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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science Media Kesehatan Masyarakat Indonesia Majalah Kedokteran Bandung Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) Journal of Maternal and Child Health JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Pharmaceutical Journal of Indonesia 2-TRIK: TUNAS-TUNAS RISET KESEHATAN PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Inovasi Farmasi Indonesia Science Midwifery Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang MAHESA : Malahayati Health Student Journal Journal of Food and Pharmaceutical Sciences Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Herawati, Fauna
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Studi Penggunaan Kemoterapi pada Pasien Kanker Serviks di RSPAL Dr. Ramelan Surabaya: Study of the Use of Chemotherapy in Cervical Cancer Patients at RSPAL Dr. Ramelan Surabaya Tukan, Listiani Anggraeni Palang; Herawati, Fauna; Kirtishanti, Aguslina; Yulia, Rika; Octavia, Stefani Kartika
Jurnal Sains dan Kesehatan Vol. 6 No. 3 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i3.1801

Abstract

Chemotherapy treatment is the most widely chosen method of treatment. The chemotherapy given not only shows effectiveness, but also has a detrimental impact on patients, namely side effects. The purpose of this study was to determine the profile of cancer patients based on stage, duration of cancer, family history of cervical cancer, and treatment cycles, determine the profile of drug use, determine the suitability of drug use, and determine side effects after administration of chemotherapy. This research is an observational study with the direction of data collection retrospectively. The research was conducted at RSPAL Dr. Ramelan Surabaya with research samples from the period August 2021 - September 2022. The results of the study with a sample of 101 samples, showed that the most results were 100% female and married sample, age range 46 - 55 years totaling 38.61%, last education level Elementary schools accounted for 34.65%, 100% payment with BPJS, Stadium IIIB was the largest stadium in the sample, namely 94.06%, the cycle that received the most samples was cycle III, which amounted to 30.69%. The suitability of the use of chemotherapy showed 100% according to the type, and 90.57% according to the dose. The most common side effect that appeared after chemotherapy was nausea with a total of 52.48%. Further research needs to be done using a prospective method to ensure the side effects that occur. Keywords:          Cervical Cancer, Chemotherapy, Suitability, Side effect   Abstrak Pengobatan kemoterapi merupakan metode pengobatan yang paling banyak dipilih. Kemoterapi yang diberikan tidak hanya menunjukkan efektivitas, namun juga memberikan dampak yang merugikan bagi pasien, yaitu efek samping. Tujuan penelitian ini adalah untuk mengetahui profil pasien kanker berdasarkan stadium, lama menderita kanker, riwayat keluarga yang mempunyai kanker serviks, dan siklus pengobatan, mengetahui profil penggunaan obat, mengetahui kesesuaian penggunaan obat, dan mengetahui efek samping setelah pemberian kemoterapi. Penelitian ini merupakan penelitian observational dengan arah pengambilan data secara retrospektif. Penelitian dilakukan di RSPAL Dr. Ramelan Surabaya dengan sampel penelitian dari periode Agustus 2021 – September 2022. Hasil penelitian dengan sampel berjumlah 101 sampel, menunjukkan hasil terbanyak adalah sampel 100% berjenis kelamin perempuan dan sudah menikah, rentang usia 46 – 55  tahun berjumlah 38,61%, tingkat pendidikan terakhir Sekolah Dasar berjumlah 34,65%, pembayaran 100% denga BPJS, Stadium IIIB merupakan stadium terbanyak pada sampel yaitu 94,06%, siklus yang diterima sampel terbanyak adalah siklus III yang berjumlah 30,69%. Kesesuaian penggunaan kemoterapi menunjukkan 100% sesuai jenis, dan 90.57% sesuai dosis. Efek samping terbanyak yang muncul setelah pemberian kemoterapi adalah mual dengan jumlah 52,48%. Penelitian lebih lanjut perlu dilakukan menggunakan metode prospektif untuk memastikan efek samping yang terjadi. Kata Kunci:         Kanker Serviks, Kemoterapi, Kesesuaian, efek samping
Laporan Kasus: Keamanan Kombinasi Terapi Nimodipine dan Nicardipine pada Pasien Cerebrovascular Accident Subarachnoid Hemorrhage (CVA SAH) Hayati, Syafira Nur; Badriah, Rani Nur; Widya, Reta Anggraeni; Pratama, Jainuri Erik; Setiadi, Antonius Adji Prayitno; Herawati, Fauna; Gondokesumo, Marisca Evalina
MAHESA : Malahayati Health Student Journal Vol 4, No 10 (2024): Volume 4 Nomor 10 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i10.15815

Abstract

ABSTRACT Hemorrhage stroke is caused by injury due to acute extravasation of blood into the brain parenchyma from rupture of small cerebral blood vessels. One of the etiologies of hemorrhage stroke is hypertension. Hypertension is a disease in which the blood pressure value exceeds normal, namely if the systolic blood pressure value is ≥ 140mmHg and/or the diastolic blood pressure value is ≥ 90mmHg. Giving calcium channel blocker drugs has good benefits. This research is a descriptive case study, namely describing the problem of the safety of using a combination of Nimodipine and Nicardipine therapy in Cerebrovascular Accident Subarachnoid Hemorrhage (CVA SAH) patients. Below we present a case of hypertension in a 59 year old female patient who was admitted to hospital with complaints of decreased consciousness, a history of diabetes mellitus, and a history of hypertension. The patient received combination therapy of Nicardipine (drip) 5-15mg and Nimodipine PO 4x60mg. For five days the patient was treated in hospital with the administration of two anti-hypertension drugs from the same class, namely the calcium channel blocker class. It can be seen from the patient's blood pressure profile that the patient's blood pressure tends to be stable so it is safe not to cause hypotension side effects that are harmful to the patient. Keywords: Case Report, Hypertension, Nimodipine, Nicardipine  ABSTRAK Stroke hemorrhage atau stroke perdarahan disebabkan oleh cedera karena ekstravasasi darah akut ke dalam parenkim otak dari pecahnya pembuluh darah otak kecil. Salah satu etiologi dari munculnya stroke hemorrhage adalah kondisi hipertensi. Hipertensi merupakan penyakit yang mana nilai tekanan darah melebihi normal, yaitu apabila nilai tekanan darah sistolik ≥ 140mmHg dan/atau nilai tekanan darah diastolik ≥ 90mmHg. Pemberian obat golongan calcium channel blocker memiliki manfaat yang baik. Penelitian ini merupakan studi kasus deskriptif mendeskripsikan kasus dari keamanan penggunaan kombinasi terapi Nimodipine dan Nicardipine pada pasien Cerebrovascular Accident Subarachnoid Hemorrhage (CVA SAH). Berikut ini kami presentasikan sebuah kasus hipertensi pada pasien perempuan berusia 59 tahun yang masuk rumah sakit dengan keluhan penurunan kesadaran, riwayat penyakit diabetes mellitus, dan riwayat penyakit hipertensi. Pasien mendapat terapi kombinasi Nicardipine (drip) 5-15mg dan Nimodipine PO 4x60mg. Selama lima hari pasien dirawat di rumah sakit dengan pemberian dua obat anti hipertensi dari golongan yang sama yaitu golongan calcium channel blocker, maka dapat dilihat dari profil tekanan darah pasien bahwa tekanan darah pasien cenderung stabil sehingga aman tidak menyebabkan munculnya efek samping hipotensi yang membahayakan pasien. Kata Kunci: Motivasi, Gaya Kepemimpinan, Perilaku Perawat, Sampah Medis
Evaluasi Penggunaan Antibiotik Profilaksis Klasifikasi Access pada Pasien Bedah Obstetri-Ginekologi (Obgyn) Zumaroh, Siti; Herawati, Fauna; Yulia, Rika
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7301

Abstract

Penggunaan antibiotik yang tidak tepat dan berlebih merupakan penyebab utama resistensi antibiotik. Unit bedah merupakan salah satu unit dengan pemakaian antibiotik yang tinggi, salah satunya adalah jenis bedah Obstetri-Ginekologi (obgyn). Pemerintah telah menetapkan indikator mutu nasional dan mewajibkan seluruh rumah sakit untuk menerapkan Program Penatagunaan Antibiotik (antibiotics stewardship) dengan mengelompokkan antibiotik dalam kategori AWaRe : Access, Watch dan Reserve. Evaluasi penggunaan antibiotik merupakan salah satu indikator mutu program pengendalian resistensi antibiotik. Penelitian ini bertujuan menganalisis pola penggunaan antibiotik profilaksis pada pasien Obstetri-Ginekologi (obgyn) dengan metode Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) dan Drug Utilization (DU) 90%, serta mengevaluasi kesesuaian berdasarkan Pedoman Penggunaan Antibiotik (PPAB) dan Formularium Nasional (FORNAS). Studi observasional retrospektif dilakukan pada 118 pasien Obgyn di sebuah rumah sakit di Surabaya selama Mei- Juni 2024. Hasil menunjukkan 100% pasien menerima antibiotik profilaksis dengan total 55,51 DDD/100 hari rawat. Penggunaan antibiotik didominasi kategori Access (54,5%), namun Ceftriaxone (Watch) paling sering digunakan (16,25 DDD/100 hari rawat). Analisis DU 90% mengidentifikasi empat jenis antibiotik yang diurutkan dari persentase terbanyak: Ceftriaxone (29,28%), Metronidazole (26,48%), Cefazolin (26,26%), dan Cefixime (14,30%). Evaluasi kepatuhan PPAB menunjukkan kesesuaian jenis dan dosis (100%) tinggi, tetapi kesesuaian waktu penyuntikan (46,7%) dan durasi pemberian (75,6%) rendah. Inappropriate and excessive use of antibiotics is the main cause of antibiotic resistance. The surgical unit is one of the sections with high antibiotic use, one of which is the Obstetrics-Gynecology (obgyn) surgical procedure. The government has set national quality indicators and requires all hospitals to implement an Antibiotics Stewardship program by grouping antibiotics into the AWaRe categories: Access, Watch, and Reserve. Evaluation of antibiotic use is one of the quality indicators of the antibiotic resistance control program. This study aims to analyze the pattern of prophylactic antibiotic use in Obstetrics-Gynecology (obgyn) patients using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) and Drug Utilization (DU) 90% methods and evaluate the suitability based on the Antibiotic Use Guidelines (PPAB) and National Formulary (FORNAS). A retrospective observational study was conducted on 118 patients at a hospital in Surabaya in May-June 2024. The results showed that 100% of patients received prophylactic antibiotics with 55.51 DDD/100 bed-days. Antibiotic use was dominated by the Access group (54.5%), but Ceftriaxone (Watch) was the most frequently used 16.25 DDD/100 bed-days. DU 90% analysis identified four main antibiotics: Ceftriaxone (29.28%), Metronidazole (26.48%), Cefazolin (26.26%), and Cefixime (14.30%). PPAB compliance evaluation showed the appropriate type and dose (100%) high, but time (46.7%) and duration of administration (75.6%) low.
Antibiotics Stewardship in Cesarean Section at a Public Hospital in Surabaya, Indonesia Herawati, Fauna; Yulia, Rika; Binta, Jihan
Indonesian Journal of Clinical Pharmacy Vol 14, No 3 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2025.v14i3.63748

Abstract

Cesarean section (CS) is a procedure performed to save the mother and fetus through an incision in the mother’s abdomen and uterus. The high rate of CS in Indonesia correlates with the risk of surgical site infections (SSI), making the use of prophylactic antibiotics important. The use of antibiotics has health impacts on the community, one of which is antibiotic resistance. This study aims to determine antibiotic usage patterns and their compliance with the National Formulary and the Antimicrobial Stewardship Program (PPRA), and the profile of mothers who experience SSI at a public hospital in Surabaya. This retrospective observational quantitative study used medical record data from CS patients from January to June 2024, and the data were analyzed using descriptive statistics and Defined Daily Dose (DDD) methodology to evaluate antibiotic utilization. The results showed cefazolin 2 grams was the most widely used antibiotic (88.64%) with a DDD/100 bed days value of 14.10. Compliance of antibiotic usage patterns with the Antimicrobial Use Guideline (PPAB) reached 88.64%. SSI occurred in 1.31% of patients, especially in pregnancies of more than 2 times. The use of antibiotics at a public hospital in Surabaya is the rational use of antibiotics, the incidence of SSI is smaller than the established standard of 1.5%.
Efektivitas Kombinasi Dosis Tetap pada Tuberkulosis Nasal-HIV Anak: Laporan Kasus Suharyati, Titin; Herawati, Fauna; Fatmawati, Umi
Indonesian Journal of Clinical Pharmacy Vol 14, No 3 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2025.v14i3.58065

Abstract

Tuberkulosis (TB) adalah penyakit yang disebabkan oleh Mycobacterium tuberculosis (MTB) yang selain mengenai parenkim paru, juga mampu menginfeksi organ lain. Tuberkulosis nasal dapat bersifat primer atau sekunder akibat tuberkulosis paru atau lupus fasialis. Tuberkulosis nasal harus dipertimbangkan dalam diagnosis banding granuloma nasal kronis. TB pada saluran pernapasan atas jarang terjadi dan hampir tidak dilaporkan dalam penelitian. Kami melaporkan kasus TB primer nasal, TB paru disertai HIV. Pasien di rawat inap di ruang isolasi khusus TB karena mengalami benjolan di hidung yang membesar dengan ukuran 3x3 cm disertai mimisan, demam yang naik turun, serta berat badan menurun dan berkurang nafsu makan. Tes bakteri tahan asam dan pemeriksaan histopatologi memastikan diagnosis tuberkulosis nasal. Gejala pasien setelah dua setengah bulan pengobatan anti-TB dan antiretroviral belum membaik. Setelah di rawat inap selama 78 hari, akhirnya pasien meninggal. Kasus ini menunjukkan bahwa memulai pengobatan segera, pengelolaan malnutrisi, serta pemantauan kejadian efek samping dan interaksi antar obat dapat memengaruhi keberhasilan terapi pada pasien dengan TB nasal.
Co-Authors Abdul Aziz Abdul Kadir Aguslina Kirtishanti Agustini, Lukisiari Alfarendra, Muhammad Daffa Anggraeni, Reta Annisa, Sandra Aryanti, Yuni Astrini, Ni Nyoman Yuni Badriah, Rani Nur Binta, Jihan Cahyanti, Reni Ika Fawandi Fuad Alkindi Hayati, Syafira Nur Indrayanti, Mufida Irawati, Adinda Jaelani, Abdul K. Kusuma, Meradiana Widya Marisca Evalina Gondokesumo, Marisca Evalina Martiniani, Endang Marzuki, Jefman Efendi Massey, Firdaus Kabiru Muliani, Nurlina Ningtyas, Widia Nuraini, April Octavia, Stefani Kartika Octavianty, Clara Oktavia, Erlin Pandu Laksono, Pandu Pratama, Jainuri Erik Pribadi, Ezra Immanuelly Putra Gunawan, I Made Rian Putri, Hidayati Adi Putri, Rizky Ayu Artama Raden Mohamad Herdian Bhakti Rahaded, Patricia Valery Rika Yulia Setiadi, Antonius Adji Prayitno Setiasih Setiasih, Setiasih Soedarsono Soedarsono Suharyati, Titin Tanayawati, Tri Tsamrotul Ilmi Tukan, Listiani Anggraeni Palang UMI FATMAWATI Utomo, Andri Viani, Ella Wattiheluw, Muhammad Hasan Wibisono, Sony Widya, Reta Anggraeni Wijaya, Afelia Mettania Wijono, Heru Wirda Anggraini Wiyono, Heru zumaroh, siti