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All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Kesehatan Manarang Biolearning Journal Jurnal Abdimasa PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Science Midwifery Jurnal Promotif Preventif Mitra Mahajana: Jurnal Pengabdian Masyarakat Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO International Journal of Health, Economics, and Social Sciences (IJHESS) Jurnal EduHealth Jurnal Sains dan Teknologi Sci-Tech Journal Jurnal Sains dan Kesehatan Jurnal Ilmiah Ilmu Terapan Universitas Jambi Journal of Pharmaceutical and Sciences. Jurnal Etnofarmasi Jurnal Mahasiswa Ilmu Kesehatan Journal of Public Health and Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmu Kesehatan Jurnal Etnofarmasi
Lukman Hardia
Program Studi Farmasi, Fakultas Farmasi, Universitas Pendidikan Muhammadiyah Sorong
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Faktor Risiko Resistensi Rifampicin Pada Pasien Tuberkulosis di RSUD Dr. J.P Wanane Kabupaten Sorong Serlin Marsela; Lukman Hardia; A.M Muslihin
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52743

Abstract

Tuberkulosis (TB) masih menjadi masalah kesehatan diindonesia. Rifampicin merupakan obat lini pertama yang paling penting dalam pengobatan tuberkulosis. Namun, ketidakpatuhan terhadap pengobatan, durasi terapi yang tidak sesuai standar, serta kondisi komorbid dapat memicu terjadinya resistensi terhadap rifampicin (TB-RO). Sehingga menurunkan keberhasilan terapi. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan kejadian resistensi rifampicin pada pasien tuberkulosis di RSUD Dr. J.P. Wanane Kabupaten Sorong menggunakan metode analitik dengan pendekatan case control study, melibatkan 130 pasien TB periode Agustus 2023-Agustus 2025, terdiri dari 39 pasien resisten dan 91 pasien sensitif rifampicin. Data diperoleh melalui rekam medis dan dianalisis menggunakan uji chi-square serta perhitungan odds rasio (OR). Empat variabel yang diteliti yaitu, usia, jenis kelamin, lama pengobatan, riwayat komorbid. Hasil penelitian menunjukkan hanya variabel lama pengobatan yang berhubungan signifikan dengan kejadian resistensi rifampin (P=0,000; P<0,005) pasien dengan durasi pengobatan > 6 bulan memiliki risiko mengalami resistensi dibandingkan pasien yang menyelesaikan pengobatan sesuai standar. Dapat disimpulkan, lama pengobatan merupakan faktor yang paling berpengaruh terhadap kejadian resistensi rifampicin pada pasien TB di RSUD Dr. J.P. Wanane Kabupaten Sorong. Kata Kunci: Tuberkulosis, Rifampicin, Resistensi Obat, Lama Pengobatan, Faktor Risiko Abstract Tuberculosis (TB) remains a major health problem in Indonesia. Rifampicin is the most important first-line drug in the treatment of tuberculosis. However, non-adherence to treatment, inadequate duration of therapy, and comorbid conditions can trigger rifampicin resistance (RO-TB), thus reducing the success of therapy. This study aims to determine the factors associated with the occurrence of rifampicin resistance in tuberculosis patients at Dr. J.P. Wanane Regional General Hospital, Sorong Regency, using an analytical method with a case-control study approach, involving 130 TB patients from August 2023 to August 2025, consisting of 39 resistant patients and 91 sensitive patients with rifampicin. Data were obtained through medical records and analyzed using the chi-square test and odds ratio (OR) calculation. Four variables studied were age, gender, duration of treatment, and history of comorbidities. The results showed that only the duration of treatment was significantly associated with the incidence of rifampin resistance (P=0.000; P<0.005). Patients with a duration of treatment >6 months had a higher risk of developing resistance compared to patients who completed treatment according to standards. It can be concluded that the duration of treatment is the most influential factor in the incidence of rifampicin resistance in TB patients at Dr. J.P. Wanane Regional Hospital, Sorong Regency. Keywords: Tuberculosis, Rifampicin, Drug Resistance, Treatment Duration, Risk Factors
Hubungan Karakteristik Sosiodemografi Terhadap Tingkat Kepuasan Pelayanan Kefarmasian di Apotek X Kota Sorong Diah Wulandari; Angga Bayu Budiyanto; Lukman Hardia
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.53162

Abstract

This study aims to determine the relationship between patient sociodemographic factors (age, gender, education, occupation, income,and travel distance) with satisfaction with pharmaceutical services at Pharmacy X, Sorong City. This study used a quantitative observational approach with a cross-sectional design and involved 181 respondents selected through a total sampling technique inthe period September - October 2025. Data collection was carried out using a questionnaire that had passed validity and reliability tests, and then analyzed using the chi-square. The results of the analysis showed that the variables of gender, age, education, occupation, and travel distance did not show a significant relationship with the level of satisfaction with pharmaceutical services (p> 0.05). Meanwhile, the income variable showed an important relationship with the level of satisfaction (p = 0.01). Overall, the levelof patient satisfaction on the five dimensions of Servqual was in the very satisfied category, especially on the dimensions of appearance, attention, and assurance. These findings illustrate that the quality of pharmaceutical services at Pharmacy X, SorongCity, is already very good, but there are differences in perceptions of satisfaction among patients with different income levels. Theresults of this study are expected to provide input for pharmacies to continuously improve service quality
In Vitro Study of The Activity of Yellow Rope (Anamirta cocculus) Extract As An Antibacterial Darmayanti Tumpu; A.M. Muslihin; Lukman Hardia
Jurnal Penelitian Pendidikan IPA Vol 11 No 4 (2025): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i4.10753

Abstract

A. cocculus is an endemic plant to Papua, which is often used as medicine. This study aims to determine the antibacterial activity of the ethanol extract of A. cocculus stems against P. acne, S. aureus, and E. coli bacteria. This research also has the potential to be used as a contextual learning resource in biology classes, especially on the topic of antibacterial and secondary metabolite testing, using experimental methods. The antibacterial activity test was carried out using the disk diffusion method, which was performed in 3 concentrations, namely 5%, 10%, and 15%. The positive control used 2 μg of clindamycin antibiotic and 30 μg of chloramphenicol antibiotic; the negative control used Aqua Pro injection. Measurement of the diameter of the inhibition zone shows that A. cocculus extract can inhibit bacterial growth, concentration 5% (P. acnes = 9.18mm/medium; S. aureus = 9.17/medium, and E. coli = 3.91/weak), concentration 10% (P. acnes = 11.86mm/strong; S. aureus = 11.88/strong, and E. coli = 5.17mm/medium), and concentration 15% (P. acnes = 11.56/strong; S. aureus = 12.9/strong, and E. coli = 5.86/medium).
Antibacterial Activity Testing of Methanol Extract of Yellow Rope Barb (Anamirta cocculus) Wa Ode Nurwahida; A.M. Muslihin; Lukman Hardia
Jurnal Penelitian Pendidikan IPA Vol 11 No 4 (2025): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i4.10760

Abstract

Indonesia has abundant natural wealth. One of the endemic plants of Papua which is often used in traditional medicine is yellow rope (A. cocculus). This study aims to determine the antibacterial activity of methanol extract of yellow rope bark (A. cocculus) against P. acnes, S. aureus, and E. coli bacteria using an experimental microbiological approach in the laboratory, and the experiment model may also serve as a contextual laboratory-based learning resource in microbiology education. The antibacterial activity test was carried out using the disc diffusion method which was made in 3 concentrations, namely 5%, 10% and 15%. The results of measuring the diameter of the inhibition zone showed that each concentration was able to inhibit the growth of P. acnes bacteria with an average diameter of 2,816 mm (Weak), 6,733 mm (Medium), 9,333 mm (Medium), and control (+) clindamycin 2 μg 14,483 mm (Strong). S. aureus bacteria with an average diameter of 3.133 mm (Weak), 6.35 mm (Medium), 8.235 mm (Medium) and control (+) clindamycin 2 μg 20.97 mm (Very strong). E. coli bacteria showed an average diameter of 3.875 mm (Weak), 6.175 mm (Medium), 8.566 mm (Medium) and control (+) ciprofloxacin 5 μg 20.783 mm (very strong). This research shows that the methanol extract of yellow stem bark (A. cocculus) has antibacterial activity.
ANALISIS BIBLIOMETRIK PENELITIAN ETNOMEDISIN A.M. Muslihin; Lukman Hardia
JURNAL ETNOFARMASI Vol. 2 No. 01 (2024): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v2i01.1713

Abstract

Ethnomedicine is the study of certain communities in using medicines. Information on the use of medicinal plants can be provided using an ethnomedicine approach. Ethnomedicine as a method that can be used to explore the use of medicinal plants can be the first step to developing new medicines. Knowledge about how to process traditional ingredients used in certain community groups can be used as a reference in developing medicinal raw materials. Research on the use of medicinal plants in various communities (cross-cultural studies) can be used to find drugs and bioactive compounds. Ethnomedicine is an important stage in screening, selecting and developing new medicines derived from plants. Ethnic communities in an area have unique culture and local wisdom due to regional differences. This has an impact on knowledge about traditional medicine and medicine. Various tribes or ethnic groups in Indonesia have their own experiences in dealing with health problems. Ethnomedicine is part of a community's traditional medicine, often empirically proven, scientifically validated, for the discovery or development of new medicinal compounds.
UJI FISIK SEDIAAN SABUN CAIR EKSTRAK ETANOL DAUN MANGROVE (Rhizophora mucronata) Rasi Fitri Yanti Tuasikal; Irwandi Irwandi; Lukman Hardia
JURNAL ETNOFARMASI Vol. 2 No. 01 (2024): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v2i01.1715

Abstract

Caffeic acid, vanillic acid, p-hydroxy benzoic acid, tannins, kau-16-ene, benzophene, phenolic compounds of the flavonoid group, phenolic acids, and dihydroflavonol tannins are all present in mangrove leaves. Alkaloids, coumarins, flavonoids, phenols and polyphenols, quinones, resins, saponins, phytosterols, tannins, xantoprotins, pigments (chlorophyll, carotenoids), and sugars are just some of the substances that can be found in plants. This plant has potential as an antibacterial, antimalarial, antiviral, and antioxidant. The purpose of this study was to obtain the formulation of Mangrove leaf ethanol extract liquid soap preparation and also know the physical properties of black mangroves leaf extract liquid soap preparation. In this study, physical tests of preparations such as organoleptic tests, pH tests, viscosity tests, and foam height tests were carried out. The results in organoleptic test research meet SNI standards, the Ph test has a high pH value of F1 12.71, the dosage properties become more alkaline, the viscosity test results meet SNI standards, while for the high test F3 foam has a high value of 84.91 so that it exceeds the SNI standard.
UJI EFEKTIVITAS ANALGESIK EKSTRAK ETANOL BUAH MERAH (Pandanus conoideus) TERHADAP MENCIT (Mus musculus) Nazla Wati Sanaky; Lukman Hardia; Irwandi Irwandi
JURNAL ETNOFARMASI Vol. 2 No. 01 (2024): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v2i01.1717

Abstract

Many traditional plants have analgesic activity and can be used as alternative therapy. One plant that can be used for analgesic activity is Buah Merah (P. conoideus). Red fruit (Pandanus conoideus) is a medicinal plant that is well known and has proven its efficacy. The results of the phytochemical screening of red fruit, contained several active compounds, namely: tannins, flavonoids, saponins and alkaloids. The aim of this research is to determine the effectiveness of red fruit (P. conoideus) ethanol extract in providing an analgesic effect on mice (Mus musculus). This research used an analgesic meter and male mice as experimental animals. Each group was given treatment, the positive control group was given paracetamol, dose group 1 was given suspension with a concentration of 10%, dose 2 was given suspension with a concentration of 20% and dose group 3 was given 30% suspension then left for 30 minutes then placed on an analgesic meter until the mice writhe, then observe the response that appears. The response of mice from each group was observed for 30, 60, 90 and 120 minutes. The results of the one-way anova test showed that there was an influence and significant differences between the treatment groups. The results show that the ethanol extract of red fruit (P. conoideus) has an analgesic effect on mice (Mus musculus) and a concentration of 20% has the most effective analgesic activity.
FORMULASI DAN UJI EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN MANGROVE (Rhizophora mucronata) TERHADAP PENYEMBUHAN LUKA SAYAT PADA MENCIT (Mus muscullus) Wiwik Triyani Wiwik; Irwandi Irwandi; Lukman Hardia
JURNAL ETNOFARMASI Vol. 2 No. 01 (2024): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v2i01.1718

Abstract

Mangrove (Rhizophora mucronata) contains flavonoids, saponins and tannins. Compounds contained in mangrove leaves have antiinflammatory, anti viral and antimicrobial activites. Based on the compound, mangrove (Rhizophora mucronata) can be used an ointment for cuts. This study aims to test the preparation ofmangrove leaf ethanol extract ointment on the healing of cuts in mice. The process of extracting mangrove leaves (Rhizophora mucronata) uses the maceration method. In testing the ointment preparations, organoleptic tests, homogeneity tests, pH tests, spreadability tests and viscosity tests were carried out. Testing the effectiveness of wound healing using 5 groups consisting of 3 mice. Each group was giffen different treatment, namale K- was given an ointment base, K+ was given betadine ointment, F1 was given an ointment with a concetration of 2,5%, F2 was given an ointment with a concentration of 5% and F3 was given an ointment with a concentration of 7,5%. The results showed that the ointment met the standard organoleptic test requirements, test homogeneity, pH test, spreadability test and viscosity test. Based on the results of the incision test on mice, the most effective ointment preparation was a preparation with a concentration of 5%
UJI EFEK HIPOGLIKEMIK EKSTRAK BUAH MERAH (Pandanus conoideus L.) TERHADAP MENCIT (Mus musculus) Dika Rahayu; Lukman Hardia; Irwandi Irwandi
JURNAL ETNOFARMASI Vol. 1 No. 01 (2023): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v1i01.1719

Abstract

Buah merah (P. conoideus L.) merupakan salah satu tanaman endemik yang secara tradisional dimanfaatkan oleh masyarakat Papua dengan cara mengambil sari buahnya dan telah digunakan oleh masyarakat untuk pengobatan berbagai penyakit degeneratif seperti diabetes mellitus. Penelitian ini bertujuan untuk mengetahui efek hipoglikemik ekstrak buah merah (Pandanus conoideus L.) terhadap mencit (Mus musculus). Penelitian ini menggunakan hewan uji mencit jantan sebanyak 25 ekor yang dibagi menjadi 5 kelompok perlakuan, tiap kelompok terdiri dari 5 ekor mencit jantan. Kelompok K+ diberi glibenklamid 0,433 mg/kg BB yang disuspensikan dengan Na-CMC 2% (kontrol positif) , kelompok K- diberi Na-CMC 2% (kontrol negatif), kelompok P1, P2, dan P3 diberi ekstrak buah merah masing-masing 0,175 g, 0,35 g, dan 0,7 g. Pemberian dilakukan dengan cara peroral dengan volume pemberian 1 mL/25 g BB, dan pengukuran kadar glukosa darah dilakukan setelah menit ke 30, 60, 90, dan 120 dengan menggunakan glukometer. Hasil penelitian menunjukan adanya aktivitas hipoglikemik pada mencit jantan yang diberikan glukosa secara oral. Konsentrasi dosis yang paling efektif dan memiliki efek sebanding dengan kontrol positif suspensi glibenklamid dalam menurunkan kadar glukosa darah mencit yaitu konsentrasi dosis 0,175 gram.
EVALUASI POLA PERESEPAN OBAT ANTI HIPERTENSI Di PUSKESMAS Aulia Mifthakul Jannah; Lukman Hardia; Angga Bayu Budiyanto
JURNAL ETNOFARMASI Vol. 1 No. 01 (2023): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v1i01.1722

Abstract

Kriteria pemakaian obat secara rasional meliputi tepat diagnosa, tepat indikasi penyakit, tepat pemilihan obat, tepat pasien, tepat dosis, tepat cara pemakaian, tepat interval waktu pemberian, tepat lama pemberian, serta waspada terhadap efek samping. Evaluasi peresepan obat penting dilakukan untuk mengetahui dan memastikan bahwa pasien telah menerima pengobatan yang sesuai dengan kebutuhan klinisnya, dalam dosis dan jangka waktu yang sesuai, dan dengan biaya terendah. Ketidakrasionalan peresepan masih sering ditemukan terutama di Puskesmas yang merupakan pusat pelayanan kesehatan tingkat 1, dimana obat dan dosis yang diresepkan oleh tenaga medis kurang sesuai akibat ketersediaan obat yang terbatas, dan salah satunya adalah obat hipertensi. Sehingga perlu dilakukan evaluasi pola peresepan obat antihipertensi di Puskesmas Mariat Kabupaten Sorong periode Juli – September 2022. Penelitian ini bertujuan Untuk mengevaluasi pola peresepan obat anti-hipertensi di Puskesmas Mariat Kabupaten Sorong. Penelitian ini menggunakan rekam medis sebanyak 63 resep. Hasil penelitian Evaluasi Peresepan obat Antihipertensi Di Puskesmas Mariat Kabupaten Sorong Periode Juli-September 2022 bahwa tepat obat sebanyak 100% tepat pasien sebanyak 100% tepat dosis sebanyak 100%, tepat interval waktu pemberian sebanyak 88,46%. Obat Antihipertensi yang diberikan kepada pasien adalah terapi kombinasi golongan CCB+ACEI (amlodipin + captopril) dengan persentase yaitu 25% dan selanjutnya monoterapi amlodipin sebanyak 75%, dan captopril sebanyak 0%.
Co-Authors A. M. Muslihin Achmad Noerkhaerin Putra Adriyani E. G. Sitanggang Agus sangka pratama Akrom Akrom Akrom, Akrom Alyssa Mileta Aponno Angga Bayu Budianto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Anisa, Meilinda Arif Budi Setianto Arif Radhika Mentari Arni, Veni Zafi Assem, Vincentia Santy Astuti, Ratih Arum Aulia Mifthakul Jannah Azzahra Vivin Mahdiya Afandy Budianto, Angga Bayu Carmel Josuhua Paulus Darmayanti Tumpu Diah Wulandari Dian Nur Khofifah Dika Rahayu Dion Fahcrul Rozi Eka Savira Ni'ma Arfiani Erawati, Rika Ernifan Ernifan Eva Maya Sari Fabanyo, Syahrul H. Fajar Maulana fania, vikafania Gilda Fransiska Hikmahtul Putri Utami Ica Damayanti Ikhwan Dahlan Rais Inda Dwi Yanti Indah Amelia Rizky Indah Diah Ningrum Innal Saitis Innal Saitis Irene Eunike Tanod Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Jannah, Aulia Mifthakul Justitia Cahyani Fadli Laela Hayu Nurani Lanipi, Retna Parica Lanipi, Retna Paricca Levina Virginia M Natsir Djide M. Yogi Riyantama Isjoni Mansyur Arief Marzella Dea Rossardy Meilinda Anisa Mika Tri Kumala Swandari Muh Ishar Difinubun Muh. Dahlan Wael Muslih Anwar Nanik Sulistyani Nanik Sulistyani Nazila Galela Nazla Wati Sanaky Ningrum, Indah Diah Nuhidayah Sarifuddin Nuhidayah Sarifuddin Nur ‘Azah Nurkhasanah Nurkhasanah Nurul Maghfirah1 Nurwahyuni Paulus, Johan Kartino Prasasti Bintarum Pratama, Agus Sangka putri puspitawati, devyana Rahayu, Dika Rasi Fitri Yanti Tuasikal Retna Parica Lanipi Retna Parica Lanipi Retna Paricca Lanipi Risanyel Elsan Tuturop Rizqi Fadil Nadila SALIM, MUH.AGUS Sanaky, Nazla Wati Sarifuddin, Nuhidayah Selfiana Iek Serlin Marsela Sintya Sari Dwi Kusumaningrum Siska Siska Siti Fatma Z.F. Siti Rahmadani Sitti Hadija Samual Sun, Suny Syahrul H. Fabanyo Titiek Hidayati Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tuasikal, Rasi Fitri Yanti Tunnazilah, Nurhikmah Tutuhatunewa, Priscillia Ryani ulandari, clarista windi Umpain, Agnes Nesa Vincentia Santy Assem Wa Ode Nurwahida Wahyuni Watora Wasaraka, Fadila Alfiah Wiwik Triyani Wiwik Wiwik, Wiwik Triyani Wiwit Ayu Fitrianti Yapsenang, Amar Jansen Yuniatri, Nur Khusna Yusnita La Goa Zf, Siti Fatma