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All Journal HAYATI Journal of Biosciences Perspektif : Review Penelitian Tanaman Industri Indonesian Journal of Pharmaceutical Science and Technology Elkawnie Majalah Obat Tradisional Abditani : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Farmasi Farmasyifa Perspektif, Review Penelitian Tanaman Industri Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Riset Informasi Kesehatan AGRIC kawanad Jurnal Medika: Medika Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacon: Jurnal Farmasi Indonesia Jurnal Farmasi Galenika
Akhirul Kahfi Syam
Fakultas Farmasi Universitas Jenderal Achmad Yani
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Control & Systems Engineering Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Pharmacon: Jurnal Farmasi Indonesia

 1 
Effect of Different Solvents on Toxicity and Secondary Metabolites of Mangkokan Leaves (Polyscias scutellaria (Burm.f.) Fosberg) by Brine Shrimp Lethality Test (BSLT) Method Syam, Akhirul Kahfi; Sabilia, Syahra Asfi; Riyanti, Soraya
Pharmacon: Jurnal Farmasi Indonesia Vol. 21 No. 1 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i1.3185

Abstract

Mangkokan (Polyscias scutellaria (Burm.f.) Fosberg) is one of the plants belonging to the Araliaceae family. Empirically, mangkokan plants, especially the leaves, are used by the community as traditionalmedicine. Mangkokan leaves need to be developed into a source of natural materials such as biopesticides, biolarvicide, and anticancer agents because they have toxic compounds. Secondary metabolite compounds of mangkokan leaves consist of flavonoids, saponins, monoterpenes-sesquiterpenes, and steroids. This study aims to determine the toxicity of n-hexane, ethyl acetate, and ethanol extracts of mangkokan leaves using the Brine Shrimp Lethality Test (BSLT) method. Mangkokan leaves were extracted by graded maceration method using n-hexane, ethyl acetate, and 96% ethanol solvents. All three extracts were tested BSLT on Artemia salina larva test animals. The toxicity level is expressed by the LC50 value obtained from the probit analysis. The LC50 value of n-hexane, ethyl acetate, and ethanol extracts was 146.724 μg/mL, respectively; 66.029 μg/mL; and 92.007 μg/mL. The results showed that all three extracts were toxic.
Co-Authors Adinda Fitriani Adinugraha, Irham M. Akbar, Tzazkia Febriyana Amedea, Esanda Zulfi Ami Soega Dwigantina Ananda Tunjung Pertiwi Anggita Esa Putri Fitrichia Anna Choirunnisa Anna Choirunnisa, Anna Aprilia, Trialisa Ari Sri Windyaswari Ari Sri Windyaswari Ari Sri Windyaswari Ari Sri Windyaswari, Ari Sri Azhar, Farah Salsabilla Saidah Dadan Suryasaputra Desti Hermawati Dewi, Renti Mutiara Dewilestari, Meyra Pratami Dwi Ayu Pratiwi Dwigantina, Ami Soega Elfahmi Elfahmi, Elfahmi Ema Mutya Esanda Zulfi Amedea Fahrauk Faramayuda Fahrauk Faramayuda, Fahrauk Faizal Hermanto Farah Salsabilla Saidah Azhar Faramayudha, Fahrauk Farhan Febrinella, Catellya Fitriani, Adinda Fitrichia, Anggita Esa Putri Florence Meliawaty Handayani, Dewi Ratih Hermawati, Desti Hestiary Ratih Ismail, Nursafira Khairunnisa Jaka Permana Julia Ratnawati Julia Ratnawati Julia Ratnawati Julia Ratnawati, Julia Juliastuti, Henny Khaerunnisa, Rahmadaniah Komar Ruslan Wirasutisna Lahagu, Helga Nitulo Berliana Limbong, Remare Halomoan Mardiana, Grace Selly Meyra Pratami Dewilestari Muhamad Insanu Muhammad Irwan Mutya, Ema Nandi Agustian Pertiwi, Ananda Tunjung Pratiwi, Dwi Ayu Purwoko, Agus Puspita Satriyani Permatasari Surasa Putri, Dhiffa Namira Alifia Rahaju, Asih Rakhmat, Iis Inayati Ramdhani, Amalia Kusuma Remare Halomoan Limbong Renata Ananda Marthasedana Renti Mutiara Dewi Sabilia, Syahra Asfi Sabirin, Indah Puti R. Septiani, Usi Septiani, Vina Sheila Nur Hasanah Sheila Nur Hasanah Sigid Pamungkas Wicaksono Soraya Riyanti Soraya Riyanti Soraya Riyanti Soraya Riyanti, Soraya Sri Restu Andriyani Suci Nar Vikasari, Suci Nar Sufyan Zainul Arifin Sukrasno Suntana, Mutiara Sukma Surasa, Puspita Satriyani Permatasari SURYANI Totik Sri Mariani Trialisa Aprilia Usi Septiani Vina Septiani Wulan Anggraeni Wulandari, Yesi Yeni Karlina Yeni Karlina Yeni Karlina, Yeni Yesi Wulandari Yuslianti, Euis Reni