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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Farmasetika Health Information : Jurnal Penelitian Jurnal Ilmiah Farmako Bahari Jurnal Locus Penelitian dan Pengabdian Multidisciplinary Indonesian Center Journal

Iyan Sopyan

Fakultas Farmasi Universitas Padjadjaran

Author-ID : 604694

Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Other

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Ko-Kristal: Teknik Pembuatan Ko-Kristal Dewi Permatasari; iyan Sopyan; Muchtaridi Muchtaridi
Farmaka Vol 14, No 4 (2016): Farmaka
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Banyak obat yang telah beredar dipasaran memiliki masalah-masalah biofarmasi seperti rendahnya kelarutan, laju disolusi, permeabilitas yang berakibat pada bioavailabilitas dan kefektifan obat tersebut dalam mengobati penyakit. Untuk mengatasi hal tersebut, teknologi formulasi sediaan farmasi semakin berkembang sehingga dapat menghasilkan obat yang lebih berkualitas. Dalam satu dekade ini, sudah banyak publikasi yang menjelaskan tentang strategi dan teknik untuk mengembangkan desain obat-obat tersebut, salah satunya adalah kokristal. Kokristal dalam farmasi merupakan metode modifikasi suatu zat aktif, seperti penambahan gugus hidrogen, antara zat aktif dan koformer. Modifikasi yang dilakukan dengan harapan dapat memperbaiki masalah yang dimiliki suatu zat aktif obat tersebut tanpa mengubah efek farmakologisnya. Teknik-teknik pembuatan kokristal yang paling sering digunakan secara umum adalah grinding dan solvent based method (solvent evaporation dan slurry). Akan tetapi, saat ini sudah diterapkan pula metode sintesis kokristal dengan penambahan antisolvent, hot melt extrusion, bahkan teknologi cairan superkritis. Pertimbangan pemilihan metode ini dilihat dari sifat zat aktif dan koformer yang digunakan, serta mempertimbangkan teknologi yang dimiliki.Keywords: ko-kristal, teknik ko-kristal, karakterisasi, kokristal farmaseutikal

DISPERSI PADAT SEBAGAI METODE PENINGKATAN KELARUTAN BAHAN OBAT DALAM TABLET: FORMULASI DAN KARAKTERISASI Aslamnur Fikri Ramadhana; Anis Yohana Chaerunisa; Iyan Sopyan
Farmaka Vol 19, No 2 (2021): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v19i2.34014

Kelarutan adalah salah satu faktor fisikokimia penting yang mempengaruhi pelepasan bahan aktif obat dalam formulasi tablet. Peningkatan kelarutan menjadi salah satu parameter yang terus dikembangkan dalam meningkatkan ketersediaan obat. Diperkirakan 40% zat obat baru yang ditemukan memiliki kelarutan dalam air yang buruk. Berbagai metode digunakan untuk meningkatkan kelarutan, namun metode tersebut masih memiliki keterbatasan. Dispersi padat adalah sebuah metode yang cukup menjanjikan untuk meningkatkan kelarutan bahan obat. Dispersi padat memiliki berbagai kelebihan dibandingkan dengan metode tradisional. Dispersi padat terbukti dapat meningkatkan kelarutan obat yang sulit larut. Review artikel ini akan menjelaskan keuntungan dan kerugian dispersi padat, metode pembuatan dispersi padat, formulasi tablet dispersi padat, dan karakterisasi tablet dispersi padat.Kata kunci: dispersi padat, kelarutan, ketersediaan hayati, teknologi dispersi padat, polimer.

Chondroitin in Transdermal Patch and Its Main Physical Properties Iyan Sopyan; Moeljadi G Tedjasaputra; Saskia Rizky Utami; Marline Abdassah
Indonesian Journal of Pharmaceutical Science and Technology Supp 1, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Chondroitin sulphate (CS) in oral dosage form has widely used to help manage osteoarthritis, but regret its bioavailability was very low at only 13%, It was due to the first passed effect in the liver and to avoid it CS is needed to be formulated into another forms of preparation like patch. This study was aimed to gure out in-vitro possibility of chondroitin sulphate (CS) to be formulated in a transdermal patch and characterized by its physical properties such as permeation profile through the Franz’s cell and partition coefficient studies. The study showed that 150 mg CS in transdermal patch given the constant permeation within 19 hours with the partition coefficient of 2.22. Based on the permeation profile and the partition coefficient study, the CS patch would become an effective preparation to be considered.Keyword : Chondroitin Sulphate (CS), Transdermal patch, Permeation profile, Partition coefficient

Preparation of organic-solvent free liposome of Piper albi Linn extract in solution and powder form Eri Amalia; Iyan Sopyan; Norisca Aliza Putriana; Sriwidodo Sriwidodo; Anas Subarnas
Indonesian Journal of Pharmaceutics Vol 3, Issue 3, Sept - Dec 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i3.38335

Piperine is bioactive alkaloid extracted from white pepper (Piper albi Linn) with several beneficial pharmacological activities. It is also known to enhance the bioavailability of several limited solubilities of other compounds such as curcumin and resveratrol. Nevertheless, due to its poorly water-soluble character, piperine and extract of white pepper are less applied among other plant extracts. Therefore, our research focussed on the engineering of white pepper extract standardized to piperine in liposome solution and liposome powder for further preparation of various pharmaceutical dosage forms.Our research in preparation of extracted white pepper in liposome delivery system successfully prepared spheric liposome solution with 98.92%±1.17% and an average size of 398.7 nm. The liposome was also successfully prepared in dry powder form with sucrose as a carrier for liposome protection. The rehydration is successfully forming a spheric shape with a similar profile to the initial liposome solution. This research paves the way for scalable white pepper extract liposome preparation without the utilization of toxic organic solvent, to produce the commercial solvent-free product in the future.Keywords: Piperine, Piper albi Linn, liposome, extract, organic solvent-free, drug delivery system, spray dry

Formulation and Evaluation of Ketoprofen Gel Preparations, Sesami Oil Soybean Oil and Oleic Acid as Enhancers Rugun Clara Samosir; Iyan Sopyan; Dolih Gozali
Indonesian Journal of Pharmaceutics Vol 1, Issue 1, Jan - April 2019
Publisher : Universitas Padjadjaran (Unpad)

Permeation is a measurable profile in drug penetration in skin. Adding increasing permeation substance (enhancer) in drug formulation is an important thing in pharmaceutical and toxicology in nowadays. The purpose of this research was to evaluate the effect of sesame oil, soybean oil, and oleic acid as enhancer in ketoprofen gel permeation. Six formula were prepared by varying concentration of sesame oil, soybean oil, and oleic acid respectively 5% and 10% and one blank, without enhancer. Permeation test was evaluated by in vitro permeation test using Franz diffusion cell method and shed snake skin of reticulated python as a membrane. Permeation test were carried out for 6 hours. The result showed that sesame oil, soybean oil, and oleic acid were able to increase ketoprofen permeation. B1 formula that contain 5% sesame oil had greatest percent permeation after 6 hours is 5.913%, while blank that contain no enhancer is 0.623%.Keywords: ketoprofen, permeation, enhancer, soybean oil, sesame oil, oleic acid.

A Novel of Floating Delivery System is a Tool to Enhance Absorption of Drug: A Review Iyan Sopyan
Indonesian Journal of Pharmaceutics Vol 2, Issue 1, Jan - April 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i1.26103

This assessment of a floating drug for a novel of new drug delivery system (NDDS) is written to elucidate FDDS based on existing literature. The most recent progresses of FDDS include the formulation and physiological variables that could affect gastric retention and formulations are discussed in detail. This review also summarizes method assessments for FDDS pharmaceutical dosage form and its classification. FDDS. FDDS is made to increase the absorption of the drug that is expected to dissolve in the stomach so that the drug enters the intestine in a dissolved state and the fraction of the absorbed drug increases. FDDS approach is the best way to deal with drugs with low solubility in the digestive tract.Keywords : Floating Tablet, Evaluation, Gastric Retentive

Mini Review : Sedem System as a Tool to Characterize Excipients in Solid Dosage Form Iyan Sopyan; Rizka Guntina Khairunisa
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.34038

SeDem System is a new system that can be applied in solid dosage form preformulation studies of medicines. It have parameters to evaluates critical quality attributes of materials that have an impact on final drug product’s quality. SeDeM studies could be used as a method for identifying the best excipient and calculating the maximum amount of excipient required for formulation. SeDeM method can , providing formulation with the lowest amount of excipients as it combines the Active Pharmaceutical Ingredients (API) with only one excipient and the standard formula of lubricants, thus avoiding the used of unnecessary excipients, such as diluents, binders and agglutinants. The information given by the SeDeM system contributes to a quality by drug design development.Keywords: SeDeM System, Excipients

Formulation and Stability Testing of Griseovulfin Microemulsion iyan sopyan; Dolih Gozali; Eka Paramudya
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.27574

The use of drugs that are less soluble in water will become clinically less efficient, this is caused by the low penetration of the drug into the body. A microemulsion is a dispersion system such as an emulsion that can increase the solubility of drugs that are sometimes difficult to dissolve in water. Microemulsions have long-term stability, clear, transparent, and good penetration capabilities. In this study, a microemulsion formulation with active ingredients griseofulvin and virgin coconut oil was conducted as an oil phase. The resulting microemulsion evaluates physical stability during 35 storage days. The results showed that the microemulsion preparation remained stable during storage time without changes in color, odor, and consistency, while the pH and dosage viscosity experienced less significant changes. The consequences of the centrifugation test at 3700 rpm for 5 hours and freezing tests for 24 days showed stable preparation and cannot be separated. The diffusion test results obtained by FG2 had the largest permeation percentages of 3.6136%, FG3 2.8724%, and the smallest FG1 2.0477%.Keywords: microemulsion, griseofulvin, stability, diffusion test

Pemilihan Jenis Koformer dan Metode Preparasi dalam Sistem Penghantaran Sediaan Ko-Amorf Febrina Aulia Dewi; Iyan Sopyan; Taofik Rusdiana
Jurnal Sains Farmasi & Klinis Vol 8, No 3 (2021): J Sains Farm Klin 8(3), Desember 2021
Publisher : Fakultas Farmasi Universitas Andalas

Ko-amorf adalah suatu sistem multikomponen padat yang mengandung zat aktif dan molekul dengan berat molekul rendah lainnya (koformer) yang dapat berupa eksipien atau zat aktif yang relevan secara farmakologis. Formulasi ko-amorf yang dibuat dengan metode preparasi dan jenis koformer yang berbeda dapat menghasilkan perbedaan yang signifikan dalam stabilitas fisik dan profil disolusi suatu bentuk ko-amorf. Tujuan penulisan dari artikel review ini adalah untuk menggali informasi lebih dalam tentang sistem ko-amorf, klasifikasi ko-amorf, karakterisasi ko-amorf serta pengaruh jenis koformer dan metode preparasi ko-amorf terhadap pembentukan ko-amorf. Artikel review ini disusun dengan literature search melalui PubMed, MDPI dan Science Direct dengan memasukkan kata kunci co-amorphous, co-amorphous formulations, co-amorphous stabilizers, co-amorphous drug formulations. Dari review ini ditemukan terdapat beberapa jenis koformer yang dapat digunakan untuk pembentukan ko-amorf yaitu dapat berupa zat aktif yang relevan secara farmakologis dan eksipien seperti diantaranya yaitu asam amino, asam karboksilat, asam tanat, quercetin, sakarin dan nikotinamid. Dan untuk metode preparasi ko-amorf yang dapat digunakan diantaranya yaitu ball milling, cryomilling, melt quenching/ quench cooling, hot melt extrusion, solvent evaporation, spray drying, freeze drying hingga teknologi seperti supercritical antisolvent dan microwave technique. Keberhasilan pembentukan ko-amorf ditentukan diantaranya oleh pemilihan jenis koformer yang melibatkan berbagai sifat yang perlu dipertimbangkan, seperti Tg, potensial ikatan hidrogen, ketercampuran/ miscibility, atau perilaku kristalisasi. Sifat zat aktif dan eksipien seperti stabilitas termal, suhu leleh dan kecenderungan kristalisasi zat aktif dan eksipien, menjadi faktor yang perlu diperhatikan dalam pemilihan metode preparasi ko-amorf.

Solubility Enhancement and Characterization of Tamoxifen Citrate Using Co-crystallization Dolih Gozali; Iyan Sopyan; Hairunnisa Hairunnisa; Siska Sari Marvita
Indonesian Journal of Chemistry Vol 22, No 2 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.70891

Tamoxifen citrate (TC) is one of the anti-estrogen agents which has low solubility in the water. As TC is still used as the main therapy in breast cancer treatment, modifications are still being made to increase the solubility of TC for a successful treatment. In this research, co-crystallization of TC was performed using Nicotinamide (NIC), Isonicotinamide (ISO), Saccharin (SAC), Aspartame (ASP), and Benzoic Acid (BNZ) as a coformer with the molar ratio of 1:1, 1:2, and 2:1. Co-crystal was prepared by solvent drop grinding (SDG) and solvent evaporation (SE) methods using methanol. The results of the solubility test showed that TC-NIC and TC-ISO co-crystals with a 1:2 molar ratio made using the SDG and SE methods gave the best results. Meanwhile, the best dissolution test results were shown by TC-ISO co-crystals with a ratio of 1:2. Based on the characterization of physical stability, the SDG method resulted in more stable TC co-crystals than the SE method. Therefore, in this case, the SDG method could be more advantageous to be used for development in the field of co-crystallization.

Co-Authors Abdassah Bratadiredja, Marline Abdullah, Astriani Ade Zuhrotun Adrian Suparman AGATHA, ALDA ANJELLA LADY CARINA PASKA AI Masitoh Aidi, Paramitha Ayu Amalia, Eri Amelia Nur Halimah Anas Subarnas Anis Yohana Chaerunisa Aslamnur Fikri Ramadhana Ayudyah Islami CYNTIA GRACESELLA HUTAMI P Detria Wulandari Dewi Permatasari Dewi, Febrina Aulia Dolih dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali DOLIH GOZALI Eka Paramudya Eri Amalia Fanny Seftiani Dwi Saputri Farisa Desy Arya, Insi Febrina Aulia Dewi Fiftianingrum, Valentina Ghassani Purnama, Muhammad Fadhil Hairunnisa Hairunnisa Hairunnisa Hairunnisa Hairunnisa Hairunnisa HOTMA GURNING WINOKAN Ina Novianti Insan Sunan Kurniawansyah, Insan Sunan Ira Maya Iyan Rifky Hidayat KUSUMAWULAN, CAHYA KHAIRANI Lutfiah Yusuf Maisyarah, Intan Timur Marline Abdassah Marline Abdassah Marline Abdassah, Marline MEGANTARA, SANDRA MEIVANA ESTHER ROSINTA TAMBUNAN Mika Febryati Kadir Moeljadi G Tedjasaputra Muchtaridi Muchtaridi Muhammad Faizal Fathurrohim Mulyanti Mulyanti Nadia Ariati Mutiana Nadya Nurul Zaman Norisca Aliza Putriana Norisca Aliza Putriana Norisca Aliza Putriana, Norisca Aliza Novaliana Devianti Sagita Nurdiani Adiningsih Nurhabibah Nurhabibah Nurike Susendi NURSIFA, HARITSA Pratama, Rizky Farhan Puspa, Inge Putri Raraswati Putri, Michelle Eka Rania Talinta L Reza Pahlevi, Muhamad Rian Triyana Rifkarosita Putri Ginaris Rizka Guntina Khairunisa Rosa Apriana Apriana Rugun Clara Samosir Salsabila Hapsari, Raira Saputra, Iwan Saskia Rizky Utami SAUSAN RIHHADATULAISY Savira Silma Aulia Setiawati, Ervina SHIBA, KAMILA Siska Sari Marvita Sriwidodo Sriwidodo Sriwidodo Sriwidodo, Sriwidodo Taofik Rusdiana Tedjasaputra, Moeljadi G Utami, Saskia Rizky Wulaningsih, Titiek Indah Yudhistira, Aulia YULINA BR SARAGIH Yuni Elsa Hadisaputri

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