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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL FARMASIMED (JFM) Pharmacoscript Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Buana Farma Jurnal Abdimas Bina Bangsa Jurnal Abdimas Kartika Wijayakusuma Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Jurnal Kesehatan Masyarakat Journal of Pharmascience
Faizal Hermanto
Program Studi Farmasi, Fakultas Farmasi, Universitas Jenderal Achmad Yani, Cimahi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Evaluation of The Chloroquine and Resveratrol Combination in Inhibiting β-Hematin Formation In Vitro Faizal Hermanto; Sri Wahyuningsih; Risky Zamzami Adnan
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jxpeda42

Abstract

Malaria, caused by the Plasmodium parasite, remains a significant global health issue, exacerbated by drug resistance. This study aimed to explore the potential of combining chloroquine (CQ) and resveratrol in inhibiting β-hematin formation, a key process in the parasite's detoxification mechanism. The research began with the preparation of various concentrations of CQ and resveratrol, which were then combined and tested for their effects on inhibiting β-hematin in vitro using an ELISA reader. The results showed that both CQ and resveratrol individually inhibited β-hematin formation at moderate levels. However, their combination demonstrated a significant increase in inhibition, with the most effective combination being CQ at 164.03 μM and resveratrol at 0.98 μM. Statistical analysis confirmed that this combination was far more effective than using each compound separately. The study concluded that the combination of CQ and resveratrol can enhance the inhibition of β-hematin formation, providing a promising approach to improving malaria treatment efficacy, especially in the face of increasing drug resistance.
Resveratrol Reduce the Severity of Anemia and Thrombocytopenia in Plasmodium berghei ANKA-Infected Mice Faizal Hermanto; Aqila Refiani; Fahmi Ahsanul Haq
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.266-271

Abstract

Background: Malaria is an infectious disease with a high mortality rate. One of the complications of malaria is blood disorders. Hematological disorders such as anemia and thrombocytopenia are common in malaria infection. Resveratrol has been reported to have antimalarial activity. Objective: This study aimed to evaluate the effect of resveratrol in reducing the severity of anemia and thrombocytopenia in Plasmodum berghei-infected mice. Methods: The study began with parasite inoculation in mice. After the mice were infected, and randomly grouped into negative control, chloroquine 20 mg/kg (positive control), and resveratrol with doses 25, 50, and 100 mg/kg. The mice's blood profile was measured on day 0 and day 4 using a hematology analyzer. Results: The results showed that after administration of resveratrol at various doses, the number of RBC, hemoglobin, hematocrit and platelets was higher than the control. Conclusion: It can be concluded that resveratrol can reduce the severity of anemia and thrombocytopenia in mice infected with P. berghei.
The Rationality of Drug Therapy in Pulmonary Anti-Tuberculosis Patients at Puskesmas Cimahi Tengah Linda Purnamawati Suherman; Muhammad Abdul Rozzaaq; Robby Ramdani; Riza Amelia; Faizal Hermanto; Vina Septiani; Alfi Nurul Islamiyah
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 3 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i32025.382-390

Abstract

Background: Tuberculosis (TB) is a significant global health challenge in Indonesia. The rational use of anti-TB drugs is essential for treatment success and for preventing drug resistance in patients with TB. Objectives: This study aimed to evaluate the rationality of anti-TB drug use in patients with pulmonary TB at the Cimahi Tengah Public Health Center (Puskemas Cimahi Tengah). Methods: This research employed a descriptive method with a retrospective approach based on observational data from the Tuberculosis Information System (SITB) between January and December 2023. Samples were selected using purposive sampling based on the predefined inclusion and exclusion criteria. Results: The results showed that All patients (100%) received treatment according to the national guidelines and WHO recommendations, including the HRZE regimen (rifampicin, isoniazid, pyrazinamide, and ethambutol). The accuracy of indication, drug selection, dosage, and administration intervals also reached 100%, demonstrating adherence to the clinical standards. Conclusion: Anti-TB drug use at the Cimahi Tengah Public Health Center complies with established treatment standards, ensuring treatment effectiveness and contributing to optimal patient outcomes.
ANALISIS TINGKAT KEPUASAN PASIEN JKN TERHADAP PELAYANAN KEFARMASIAN MENGGUNAKAN METODE SERVQUAL DAN IMPORTANCE PERFORMANCE ANALYSIS (IPA) DI SALAH SATU PUSKESMAS KOTA CIMAHI Ramdani Robby; Dewi Puspa Sari; Islamiyah Alfi Nurul; Hermanto Faizal; Putri Imeldha R Pramesty
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2348

Abstract

Kebijakan pelayanan berjenjang dalam program Jaminan Kesehatan Nasional (JKN) menyebabkan meningkatnya beban pelayanan di Fasilitas Kesehatan Tingkat Pertama (FKTP) seperti Puskesmas, sehingga berpotensi menurunkan mutu pelayanan, termasuk pelayanan kefarmasian. Kondisi ini dapat berdampak pada kepuasan pasien, yang merupakan indikator penting kualitas pelayanan. Pelayanan ini bertujuan untuk menganalisis tingkat kepuasan pasien JKN terhadap pelayanan kefarmasian di salah satu Puskesmas Kota Cimahi, serta menentukan prioritas perbaikan dan atribut layanan yang perlu dipertahankan menggunakan metode Service Quality (ServQual) dan Importance Performance Analysis (IPA). Penelitian ini menggunakan desain deskriptif cross sectional dengan metode purposive sampling terhadap 378 responden yang memenuhi kriteria inklusi. Data diperoleh melalui kuesioner yang teruji validitas dan reliabilitasnya, kemudian dianalisis menggunakan SPSS Statistic 30. Hasil penelitian menunjukkan bahwa seluruh analisis ServQual-IPA memiliki nilai gap negatif, dengan urutan kesenjangan terbesar pada dimensi Jaminan (-0,21;0,94), Empati (-0,19;0,95), Kehandalan (-0,12;0,96), Bukti Fisik (-0,11;0,97) dan Daya Tanggap (-0,08;0,97). Berdasarkan analisis IPA, waktu tunggu pelayanan obat dan kejelasan informasi penggunaan obat termasuk dalam prioritas utama perbaikan (Kuadran I), sedangkan atribut yang harus dipertahankan meliputi fasilitas prioritas bagi ibu hamil dan lansia, keramahan petugas, ketersediaan obat, serta pelayanan konseling (Kuadran II). Penelitian ini menunjukkan bahwa perbaikan sistem antrian, optimalisasi SDM farmasi, dan peningkatan komunikasi terapeutik perlu menjadi fokus utama Puskesmas untuk meningkatkan mutu pelayanan kefarmasian dan memperkuat kepercayaan peserta JKN terhadap pelayanan kesehatan primer.
REVIEW: KETERSEDIAAN OBAT INDIKATOR DAN DISPARITAS WILAYAH PADA UPTD FARMASI DINAS KESEHATAN DI INDONESIA Dora Dewi Rahmahwati; Faizal Hermanto
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1675

Abstract

Drug availability is one of the main indicators of the quality of health services in Indonesia. Effective drug planning and distribution in the Regional Technical Implementation Unit (UPTD) of the Health Office Pharmacy is key to ensuring public access to essential drugs. This review aims to evaluate drug planning and distribution indicators in the UPTD Pharmacy of Health Offices throughout Indonesia based on recent published studies. A narrative review was conducted through a systematic search of academic databases for the period 2024-2025. Inclusion criteria included studies that evaluated drug planning, distribution, and availability in Indonesian health facilities. Data extracted included study location, study design, sample size, drug availability rate, planning accuracy, and stock-out rate. Of the 12 studies analyzed, drug availability rates varied between 78.5% and 95.2%, with an average of 87.5%. Medicine planning accuracy ranged from 75.2% to 98.5%. Stock-out rates showed significant variation between 4.1% and 22.1%, with an average of 13.7%. The study in Medan with the implementation of Distribution Requirement Planning showed the best results with 95.2% availability and 98.5% planning accuracy. Eastern Indonesia, such as Keerom and East Sumba, showed lower performance with availability below 85%. There are significant disparities in drug planning and distribution between regions in Indonesia. The implementation of integrated information systems and data-based planning methods such as Distribution Requirement Planning can improve drug availability and reduce stockouts. Special attention is needed in remote and eastern regions of Indonesia to improve access to essential drugs.
EFEKTIVITAS DAN IMPLEMENTASI REJIMEN BERBASIS DOLUTEGRAVIR PADA PASIEN HIV DI INDONESIA: TINJAUAN TERHADAP OUTCOME KLINIS DAN TANTANGAN PELAYANAN Faizal Hermanto; Sylvia Octora Dewi
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1679

Abstract

Dolutegravir-based regimens, including TLD (Tenofovir-Lamivudine-Dolutegravir), have become the first-line therapy recommended by WHO for HIV treatment. Indonesia has adopted this regimen in accordance with the Minister of Health Regulation No. 23/2022. This review analyzes the clinical effectiveness and implementation of dolutegravir-based regimens in HIV patients based on data from various health facilities in Indonesia. The purpose of this review article is to analyze the clinical outcomes of dolutegravir-based regimens, including viral load suppression, quality of life, and patient adherence. This review was conducted through a comprehensive search in the PubMed and Google Scholar databases for the period 2015-2025. The search query included the keywords “TLD regimen”, “dolutegravir”, “HIV”, “viral load suppression”, “Indonesia”, “clinical effectiveness”, “tenofovir”, and “lamivudine”. Articles were selected based on studies conducted in Indonesian healthcare facilities, involving adult HIV patients receiving dolutegravir-based regimens, and reporting clinical outcomes or program implementation. Six articles met the inclusion criteria and were analyzed. Results showed that dolutegravir-based regimens have good clinical outcomes in various health facilities in Indonesia. Studies in Palembang demonstrated high viral load suppression among patients receiving antiretroviral therapy. Multi-center studies showed significant improvement in quality of life after switching from nevirapine-based to dolutegravir-based regimens. Studies at the primary care level underscored the importance of medication adherence and adequate monitoring. The review concluded that dolutegravir-based regimens demonstrated good clinical effectiveness with diverse outcomes in HIV patients in Indonesia. Implementation requires strengthening viral load monitoring, adherence management, and capacity building at the primary care level.
SYSTEMATIC REVIEW RASIONALITAS ANTIHIPERTENSI PADA PREEKLAMSIA DI BEBERAPA RUMAH SAKIT DI INDONESIA MENGGUNAKAN PENDEKATAN PRISMA Yastin Nurfauziah; Faizal Hermanto
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1681

Abstract

Globally, preeclampsia is one of the main contributors to maternal mortality. In Indonesia, discrepancies between clinical practice and guideline recommendations for antihypertensive use in preeclampsia cases remain relatively high, potentially increasing risks for both mothers and fetuses. This study is a PRISMA-based systematic review that aims to evaluate the rational use of antihypertensive drugs in preeclampsia patients across various hospitals in Indonesia. A literature search was conducted in PubMed and Google Scholar for the period 2015–2025, identifying 76 articles, of which 11 met the inclusion and exclusion criteria. Most studies assessed three parameters of rationality—appropriate drug, appropriate indication, and appropriate dose—with mean adherence rates of 92.55%, 91.69%, and 86.73%, respectively. Nifedipine was the most commonly used first-line agent, while methyldopa was frequently used as an alternative or in combination; however, several hospitals still reported the use of drugs that are not recommended, such as candesartan. Variations in practice were mainly related to limited availability of first-line drugs and inconsistent implementation of dosing protocols, as reflected by one hospital where dose appropriateness reached only 5.3%. Overall, the use of antihypertensive therapy for preeclampsia in Indonesia is generally in line with existing guidelines; nevertheless, equitable access to essential medicines and ongoing training for healthcare workers are still needed to address therapy discrepancies arising from resource limitations.
The Ins and Outs of Alpha-mangostin’s Potential as an Antimalarial Susy Tjahjani; Faizal Hermanto; Muchtaridi Muchtaridi; Diah Lia Aulifa; Fahmi Ahsanul Haq
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.19307

Abstract

Malaria drug resistance, including to development of resistance against artemisinin based treatments, poses a major challenge to elimination efforts. Alpha-mangostin, an antioxidant with in vitro antimalarial activity, is hindered by its poor solubility. This study explores the antimalarial effects of water-soluble alpha-mangostin chitosan-alginate nanoparticles (ACAN) in mice with berghei malaria. Mice were treated with various doses of ACAN, compared to alpha-mangostin in polyethylene glycol (PEG), as well as in corn oil (ACO) and chloroquine as a standard. Growth inhibition rates were assessed, revealing no inhibition in the PEG and normal control (NC) groups, while ACO was less active. The effective dose 50 (ED50) of ACAN was 264.5 mg/kg BW, containing only 15.87 mg of alpha-mangostin, suggesting that alpha-mangostin in ACAN may offer promising in vivo antimalarial activity. Further investigation is needed.
Co-Authors Abda Abda Achmad Zainuddin Ade Kania Ningsih, Ade Kania Adedhyfa Ayuning Tyas Adiningsih, Martha Afifah Bambang Sutjiatmo, Afifah Bambang Akhirul Kahfi Syam Akmal Rizwan Alfi Nurul Islamiyah Amanda Arifianti Essen Andreanus A Soemardji Anna Choirunissa Aqila Refiani Ari Sri Windyaswari Arif Rahman Hakim Diah Lia Aulifa Dora Dewi Rahmahwati Elin Yulinah Euis Julaeha Fahmi Ahsanul Haq Fahrauk Faramayuda, Fahrauk Fani Wahyuni, Fani Febrinella, Catellya Fikri Alatas Gusdilla, Windy Haq, Fahmy Ahsanul Hartyana Sutarna, Titta Hasna Hestiary Ratih Islamiyah Alfi Nurul Lilis Siti Aisyah, Lilis Siti Linda Purnamawati Suherman Lutfi, Mutiara Hadi M. Yogi Riyantama Isjoni Mochammad Luthfi Pramukti, Mochammad Luthfi Muchtaridi Muchtaridi Muhammad Abdul Rozzaaq Nur Melsandy Pratama, Gumilar Putra , Erwin Ekadharma Putri Imeldha R Pramesty Rachmawan, Lucky Rachmawan, R. Lucky Rachmawati, Ita Ramdani Robby Rani Sugandi, Rani Ririn Puspadewi Riskia Putri Peratiwi, Riskia Putri Risky Zamzami Adnan Riza Amelia Riza Amelia Riza Amelia Riza Amelia Robby Ramdani Rochmah, Nur Syifa Sembiring, Rinawati Shalsabina, Vina Simatupang, Elivas Siti Nur Aeni, Siti Nur Solihah, Puspa Sari Dewi Soraya Riyanti Soraya Riyanti, Soraya Sri Wahyuningsih Sri Wahyuningsih Suci Nar Vikasari, Suci Nar Suherman, Linda Purnamawati SURYANI Susy Tjahjani Sylvia Octora Dewi Tati Herlina Tri Reksa Saputra, Tri Reksa Unang Supratman Vina Septiani Viola Aditya Nurhayati Yastin Nurfauziah Yenny Febriani Yun, Yenny Febriani Yuliana Agustin