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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL FARMASIMED (JFM) Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Buana Farma Jurnal Abdimas Bina Bangsa Jurnal Abdimas Kartika Wijayakusuma Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Jurnal Kesehatan Masyarakat
Faizal Hermanto
Department Of Pharmacology And Toxicology, Faculty Of Pharmacy, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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PENGARUH RESVERATROL TERHADAP JALUR PERMEABILITAS BARU SEBAGAI TARGET KERJA ANTIMALARIA Haq, Fahmy Ahsanul; Hermanto, Faizal; Sutjiatmo, Afifah Bambang; Lutfi, Mutiara Hadi
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1157

Abstract

Plasmodium is a parasite that causes malaria, which is transmitted to humans through the bite of female Anopheles mosquitoes. Plasmodium that infects red blood cells will cause the formation of new permeability pathway (NPP) in the red blood cell membrane. This change makes the red blood cell membrane more permeable, allowing various nutrients the parasite needs to enter the red blood cells. Resveratrol is a polyphenol compound that is reported to have antimalarial activity by inhibiting the growth of Plasmodium berghei. This study aims to activate the activity of resveratrol in inhibiting NPP. The study began with the preparation of blood suspensions that showed infection and non-infection, then test preparations were added and induced using sorbitol, and then hemolysis was measured using a UV-visible spectrophotometer. The test group consisted of normal groups, control and various concentrations of resveratrol, namely 1.25, 2.5, 5, 10 and 20 μM. The observation parameters in this study were the percentage of hemolysis inhibition. Based on the study’s results, the percentage of hemolysis inhibition increased with increasing resveratrol concentration. The IC50 value of the NPP inhibition activity test of resveratrol was 1.025 μM. This study concludes that resveratrol can inhibit NPP in erythrocytes infected with Plasmodium berghei.
REVIEW: TINGKAT KESESUAIAN PENULISAN RESEP SESUAI FORMULARIUM RUMAH SAKIT Rachmawati, Ita; Hermanto, Faizal
Jurnal Abdimas Bina Bangsa Vol. 5 No. 2 (2024): Jurnal Abdimas Bina Bangsa
Publisher : LPPM Universitas Bina Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46306/jabb.v5i2.1269

Abstract

The hospital formulary is a list of drugs compiled by the Pharmacy and Therapy Team (TFT) and agreed upon by the medical staff and refers to the national formulary, which is determined and enforced by the hospital leadership. Discrepancies in drug prescriptions with the hospital formulary can result in a decrease in the quality of hospital services and inefficient costs used. This research aims to determine the percentage of prescriptions discrepancies with the hospital formulary. This research uses a narrative review method, namely by using articles or journals that were published in 2013-2023, a literature search was carried out on Pubmed and Google Scholar. The literature obtained was from 11 journals and was included in the inclusion criteria. The results obtained indicate that the percentage of conformity between prescription writing and the formulary has not reached 100%. This shows that the suitability of prescribing has not reached the minimum one hundred percent service standard set by the government
REVIEW: EVALUASI RASIONALITAS PENGGUNAAN OBAT ANTIHIPERTENSI DI BEBERAPA RUMAH SAKIT DI INDONESIA Gusdilla, Windy; Hermanto, Faizal
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1298

Abstract

Approximately 1 billion people, or about a quarter of the world's adult population, are estimated to suffer from hypertension, and this number continues to grow. By 2025, the number of people with hypertension is predicted to reach 1.6 billion. Inaccuracy in the use of drugs can lead to increased morbidity and mortality, especially in patients with chronic diseases. Therefore, the selection of drugs must always follow the established treatment standards. This review article aims to evaluate the rationality of the use of antihypertensive drugs in several hospitals in Indonesia. The method used is a narrative literature review through a search of 11 articles with publication years 2019-2024. Literature searches were conducted on the Google Scholar, PubMed, and ScienceDirect databases. The keywords used in the search are "Antihypertension and "Rationality". The results of the literature review indicate that the use of antihypertensive drugs in the hospital has been rational based on accurate diagnosis, accurate indication, accurate drug selection, accurate dosage, accurate method of administering drugs, accurate interval of administration, accurate duration of administration, and accurate assessment of patient conditions in accordance with existing therapy guidelines. Evaluation of the rationality of the use of antihypertensive drugs shows that the practice of this treatment in several hospitals in Indonesia is in accordance with the established standards, the use of antihypertensive drugs in the hospital is quite effective and safe for patients.
PERAN APOTEKER DALAM MENINGKATKAN HASIL PENGOBATAN PASIEN DIABETES TIPE 2: TINJAUAN INTERVENSI DI FASILITAS KESEHATAN INDONESIA Amelia, Riza; Hermanto, Faizal
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1342

Abstract

Type 2 diabetes mellitus is one of the chronic diseases with low treatment success rates. This article aims to assess the effectiveness of pharmacist interventions in improving treatment outcomes for patients with type 2 diabetes. The research method used is a narrative review through searching the PubMed and Google Scholar databases. This study reviewed journals from the years 2015 to 2025, resulting in 791 articles. A total of 11 articles met the inclusion criteria. The results of the research indicate that pharmacist interventions can significantly improve treatment outcomes, including increased adherence, improved quality of life for patients with type 2 diabetes, and achievement of stable glucose levels.
Tantangan Industri Farmasi Indonesia di Era Pandemik COVID-19 Windyaswari, Ari Sri; Hermanto, Faizal; Vikasari, Suci Nar; Riyanti, Soraya; Syam, Akhirul Kahfi; Febrinella, Catellya
Jurnal Abdimas Kartika Wijayakusuma Vol 1 No 2 (2020): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.939 KB) | DOI: 10.26874/jakw.v1i2.74

Abstract

Abstrak: Situasi pandemik COVID-19 di Indonesia mempengaruhi beberapa sektor penting, diantaranya adalah sektor kesehatan. Farmasi sebagai salah satu garda penting di bidang kesehatan mempunyai tugas fungsi pokok untuk menyediakan obat yang aman, berkhasiat dan berkualitas. Industri farmasi merupakan bagian terdepan yang memiliki peranan penting tersebut sekaligus merupakan bagian terdepan yang terkena dampak dari situasi pandemik COVID-19. Tekanan untuk penemuan vaksin/obat baru sebagai antivirus COVID19 hingga produksi vitamin dan produk nutrisi lain sebagai upaya preventif untuk melindungi masyarakat Indonesia dari peningkatan penularan virus COVID-19 di Indonesia menghadapi berbagai kendala. Pembatasan Sosial Berskala Besar (PSBB), kegiatan karantina serta isolasi merupakan salah satu kendala di dalam bidang produksi. Disisi lain, permintaan akan produk obat meningkat tajam. Apoteker industri dan apoteker komunitas bekerja sama untuk memastikan ketersediaan dan efek terapi obat dapat digunakan oleh masyarakat Indonesia. Tujuan dilaksanakannya webinar ini adalah untuk mengubah paradigma permasalahan menjadi suatu tantangan yang harus diselesaikan oleh sejawat apoteker di seluruh Indonesia. Metode webinar dilaksanakan melalui penyampaian materi dan diskusi panel dari platform ZOOM dan youtube. Hasil post test yang dilaksanakan terhadap 1.700 peserta secara garis besar menunjukkan pemahaman dan kepedulian masyarakat dalam mengatasi berbagai permasalahan di bidang farmasi industry Indonesia. Kata kunci: Apoteker, Industri Farmasi, COVID-19.
UJI AKTIVITAS EKSTRAK ETANOL 50% AKAR GINSENG JAWA (Talinum paniculatum Jacq. (Gaert)) SEBAGAI INHIBITOR STRESS OKSIDATIF Rachmawan, R. Lucky; Wahyuningsih, Sri; Suryani; Hermanto, Faizal; Rochmah, Nur Syifa
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1391

Abstract

Oxidative stress is a condition in which an imbalance occurs between the production of free radicals and the body’s antioxidant defense system, potentially leading to various degenerative diseases. Java ginseng (Talinum paniculatum Jacq. (Gaertn)) is a medicinal plant known to contain bioactive compounds with free radical–reducing potential. This study aimed to identify the mechanism of nitric oxide (NO) inhibition through the decomposition of sodium nitroprusside in the Reactive Nitrogen Species (RNS) pathway and to evaluate the increase of catalase enzyme activity in the Reactive Oxygen Species (ROS) pathway using 50% ethanol extract of Java ginseng root. The root extract was obtained using Soxhlet extraction with 50% ethanol as the solvent, and five different extract concentrations were tested: 20, 40, 60, 80, and 100 μg/mL. Antioxidant activity was assessed by measuring the inhibition of NO radical formation and the enhancement of catalase activity, with vitamin C as a comparator. The ethanol extract of Java ginseng root inhibited NO radical formation with an IC50 value of 42.45 μg/mL, which is classified as a very strong antioxidant. In comparison, vitamin C showed an IC50 of 6.47 μg/mL, also categorized as very strong. Furthermore, the extract increased catalase activity proportionally to its concentration, although the effect was still lower than that of vitamin C. These results indicate that the 50% ethanol extract of Java ginseng root possesses significant potential as an oxidative stress inhibitor through NO inhibition and catalase activation, though its effectiveness remains lower than vitamin C.
The Ins and Outs of Alpha-mangostin’s Potential as an Antimalarial Tjahjani, Susy; Hermanto, Faizal; Muchtaridi, Muchtaridi; Aulifa, Diah Lia; Ahsanul Haq, Fahmi
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.19307

Abstract

Malaria drug resistance, including to development of resistance against artemisinin based treatments, poses a major challenge to elimination efforts. Alpha-mangostin, an antioxidant with in vitro antimalarial activity, is hindered by its poor solubility. This study explores the antimalarial effects of water-soluble alpha-mangostin chitosan-alginate nanoparticles (ACAN) in mice with berghei malaria. Mice were treated with various doses of ACAN, compared to alpha-mangostin in polyethylene glycol (PEG), as well as in corn oil (ACO) and chloroquine as a standard. Growth inhibition rates were assessed, revealing no inhibition in the PEG and normal control (NC) groups, while ACO was less active. The effective dose 50 (ED50) of ACAN was 264.5 mg/kg BW, containing only 15.87 mg of alpha-mangostin, suggesting that alpha-mangostin in ACAN may offer promising in vivo antimalarial activity. Further investigation is needed.
In Vivo Uricosuric Effect of Red Betel Leaves (Piper crocatum RUIZ & PAV) Ethanol Extract Hermanto, Faizal; Wahyuningsih, Sri
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.2135

Abstract

Hyperuricemia a condition where a person has high levels of uric acid in the blood. Red betel (Piper crocatum RUIZ & PAV) is a plant empirically used to reduce uric acid levels. This study aimed to determine the effective dose of red betel plant in reducing urinary uric acid levels in male Wistar rats with hyperuricemia. Hyperuricemia condition was obtained by giving chicken liver juice 25 mL/kg orally and potassium oxonate 250 mg/kg intraperitoneally. Red betel extract (RBE) is made by maceration using 50% ethanol. Male Wistar rats were divided into five groups: negative control (CMC-Na 0.5%), Positive control (Probenecid 4, 5 mg/kg), and extract at doses 11.5, 23 and 46 mg/kg.  The results showed that the RBE increased uric acid secretion through urine (uricosuric) compared to controls. The optimal dose for the uricosuric effect of the extract is 46 mg/kg, although this effect is lower than probenecid.   Keywords:          Red betel, uric acid, potassium oxonate, uricosuric
Evaluation of The Chloroquine and Resveratrol Combination in Inhibiting β-Hematin Formation In Vitro Hermanto, Faizal; Wahyuningsih, Sri; Zamzami Adnan, Risky
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jxpeda42

Abstract

Malaria, caused by the Plasmodium parasite, remains a significant global health issue, exacerbated by drug resistance. This study aimed to explore the potential of combining chloroquine (CQ) and resveratrol in inhibiting β-hematin formation, a key process in the parasite's detoxification mechanism. The research began with the preparation of various concentrations of CQ and resveratrol, which were then combined and tested for their effects on inhibiting β-hematin in vitro using an ELISA reader. The results showed that both CQ and resveratrol individually inhibited β-hematin formation at moderate levels. However, their combination demonstrated a significant increase in inhibition, with the most effective combination being CQ at 164.03 μM and resveratrol at 0.98 μM. Statistical analysis confirmed that this combination was far more effective than using each compound separately. The study concluded that the combination of CQ and resveratrol can enhance the inhibition of β-hematin formation, providing a promising approach to improving malaria treatment efficacy, especially in the face of increasing drug resistance.
Evaluation of The Rationality of Hypertension Medication Use in Puskesmas Central Cimahi Hermanto, Faizal; Choirunissa, Anna; Sutarna, Titta Hartyana; Amelia, Riza; Rizwan, Akmal
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8673

Abstract

A persistent and abnormal increase in blood pressure in the arteries is known as hypertension (HT. This research aims to assess the consumption of antihypertension at the Puskesmas Central Cimahi. Non-analytical descriptive methods were used in this investigation. Retrospective data was collected by accessing patient prescriptions and medical record data. Fifty-six patient samples in this study met the inclusion requirements. Quantitative and qualitative methods are used to evaluate rationality. Quantitative data analysis is processed to determine the number of patients, gender, age, and type of drug classification. Qualitative data analysis is processed to evaluate the appropiate of the indication, drug, patient and dose. Based on the research results, 52 people suffered from stage 1 hypertension, and four patients suffered from stage 2 hypertension. Amlodipine monotherapy was the most frequently prescribed drug, namely 92%. While the combination of amlodipine, captropil, amlodipine, and hydrochlorothiazide amounted to 4%. The rationality of treating hypertensive patients who meet the right indications, the right drug, the right patient and the right dose is 100%. It can be concluded that the evaluation and use of hypertension medication at the Puskesmas Central Cimahi as a whole meets the criteria for rational treatment.
Co-Authors Achmad Zainuddin Ade Kania Ningsih, Ade Kania Adiningsih, Martha Afifah Bambang Sutjiatmo, Afifah Bambang Ahsanul Haq, Fahmi Akhirul Kahfi Syam Andreanus A Soemardji Ari Sri Windyaswari, Ari Sri Arif Rahman Hakim Arifianti Essen, Amanda Choirunissa, Anna Diah Lia Aulifa Elin Yulinah Sukandar Euis Julaeha Fahrauk Faramayuda, Fahrauk Fani Wahyuni, Fani Febrinella, Catellya Fikri Alatas Gusdilla, Windy Haq, Fahmy Ahsanul Hartyana Sutarna, Titta Hasna Hestiary Ratih Lilis Siti Aisyah, Lilis Siti Linda Purnamawati Suherman Lutfi, Mutiara Hadi Mochammad Luthfi Pramukti, Mochammad Luthfi Muchtaridi Muchtaridi Nur Melsandy Pratama, Gumilar Puspa Sari Dewi Putra , Erwin Ekadharma Rachmawan, Lucky Rachmawan, R. Lucky Rachmawati, Ita Rani Sugandi, Rani Refiani , Aqila Ririn Puspadewi, Ririn Riskia Putri Peratiwi, Riskia Putri Riza Amelia Riza Amelia Rizwan, Akmal Rochmah, Nur Syifa Sembiring, Rinawati Shalsabina, Vina Simatupang, Elivas Siti Nur Aeni, Siti Nur Soraya Riyanti, Soraya Sri Wahyuningsih Sri Wahyuningsih Suci Nar Vikasari, Suci Nar SURYANI Susy Tjahjani Tati Herlina Tri Reksa Saputra, Tri Reksa Unang Supratman Yenny Febriani Yun, Yenny Febriani Yuliana Agustin Zamzami Adnan, Risky