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Pengaruh Sosiodemografi Terhadap Keberhasilan Pengobatan Pasien TB-RO di RSUD Dr. J. P. Wanane Tutuhatunewa, Priscillia Ryani; Hardia, Lukman; Irwandi
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32421

Abstract

Tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis, penggunaan obat secara berulang dan lama seringkali menyebabkan pasien kurang patuh terhadap terapi yang mengakibatkan resisten. Indonesia masih berada di posisi penderita TB ke-2 terbanyak setelah India dengan perkiraan TB-RO sebanyak 37.197, Papua barat menempati peringkat ke-12 secara nasional dalam penemuan kasus TB-RO sebanyak 47% dengan Kabupaten Sorong menduduki peringkat terakhir angka success rate TB dari 10 Kabupaten/kota di Provinsi Papua Barat yaitu 25% (Dinas Kesehatan Provinsi Papua Barat, 2019). Tujuan penelitian ini adalah mengetahui hubungan antara variabel sosiodemografis dengan keberhasilan pengobatan terapi pengobatan pasien TB-RO di poliklinik TB DOTS RSUD Dr. J. P. Wanane. Penelitian observasional dengan desain cross sectional dan teknik sampling yaitu total sampling. Penelitian dilaksanakan dari bulan mei hingga juni 2024 di RSUD Dr. J. P. Wanane Kabupaten Sorong. Data yang didapat yaitu terdapat 100 orang penderita TB-RO tahun 2020-2023, sampel yang sesuai dengan kriteria inklusi sebanyak 55 orang. Analisis data menggunakan uji chi square, dengan faktor sosiodemografi berhubungan dengan keberhasilan pengobatan jika nilai P<0,05. Hasil analisis mendapatkan nilai antara umur (P = 1), jenis kelamin (P = 0,157), tingkat pendidikan (P = 0,166), jarak ke RSUD (P = 0,639), status pekerjaan (P = 1), suku (P = 0,867), penyakit komorbid (P = 1). Dari hasil analisis menunjukkan bahwa umur, jenis kelamin, tingkat pendidikan, jarak ke RSUD, status pekerjaan, suku dan penyakit komorbid tidak memiliki hubungan dengan keberhasilan pengobatan pasien TB-RO tahun 2020-2023 di RSUD Dr. J. P. Wanane Kabupaten Sorong.
Research Trends of Stunting Related to Insulin-Like Growth Factor-1: Bibliometric Analysis Hardia, Lukman; Pratama, Agus Sangka; Muslihin, A. M.
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6903

Abstract

Stunting is a condition in which a person's height is less than normal based on age and gender. The prevalence of stunting in Indonesia in 2021 is 24.4%. This illustrates that stunting is still a problem that cannot be resolved in Indonesia. Research on the incidence of stunting was carried out to determine its relationship with insulin-like growth factor-1 (IGF-1) levels. Search results on the Pubmed database obtained 446 English-language articles published from 1993 – April 12, 2023. The results of bibliometric analysis and VOSViewer show that new research trends began to be seen in 2018 to 2023 even though there had been publications previously in 1993 and 2000, but very minimal amount. The most dominating document types were journal articles with 310 publications (69.51%) and reviews with 89 publications (19.96%). The most trending keywords are humans (268), female (176), male (145), animals (142), insulin-like growth factor i/metabolism (94), child (74), adult (60), mice (56), pregnancy (47) and child preschool (43). The publishing journals that published the most articles were Frontiers in Endochronolgy (22 publications), International Journal of Molecular Sciences (19 publications), Scientific Reports (13 publications). The highest number of author collaborations is from the USA with 78 articles being the country with the most collaboration on both SCP and MCP with an MCP to SCP ratio of 0.244. China ranks second with the number of articles of 63 with an MCP ratio of 0.190.
Anthocyanin Compounds from Ethanol Extract of Red Fruit (Pandanus conideus L.): A Functional Group Analysis Rizky, Indah Amelia; Budiyanto, Angga Bayu; Hardia, Lukman
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.9321

Abstract

Red Fruit (Pandanus conoideus L.) is a typical Papuan plant that is rich in bioactive compounds such as anthocyanins, which have the potential to act as antioxidants. This research aims to analyze the chemical structure of anthocyanin compounds from red fruit ethanol extract using Fourier Transformed Infrared (FTIR) spectroscopy. FTIR is a spectroscopic tool widely used to characterize or detect functional groups and qualitatively identify compounds in samples. Anthocyanins act as antioxidants and have various biological activities such as preventing cancer, cardiovascular disease, and diabetes. Extraction was carried out using the maceration method using 70% ethanol solvent, and characterization was performed using FTIR in the wave range 4000-450 cm⁻¹. The results of the research that has been carried out show that the ethanol extract of red fruit contains secondary metabolites such as flavonoids, alkaloids, and saponins. The FTIR results of red fruit extract show the presence of functional groups characterized by the presence of the O-H, C-O-C, C-O, and C=C functional groups which are important indicators of the antioxidant properties of anthocyanins. This research confirms the potential of Red Fruit as a natural source of anthocyanins which are useful as antioxidants
The Effectiveness of Herbal Supplements on Improving the Anthropometric Status of Stunted Children Hardia, Lukman; Akrom, Akrom; Sulistyani, Nanik
Jurnal Kesehatan Manarang Vol 11 No 3 (2025): December 2025
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v11i3.1597

Abstract

Stunting has become a health issue that threatens the future generation of Indonesia, which is why the government has set a target prevalence of stunting at 14% by 2024. This has become a challenge because some areas, such as Sorong Regency, still have a higher prevalence of stunting compared to the national prevalence. One of the causes of stunting is malnutrition, so efforts are needed to address this issue by utilizing Indonesia's natural wealth, such as herbal honey, Curcuma xanthorrhiza, and black cumin, which are widely used by the community to tackle various health problems. The objective is to determine the effect of administering herbal honey made from temulawak and black cumin on changes in the anthropometric status of stunted children in Sorong Regency. This type of research is quantitative, using a quasi-experimental research design with a pre- and post-test with a control group design. The sampling technique used is purposive sampling, with a total sample of 60 children divided into 3 groups: the normal control group (20 children), the stunting control group (20 children), and the stunting intervention group (20 children). The data analysis techniques used in the research are paired-samples t-test and independent-samples t-test. The statistical test of the mean difference between the pre- and post-test between the intervention group and the control group showed a significant increase in body weight (average increase of 1.60 ± 0.66 kg, p < 0.001), height (1.49 ± 0.74 cm, p < 0.001), and z-score height-for-age (-0.42 ± 0.22 SD, p < 0.001). The administration of herbal honey, Curcuma xanthorrhiza, and black cumin can improve the anthropometric status of stunted children in Sorong Regency.
Kajian Kelengkapan Adiministrasi dan Farmasetik Resep Pasien IGD di RSUD Dr. J. P. Wanane Kabupaten Sorong Paulus, Johan Kartino; Hardia, Lukman
Jurnal Promotif Preventif Vol 8 No 6 (2025): Desember 2025: JURNAL PROMOTIF PREVENTIF
Publisher : Fakultas Kesehatan Masyarakat Universitas Pancasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47650/jpp.v8i6.2358

Abstract

Resep merupakan permintaan tertulis dari dokter kepada apoteker yang berfungsi sebagai dokumen medis legal dan krusial, terutama di Instalasi Gawat Darurat (IGD) yang menuntut pelayanan cepat dan tepat. Penelitian ini bertujuan menilai tingkat kelengkapan administrasi dan farmasetik pada resep pasien IGD RSUD Dr. J. P. Wanane Kabupaten Sorong. Penelitian menggunakan desain deskriptif retrospektif dengan total sampling terhadap 2.636 lembar resep yang dilayani instalasi farmasi periode April–Juni 2024. Penilaian dilakukan berdasarkan 12 komponen administrasi dan 6 komponen farmasetik sesuai Permenkes No. 58/2014 dan Permenkes No. 73/2016. Hasil penelitian menunjukkan tingkat kelengkapan resep sebesar 71%, terdiri dari 1.872 resep lengkap dan 764 resep tidak lengkap. Komponen administrasi dengan kelengkapan tertinggi meliputi nama pasien (100%), tanggal resep (96%), dan paraf dokter (93,5%), sedangkan terendah adalah alamat pasien (0,08%), berat badan (1,5%), jenis kelamin (9,6%), SIP dokter (10,3%), dan umur pasien (14,2%). Aspek farmasetik tergolong sangat baik dengan kelengkapan 100% pada nama obat, jumlah obat, aturan pakai, serta stabilitas dan kompatibilitas, meskipun bentuk sediaan (83,9%) dan kekuatan dosis obat (85,7%) belum sepenuhnya lengkap. Temuan ini menunjukkan bahwa kelengkapan resep IGD masih perlu ditingkatkan, terutama pada komponen administrasi.
Daun Mantangan Sebagai Kandidat Bahan Baku Obat: Uji Pra-Klinik Sebagai Obat Analgesik Selfiana Iek; A. M. Muslihin; Lukman Hardia
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52546

Abstract

Nyeri merupakan indikator alamiah tubuh yang bekerja dengan mekanisme peningkatan ekskresi dari berbagai mediator nyeri, seperti prostaglandin, histamin, dan bradikin. Penanganan nyeri secara farmakologis melibatkan penggunaan obat-obatan analgesik. Meskipun efektif, penggunaan jangka panjang dari obat-obatan sintetis dapat menimbulkan berbagai efek samping. Hal ini mendorong peningkatan kesadaran masyarakat akan pentingnya mencari alternatif pengobatan alami yang lebih aman dengan efek samping yang minimal. Salah satu tanaman yang menarik perhatian adalah daun mantangan (Meremia peltata L. Merr.) yang memiliki kandungan flavonoid, saponin, tanin, dan steroid yang diyakini dapat mengatasi masalah nyeri. Tujuan: mengidentifikasi pengaruh ekstrak daun mantangan sebagai obat analgesik. Metode penelitian yaitu kuantitatif dengan desain eksperimental laboratorium pre and post-test with control group design. Data dianalisa menggunakan paired sample t-test dan independent sample t-test. Hasil: mencit (Mus musculus) yang diberi perlakuan ekstrak daun mantangan (Meremia peltata L. Merr.) dosis 26, 58, dan 115 mg/kgBB secara efektif dapat meningkatkan toleransi nyeri secara signifikan (p-value <0,05) jika dibandingkan dengan kontrol negatif yang diberikan suspensi na. cmc, dan berbeda tidak signifikan (p-value >0.05) jika dibandingkan dengan kelompok kontrol positif yang diberikan suspensi na. diklofenak. Kesimpulan: ekstrak daun mantangan (Meremia peltata L. Merr.) memiliki potensi sebagai obat analgesik pada dosis 26, 58, dan 115 mg/kgBB.
Analisa Kandungan Flavonoid dan Uji Efek Nefrotoksik Ekstrak Metanol Kulit Pisang Raja (Musa paradisiaca var. Sapientum) Sintya Sari Dwi Kusumaningrum; Lukman Hardia; A.M Muslihin
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52699

Abstract

Kulit pisang raja (Musa paradisiaca var. Sapientum) merupakan limbah organik yang berpotensi mencemari lingkungan, namun mengandung senyawa bioaktif terutama flavonoid yang memiliki berbagai aktivitas biologis. Pemanfaatannya masih belum optimal dan data ilmiah terkait keamanan serta efeknya terhadap fungsi ginjal masih terbatas. Penelitian ini bertujuan untuk menentukan rendemen ekstrak metanol kulit pisang raja, kadar flavonoid total, serta mengevaluasi pengaruh pemberiannya terhadap kadar kreatinin serum tikus sebagai indikator fungsi ginjal. Simplisia disiapkan melalui proses sortasi, pengeringan, dan penghalusan, kemudian diekstraksi dengan metode maserasi menggunakan pelarut metanol. Penetapan kadar flavonoid total dilakukan secara spektrofotometri ultraviolet-visible menggunakan pereaksi aluminium klorida. Pengujian efek nefrotoksisitas dilakukan dengan mengukur kadar kreatinin serum sebelum dan sesudah perlakuan, kemudian dianalisis menggunakan uji paired sample t-test. Hasil menunjukkan bahwa dari 467 gram simplisia diperoleh 84 gram ekstrak kental dengan rendemen 17,99%. Kadar flavonoid total sebesar 29,6 mg/g atau setara 2959,9 QE. Analisis statistik menunjukkan tidak terdapat perbedaan signifikan kadar kreatinin serum sebelum dan sesudah perlakuan (p>0,05). Disimpulkan bahwa ekstrak metanol kulit pisang raja memiliki kandungan flavonoid tinggi dan relatif aman terhadap fungsi ginjal, sehingga berpotensi dikembangkan sebagai bahan alami bernilai farmakologis sekaligus mengurangi limbah organik.
Faktor Risiko Resistensi Rifampicin Pada Pasien Tuberkulosis di RSUD Dr. J.P Wanane Kabupaten Sorong Serlin Marsela; Lukman Hardia; A.M Muslihin
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52743

Abstract

Tuberkulosis (TB) masih menjadi masalah kesehatan diindonesia. Rifampicin merupakan obat lini pertama yang paling penting dalam pengobatan tuberkulosis. Namun, ketidakpatuhan terhadap pengobatan, durasi terapi yang tidak sesuai standar, serta kondisi komorbid dapat memicu terjadinya resistensi terhadap rifampicin (TB-RO). Sehingga menurunkan keberhasilan terapi. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan kejadian resistensi rifampicin pada pasien tuberkulosis di RSUD Dr. J.P. Wanane Kabupaten Sorong menggunakan metode analitik dengan pendekatan case control study, melibatkan 130 pasien TB periode Agustus 2023-Agustus 2025, terdiri dari 39 pasien resisten dan 91 pasien sensitif rifampicin. Data diperoleh melalui rekam medis dan dianalisis menggunakan uji chi-square serta perhitungan odds rasio (OR). Empat variabel yang diteliti yaitu, usia, jenis kelamin, lama pengobatan, riwayat komorbid. Hasil penelitian menunjukkan hanya variabel lama pengobatan yang berhubungan signifikan dengan kejadian resistensi rifampin (P=0,000; P<0,005) pasien dengan durasi pengobatan > 6 bulan memiliki risiko mengalami resistensi dibandingkan pasien yang menyelesaikan pengobatan sesuai standar. Dapat disimpulkan, lama pengobatan merupakan faktor yang paling berpengaruh terhadap kejadian resistensi rifampicin pada pasien TB di RSUD Dr. J.P. Wanane Kabupaten Sorong. Kata Kunci: Tuberkulosis, Rifampicin, Resistensi Obat, Lama Pengobatan, Faktor Risiko Abstract Tuberculosis (TB) remains a major health problem in Indonesia. Rifampicin is the most important first-line drug in the treatment of tuberculosis. However, non-adherence to treatment, inadequate duration of therapy, and comorbid conditions can trigger rifampicin resistance (RO-TB), thus reducing the success of therapy. This study aims to determine the factors associated with the occurrence of rifampicin resistance in tuberculosis patients at Dr. J.P. Wanane Regional General Hospital, Sorong Regency, using an analytical method with a case-control study approach, involving 130 TB patients from August 2023 to August 2025, consisting of 39 resistant patients and 91 sensitive patients with rifampicin. Data were obtained through medical records and analyzed using the chi-square test and odds ratio (OR) calculation. Four variables studied were age, gender, duration of treatment, and history of comorbidities. The results showed that only the duration of treatment was significantly associated with the incidence of rifampin resistance (P=0.000; P<0.005). Patients with a duration of treatment >6 months had a higher risk of developing resistance compared to patients who completed treatment according to standards. It can be concluded that the duration of treatment is the most influential factor in the incidence of rifampicin resistance in TB patients at Dr. J.P. Wanane Regional Hospital, Sorong Regency. Keywords: Tuberculosis, Rifampicin, Drug Resistance, Treatment Duration, Risk Factors
Hubungan Karakteristik Sosiodemografi Terhadap Tingkat Kepuasan Pelayanan Kefarmasian di Apotek X Kota Sorong Diah Wulandari; Angga Bayu Budiyanto; Lukman Hardia
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.53162

Abstract

This study aims to determine the relationship between patient sociodemographic factors (age, gender, education, occupation, income,and travel distance) with satisfaction with pharmaceutical services at Pharmacy X, Sorong City. This study used a quantitative observational approach with a cross-sectional design and involved 181 respondents selected through a total sampling technique inthe period September - October 2025. Data collection was carried out using a questionnaire that had passed validity and reliability tests, and then analyzed using the chi-square. The results of the analysis showed that the variables of gender, age, education, occupation, and travel distance did not show a significant relationship with the level of satisfaction with pharmaceutical services (p> 0.05). Meanwhile, the income variable showed an important relationship with the level of satisfaction (p = 0.01). Overall, the levelof patient satisfaction on the five dimensions of Servqual was in the very satisfied category, especially on the dimensions of appearance, attention, and assurance. These findings illustrate that the quality of pharmaceutical services at Pharmacy X, SorongCity, is already very good, but there are differences in perceptions of satisfaction among patients with different income levels. Theresults of this study are expected to provide input for pharmacies to continuously improve service quality
In Vitro Study of The Activity of Yellow Rope (Anamirta cocculus) Extract As An Antibacterial Darmayanti Tumpu; A.M. Muslihin; Lukman Hardia
Jurnal Penelitian Pendidikan IPA Vol 11 No 4 (2025): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i4.10753

Abstract

A. cocculus is an endemic plant to Papua, which is often used as medicine. This study aims to determine the antibacterial activity of the ethanol extract of A. cocculus stems against P. acne, S. aureus, and E. coli bacteria. This research also has the potential to be used as a contextual learning resource in biology classes, especially on the topic of antibacterial and secondary metabolite testing, using experimental methods. The antibacterial activity test was carried out using the disk diffusion method, which was performed in 3 concentrations, namely 5%, 10%, and 15%. The positive control used 2 μg of clindamycin antibiotic and 30 μg of chloramphenicol antibiotic; the negative control used Aqua Pro injection. Measurement of the diameter of the inhibition zone shows that A. cocculus extract can inhibit bacterial growth, concentration 5% (P. acnes = 9.18mm/medium; S. aureus = 9.17/medium, and E. coli = 3.91/weak), concentration 10% (P. acnes = 11.86mm/strong; S. aureus = 11.88/strong, and E. coli = 5.17mm/medium), and concentration 15% (P. acnes = 11.56/strong; S. aureus = 12.9/strong, and E. coli = 5.86/medium).
Co-Authors A. M. Muslihin Achmad Noerkhaerin Putra Akrom, Akrom Angga Bayu Budianto Angga Bayu Budiyanto Angga Bayu Budiyanto Anisa, Meilinda Aponno, Alyssa Mileta Arif Radhika Mentari Arni, Veni Zafi Assem, Vincentia Santy Astuti, Ratih Arum Aulia Mifthakul Jannah Budianto, Angga Bayu Darmayanti Tumpu Diah Wulandari Dika Rahayu Dion Fahcrul Rozi Eka Savira Ni'ma Arfiani Erawati, Rika Eva Maya Sari Fabanyo, Syahrul H. fania, vikafania Fransiska, Gilda Indah Diah Ningrum Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Jannah, Aulia Mifthakul Lanipi, Retna Parica Lanipi, Retna Paricca Levina Virginia M Natsir Djide M. Yogi Riyantama Isjoni Mansyur Arief Maulana, Fajar Meilinda Anisa Muh Ishar Difinubun Nanik Sulistyani Nazla Wati Sanaky Ningrum, Indah Diah Nuhidayah Sarifuddin Nuhidayah Sarifuddin Nur ‘Azah Nurwahyuni Paulus, Johan Kartino Pratama, Agus Sangka putri puspitawati, devyana Rahayu, Dika Rasi Fitri Yanti Tuasikal Retna Parica Lanipi Retna Parica Lanipi Retna Paricca Lanipi Rizky, Indah Amelia Rossardy, Marzella Dea Sanaky, Nazla Wati Sarifuddin, Nuhidayah Selfiana Iek Serlin Marsela Sintya Sari Dwi Kusumaningrum Siska Siska Siti Fatma Z.F. Sun, Suny Syahrul H. Fabanyo Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tuasikal, Rasi Fitri Yanti Tunnazilah, Nurhikmah Tutuhatunewa, Priscillia Ryani ulandari, clarista windi Umpain, Agnes Nesa Utami, Hikmahtul Putri Vincentia Santy Assem Wa Ode Nurwahida Wael, Muh. Dahlan Wasaraka, Fadila Alfiah Watora, Wahyuni Wiwik Triyani Wiwik Wiwik, Wiwik Triyani Yanti, Inda Dwi Yapsenang, Amar Jansen Yuniatri, Nur Khusna Yusnita La Goa Zf, Siti Fatma