome was the difference in the proportion of responders between the two groups. Secondary outcomes were analyzing the different improvements in quality of life (QoL), EEG feature, and time to achieve seizure reduction in both groups. The QoL was assessed by Quality of Life in Childhood Epilepsy Questionnaire 55 (QOLCE-55) to assess cognitive, emotional, social, and physical functions. Results There were no significant differences in the proportion of responders between the substitution therapy group (62.5%) and the standard therapy group (68.4%). Both groups experienced substantial reductions in seizure frequency, ranging from 78% to 80%. For further analysis, the average difference of seizure frequency before and after intervention was statistically significant in each group, it was P=0.000 in substitution group and P=0.00 in standard group. The analysis of quality of life showed the mean of total score in both groups was low even though the score was higher in the substitution group. For spesific function of quality of life, the cognitive and social function, was improved significantly in the group p<0.05). However, there were no significant differences of EEG improvement, seizure duration, time to achieve seizure frequency reduction, or adverse effects between the two groups. Conclusions First-line AEDs have comparable efficacy as second-line AEDs with mild to moderate adverse effects in DRE children. Thus, the repeated use of first-line AEDs as substitution therapy might be an option for children who resistant to second line AEDS.
Co-Authors Ali Alhadar Aman Bhakti Pulungan, Aman Bhakti Antonius H Pudjiadi, Antonius H Arief, Wresty Badriul Hegar Syarif Benedictus Bermanshah, Evita Karianni Budi Wiweko Corrie Wawolumaja Dania Mirza Ramadhanty Dave Anderson Dewi Anggraeni Dewi Friska Dharma Asih, Ni Ketut Susila Diana Sunardi Elina Waiman Erfi Prafiantini Erni Hernawati Purwaningsih, Erni Hernawati Ervira Wahyuni Erwin Hendrata Ganda Ilmana Gitayanti Gitayanti H.F. Wulandari Hanifah Oswari Hartono Gunardi Hartono Gunardi Hartono Gunardi Hartono Gunardi Hartono Gunardi Hikari Ambara Sjakti, Hikari Ambara I Boediman Ikhsan Johnson Ikhsan Johnson Intan Tumbelaka Irawan Mangunatmadja Irene Yuniar, Irene Ismi Citra Ismail, Ismi Citra Jessica Ferdi Jessica Ferdi Joedo Prihartono Jose RL Batubara Kartika Erida Brohet Kholisah Nasution Krishna Adi Wibisana Lee, Hee Jae Lenora Mohd. Ishak Lina Ninditya Liza Pratiwi M. Azharry Rully Sjahrullah M. Ramdhani Yassien Marie Christabelle Muhammad Faizi, Muhammad Muhammad Prasetio Wardoyo Muzal Kadim Naela Fadhila Nastiti Kaswandani Novie Amelia Chozie Nuri Purwito Adi Olfriani, Ciho Priscilla, Birgitta Priyono, Harim Pustika Amalia Wahidiyat Putri Maharani Tristanita Marsubrin Ray Wagiu Basrowi Ray Wagiu Basrowi Renno Hidayat Retnaningdyah, Windri Reza, Maulana Okta Rini Mulia Sari Rini Sekartini Rini Sekartini Rini Sekartini Rini Sekartini Rini Sekartini Rizki Yusrini Pohan Roro Rukmi Windi Perdani, Roro Rukmi Rosalina Dewi Roeslani Saptawati Bardosono Saptawati Bardosono Setyo Handryastuti Silva Audya Perdana Soebadi, Amanda Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soedjatmiko Soesanti, Frida Sreshta Mukhi Sreshta Mukhi Sukamto Koesnoe Suzy Maria Thandavarayan, Rajarajan Amirthalingam Tirza Z. Tamin Titi Sularyo Titis Prawitasari, Titis Tjhin Wiguna Tjhin Wiguna Trevino Pakasi Tri Lestari H Wahyuni Indawati, Wahyuni Wahyuni, Luh Kurnia Wangke, Lydia Wardani, Amanda Saphira Wawaimuli Arozal Wirahmadi, Angga Yoga Devaera Yoga Devaera, Yoga Yogi Prawira Yulianti Wibowo Yulianti Wibowo Zakiudin Munasir Zakiudin Munasir Zizlavsky, Semiramis