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Journal : CHEMPUBLISH JOURNAL

Potential of Organometallic Complex Compounds as Anticancer Drugs: A Review Ardhani, Zaliari Nafisa; Pasaribu, Marvin Horale; Prisnanda, Risky; Anggraeni, Maya Erliza; Iqbal, Rendy Muhamad
Chempublish Journal Vol. 8 No. 1 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i1.31409

Abstract

Cancer is one of the deadliest diseases in the world. Currently, there are various types of anticancer drugs that are used to treat cancer, but they still have various side effects that can interfere with the quality of life of patients. Organometallic complexes (OCOs) are chemical compounds consisting of metal atoms bonded to carbon atoms. OCOs have various potential to be used as anticancer drugs, including their ability to specifically target cancer cells, inhibit cancer cell growth, and reduce the side effects of other anticancer drugs. The mechanism of action of OCOs involves interactions with nucleophilic molecules within the cell, including DNA, RNA, and proteins, as well as the formation of additional platinum products. In this review, we will discuss organometallic compounds that can function as anticancer drugs, such as platinum, ruthenium, iron, carboplatin, and oxaliplatin, which have been shown to be effective in fighting cancer. We will also discuss the mechanism of action of these compounds in cancer cells and the types of cancer cells that can be treated with organometallic compounds.
Synthesis of Sulfated and CaO-Modified UiO-66 Bifunctional Catalysts from Zircon Sand for Conversion of Waste Cooking Oil Pasaribu, Marvin Horale; Agnestisia, Retno; Pratika, Remi Ayu; Toepak, Erwin Prasetya; Karelius , Karelius
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.49575

Abstract

Zircon-based UiO-66 metal–organic frameworks (MOFs) were synthesized from Central Kalimantan zircon sand and modified into bifunctional catalysts for two-step biodiesel production from waste cooking oil (WCO). Zirconium oxychloride (ZrOCl₂·8H₂O), obtained via acid leaching of zircon sand, served as the precursor for solvothermal UiO-66 synthesis using terephthalic acid (H₂BDC) as a linker. Post-synthetic modifications yielded sulfated UiO-66 (UiO-66/SO₄) as an acid catalyst and CaO-modified UiO-66 (UiO-66/CaO) as a base catalyst. XRD analysis displayed sharp reflections at 2θ = 7.4°, 8.5°, 25.8°, and 30.8° for UiO-66, with additional peaks at 17.7°, 33.8°, and 46.8° corresponding to CaO and Ca(OH)₂ phases, and a new band at 1114 cm-1 confirming sulfate incorporation—indicating successful formation of acid–base composite structures. Catalytic tests were conducted at varying catalyst loadings of 0.25%, 0.5%, and 0.75%. The UiO-66/SO₄ catalyst achieved the highest esterification efficiency at 0.5% loading, reducing the free fatty acid (FFA) content by 51.7%. Similarly, UiO-66/CaO exhibited optimum transesterification activity at 0.5% loading, yielding 61.82% biodiesel. FTIR spectra of the products confirmed fatty acid methyl ester (FAME) formation with characteristic C=O (1744 cm-1), C–O (1165, 1031 cm-1), and CH₃ (1456 cm-1) vibrations. These results demonstrate that zircon-sand-derived UiO-66 catalysts possess excellent structural stability, synergistic acid–base functionality, and strong catalytic efficiency, providing a sustainable pathway for biodiesel production from waste cooking oil
Co-Authors Abed Nego Purba Adinata , Septian Aditya Ramadhani Aji, Galih Prasetya Alfanaar, Rokiy Alfanaar, Rokiy Aliya Al-Hadi, Risfa Aman Sentosa Panggabean Amelia Natalia, Wita Anggraeni, Maya Erliza Apriani , Resti Ardhani, Zaliari Nafisa Ariefin, Mokhamat Averro , Franzois Br Siringo-ringo, Florens Cahyani, Risfiah Ruli cemara, Tutus Septiani Chuchita Damsyik, Akhmad Dicky Perwira Ompusunggu Dongoran, Junita Efriyana oksal Elvina Dhiaul Iftitah Erwin Prasetya Toepak Erwin Prasetya Toepak Erwin Prasetya Toepak Esra Noviyanti Br. Karo Ester Damayanti Manik Fatchiyatun Ni’mah Febriana Kesuma, Ruth Febriyanti , Elfrida Ferdinand Hidayat Gabriela Elsandika Hakim, Muh. Supwatul Hasanul Haq, Muhammad Ipah2, Puja Iqbal, Rendy Muhamad Isaura Silalahi, Anastasya Junita Dongoran Karelius , Karelius Karelius Karelius Komara, Nisa Kartika Krissilvio, Eka Jhonatan Kristina , Dhea Gresela Lilis Rosmainar Luviany, Mahwahdah Made Dirgantara Manurung, Tety Wahyuningsih Mauliyani Miranti Maya Sylvani Mokhamat Ariefin Muhammad Hilmi Afthoni Muhammad Irmawan Multazam Nababan, Jessicca Nainggolan, Yuni Nanda Nanda Natania Gracia, Amanda Nurliani, Navila Oksal, Efriyana Okta Prianus Oktaviani, Revalina Paksi, Pandu Gizta Rapi Pebriani, Nova Prahasti, Meidhita Pramudita, Dimas Pratama, Gilang Anggara Prianus, Okta Priscilia , Mei Shinta Prisnanda, Risky Purba, Abed Nego Putri , Dwi Chandri Kurnia Putri, Hanna Della Rahmi Wulandari, Oktavia Remi Ayu Pratika Retno Agnestisia Riandy Putra Rizki Rachmad Saputra Ryu Pratiwi, Djihan Savitri, Afridha Cita Simangunsong, Sri Yulandari Simbolon, Wenika Siti Unvaresi Misonia Beladona Steven , Kur Yehezkiel Sugiani, Tina Sulistiawati, Putri Suma, Joy Angel Aria Sun Theo Constan Lotebulo Ndruru Surbakti, Ranintha Br. Syaputra, Noor Angga Tanggara , Revi Hidayatullah Tesalonika, Lidya Tety Wahyuningsih Manurung Titik Andriani, Titik Toepak, Erwin Prasety Utami Irawati Wahyuningsih Manurung, Tety Wati, Laely Septiya Ysrafil, Ysrafil Yuliana Yuliana Yuliana Yuneta Yuyun Yuniarti, Yuyun Zahra, Laila Zimon Pereiz