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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Farmasetika Health Information : Jurnal Penelitian Jurnal Ilmiah Farmako Bahari BERNAS: Jurnal Pengabdian Kepada Masyarakat AKSELERASI: Jurnal Ilmiah Nasional Jurnal Locus Penelitian dan Pengabdian Jurnal Manajemen, Akuntansi, Ekonomi Journal of Artificial Intelligence and Digital Business Multidisciplinary Indonesian Center Journal
Iyan Sopyan
Fakultas Farmasi Universitas Padjadjaran
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Increasing Solubility of Simvastatin Via Salting Form Using Isonicotinamide As Co-Formers Sopyan, Iyan; Puspa, Inge; Salsabila Hapsari, Raira
Indonesian Journal of Pharmaceutics Vol 6, Issue 2, May - August 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i2.60538

Abstract

Simvastatin is a drugs used to lower plasma cholesterol. Simvastatin is a class II BCS drug that has low solubility and high permeability. One of the efforts made to increase the solubility of simvastatin is the formation of multicomponent crystals (co-crystals and salts). The purpose of this study was to determine the solubility and dissolution profile of multicomponent crystal simvastatin with the best co-former candidate from the in silico test. Simvastatin-co-former multicomponent crystal were prepared using solvent drop grinding method with a mol ratio of 1:1 ; 1:2 and 2:1. Based on the result of value of binding affinity and ability to form hydrogen bonds, isonicotinamide was chosen as the co-former in this research. Evaluation of multicomponent crystals was carried out by solubility and dissolution tests. The evaluation results showed an increase in the solubility and dissolution of the simvastatin-isocotinamide multicomponent crystal with the highest increase occurring in the simvastatin-isocotinamide multicomponent crystal with a mol ratio of 1:2. Multicomponent crystal characterization was carried out to determine physicochemical characteristics. The results of characterization using infrared spectrophotometry showed a spectrum shift. The results of the Differential Scanning Calorimetry (DSC) analysis show a decrease in the melting point. The results of Powder X-ray diffraction analysis showed that there were differences in the shape of the crystals indicated by the formation of new peaks on the diffractogram. So, it can be concluded that simvastatin-isocotinamide multicomponent crystals are able to increase solubility and dissolution compared to pure simvastatin.
 A Concise ReviewThe Ph Triggered Concept In Situ Ophthalmic Gel Of Sodium Cromoglycate, Diclofenac Sodium and Aceclofenac Kurniawansyah, Insan Sunan; Farisa Desy Arya, Insi; Sopyan, Iyan
Indonesian Journal of Pharmaceutics Vol 6, Issue 3, Sept - Dec 2024
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v6i3.52748

Abstract

The ophthalmic solutions have a major problem that is the poor bioavailability, such as the attainment of optimal drug concentration at the site of action, which is compromised mainly due to precorneal loss resulting in only small fraction of the drug being ocularly absorbed. This is overcome by developing an in situ ophthalmic gel which increases the retention time of the drug. The present review describes the formulation and evaluation of in situ gel-forming ophthalmic drug delivery system of an anti allergy drug sodium cromoglycate, an anti-inflammatory drug diclofenac sodium and aceclofenac based on the pH triggered concept in situ gelation. All the formulations varies in concentration and the content used. Based on the results obtained, Sodium cromoglycate which has been formulated with gelrite and HPMC E15LV has the highest ocular residence time compared to the other two formulations.Keywords: Ophthalmic in situ gel,sodium cromoglycate, diclofenac sodium,                      aceclofenac, gelrite, HPMC E15LV
REVIEW ARTICLE: UJI EFEKTIVITAS IN VIVO DAN IN VITRO ANTI-AGING PADA SEDIAAN KOSMETIK SHIBA, KAMILA; NURSIFA, HARITSA; KUSUMAWULAN, CAHYA KHAIRANI; SOPYAN, IYAN
Farmaka Vol 20, No 3 (2022): Farmaka (November)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v20i3.38775

Abstract

Penuaan terjadi secara alamiah pada manusia yang ditandai dengan munculnya keriput dan hiperpigmentasi.  Penuaan menjadi hal yang mendapat perhatian lebih oleh kaum wanita pada umumnya karena mempengaruhi penampilan. Banyak tanaman herbal maupun senyawa sintetis yang ditujukan sebagai agen anti penuaan. Bahan aktif tersebut diformulasikan menjadi bentuk sediaan kosmetik untuk memudahkan penggunaan pada konsumen dan mencapai efek yang maksimum. Dalam pembuktiannya, dibutuhkan pengujian yang komprehensif. Pengujiaan ini dapat berupa metode pengujian in vivo dan in vitro. Adapun penelitian ini dilakukan dengan metode article review dan didapatkan jurnal dari literature online jurnal lokal dan jurnal internasional yaitu pencarian secara elektronik dengan kata kunci efektivitas anti-aging, in vitro, in vivo, anti-aging dan sediaan kosmetik pada situs web yaitu Google Scholar. Hasil studi article review didapatkan bahwa beberapa metode yang digunakan adalah metode DPPH, kultur fibroblast dermal manusia, uji pada tikus, dan uji klinis pada manusia.Kata Kunci: Efektivitas anti-aging, in vitro, in vivo, anti-aging dan sediaan kosmetik 
LITERASI DIGITAL; TINGKATKAN KAPASITAS PEMAHAMAN SISWA-SISWI SEKOLAH DI BAWAH BINAAN LP MA’ARIF MAJALENGKA Syamsul , E. Mulya; Rustandi , Enang; Gumilang Lestari, Ayu; Prayitno , Anggi; Sopyan , Iyan
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 6 No. 3 (2025)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v6i3.13752

Abstract

Perkembangan zaman terus mengalami perubahan seiring dengan perkembangan teknologi, dunia teknologi telah banyak menghantarkan perubahan bagi kehidupan masyarakat di seantero dunia tak terkecuali masyarakat bangsa Indonesia, namun dalam kenyataannya perkembnagan tekonoli belum mampu di cerna oleh seluruh masyarakat Indononesia, melalui kegiatan pengabdian ini literasi digital menjadi jawaban yang kongkrit untuk membangun kesadaran masyarakat dalam dunia digital agar wujud dari digital itu menjadi penguat dalam perkembangan zaman dan peradaban yang berkelanjutan oleh karenanya melalui pengabdian masyarakat ini yang dilakukan dengan acara workshop mengambil segmen masyarakat tingkat pendidikan menengah yang terkordinir melalui guru sekolah dibawah pembinaan LP Ma’arif menjadi modal besar agar mereka dapat meliterasi ulang kepada masyarakat lainnya diluar kegiatan Pengabdian tersebut
Review: Preparation of Flavonoid Nanoparticles using the Nanoprecipitation Method Pratama, Rizky Farhan; Sopyan, Iyan; Rusdiana, Taofik
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.40849

Abstract

Flavonoids are polyphenolic compounds that have 15 carbon chains, 2 benzene rings and a heterocyclic pyran ring. From the literature study, it is known that flavonoids have various pharmacological activities such as anticancer, antimicrobial, antiviral, antiangiogenic, antimalarial, antioxidant, neuroprotective, antitumor, and antiproliferative agents. However, flavonoids have limited oral bioavailability which may be due to their poor solubility, low permeability, and low stability, which impair their effectiveness as therapeutic agents. One of the efforts to increase solubility is nanoparticle technology where the active compound particles are reduced to the nanometer scale, usually up to 100 nm. Nanoprecipitation is a method of preparing nanoparticles by dissolving the active drug substance and polymer into an organic solvent and then adding an anti-solvent such as water. The advantages of this method are the production is relatively fast, inexpensive, does not require a lot of energy, and does not require emulsion precursors. The purpose of this literature review is to examine the technique of making flavonoid nanoparticles using the nanoprecipitation method, the results of their characterization and evaluation. Based on a literature review that has been carried out on 30 journals, there are 20 flavonoid secondary metabolites that have been prepared into nanoparticles using the nanoprecipitation method. Some of the polymers used were effective in achieving satisfactory particle size, polydispersity index (PDI), Zeta potential and Encapsulation Efficiency (EE%). Thus, the nanoprecipitation method can be used to make flavonoid nanoparticles with optimal formulations to improve the physicochemical properties of flavonoids for drug development in the future.
PENGARUH SARANA DAN TINGKAT PENDIDIKAN TERHADAP KUALITAS PELAYANAN PEMERINTAHAN DESA (STUDI EKSPLANATORY PADA PEMERINTAH DESA SE-KECAMATAN SUKARESIK) Saputra, Iwan; Sopyan, Iyan
Multidisciplinary Indonesian Center Journal (MICJO) Vol. 1 No. 1 (2024): Vol. 1 No. 1 Edisi Januari 2024
Publisher : PT. Jurnal Center Indonesia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62567/micjo.v1i1.70

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh Sarana secara parsial terhadap Kualitas Pelayanan Pemerintah Desa Se-Kecamatan Sukaresik Kabupaten tasikmalaya, untuk mengetahui pengaruh Tingkat Pendidikan secara parsial terhadap Kualitas Pelayanan Pemerintah Desa Se-Kecamatan Sukaresik Kabupaten tasikmalaya, dan untuk mengetahui pengaruh Sarana dan Tingkat Pendidikan terhadap Kualitas Pelayanan Pemerintah Desa Se-Kecamatan Sukaresik Kabupaten tasikmalaya. Metode penelitian ini menggunakan metode mix deskriptif dengan pendekatan kuantitatif dan kualitatif. Metode pengumpulan data yang digunakan adalah kuesioner, observasi, wawancara dan dokumentasi. Teknik penarikan sampel menggunakan total sampling yaitu seluruh Perangkat Desa Se-Kecamatan Sukaresik Kabupaten Tasikmalaya yang berjumlah 104 orang. Analisis data yang digunakan yaitu uji validitas, uji reliabilitas, uji normalitas, uji multikolinearitas, uji heterokedastisitas, regresi linier berganda, koefisien korelasi, koefisien determinasi, dan uji hipotesis. Berdasarkan Hasil Penelitian membuktikan adanya pengaruh signifikan antara sarrana terhadap kualitas pelayanan di pemerintah desa se-kecamatan sukaresik kabupaten tasikmalaya dengan nilai koefisien regresi variabel sarana dan tingkat Pendidikan terhadap kualitas pelayanan secara simultan sarana dan tingkat Pendidikan berpengaruh signifikan terhadap kualitas pelayanan dengan diperoleh angka R, maka dapat disimulkan bahwa sarana dan tingkat Pendidikan berpengaruh terhadap kualitas pelayanan terdapat hubungan yang sedang atau positif. menunjukan presentase variabel independent (sarana dan tingkat Pendidikan) terhadap variabel dependen (kualitas pelayanan) berpengaruh terhadap kualitas pelayanan, sehingga disarankan agar perangkat memfokuskan kepada dua hal tersebut sebagai strateginya untuk kualitas pelayanan.
Pre-formulations Study of Active Pharmaceutical Ingredients Amiodaron in the Development of Oral Tablet Pharmaceutical Preparations as an Anti-Arrhythmia Drug Anindya, Nisrina Raya; Fadiya, Refeyfa Najwa; Palupi, Anindya Taruni; Jannah, Aisa Zahratul; Deandrea, Helena Jessie; Sopyan , Iyan
RIGGS: Journal of Artificial Intelligence and Digital Business Vol. 4 No. 4 (2026): November - January
Publisher : Prodi Bisnis Digital Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/riggs.v4i4.5035

Abstract

Amiodaron is a broad-spectrum antiarrhythmic drug that is widely used in the management of various cardiac rhythm disorders, including ventricular and supraventricular arrhythmias. Despite its therapeutic effectiveness, Amiodaron presents complex physicochemical characteristics that pose significant challenges in the development of oral solid dosage forms, particularly tablet preparations. Therefore, a comprehensive pre-formulation study is essential to ensure the development of stable, safe, and effective pharmaceutical products. This study aims to examine the pre-formulation aspects of Amiodaron hydrochloride as a scientific basis for tablet formulation development. The research method employed was a literature-based study focusing on the physicochemical properties of Amiodaron, including ionization constants (pKa), partition coefficients (log P), solubility, dissolution behavior, polymorphism, chemical and physical stability, as well as particle and powder characteristics. Relevant data were obtained from scientific journals, pharmacopeias, and authoritative pharmaceutical references. The results indicate that Amiodaron hydrochloride is classified as a Biopharmaceutics Classification System (BCS) class II drug, characterized by low aqueous solubility and high membrane permeability. The compound is highly lipophilic, weakly basic, and sensitive to environmental factors such as light, heat, and alkaline pH conditions, which may lead to degradation. Furthermore, Amiodaron powder exhibits poor flowability and compressibility, making direct compression during tablet manufacturing difficult. Based on these findings, appropriate formulation strategies are required, including the use of inclusion complexes, hydrophilic polymers, granulation techniques, and careful selection of excipients to enhance solubility, stability, and bioavailability. This pre-formulation study is expected to provide a strong scientific foundation for the development of optimal Amiodaron tablet formulations.
Article Review: Glimepiride Solubility Enhancement Strategy as Diabetes Treatment Therapy Fiftianingrum, Valentina; Sopyan, Iyan; Gozali, Dolih
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 5 (2025): JURNAL LOCUS: Penelitian & Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i5.4010

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease characterized by high blood glucose levels due to impaired insulin secretion. The prevalence of diabetes in Indonesia always increases every year. Glimepiride is a type 2 antidiabetic drug of the sulfonylurea class that works by stimulating insulin secretion of pancreatic beta cells. Glimepiride is given through the oral route of administration and is widely used because it has a longer half-life and can be used as treatment monotherapy. Glimepiride itself has physicochemical properties that can penetrate the stratum corneum with a dose of less than 10 mg, a molecular weight of 490.62 g/mol, a melting point of 207°C, and a lipophilicity value (LogP) of 3.5. However, oral glimepiride in therapy has bioavailability problems due to its poor solubility in the gastrointestinal tract. It has very low solubility values at acidic and neutral pH of approximately less than 0.004 mg/mL (BCS 2). Due to the low aqueous solubility of glimepiride is a major challenge in drug formulation development. This low solubility has an impact on its bioavailability, which is not optimal, thus reducing its therapeutics. Various efforts were made in order to increase the solubility of glimepiride, including the use of formulation techniques such as the preparation of solid dispersion systems, the formation of inclusion complexes, as well as the utilization of nanoparticle technologies such as nanosuspensions, nanoemulgels, and nanoemulsions. In addition, chemical modification approaches and various others are used to improve the solubility of glimepiride. Recent studies have shown that the combination of the latest formulation technologies with suitable carrier materials can significantly improve its solubility and stability, thereby enhancing the therapeutic effectiveness of glimepiride in the management of type 2 diabetes. Thus, innovations in glimepiride formulation are expected to provide better therapeutic solutions for patients with type 2 diabetes.
Co-Authors Abdassah Bratadiredja, Marline Abdullah, Astriani Ade Zuhrotun Adrian Suparman AGATHA, ALDA ANJELLA LADY CARINA PASKA Ahda Salsabila Izzaturrahmi AI Masitoh Aidi, Paramitha Ayu Amalia, Eri Amelia Nur Halimah Anas Subarnas Anindya, Nisrina Raya Anis Yohana Chaerunisa Aslamnur Fikri Ramadhana Ayudyah Islami CYNTIA GRACESELLA HUTAMI P Deandrea, Helena Jessie Detria Wulandari Dewi Kurniasari Dewi Permatasari Dewi, Febrina Aulia Dinda Firanitha Tsamarah Dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali Eka Paramudya Eri Amalia Fadiya, Refeyfa Najwa Fanny Seftiani Dwi Saputri Febrina Aulia Dewi Fiftianingrum, Valentina Gawik Setiawan Ghassani Purnama, Muhammad Fadhil Gumilang Lestari, Ayu Hairunnisa Hairunnisa Hairunnisa Hairunnisa Hairunnisa Hairunnisa Hesti Siti Nurbarkah HOTMA GURNING WINOKAN Ikhsan Nugraha Ina Novianti Insan Sunan Kurniawansyah, Insan Sunan Insi Farisa Desy Arya Ipan Solihin Ira Maya Iyan Rifky Hidayat Jannah, Aisa Zahratul KUSUMAWULAN, CAHYA KHAIRANI Lutfiah Yusuf Maisyarah, Intan Timur Marline Abdassah Marline Abdassah Marline Abdassah, Marline MEGANTARA, SANDRA MEIVANA ESTHER ROSINTA TAMBUNAN Mika Febryati Kadir Moeljadi G Tedjasaputra Muchtaridi Muchtaridi Muhammad Faizal Fathurrohim Mulyanti Mulyanti Nadia Ariati Mutiana Nadiyah Salma Athaya Nadya Nurul Zaman Norisca Aliza Putriana Norisca Aliza Putriana Norisca Aliza Putriana, Norisca Aliza Novaliana Devianti Sagita Nurdiani Adiningsih Nurdiani Adiningsih Nurhabibah Nurhabibah Nurike Susendi NURSIFA, HARITSA Palupi, Anindya Taruni Pratama, Rizky Farhan Prayitno , Anggi Puspa, Inge Putri Raraswati Putri, Michelle Eka Rania Talinta L Reza Pahlevi, Muhamad Rian Triyana Rifkarosita Putri Ginaris Rizka Guntina Khairunisa Rosa Apriana Apriana Rosmiati, Neni Rugun Clara Samosir Rustandi , Enang Salsabila Hapsari, Raira Saputra, Iwan Saskia Rizky Utami SAUSAN RIHHADATULAISY Savira Silma Aulia Setiawati, Ervina SHIBA, KAMILA Siska Sari Marvita Siska Sari Marvita Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Syamsul , E. Mulya Taofik Rusdiana Tedjasaputra, Moeljadi G Utami, Saskia Rizky Wulaningsih, Titiek Indah Yudhistira, Aulia YULINA BR SARAGIH Yuni Elsa Hadisaputri