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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Pendidikan Biolearning Journal Jurnal Abdimasa PREPOTIF : Jurnal Kesehatan Masyarakat Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Jurnal Promotif Preventif Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO International Journal of Health, Economics, and Social Sciences (IJHESS) Jurnal EduHealth Jurnal Sains dan Teknologi Sci-Tech Journal Jurnal Ilmiah Ilmu Terapan Universitas Jambi Jurnal Etnofarmasi Jurnal Mahasiswa Ilmu Kesehatan Journal of Public Health and Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmu Kesehatan
Lukman Hardia
Universitas Pendidikan Muhammadiyah Sorong
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Antibacterial Activity Test of Passiflora Foetida Linn Leaves Extract on Propionibacterium Acne Arni, Veni Zafi; Irwandi, Irwandi; Hardia, Lukman
Journal La Medihealtico Vol. 5 No. 3 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i3.1346

Abstract

Acne is a chronic inflammatory skin disease affecting the sebaceous glands, primarily caused by the growth of Propionibacterium acne. A significant natural antibacterial agent against the bacteria is Rambusa (Passiflora foetida Linn) leaves, which contain active compounds such as alkaloids, flavonoids, tannins, saponins, and terpenoids/steroids. Therefore, this research aimed to evaluate antibacterial activity of ethanol extract from Rambusa leaves against Propionibacterium acne growth and determine the effective concentration of test solution inhibiting bacteria growth. The leaves were subjected to extraction through the maceration method using 96% ethanol solvent. The resulting extract was tested for antibacterial activity using the disc diffusion method. This research used three concentrations, including 10% b/v, 15% b/v, and 20% b/v. The positive control used 2 µg clindamycin disks, and the negative control used aqua pro injection. The analysis results showed that there was no clear zone area around disks containing Rambusa leaves extract at any concentration. In conclusion, the ethanol extract of leaves lacked antibacterial activity against Propionibacterium acne.
ANALISIS PENGELOLAAN OBAT TAHAP PENGGUNAAN PADA PASIEN BPJS RAWAT INAP DI INSTALASI FARMASI RSUD Dr. J. P. WANANE KABUPATEN SORONG ulandari, clarista windi; Budiyanto, Angga Bayu; Hardia, Lukman
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 5 No 02 (2024): HERCLIPS VOL 05 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v5i02.6936

Abstract

Tahap penggunaan memiliki peran penting dengan tujuan agar memberikan obat yang tepat, rasional, efektif, aman dan ekonomis. Penggunaan obat jika dilakukan secara efisien tentu akan memberikan manfaat yang optimal bagi rumah sakit selaku penyelenggara pengobatan ataupun pasien yang merasakannya. Tujuan penelitian ini untuk mengetahui capaian standar tahap penggunaan pada pasien BPJS rawat inap di instalasi farmasi menurut WHO 1993 di RSUD Dr. J.P. Wanane Kabupaten Sorong yang mencakup beberapa parameter yaitu, rata-rata jumlah item obat perlembar resep, obat yang diresepkan sesuai dengan formularium rumah sakit, obat dengan nama generik, obat antibiotik, dan sediaan injeksi bulan januari-juni 2022 di Instalasi Farmasi RSUD Dr. J.P. Wanane Kabupaten Sorong. Penelitian ini merupakan penelitian deskriptif dengan cara pengambilan data secara retrospektif pada bulan Januari-Juni 2022 berupa resep pasien bpjs rawat inap di Instalasi Farmasi RSUD Dr. J.P. Wanane Kabupaten Sorong. Hasil penelitian menunjukan Tahap Penggunaan obat yang sudah sesuai standar adalah obat dengan nama generik (84,26%) dan Tahap Penggunaan obat yang belum sesuai standar adalah item obat perlembar resep (3,5%), obat yang diresepkan sesuai formularium rumah sakit (98,71%), obat dengan antibiotik (23,27%), obat dengan injeksi (18,45%)
Analgesic Effectiveness of ant Nest Ethanol Extract (Myrmecodia Pendens) on white Mice (Mus Musculus) Maulana, Fajar; Lukman Hardia; Angga Bayu Budiyanto
International Journal of Health, Economics, and Social Sciences (IJHESS) Vol. 6 No. 4: October 2024
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/ijhess.v6i4.5901

Abstract

Pain is an unpleasant sensation emotionally and subjectively, indicating damaged tissue such as inflammation or a more significant condition. Myalgia, or often known as muscle pain. In Indonesia, the percentage of Myalgia sufferers is around 45-59%. This study applies an experimental method with a pretest-posttest group design. In this study, 25 mice were used which were divided into 5 groups, namely negative control (Na CMC 1%), positive control (mefenamic acid) and 3 groups given a dose of ant nest extract (17.5 mg/kgBW, 35 mg/ kgBW, 70 mg/kgBW). The analgesic effectiveness test used was the hot plate method with the writhing response parameter measured for 3 hours with a measurement interval of every 30 minutes. The results showed that the ethanol extract of ant nests showed positive tannin, alkaloid and flavonoid compounds. Data analysis on the comparison of dose groups showed that the doses of 17.5 mg and 35 mg had a significant value of <0.05 with a dose of 70 mg, in the positive control group had a significant value of >0.05 compared to the 70 mg ant nest extract dose group, which means there is no significant difference between the two. On the contrary, the negative control group showed a significant value of <0.05 compared to all treatment groups, which indicates a significant difference. The conclusion of this study is that the dose of ethanol extract of ant nest 70 mg has good analgesic effectiveness, approaching the effectiveness of the positive control of mefenamic acid.
TESTING THE ANTIHYPERGLYCEMIC POTENTIAL OF THE ETHANOL EXTRACT OF PAPUAN ANTS' NESTS (Myrmecodia pendans) ON MENCIT (Mus musculus) fania, vikafania; Hardia, Lukman; Astuti, Ratih Arum
Jurnal Ilmiah Ilmu Terapan Universitas Jambi Vol. 7 No. 2 (2023): Volume 7, Nomor 2, December 2023
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jiituj.v7i2.31654

Abstract

The use of synthetic drugs has potential pose a risk of complications in sufferers of hyperglycemia. WHO recommends the use of traditional medicine to prevent & treat chronic diseases. The problem formulation includes the effectiveness of the original Papuan EESS test in treating hyperglycemia in mice, with a comparison of results at doses of 100.8 mg/kgBB, 50.4 mg/kgBB, and 25.2 mg/kgBB. This research aims to prove effectiveness of native Papuan EESS in treating hyperglycemia with mice & compare the effectiveness at different doses. The research uses an experimental laboratory design. Male mice aged 2 – 3 months with body weight of 20 – 30 grams, divided into five groups: control + glibenclamide 13.39 mg/kgBW, control - NaCMC 1%, native Papuan EESS treatment dose 100.8 mg/kgBW, 50.4 mg/kgBB, and 25.2 mg/kgBB. Alloxan 4.54 mg/kgBW was administered to create hyperglycemia in mice. Extraction used the maceration method with 70% ethanol solvent. The research results showed that EESS suspension was effective in treating hyperglycemia. The dose of 100.8 mg/kgBB had an average decrease in blood sugar of 122.17 mg/dL, higher than the dose of 50.4 mg/kgBB (decrease of 155.00 mg/dL) and 25.2 mg/kgBB (decrease 200.33mg/dL). In the control group, control + with 13.39 mg/kgBW glibenclamide showed a greater reduction (121.87 mg/dL) than control - with 1% NaCMC (205.83 mg/dL reduction). EESS is native to Papua antihyperglycemia is effective in mice with hyperglycemia. Comparison of the effectiveness of EESS doses showed a significant difference in response.
ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT Areca catechu L. Stalk USING THE DPPH METHOD Tunnazilah, Nurhikmah; Arum Astuti, Ratih; Hardia, Lukman
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1667

Abstract

A monocotyledonous plant from the wild palm group, the areca nut (Areca actechu L.), has numerous health advantages. Most people in Sorong City empirically cure illnesses with areca nut medication. Using the DPPH (2,2 diphenyl-1-picrylhydrazyl) technique, the secondary metabolite chemicals and antioxidant activity were determined. The areca palm stalks were extracted using a maceration method with a 96% ethanol filter. The IC50 value was used to test for antioxidants using UV-Vis spectrophotometry. Phytochemical analysis revealed that the areca stem extract contained tannins, alkaloids, steroids, and flavonoids.The results of the antioxidant activity test of areca nut stalk extract showed that the IC50 value in replication 1 was 32.66µg/mL, replication 2 was 32.88µg/mL, and replication 3 was 32.84 µg/mL. Conclusion: Ethanol extract of areca stalk (Areca catechu L.) has secondary metabolite compounds and antioxidant activity with an average IC50 value of mean ± SD = 32,79 ± 0,114. Keywords: antioxidants, dpph method, Areca catechu L.
Evaluation of Herbal Honey with Black Cumin and Curcuma xanthorriza as an Antioxidant Supplement for Stunting Prevention Hardia, Lukman; Akrom, Akrom; Hidayati, Titiek; Sulistyani, Nanik
Journal of Public Health and Pharmacy Vol. 5 No. 1: MARCH 2025
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i1.5549

Abstract

Introduction: Honey has been widely used as a nutritional supplement and medicine. Many herbal honey products are developed as nutritional supplements that are combined with SFM to make them more effective, but there are still many shortcomings due to the unpleasant taste produced, unattractive physical appearance, and high susceptibility to oxidation reactions that cause severe damage to the quality of honey, especially in the content of active substances, viscosity, and pH, which can cause the effectiveness of honey to decrease and result in product failure as nutritional supplements to treat stunting problems. We have developed an herbal honey multi-nutrient supplement that combines honey with black cumin oil and Curcuma xanthorriza extract called HBCX. Adding Curcuma xanthorriza extract and black cumin oil to honey is expected to increase honey's benefits as an antioxidant. This study aims to determine the physicochemical characteristics (pH and viscosity), heavy metal contamination content, polyphenols, and antioxidant activity. Methods: This experimental laboratory research was conducted at the Pharmacy Lab, Faculty of Pharmacy, UAD. The viscosity and pH of HBCX were observed using an Ostwald viscometer and a pH meter. Total phenol determined by Folin-Ciocalteau reagent and gallic acid standard. Determination of antioxidant activity using the DPPH method. The data are presented in a quantitative descriptive manner and matched with the SNI honey standard. Results: The results showed that HBCX herbal honey had a higher viscosity than the sampled honey from the market but was still lower than the SNI requirements. HBCX honey has a lower pH than sample honey products from the market but still complies with national standards. HBCX honey is safe from heavy metal contamination and contains polyphenols. The antioxidant activity of HBCX honey is relatively high, with IC50=54.78 ppm. Conclusion: HBCX has high polyphenol content, is safe from heavy metal contamination, and has sufficient antioxidant activity.
Literature Review : Aktivitas Antioksidan Ekstrak Tongkol Jagung (Zea mays L.) Anisa, Meilinda; Hardia, Lukman; Budiyanto, Angga Bayu
JIKES : Jurnal Ilmu Kesehatan Vol. 2 No. 1 (2023): Juli-Desember 2023
Publisher : Yayasan Pendidikan Tanggui Baimbaian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71456/jik.v2i1.601

Abstract

Tongkol jagung (Zea mays L.) adalah salah satu limbah tanaman jagung yang berfungsi sebagai antioksidan. Aktivitas antioksidan tongkol jagung telah banyak diteliti. Oleh karena itu, perlu dilakukan literature review untuk mengumpulkan penelitian terbaru agar dapat dijadikan sebagai panduan bagi para peneliti dalam mempelajari lebih lanjut tentang antioksidan dari tongkol jagung atau untuk menghasilkan konsep baru. Tujuan dari penelitian literature review ini yaitu untuk mengetahui aktivitas antioksidan ekstrak tongkol jagung dan mengetahui kandungan senyawa pada tongkol jagung yang memiliki aktivitas antioksidan sehingga dapat dimanfaatkan menjadi antioksidan alami. Metode yang digunakan dalam penelitian ini yaitu literature review dengan pendekatan sistematis. Oleh karena itu, pedoman PRISMA digunakan dalam pengambilan data. Database yang digunakan dalam penelitian ini yaitu Scopus dan ditemukan 19 artikel yang sesuai setelah disaring. Temuan analisis menunjukkan bahwa tongkol jagung memiliki aktivitas sebagai antioksidan, kandungan senyawa pada tongkol jagung yang memiliki aktivitas antioksidan antara lain karotenoid, tanin, asam fenolik seperti asam hidroksisinamat dan asam hidroksibenzoat serta flavonoid seperti flavonol dan berbagai jenis antosianin.
Potential Antianemia Activity of Cokelat Seaweed Extract (Sargassum Duplicatum) on Mencit (Mus Musculus) Injured With NaNO2 Umpain, Agnes Nesa; Lukman Hardia; Ratih Arum Astuti
Jurnal EduHealth Vol. 16 No. 02 (2025): Jurnal EduHealt, Edition April - June , 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Seaweed is one of the leading commodities that is rich in nutrients and bioactive compounds that have potential for human health. The content contained in brown seaweed can be used as a therapy in increasing hemoglobin levels in anemia problems. The purpose of this study was to see the potential antianemia activity of brown seaweed extract (Sargassum duplicatum) against white mice (Mus musculus) and what dose can increase hemoglobin levels in mice. This research method is an experimental method with the Hb stick method carried out on 20 white mice, which were divided into 5 groups, namely the positive control group (blood supplement tablets), negative control group NaCMC 1%, treatment group 1 dose of 21 mg / kgBB, treatment group 2 dose 42 mg / kgBB, and treatment group 3 doisis 84 mg / kgBB. Testing the potential antianemia activity of brown seaweed was carried out on mice that had been induced with NaNo 2and then given a dose of extract treatment. The data were analyzed statistically using paired-sample t-test analysis to analyze the effectiveness of the treatment indicated by the difference in the average before and average after treatment. The results of the study Hemoglobin (Hb) g/dl levels on day 1 to day 15 showed a very significant increase in hemoglobin where the parameters of the dose group were close to the normal condition of the positive control group (blood supplement tablets), namely group 3 dose of 84 mg/KgBB, so it can be concluded that brown seaweed extract (Sargassum duplicatum) in group 3 dose of 84 mg/KgBB has potential antianemia activity comparable to the positive control dose (blood supplement tablets).
PERBANDINGAN AKTIVITAS ANTIBAKTERI EKSTRAK TUNGGAL DAN EKSTRAK KOMBINASI DAUN KEMANGI (OCIMUM SANCTUM L) DAN DAUN KENIKIR (COSMOS CAUDATUS KUNTH) TERHADAP BAKTERI ESCHERICHIA COLI putri puspitawati, devyana; Irwandi, Irwandi; Hardia, Lukman
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.44768

Abstract

Escherichia coli ialah bakteri Gram-negatif yang ada secara alami di dalam sistem pencernaan manusia namun beberapa strainnya bersifat patogen dan dapat menyebabkan infeksi saluran pencernaan, saluran kemih hingga sepsis. Daun kemangi (Ocimum sanctum L.) dan daun kenikir (Cosmos caudatus Kunth) telah terdeteksi senyawa aktif di dalamnya seperti flavonoid, saponin dan minyak atsiri yang mempunyai potensi sebagai agen antibakteri. Tujuan dari penelitian ini adalah untuk membandingkan aktivitas antibakteri ekstrak etanol tunggal dan kombinasi kedua tanaman terhadap E. coli. Ekstraksi menggunakan metode maserasi dengan etanol 70% sebagai pelarut. Pengujian aktivitas antibakteri dilakukan menggunakan metode difusi pada konsentrasi bertingkat: daun kemangi (12,5%, 25%, 50%), daun kenikir (15%, 30%, 60%) serta kombinasi (12,5%:15%, 25%:30%, 50%:60%). Berdasarkan hasil penelitian ekstrak daun kenikir konsentrasi 60% memberikan zona hambat terbesar yaitu 9,41 mm yang lebih tinggi dibandingkan dengan ekstrak daun kemangi konsentrasi 50% (6,58 mm) dan kombinasi 50%:60% (5,75 mm). Analisis data dengan uji ANOVA yang diteruskan dengan uji Tukey HSD mengindikasikan adanaya selisih yang signifikan antar kelompok perlakuan (p<0,05). Kesimpulan dari studi ini mengungkapkan bahwa ekstrak tunggal daun kenikir lebih efektif sebagai antibakteri terhadap E. coli dibandingkan dengan ekstrak tunggal daun kemangi maupun keduanya. Ketidaktercapaian efek sinergis pada kombinasi ekstrak diduga disebabkan oleh perbedaan atau interaksi antar senyawa aktif yang terkandung dalam masing-masing tanaman.
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN BUNGKUS (SMILAX ROTUNDIFOLIA) Yapsenang, Amar Jansen; Muslihin, AM.; Hardia, Lukman
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.43783

Abstract

Penyakit degeneratif disebabkan oleh radikal bebas yang merusak sel dalam tubuh manusia. Radikal bebas dapat dinetralisir oleh senyawa antioksidan. Antioksidan merupakan zat yang berperan penting dalam menjaga kesehatan karena kemampuannya menetralkan molekul radikal bebas. antioksidan dikategorikan menjadi dua jenis: antioksidan sintetis dan antioksidan alami. Antioksidan alami lebih umum ditemukan dari pada antioksidan sintetis, karena antioksidan sintetis dapat menimbulkan efek samping, sehingga antioksidan alami menjadi alternatif yang diperlukan. Salah satu sumber antioksidan eksogen adalah daun bungkus (Smilax rotundifolia). Secara tradisional dan penelitian, daun bungkus sering digunakan masyarakat papua sebagai obat kejantanan. Penelitian ini dilakukan untuk mengetahui aktivitas antioksidan dari daun bungkus (Smilax rotundifolia) yang diukur dengan metode DPPH (2,2-diphenyl-1- picrylhydrazyl) Penelitian ini dilakukan secara observasional dengan sampel yang diambil dari Kabupaten Sorong, Papua Barat Daya. Ekstrak daun bungkus dibuat dengan metode meserasi menggunkan pelarut etanol 96%. Pengujian aktivitas antioksidan daun bungkus dengan menggunakan konsentrasi 25 ppm, 50 ppm, 75 ppm, 100 ppm, 125 ppm. Vitamin C digunakan sebagai control positif. Absorbansi diukur dengan menggunakan spektrovotometer UV-Vis pada panjang gelombang 600 nm. Hasil dari skrining fitokimia menunjukkan adanya flavonoid, steroid, alkaloid, tanin, dan saponin. Uji DPPH dari penelitian ini menunjukkan IC50 ekstrak daun bungkus dengan pelarut etanol 96% didapatkan bernilai 190.26 ppm. Berdasarkan hasil penelitian yang dilakukan dapat disimpulkan bahwa ekstrak daun bungkus menggunakan pelarut etanol 96% tergolong ke dalam antioksidan lemah berdasarkan klasifikasi Blois
Co-Authors A. M. Muslihin Achmad Noerkhaerin Putra Akrom, Akrom Angga Bayu Budiyanto Anisa, Meilinda Arif Radhika Mentari Arni, Veni Zafi Assem, Vincentia Santy Astuti, Ratih Arum Budianto, Angga Bayu Dion Fahcrul Rozi Eka Savira Ni'ma Arfiani Erawati, Rika Eva Maya Sari Fabanyo, Syahrul H. fania, vikafania Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Jannah, Aulia Mifthakul Lanipi, Retna Parica Lanipi, Retna Paricca Levina Virginia M Natsir Djide Mansyur Arief Maulana, Fajar Meilinda Anisa Muh Ishar Difinubun Nanik Sulistyani Ningrum, Indah Diah Nurwahida, Wa Ode Nurwahyuni Pratama, Agus Sangka putri puspitawati, devyana Rahayu, Dika Rizky, Indah Amelia Sanaky, Nazla Wati Sarifuddin, Nuhidayah Siska Siska Siti Fatma Z.F. Sun, Suny Syahrul H. Fabanyo Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tuasikal, Rasi Fitri Yanti Tumpu, Darmayanti Tunnazilah, Nurhikmah Tutuhatunewa, Priscillia Ryani ulandari, clarista windi Umpain, Agnes Nesa Wasaraka, Fadila Alfiah Watora, Wahyuni Wiwik, Wiwik Triyani Yapsenang, Amar Jansen Yuniatri, Nur Khusna Yusnita La Goa Zf, Siti Fatma