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All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi The Indonesian Journal of Dental Research Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Health Notions Meditory : The Journal of Medical Laboratory SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Medica Hospitalia Jurnal Kesehatan Denta: Jurnal Kedokteran Gigi Odonto dental journal Jurnal Hasil Pengabdian Kepada Masyarakat Universitas Jember Dental Agromedis ABDIGI: Jurnal Pengabdian Masyarakat Kesehatan Gigi
Agustin Wulan Suci Dharmayanti
Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

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BIOVIABILITY OF BIDURI LEAF EXTRACT (Calotropis Gigantea L.) ON FIBROBLAST CELL CULTURE Setyaningsih, Sari; Astuti, Pudji; Meilawaty, Zahara; Dharmayanti, Agustin Wulan Suci
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.4049

Abstract

Background: Biduri is recognized for its medicinal properties, particularly in wound healing. The active compounds influence the number of fibroblast cells, which play a role in wound healing. Research on the bioviability of biduri leaf extract has never been conducted, so in vitro testing is necessary to determine the ability of biduri leaf extract to influence fibroblast cells.Objective:  To assess the effect of Biduri leaf extract on the viability of BHK-21 fibroblast cells in vitro. Methods: This experiment used a posttest-only group Design with an MTT assay to assess the viability of BHK-21 fibroblast cells after exposure to different concentrations of Biduri leaf extract. The study employed four treatment groups with varying extract concentrations and used one-way ANOVA followed by an LSD test to analyze the proportion of living cells statistically.Results:  The viability percentages of fibroblast cells varied with the concentration of Biduri leaf extract. The highest viability was observed at 5% concentration (80.82%), while the lowest was at 20% concentration (60.25%). A one-way ANOVA test was used to analyze the data, and differences were considered statistically significant at p 0.05..Conclusions: The highest viability was observed at 5%, while the lowest was at 20% concentration. All treatment groups had cell viability above 60%, indicating that the Biduri extract is generally biocompatible with fibroblast cell culture.
Examining the Impact of Porphyromonas gingivalis Infection on Ovarian Health: A Reduction in Primordial Follicles in a Female Periodontitis Model Meilawaty, Zahara; Galau, Argha Sirna; Permatasari, Sabania Dinar; Setyaningsih, Sari; Astuti, Pudji; Setiawatie, Ernie Maduratna; Hendarto, Hendy; Suci Dharmayanti, Agustin Wulan
Jurnal Kesehatan Gigi Vol. 12 No. 1 (2025): Juni 2025
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v12i1.12547

Abstract

Periodontitis is a chronic inflammation of the periodontal tissues caused by periodontal pathogens, such as Porphyromonas gingivalis (P. gingivalis). P. gingivalis possesses several virulence factors that enable it to invade and spread through the bloodstream to other organs, including the ovaries. It triggers inflammation, which may impact the number of primordial follicles. The aim of this study was to assess the effects of P. gingivalis infection on the number of primordial follicles in the ovaries. This study was a laboratory experiment with a post-test control group design. The rats were divided into control and periodontitis groups. The periodontitis group consisted of rats induced with P. gingivalis in their sulcus gingiva of the first mandible molar every three days for 19 days. Therefore, control groups were without P. gingivalis induction. Seven days after the last induction of P. gingivalis, the rats were euthanized, and their ovarian tissues were collected for histological preparation. The primordial follicles were counted under 400x magnification. The results indicated that the treatment group had a significantly lower number of primordial follicles (2.2 ± 2.61) compared to the control group (12.4 ± 2.41). The study concludes that P. gingivalis infection led to a reduction in the number of ovarian primordial follicles in periodontitis models.
The role of fibrinogen-like protein 1 in immune escape and tumor growth mechanism of Warthin's tumor Arifin, Grandissyaikhu Kamila; Indriana, Tecky; Kosasih, Jane; Dharmayanti, Agustin Wulan Suci; Syafriadi, Mei
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 2 (2024): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i2.p139-144

Abstract

Background: One of the benign tumors of the salivary glands is Warthin's Tumor (WT), which consists of cystic bilayer papillary epithelial cells accompanied by the presence of a lymphoid stroma. Several cases have been reported to turn malignant. One of the markers developed to identify tumor proteins is fibrinogen-like protein 1 (FGL1). Along with lymphocyte-activation gene 3 (LAG-3), FGL1 establishes an immune checkpoint pathway that plays a role in the mechanism of tumor immune escape. Not much has been reported regarding FGL1 expression in WT, but some studies have reported that its expression is associated with tumor growth. Purpose: This study aims to analyze the location of FGL1 expression in WT and its relation to the mechanism of tumor immune release through the interaction between FGL1 and LAG-3. Methods: Cases of WT (n = 11) and breast cancer (n = 1) were used as positive controls. All cases were stained with hematoxylin-eosin and Recombinant Anti-FGL1 antibody. The FGL1 expression was observed in the cell membrane, cytoplasm, and lymphoid stroma. The results are presented in the form of figures. Results: All cases of WT expressed FGL1 in the cell membrane, cytoplasm, and lymphoid stroma. Its expression in the cell membrane and cytoplasm is possibly related to the process of tumorigenesis and the increasing size of the lesion. Additionally, its expression is seen in the lymphoid stroma, which is closely related to immune escape by inhibiting lymphocytes against tumor cells. Conclusion: Warthin's tumor cells express FGL1, and this expression plays a role in tumor immune escape mechanisms and tumor growth.
THE EFFECT OF PORPHYROMONAS GINGIVALIS INFECTION ON MENOPAUSE TO THE MECHANICAL STRENGTH OF THE MANDIBLE AND FEMUR Dharmayanti, Agustin Wulan Suci; Budirahardjo, Roedy; Febrianto, Bangun
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.773 KB) | DOI: 10.30659/odj.9.1.119-129

Abstract

Background: Menopause is physiological condition signed estrogen deficiency. Porphyromonas gingivalis (Pg), Gram-negative bacteria, and the products might induce estrogen deficiency. Estrogen is a sex steroid hormone played an essential role in bone remodeling. The purpose of this study was to determine the effect of Pg infection to menopause on the mechanical strength of the mandible and the femur. Following this study, we suggested that there were efforts to improve the health of oral, reproductive, and bones, particularly improving women's quality of life. This study was an experimental laboratory by post-test only control group design.Method: This study used female Wistar rats (Rattus norvegicus) divided into four groups. The groups were the control group (K), ovariectomy (OVX), Pg- induced (PG), and Pg-induced ovariectomy (OPG). OVX indicated ovarian dysfunction due to physiological processes. PG indicated experimental animals infected with Pg bacteria which was suspected of causing ovarian dysfunction. OPG indicated that experimental animals infected with Pg bacteria were in a state of menopause. A three-point bending test analyzed bone strength. Result: The results showed that the average mechanical strength of the mandibular bone in the control group and the treatment group had a significant difference (p<0.05), but there was no significant difference between the strength of the femur bone between the control group and the PG group (p>0.05).Conclusion: Pg infection in menopause triggered a decrease in the mechanical strength of bones, especially the mandibular bone.
The Effect of Proanthocyanidin Cocoa Pod Rind Extract (Theobroma cacao L.) on MMP-8 Expession in Gingival Tissue of Periodontitis Rats Model Yani Corvianindya Rahayu; Agustin Wulan Suci Dharmayanti; Anya Tania Larasati
Denta Journal Kedokteran Gigi Vol 14 No 2 (2020): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v14i2.6

Abstract

Background: Periodontitis is periodontal tissue inflammation due to Porphyromonas gingivalis which invades the gingival tissue due to the activity of virulence factors. This causes the host immune system changes and increases MMP-8 production in periodontal tissue so resulting excessive tissue destruction. Cocoa pod rind containing proanthocyanidin compound as anti-inflammatory drugs is given to reduce MMP-8 and cure periodontitis. Objective: To examine the effect of proanthocyanidin extract of cocoa pod rind (Theobroma cacao L.) on decreasing MMP-8 expression in gingival tissue of periodontitis rats model. Materials and Methods: The samples used were 16 male Wistar rats divided into 2 groups, placebo gel for the control group and proanthocyanidins gel for the treatment group. ). Each group was induced by P.gingivalis bacteria every 3 days for 14 days and then smeared with placebo gel and proanthocyanidin gel for 7 and 14 days. Then all rats’ gingival tissue were taken and made preparations to be observed under a microscope and analyzed using immunoratio software. Result: There were differences in MMP-8 expression based on observation time (p<0.05). MMP-8 expression in the 7th day control group was lower than the 14th day and MMP-8 expression in the 7th day treatment group was higher than the 14th day. Conclusion: Proanthocyanidin of cocoa pod rind extract (Theobroma cacao L.) can reduce MMP-8 expression in gingival tissue of periodontitis rats model.
Edukasi Isi Piringku Sebagai Upaya Pencegahan Stunting di Desa Pesanggrahan Adriyanti Ailsa Luthfie; Ahmad Bagus Prayoga; Desy Putri Dwi Fitriana; Eka Risky Fitria Fauziah; Fina Khoirun Nisa’; Fiqih Haikal; Hidayatur Rofi’ah; Mochamad Nofal Abdulloh; Mukti Aji Nugrah Ramadhan; Nadza Qur’rotun A’ini; Nur Nafisah Wulandari; Riska Dwi Fajariyanti; Agustin Wulan Suci Dharmayanti
ABDIGI : JURNAL PENGABDIAN MASYARAKAT KESEHATAN GIGI Vol. 3 No. 2 (2025): October 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Stunting merupakan masalah kesehatan serius di Indonesia, terutama pada anak usia di bawah lima tahun. Kondisi ini ditandai dengan pertumbuhan anak yang terhambat sehingga tinggi badannya lebih rendah dari standar usianya. Stunting tidak hanya memengaruhi kondisi fisik anak, tetapi juga menyebabkan perkembangan otak terganggu, yang berdampak pada kemampuan kognitif, kesehatan secara keseluruhan, serta meningkatkan risiko penyakit kronis seperti diabetes dan penyakit jantung di usia dewasa. Meskipun pemerintah telah berupaya menekan angka stunting, namun prevalensinya masih cukup tinggi di beberapa daerah. Untuk membantu mengatasi masalah ini, Kuliah Kerja Nyata (KKN) Universitas Jember (UNEJ) Kelompok 181 menginisiasi intervensi penurunan dan pencegahan stunting di Desa Pesanggrahan. Program ini meliputi penyuluhan kepada ibu hamil dan ibu yang memiliki balita tentang pentingnya gizi seimbang, dampak stunting, dan cara pencegahannya. Edukasi juga dilakukan dengan memperkenalkan makanan lokal yang kaya akan zat gizi serta praktik pembuatan makanan bergizi yang dapat diakses oleh masyarakat. Penelitian ini bertujuan untuk mengevaluasi efektivitas program kerja KKN Kelompok 181 UNEJ dalam pencegahan stunting, serta mengidentifikasi tantangan dan faktor pendukung keberhasilan program di Desa Pesanggrahan.
Co-Authors Adriyanti Ailsa Luthfie Ahmad Bagus Prayoga Amandia Dewi Permana Shita Amandia Dewi Permana Shita Amelia Nur Ilahi Anggun Kharisma Putri Anya Tania Larasati Arifin, Grandissyaikhu Kamila Asadi, Ahmad Ahya Bangun Febrianto Banun Kusumawardani Banun Kusumawardani Budi Yuwono Deasy Kusuma Ardiani Desy Putri Dwi Fitriana Dhea Ayu Dewanti Dian Nurjannah Dina Tsalis Wildana Dina Tsalis Wildana Dwi Aji Nugroho, Dwi Dwi Kartika Apriono Dwi Kartika Apriono, Dwi Kartika Dwi Merry Christmarini Robin Dwi Warna Aju Fatmawati Dwi Warna Aju Fatmawati Dwi Warna Aju Fatmawati Edwyn Saleh Eka Risky Fitria Fauziah Endah Aryati Eko Ningtyas Erfin Ramadana Pratama Erlina Sih Mahanani, Erlina Sih Ernie Maduratna Setiawatie Fajar Risqi Zaenulloh Farizan Zata Hadyan, Farizan FEBRIANTO, BANGUN Fina Khoirun Nisa’ Fiqih Haikal Fitriyana, Nurul Isnaini Galau, Argha Sirna Hendy Hendarto Hidayatur Rofi’ah I Dewa Ayu Susilawati Ita Kurniawati Kosasih, Jane Kusuma Ardiani, Deasy Kusuma Ardiani, Deasy Lusi Hidayati Lusi Hidayati Lusi Hidayati, Lusi Lutfi Meiga Sari Lutfia Siti Hanifatunnisa Mei Syafriadi Mochamad Nofal Abdulloh Muhammad Nurul Amin Mukti Aji Nugrah Ramadhan Nadza Qur’rotun A’ini Nanda Afnita Nugraha Agung Marda Nur Nafisah Wulandari Octaviana Putri Puspita Sari Oktavia Nur Vitasari Paramudibta Lungit Kuncaraningtyas Peni Pujiastuti Permata, Dea Permatasari, Sabania Dinar Permatasari, Yulita Indah Prafitasari, Dinar Pudji Astuti PUDJI ASTUTI Ratna Dewanti, I Dewa Ayu Ratu Millenia Dua Rendra Chriestedy Prasetya Rido Tri Andika Firdyansyach Riska Dwi Fajariyanti Roedy Budirahardjo Rothschildi, Dhesyarmani Putri Rudi Budirahardjo, Rudi Safira Niza Ulfita Safitri, Rizkiya Agnes Sari Setyaningsih Sartika Puspita Selvia Magdalena Setyaningsih, Sari Sri Lestari Suhartini Suhartini Suhartini Suhartini Syafira Az Zahro Tarmizi, Thariq Ibnu Tecky Indriana Tsalis, Dina Widodo, Alaya Dwi Salvahira Yani Corvianindya Rahayu Yunianti, Ervisya Nandya Zahara Meilawaty Zahara Meylawaty Zahreni Hamzah Zain, Adi Pradana Rahmatullah Zainul Cholid