Garuda - Garba Rujukan Digital

p-Index From 2021 - 2026

5.216

P-Index

This Author published in this journals

All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Farmasetika Health Information : Jurnal Penelitian Jurnal Ilmiah Farmako Bahari BERNAS: Jurnal Pengabdian Kepada Masyarakat AKSELERASI: Jurnal Ilmiah Nasional Jurnal Locus Penelitian dan Pengabdian Jurnal Manajemen, Akuntansi, Ekonomi Journal of Artificial Intelligence and Digital Business Multidisciplinary Indonesian Center Journal

Iyan Sopyan

Fakultas Farmasi Universitas Padjadjaran

Author-ID : 604694

Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 58 Documents Claim Missing Document

Claim Missing Document

Articles

2 3 4 5 6

Solubility Enhancement and Characterization of Tamoxifen Citrate Using Co-crystallization Dolih Gozali; Iyan Sopyan; Hairunnisa Hairunnisa; Siska Sari Marvita
Indonesian Journal of Chemistry Vol 22, No 2 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.70891

Tamoxifen citrate (TC) is one of the anti-estrogen agents which has low solubility in the water. As TC is still used as the main therapy in breast cancer treatment, modifications are still being made to increase the solubility of TC for a successful treatment. In this research, co-crystallization of TC was performed using Nicotinamide (NIC), Isonicotinamide (ISO), Saccharin (SAC), Aspartame (ASP), and Benzoic Acid (BNZ) as a coformer with the molar ratio of 1:1, 1:2, and 2:1. Co-crystal was prepared by solvent drop grinding (SDG) and solvent evaporation (SE) methods using methanol. The results of the solubility test showed that TC-NIC and TC-ISO co-crystals with a 1:2 molar ratio made using the SDG and SE methods gave the best results. Meanwhile, the best dissolution test results were shown by TC-ISO co-crystals with a ratio of 1:2. Based on the characterization of physical stability, the SDG method resulted in more stable TC co-crystals than the SE method. Therefore, in this case, the SDG method could be more advantageous to be used for development in the field of co-crystallization.

KO-KRISTAL: NIKOTINAMID SEBAGAI KOFORMER Hairunnisa Hairunnisa; Iyan Sopyan; Dolih Gozali
Jurnal Ilmiah Farmako Bahari Vol 10, No 2 (2019): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Kokristal merupakan cara alternatif yang dapat dilakukan untuk meningkatkan kemampuan melarut obat yang sukar larut dalam air dan meningkatkan bioavailabilitas obat yang buruk. Ada berbagai teknik yang dapat dilakukan dalam pembuatan kokristal seperti Hot Melt Extrusion, solvent evaporation, solvent drop grinding, slurry. Nikotinamid telah banyak digunakan sebagai koformer dalam pembentukan ko-kristal. Berdasarkan struktur kimianya, nikotinamid memiliki peluang besar untuk membentuk ko-kristal dengan berbagai macam bahan aktif farmasi. Modifikasi kokristal bahan aktif farmasi juga dapat maningkatkan laju disolusi dari bahan aktif farmasi itu sendiri dibandingkan kecepatan disolusi bahan aktif farmasi murninya Kata kunci: kokristal, nikotinamid, disolusi

REVIEW MODIFIKASI KELARUTAN PIROKSIKAM Ayudyah Islami; Iyan Sopyan; Dolih Gozali; Hairunnisa Hairunnisa
Jurnal Ilmiah Farmako Bahari Vol 11, No 1 (2020): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Piroksikam, merupakan golongan NSAID, digunakan pada rheumatoid arthritis dan osteoarthritis untuk mengurangi rasa sakit. Waktu paruh piroksikam adalah 24 hingga 48 jam. Berdasarkan Biopharmaceutical Classification System (BCS), piroksikam termasuk dalam kelas II yang memiliki kelarutan air rendah, titik lelehnya 190-200oC, nilai log P 3,06, nilai pKa 6,3, dan Vd 0,14 L / kg. Kelarutan piroksikam ditentukan oleh tingkat ionisasi. Ketika pH diperoleh melalui pKa, terjadi peningkatan kelarutan dan disolusi. Oleh karena itu, modifikasi piroksikam dengan dispersi padat dan teknik kristristalisasi diharapkan dapat meningkatkan kelarutan piroksikam dan memfasilitasi formulasi piroksikam menjadi bentuk sediaan yang efektif. Namun, setiap modifikasi memiliki kelebihan dan kekurangan masing-masing yang dapat dipertimbangkan ketika merancang piroksikam menjadi bentuk sediaan. Kata kunci: kokristal, dispersi padat, piroksikam, kelarutan, disolusi

Review: Methods for Enhancing Solubility of Carvedilol Iyan Sopyan; Rania Talinta L; Nurdiani Adiningsih; Norisca Aliza Putriana; Sandra Megantara2 Megantara
Indonesian Journal of Pharmaceutics Vol 4, Issue 1, Jan - April 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i1.39321

The oral route of administration is the most frequently used route of drug administration and is generally the most convenient for patients. For an oral drug to be effective, a therapeutic concentration in the blood must be achieved. Solubility in water and permeability of active pharmaceutical ingredients are often used as the main conditions for rapid and complete absorption and high bioavailability. Carvedilol is beta blockers that works as an antihypertensive drug and included in biopharmaceutical classification system (BCS) class II with high permeability but low solubility. Due to this, the goal of this review is to go through a few different methods for increasing solubility of carvedilol. dissolution, and bioavailability. Various solubility enhancement techniques have been applied to carvedilol, including co-crystallization, liquidsolid technique, cyclodextrin inclusion complex, nanoparticles, hydrotrophy, nanosuspension, solid dispersion, nanoemulsion, and dendrimers. These techniques have been shown to increase the solubility and dissolution rate of carvedilol thereby increasing its bioavailability.Keyword: carvedilol, solubility enhancement, BCS class II

Potential of Essential Oil as Anti-Dandruff in Scalp Treatment Preparations Detria Wulandari; Iyan Sopyan; Rifkarosita Putri Ginaris; Muhammad Faizal Fathurrohim; Ira Maya
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.5600

Most scalp problems in the community are dandruff. The most widely known microorganism that contributes to dandruff is Malassezia spp. The currently available treatment options for anti-dandruff are mostly synthetic substances. Unfortunately, these synthetic substances can cause various problems, such as side effects and drug resistance, especially the compliance of the patient. Herbal remedies that can be used to reduce the risks are essential oils. There are several essential oils that have been researched on anti-dandruff potential are Tea Tree, Lemongrass, Lavender, Rosemary, Eucalyptus, Coleus amboinicus, etc. The potential of essential oils as anti-dandruff ingredients in scalp remedies will be discussed in this article review. This article review was conducted using a comparative research method from a variety of sources, including online research journals and other sources. The outcome of this review article revealed that the previously mentioned essential oils have positive results in inhibiting the growth of the Malassezia sp., in its pure form, a combination of pure essential oils, or when in product form.

Solubility Enhancement of Carvedilol by Solid Dispersion Technique Using Sodium Alginate, Guar Gum, Xanthan Gum, and Locust Bean Gum as Polymers Iyan Sopyan; Nurdiani Adiningsih; Sandra Megantara; Siska Sari Marvita
Indonesian Journal of Chemistry Vol 23, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.77698

Carvedilol (CVD) is a non-selective β-blocker. CVD is included in BCS class II. It has low water solubility. In this research, solid dispersion was used to increase the solubility and dissolution profile of CVD. In silico study using the ligand-ligand docking method. The preparation of solid dispersion using the kneading method with a weight ratio of 1:1, 1:2, 1:3, and 1:4, evaluation of solid dispersion includes solubility and dissolution. The best solid dispersion was characterized using FTIR, DSC, and PXRD. In silico study showed complexes CVD-SA, CVD-GG, CVD-XG and CVD-LBG have a hydrogen interaction. SA and XG were chosen as carriers in solid dispersion. CVD solid dispersion showed increased solubility in all samples, with the highest increase at 90.63 times at CVD: XG (1:4). The results of the dissolution profile obtained at 60 min are 64.95 ± 0.45% at pure CVD, 83.32 ± 1.19% at CVD:SA (1:4), and 72.56 ± 3.62% at CVD: XG (1:4). The FTIR spectrum indicates an interaction between CVD and SA. The thermogram indicated the amorphous drug, and the diffractogram showed a decrease in crystallinity. Solid dispersion is proven to increase the solubility and dissolution profile of CVD. Solid dispersion CVD: SA (1:4) showed the highest solubility and dissolution profile.

Review: Solubility And Bioavailability Enhancement Of Carvedilol Using Multicomponent Crystal Method Nadiyah Salma Athaya; Iyan Sopyan
Indonesian Journal of Pharmaceutics Vol 4, Issue 2, May - August, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i2.44137

Carvedilol is included in the BCS class 2 classification, drugs that have low solubility and high permeability. Drugs with low solubility pose a major challenge for oral drugs in achieving the desired systemic circulation. Moreover, carvedilol is indicated for the treatment of cardiovascular disease and hypertension which requires a rapid pharmacological response. A way to increase drug solubility is by forming multicomponent crystals, including solvates, cocrystals, and salts. Cocrystal and salt formation methods are the most frequently used methods in the pharmaceutical field. The multicomponent crystal approach is a process of combining active drug ingredients with other compounds known as coformers which then interact through molecular bonds. Multicomponent crystals provide benefits to improve the physicochemical properties of drugs without affecting their pharmacological properties. In this review, we discuss the multicomponent crystal approach as an effort to increase the solubility and bioavailability of carvedilol. The main reference data used in this review are research journals published in the last 10 years (2012-2022) using the keywords carvedilol, multicomponent crystal, solubility, bioavailability, and using Google Scholar as a database. There is also a discussion on regulation of cocrystals, methods for forming multicomponent crystals, and characterization of multicomponent crystals. The multicomponent crystal approach has promising benefits in increasing the solubility and bioavailability of carvedilol in the body. Keywords: Carvedilol, multicomponent crystal, solubility, bioavailability

Sistem Penghantaran Obat Limfatik: Peningkatan Bioavailabilitas Obat dengan Nanopartikel Dinda Firanitha Tsamarah; Ahda Salsabila Izzaturrahmi; Iyan Sopyan
Majalah Farmasetika Vol 8, No 5 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v8i5.47852

Sistem limfatik saat ini telah banyak digunakan sebagai jalur penghantaran obat terutama pada terapi antikanker, antivirus, dan imunologi. Jalur ini juga telah terbukti memiliki keunggulan yang dapat memberikan efek terapi yang lebih baik. Akan tetapi, sediaan farmasi untuk obat-obatan bertarget di limfatik kini termasuk pada Biopharmaceutics Classification System (BCS) kategori II, yaitu sediaan dengan kelarutan yang rendah dan permeabilitas yang baik. Hal ini akan berdampak pada bioavailabilitas dan efektivitas suatu sediaan untuk mencapai efek terapeutiknya. Masalah ini dapat diatasi dengan formulasi nanopartikel. Artikel ini akan membahas upaya peningkatan bioavailabilitas suatu sediaan dengan nanopartikel. Metode yang digunakan adalah studi literatur jurnal internasional yang dipublikasikan pada Pubmed dan Scopus dengan batas waktu 10 tahun terakhir. Berdasarkan hasil beberapa penelitian terkait, nanopartikel seperti liposom, solid lipid nanoparticle, SMEDDS, dan beberapa nanopartikel lainnya telah teruji dapat meningkatkan bioavailabilitas sediaan farmasi yang bertarget pada sistem limfatik dan dapat dikembangkan lebih lanjut agar memberikan hasil yang lebih maksimal.

PEMETAAN SUHU GUDANG PENYIMPANAN PADA SALAH SATU PEDAGANG BESAR FARMASI (PBF) DI KOTA BANDUNG Putri, Michelle Eka; Sopyan, Iyan
Farmaka Vol 21, No 2 (2023): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v21i2.46748

Cara Distribusi Obat yang Baik (CDOB) merupakan standar yang ditetapkan untuk mengatur penyaluran dan penyerahan obat dengan tujuan menjaga produk tetap dalam kualitas yang sama sampai ke tangan konsumen. Pedagang Besar Farmasi (PBF) sebagai salah satu dari pihak yang terlibat dalam penyimpanan dan pendistribusian sediaan obat atau bahan obat dalam jumlah yang besar harus memenuhi persayaratan yang telah ditetapkan yaitu CDOB dalam pelaksanaanya. Penyimpanan obat memiliki syarat-syarat khusus yang harus dipenuhi, salah satunya adalah suhu yang sesuai dengan kondisi penyimpanan yang dipersyaratkan. Pemetaan suhu merupakan prosedur yang dilakukan dengan tujuan kualifikasi dan verifikasi ruangan yang akan digunakan untuk penyimpanan obat atau bahan obat. Hasil dari pemetaan suhu yang dilakukan di salah satu PBF di Kota Bandung sudah memenuhi persyaratan suhu yang ditetapkan.

Review: Alternatif Palatability Enhancer Sebagai Peningkat Palabilitas Formula Sediaan Pet Untuk Industri Obat Hewan Mulyanti, Mulyanti; Sopyan, Iyan
Farmaka Vol 22, No 1 (2024): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i1.52452

Sediaan pet merupakan jenis sediaan yang penggunaannya ditujukkan untuk hewan kesayangan atau hewan peliharaan, umumnya seperti kucing dan anjing. Pengembangan formula sediaan pet berkembang pesat seiring berkembangnya zaman. Hal ini didorong oleh kemajuan teknologi dan semakin tingginya kebutuhan pasar terhadap sediaan pet. Palatabilitas menjadi faktor yang sangat penting dan dapat menentukan keberhasilan formulasi sediaan pet. Tinjauan artikel ini bertujuan untuk melihat alternatif palatability enhancher yang dapat digunakan untuk meningkatkan palatabilitas sediaan pet. Metode penelitian ini yaitu studi pustaka terhadap artikel penelitian yang telah dipublikasikan yang diperoleh melalui pencarian di GoogleScholar dan ScienceDirect mengenai palatability enhancer untuk kucing dan anjing berupa artikel yang dipublikasi 10 tahun terakhir. Hasil tinjauan artikel diperoleh beberapa alternatif palatability enhancer yang dapat digunakan sebagai peningkat palatabilitas sediaan pet diantaranya hydrolized chicken liver powder, enzim phytase dan karbohidrase, Schizochytrium sp., minyak bunga matahari, serat singkong (cassava fibre), produk fermentasi Saccharomyces cerevisiae, tea poliphenols, corn fermented protein, pati kentang, yeast extract (Brewer’s yeast extract Saccharomyces cerevisiae), dried apple pomace, hati kambing dan sapi, dried yeast (Saccharomyces cerevisiae) dan medium chain triglyceride oil. Beberapa palatability enhancer tersebut berpotensi untuk digunakan sebagai alternatif peningkat palatabilitas sediaan pet pada industri obat hewan.

Co-Authors Abdassah Bratadiredja, Marline Abdullah, Astriani Ade Zuhrotun Adrian Suparman AGATHA, ALDA ANJELLA LADY CARINA PASKA Ahda Salsabila Izzaturrahmi AI Masitoh Aidi, Paramitha Ayu Amalia, Eri Amelia Nur Halimah Anas Subarnas Anindya, Nisrina Raya Anis Yohana Chaerunisa Aslamnur Fikri Ramadhana Ayudyah Islami CYNTIA GRACESELLA HUTAMI P Deandrea, Helena Jessie Detria Wulandari Dewi Kurniasari Dewi Permatasari Dewi, Febrina Aulia Dinda Firanitha Tsamarah Dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali Dolih Gozali Eka Paramudya Eri Amalia Fadiya, Refeyfa Najwa Fanny Seftiani Dwi Saputri Febrina Aulia Dewi Fiftianingrum, Valentina Gawik Setiawan Ghassani Purnama, Muhammad Fadhil Gumilang Lestari, Ayu Hairunnisa Hairunnisa Hairunnisa Hairunnisa Hairunnisa Hairunnisa Hesti Siti Nurbarkah HOTMA GURNING WINOKAN Ikhsan Nugraha Ina Novianti Insan Sunan Kurniawansyah, Insan Sunan Insi Farisa Desy Arya Ipan Solihin Ira Maya Iyan Rifky Hidayat Jannah, Aisa Zahratul KUSUMAWULAN, CAHYA KHAIRANI Lutfiah Yusuf Maisyarah, Intan Timur Marline Abdassah Marline Abdassah Marline Abdassah, Marline MEGANTARA, SANDRA MEIVANA ESTHER ROSINTA TAMBUNAN Mika Febryati Kadir Moeljadi G Tedjasaputra Muchtaridi Muchtaridi Muhammad Faizal Fathurrohim Mulyanti Mulyanti Nadia Ariati Mutiana Nadiyah Salma Athaya Nadya Nurul Zaman Norisca Aliza Putriana Norisca Aliza Putriana Norisca Aliza Putriana, Norisca Aliza Novaliana Devianti Sagita Nurdiani Adiningsih Nurdiani Adiningsih Nurhabibah Nurhabibah Nurike Susendi NURSIFA, HARITSA Palupi, Anindya Taruni Pratama, Rizky Farhan Prayitno , Anggi Puspa, Inge Putri Raraswati Putri, Michelle Eka Rania Talinta L Reza Pahlevi, Muhamad Rian Triyana Rifkarosita Putri Ginaris Rizka Guntina Khairunisa Rosa Apriana Apriana Rosmiati, Neni Rugun Clara Samosir Rustandi , Enang Salsabila Hapsari, Raira Saputra, Iwan Saskia Rizky Utami SAUSAN RIHHADATULAISY Savira Silma Aulia Setiawati, Ervina SHIBA, KAMILA Siska Sari Marvita Siska Sari Marvita Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Syamsul , E. Mulya Taofik Rusdiana Tedjasaputra, Moeljadi G Utami, Saskia Rizky Wulaningsih, Titiek Indah Yudhistira, Aulia YULINA BR SARAGIH Yuni Elsa Hadisaputri

Title

Found 58 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 58 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 58 Documents
Search