Article Per Year (5 Year)
p-Index From 2021 - 2026
4.393
P-Index
This Author published in this journals
All Journal e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi The Indonesian Journal of Dental Research Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Jurnal Kesehatan Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Health Notions Meditory : The Journal of Medical Laboratory SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Medica Hospitalia Jurnal Kesehatan Denta: Jurnal Kedokteran Gigi Odonto dental journal Jurnal Hasil Pengabdian Kepada Masyarakat Universitas Jember Dental Agromedis
Agustin Wulan Suci Dharmayanti
Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Jember
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

Published : 55 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 55 Documents
Search

 2   3   4   5   6 
Inovasi Pembuatan Handsanitizer dan Pencegahan Penyakit Menular Melalui Pemberdayaan Wanita Dharmayanti, Agustin Wulan Suci; Tsalis, Dina; Indriana, Tecky; Fatmawati, Dwi Warna Aju; Permatasari, Yulita Indah
Dental Agromedis Vol. 3 No. 1 (2025): Mei
Publisher : Fakultas Kedokteran Gigi, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/da.v3i1.5969

Abstract

In recent years, the Covid-19 pandemic has highlighted the importance of personal hygiene to prevent the spread of infectious diseases. This article examines the innovation of natural ingredient-based hand sanitizer production and the empowerment of women through training in Dusun Krajan, Lengkong Village, Mumbulsari District, Jember. By providing education and practical training in making hand sanitizer and moringa leaf tea, this initiative aims to enhance women's capacity to maintain family and community health. The training results indicate an increase in participants' knowledge and skills in producing safe sanitation and strengthening women's participation in public health. In conclusion, the empowerment of women through this initiative can enhance the well-being of families and communities as a whole.Keywords: battle leaves, hand sanitizer, infectious diseases, moringa tea, women empowerment
Ekstrak daun biduri (Calotropis gigantea) sebagai anti inflamasi dalam menurunkan jumlah neutrofil pada model tikus inflamasi: studi eksperimental Permata, Dea; Meilawaty, Zahara; Astuti, Pudji; Dharmayanti, Agustin Wulan Suci; Setyaningsih, Sari; Prasetya, Rendra Chriestedy
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 37, No 2 (2025): Agustus 2025
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v37i2.61210

Abstract

Pendahuluan: Inflamasi adalah respons imun terhadap rangsangan berbahaya yang bertujuan untuk menghilangkan kerusakan dan memulai penyembuhan. Proses inflamasi dimulai dengan pelepasan neutrofil yang mengatur dan memperkuat respon inflamasi namun. Obat Anti-Inflamasi Non-Steroid (NSAID), seperti aspirin, sering digunakan sebagai anti inflamasi tetapi memiliki efek samping. Ekstrak daun biduri (Calotropis gigantea)  yang kaya akan flavonoid, tanin, dan saponin, yang memiliki sifat anti-inflamasi dan penyembuhan luka dengan efek samping yang lebih sedikit dapat digunakan sebagai obat alami alternatif. Penelitian ini bertujuan untuk menganalisis perbedaan kemampuan ekstrak daun biduri (Calotropis gigantea) dalam menurunkan jumlah neutrofil pada inflamasi akut dan subakut pada model tikus inflamasi. Metode: Penelitian ini adalah studi eksperimental in vivo menggunakan desain serial group design. Daun biduri diekstrak menggunakan metode maserasi dengan pelarut etanol 70%. Dosis ekstrak daun biduri yang digunakan adalah 100 mg/kg BB, 200 mg/kg BB, dan 300 mg/kg BB. Tikus wistar diinjeksi dengan karagenan 2% pada punggungnya secara subkutan sebagai model inflamasi. Sampel darah diambil pada interval tertentu untuk membuat hapusan darah, selanjutnya dilakukan penghitungan jumlah neutrofil. Analisis menggunakan Two-way Anova yang dilanjutkan dengan uji LSD. Hasil: Ekstrak daun Calotropis gigantea pada dosis 100 mg/Kg BB, 200 mg/Kg BB, dan 300 mg/Kg BB terbukti dapat mengurangi jumlah neutrofil, terutama pada hari ke-3, dengan dosis 300 mg/Kg BB memberikan hasil terbaik (P=0,001). Simpulan: Pemberian ekstrak daun biduri (Calotropis gigantea) dosis 300 mg/Kg BB memberikan hasil terbaik dalam menurunkan jumlah sel neutrofil pada inflamasi akut dan subakut pada model tikus inflamasi.Calotropis gigantea leaf extract as an anti-inflammatory agent in reducing neutrophil count in an inflammatory rat model: an experimental studyIntroduction: Inflammation is an immune response to harmful stimuli that serves to eliminate tissue damage and initiate healing. The inflammatory process begins with the release of neutrophils, which regulate and amplify the inflammatory response. Non-steroidal anti-inflammatory drugs (NSAIDs), such as aspirin, are commonly used to treat inflammation but may cause side effects. Biduri leaf (Calotropis gigantea)extract which is rich in flavonoids, tannins, and saponins, possesses anti-inflammatory and wound-healing properties with fewer side effects, making it a potential natural alternative medicine. This study aims to evaluate the effectiveness of biduri leaf extract (Calotropis gigantea) in reducing the number of neutrophils during acute and subacute inflammation in an experimental rat model. Methods: This study is an in vivo experimental study using a serial group design. Biduri leaves were extracted using the maceration method with 70% ethanol as the solvent. The biduri leaf extract was administered at doses of 100 mg/kg BW, 200 mg/kg BW, and 300 mg/kg BW. Wistar rats were injected subcutaneously with 2% carrageenan on the dorsal region to induce inflammation. Blood samples were collected at predetermined intervals to prepare blood smears, followed by neutrophil counting. Data were analyzed using two-way ANOVA followed by the LSD post-hoc test. Results: Calotropis gigantea leaf extract at doses of 100 mg/Kg BW, 200 mg/Kg BW, and 300 mg/Kg BW significantly reduced neutrophil counts, particularly on day 3, with the 300 mg/Kg BW dose showing the most pronounced effect (p=0.001). Conclusion: Administration of biduri leaf (Calotropis gigantea) extract at a dose of 300 mg/Kg BW demonstrated the highest effectiveness in reducing neutrophil count during acute and subacute inflammation in an inflammation rat model.
BIOVIABILITY OF BIDURI LEAF EXTRACT (Calotropis Gigantea L.) ON FIBROBLAST CELL CULTURE Setyaningsih, Sari; Astuti, Pudji; Meilawaty, Zahara; Dharmayanti, Agustin Wulan Suci
Meditory : The Journal of Medical Laboratory Vol 13, No 1 (2025): Meditory, Volume 13 No. 1 Tahun 2025
Publisher : Jurusan Teknologi Laboratorium Medis, Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/meditory.v13i1.4049

Abstract

Background: Biduri is recognized for its medicinal properties, particularly in wound healing. The active compounds influence the number of fibroblast cells, which play a role in wound healing. Research on the bioviability of biduri leaf extract has never been conducted, so in vitro testing is necessary to determine the ability of biduri leaf extract to influence fibroblast cells.Objective:  To assess the effect of Biduri leaf extract on the viability of BHK-21 fibroblast cells in vitro. Methods: This experiment used a posttest-only group Design with an MTT assay to assess the viability of BHK-21 fibroblast cells after exposure to different concentrations of Biduri leaf extract. The study employed four treatment groups with varying extract concentrations and used one-way ANOVA followed by an LSD test to analyze the proportion of living cells statistically.Results:  The viability percentages of fibroblast cells varied with the concentration of Biduri leaf extract. The highest viability was observed at 5% concentration (80.82%), while the lowest was at 20% concentration (60.25%). A one-way ANOVA test was used to analyze the data, and differences were considered statistically significant at p 0.05..Conclusions: The highest viability was observed at 5%, while the lowest was at 20% concentration. All treatment groups had cell viability above 60%, indicating that the Biduri extract is generally biocompatible with fibroblast cell culture.
Examining the Impact of Porphyromonas gingivalis Infection on Ovarian Health: A Reduction in Primordial Follicles in a Female Periodontitis Model Meilawaty, Zahara; Galau, Argha Sirna; Permatasari, Sabania Dinar; Setyaningsih, Sari; Astuti, Pudji; Setiawatie, Ernie Maduratna; Hendarto, Hendy; Suci Dharmayanti, Agustin Wulan
Jurnal Kesehatan Gigi Vol. 12 No. 1 (2025): Juni 2025
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkg.v12i1.12547

Abstract

Periodontitis is a chronic inflammation of the periodontal tissues caused by periodontal pathogens, such as Porphyromonas gingivalis (P. gingivalis). P. gingivalis possesses several virulence factors that enable it to invade and spread through the bloodstream to other organs, including the ovaries. It triggers inflammation, which may impact the number of primordial follicles. The aim of this study was to assess the effects of P. gingivalis infection on the number of primordial follicles in the ovaries. This study was a laboratory experiment with a post-test control group design. The rats were divided into control and periodontitis groups. The periodontitis group consisted of rats induced with P. gingivalis in their sulcus gingiva of the first mandible molar every three days for 19 days. Therefore, control groups were without P. gingivalis induction. Seven days after the last induction of P. gingivalis, the rats were euthanized, and their ovarian tissues were collected for histological preparation. The primordial follicles were counted under 400x magnification. The results indicated that the treatment group had a significantly lower number of primordial follicles (2.2 ± 2.61) compared to the control group (12.4 ± 2.41). The study concludes that P. gingivalis infection led to a reduction in the number of ovarian primordial follicles in periodontitis models.
The role of fibrinogen-like protein 1 in immune escape and tumor growth mechanism of Warthin's tumor Arifin, Grandissyaikhu Kamila; Indriana, Tecky; Kosasih, Jane; Dharmayanti, Agustin Wulan Suci; Syafriadi, Mei
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 2 (2024): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i2.p139-144

Abstract

Background: One of the benign tumors of the salivary glands is Warthin's Tumor (WT), which consists of cystic bilayer papillary epithelial cells accompanied by the presence of a lymphoid stroma. Several cases have been reported to turn malignant. One of the markers developed to identify tumor proteins is fibrinogen-like protein 1 (FGL1). Along with lymphocyte-activation gene 3 (LAG-3), FGL1 establishes an immune checkpoint pathway that plays a role in the mechanism of tumor immune escape. Not much has been reported regarding FGL1 expression in WT, but some studies have reported that its expression is associated with tumor growth. Purpose: This study aims to analyze the location of FGL1 expression in WT and its relation to the mechanism of tumor immune release through the interaction between FGL1 and LAG-3. Methods: Cases of WT (n = 11) and breast cancer (n = 1) were used as positive controls. All cases were stained with hematoxylin-eosin and Recombinant Anti-FGL1 antibody. The FGL1 expression was observed in the cell membrane, cytoplasm, and lymphoid stroma. The results are presented in the form of figures. Results: All cases of WT expressed FGL1 in the cell membrane, cytoplasm, and lymphoid stroma. Its expression in the cell membrane and cytoplasm is possibly related to the process of tumorigenesis and the increasing size of the lesion. Additionally, its expression is seen in the lymphoid stroma, which is closely related to immune escape by inhibiting lymphocytes against tumor cells. Conclusion: Warthin's tumor cells express FGL1, and this expression plays a role in tumor immune escape mechanisms and tumor growth.
Co-Authors Amandia Dewi Permana Shita Amandia Dewi Permana Shita Amelia Nur Ilahi Anggun Kharisma Putri Anya Tania Larasati Arifin, Grandissyaikhu Kamila Asadi, Ahmad Ahya Bangun Febrianto Banun Kusumawardani Banun Kusumawardani Budi Yuwono Deasy Kusuma Ardiani Dhea Ayu Dewanti Dian Nurjannah Dina Tsalis Wildana Dina Tsalis Wildana Dwi Aji Nugroho, Dwi Dwi Kartika Apriono Dwi Kartika Apriono, Dwi Kartika Dwi Merry Christmarini Robin Dwi Warna Aju Fatmawati Dwi Warna Aju Fatmawati Dwi Warna Aju Fatmawati Edwyn Saleh Endah Aryati Eko Ningtyas Erfin Ramadana Pratama Erlina Sih Mahanani, Erlina Sih Ernie Maduratna Setiawatie Fajar Risqi Zaenulloh Farizan Zata Hadyan, Farizan Fitriyana, Nurul Isnaini Galau, Argha Sirna Hendy Hendarto I Dewa Ayu Susilawati Ita Kurniawati Kosasih, Jane Kusuma Ardiani, Deasy Kusuma Ardiani, Deasy Lusi Hidayati Lusi Hidayati Lusi Hidayati, Lusi Lutfi Meiga Sari Lutfia Siti Hanifatunnisa Mei Syafriadi Muhammad Nurul Amin Nanda Afnita Nugraha Agung Marda Octaviana Putri Puspita Sari Oktavia Nur Vitasari Paramudibta Lungit Kuncaraningtyas Peni Pujiastuti Permata, Dea Permatasari, Sabania Dinar Permatasari, Yulita Indah Prafitasari, Dinar Pudji Astuti PUDJI ASTUTI Ratna Dewanti, I Dewa Ayu Ratu Millenia Dua Rendra Chriestedy Prasetya Rido Tri Andika Firdyansyach Roedy Budirahardjo Rothschildi, Dhesyarmani Putri Rudi Budirahardjo, Rudi Safira Niza Ulfita Safitri, Rizkiya Agnes Sari Setyaningsih Sartika Puspita Selvia Magdalena Setyaningsih, Sari Sri Lestari Suhartini Suhartini Suhartini Suhartini Syafira Az Zahro Tarmizi, Thariq Ibnu Tecky Indriana Tsalis, Dina Widodo, Alaya Dwi Salvahira Yani Corvianindya Rahayu Yunianti, Ervisya Nandya Zahara Meilawaty Zahara Meylawaty Zahreni Hamzah Zain, Adi Pradana Rahmatullah Zainul Cholid