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All Journal Global Medical and Health Communication Universa Medicina Jurnal Biomedika dan Kesehatan Jurnal Dharma Bhakti Ekuitas Bioscientist : Jurnal Ilmiah Biologi JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Asian Journal of Healthcare Analytics Jurnal Pengabdian Nasional (JPN) Indonesia Jurnal Kedokteran Meditek
Eveline Margo, Eveline
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Kadar Vitamin D dengan Sindrom Mata Kering pada Karyawan Margo, Eveline; Meiyanti, Meiyanti; Kartadinata, Erlani; Kartadinata, Noviani
Jurnal Biomedika dan Kesehatan Vol 6 No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.264-274

Abstract

Background Dry eye syndrome (DES) is the most common eye disease with a prevalence of around 5 – 50% of the worldwide population. In Indonesia alone, the prevalence of DES is around 27.5%. DES is a multifactorial disorder indicating that inflammation plays an important role in the pathophysiology of DES. The inflammation causes increased oxidative stress which can cause decreased tear production and inflammation on the ocular surface can cause an increase in excessive tear evaporation, causing instability of the tear film. Vitamin D has an anti-inflammation effect. The role of vitamin D in the eye through receptor vitamin D (VDR), which is expressed in the retinal pigment epithelium, retinal photoreceptors, ganglion cells layer, ciliary body, lens, cornea epithelium, and endothelium, as well as in aqueous humor, vitreous humor, and tears film. Vitamin D deficiency is said to have a contribution to DES. For that reason, this study aims to examine the relationship between vitamin D levels with DES. Methods The research design in this study was an observational analytic with a cross-sectional approach, which was followed by FK USAKTI employees in February – March 2021. Fifty-seven employees aged 25 – 60 were according to criteria and willing to take part in this study. OSDI questionnaire, Schimer’s test and tear break-up time (TBUT) were used to examine DES. Examination of vitamin D by measuring 25(OH)D levels. The data were analyzed using a chi-square test with significance level p<0.05. Results The vitamin D levels examination with DES using Schimer’s test was found to be unrelated (p=0.948), comparing vitamin D levels with the TBUT test, it was found significantly related to DES (p=0.030), meanwhile using the OSDI questionnaire was found to be unrelated (p=0.285). Conclusions There is a significant relationship between vitamin D levels and DES through TBUT examination.
Pterigium berhubungan dengan Sindroma Mata Kering pada Pengemudi Ojek Online Kartadinata, Erlani; Amalia, Husnun; Adiwardhani, Anggraeni; Witjaksana, Riani; Prasetyaningsih, Noviani; Margo, Eveline; Yohana, Yohana
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.71-81

Abstract

Background Dry eye syndrome (DES) is an eye disease caused by many factors involving the ocular surface, with characteristic damage to tear layer homeostasis accompanied by ocular symptoms due to tear layer instability, hyperosmolarity, damage and inflammation of the ocular surface, and neurosensory abnormalities. Delivery motorbike drivers are often on the streets where the role of environmental factors will be able to pose a risk of experiencing DES. This study aims to assess risk factors associated with the incidence of dry eye syndrome in delivery motorbike drivers.  The benefit of this research is to improve public health, especially in preventive behavior against factors associated with dry eye syndrome. Methods This study used observational analytical methods with a cross-sectional research design.  The selection of samples by consequential non-random sampling amounted to 124 with the criteria of inclusion of delivery motorbike drivers, exclusion of not using artificial tears eye drops, and not use of contact lenses.  Data were collected by filling out a DES risk factor questionnaire and a Tear Break Up Time (TBUT) examination to assess DES. The research data were analyzed using the Chi-Square test. Results This study's results show that subjects with dry eye syndrome are dominated by adults aged 19–44 and male sex. Subjects who experienced DES 76.6%, adult age 78.2%, male 80.6%, no pterygium 66.1%, working period 2-5 years 62.9%, length of work ≥8 hours 94.4%, always using a closed helmet 83.9%, not using protective glasses 39.5%, coffee consumption 71.8%, active smokers 66.1%, using gadgets >6 hours 91.9%.  There is no significant relationship between subjects' characteristics and DES (p>0.05). The incidence of DES in pterygium showed significant results (p= 0.001). Conclusions There is a significant relationship between the incidence of pterygium and DES.
Hubungan Kadar Magnesium dan Kebugaran dengan Tingkat Stress pada Pengemudi Ojek Online Chondro, Fransisca; Margo, Eveline; Handayani, Astri; Chudri, Juni
Jurnal Biomedika dan Kesehatan Vol 7 No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2024.v7.82-90

Abstract

Background Most countries around the world suffered from the high-level transmission COVID-19. Thus, the government enforced a policy for the citizens to work from home. These restrictions impact the mental health of the citizens, and the prevalence of stress increases. Some of the factors that affect stress are magnesium intake and physical fitness. The study found that magnesium levels and fitness are correlated with stress levels. But some studies got different results. Thus, learning more about the relationship between magnesium level, fitness, and stress level is necessary. Methods This is a cross-sectional design study with consecutive non-random sampling methods. This study involving online drivers was held in Kampus B, Fakultas Kedokteran Universitas Trisakti, in September 2022. The inclusion criteria are aged 15-64 years, willing to sign the informed consent, can communicate well, while the exclusion criteria are in the therapy of anti-depressant or anti-anxiety drugs, and has a history of heart attack within one month. Results Based on the data, it can be concluded that most respondents are male, from the middle-aged group, and suffer from obesity, and about 50% of the respondents suffer from high blood pressure. Most respondents have normal blood-magnesium levels and medium levels of stress, while all the respondents have poor or very poor physical fitness. On the Chi-square test between age, sex, body mass index, blood pressure, physical fitness and stress level, the level of significance consecutively are 0.645; 0.208; 0.364; 0.451 and 1.000. While on the Fisher test, the significance level between blood magnesium level and stress level is 0.099. Conclusions Based on the bivariate test, it can be concluded that there is no significant relationship between age, sex, body mass index, blood pressure, physical fitness and blood magnesium level with the stress level.
mRNA Relative Expression Catalase in Hypertension Yohana, Yohana; Faradilla, Meutia Atika; Meiyanti, Meiyanti; Hartanti, Monica Dwi; Margo, Eveline; Anastasya, Karina Shasri
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12825

Abstract

Hypertension is number one worldwide disease which lead to death. Initially hypertension is caused by changes in the walls of blood vessels. These vascular changes are due to the accumulation of ROS (Reactive Oxygen Species). ROS is the result of the balance between antioxidants and oxidants, but uncontrolled conditions will cause vascular damage. One of ROS product from metabolism which could played role in downregulation antioxidant gene expression is hydrogen peroxide. Hydrogen peroxide could be neutralized by catalase enzyme. Studies about catalase expression in hypertension subject is still limited. This research aims to determine mRNA relative expression catalase in hypertension. In this case control study, thrity subject hypertension and normotension subject were recruited within the age of 50-60 years. Hypertension subject was chosen according to JNC 8. Two millilitres vein blood was isolated into RNA. mRNA expression was detected by qRT PCR with 2 steps. Relative expression was determined using livak method. The data was analyzed using Mann Withney test with GraphPad software. Research results show that (1) catalase mRNA relative expression was 0,6 fold in hypertension; (2) catalase relative expression was not significantly lower in hypertension; (3) other antioxidants might have other mechanism to detoxify ROS and prevent hypertension.
Quick Sequential Organ Failure Assessment with Duration Stay for Intensive Care Patients Prajgayatri, Galena Devi; Margo, Eveline
Asian Journal of Healthcare Analytics Vol. 4 No. 2 (2025): November 2025
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ajha.v4i2.15521

Abstract

An important metric for managing managing patients with serious illnesses is the duration of stay in the intensive care unit (ICU). According to data from Indonesia (2023), 68.2% among patients who were given treatment in the ICU for at least five days. Although research on this topic is still unclear, the quick Sequential Organ Failure Assessment (qSOFA) score is employed to forecast organ failure and the probability of prolonged duration stay. The aim of this study is to ascertain whether ICU patients' duration of stay and their qSOFA score are related. Getting secondary data from ICU patients admitted from the emergency room between January and December 2024, this observational study with a retrospective cohort design was carried out at Rumah Sakit Angkatan Laut Dr. Mintohardjo, Jakarta. 205 participants that met the inclusion criteria were chosen through successive sampling from all patients. For statistical analysis, the chi-square test was used with a significance level of p = 0.05. 50.2% of the individuals were between the ages of 18 and 59, and 54.1% of them were men, with an average stay of 4.84±3.46 days, the most prevalent qSOFA score was 2 (43.9%). The duration of stay in the ICU did not significantly correlate with the qSOFA score (p value = 0.326, p > 0.05).
Co-Authors Alvina Lesmana, Alvina Anastasya, Karina Shasri Anggraeni Adiwardhani Erlani Kartadinata, Erlani Faradilla, Meutia Atika Fransisca Chondro, Fransisca Handayani, Astri Husnun Amalia, Husnun Juni Chudri Kartadinata, Noviani Kurniasari Lie Tanu Merijanti, Lie Tanu Meiyanti Meiyanti Meiyanti, Meiyanti Monica Dwi Hartanti, Monica Dwi Murthi, Aditya Prajgayatri, Galena Devi Prasetyaningsih, Noviani Pusparini Pusparini Rachmadanti, Tharisa Reni Zuraida sisca Wibowo, Elsi Septira Witjaksana, Riani Xavierees, Endrico Yohana Yohana Yohana