Article Per Year (5 Year)
p-Index From 2020 - 2025
4.153
P-Index
This Author published in this journals
All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science Media Kesehatan Masyarakat Indonesia Majalah Kedokteran Bandung Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) Journal of Maternal and Child Health JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Pharmaceutical Journal of Indonesia 2-TRIK: TUNAS-TUNAS RISET KESEHATAN PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Inovasi Farmasi Indonesia Science Midwifery Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang MAHESA : Malahayati Health Student Journal Journal of Food and Pharmaceutical Sciences Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Herawati, Fauna
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

Published : 32 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 32 Documents
Search

 1   2   3   4 
Impaired Liver Function in the Use of Clozapine as an Antipsychotic Aziz, Abdul; Herawati, Fauna; Pratama, Jainuri Erik; Gondokesumo, Marisca Evalina
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20811

Abstract

Clozapine is an atypical antipsychotic used to treat psychosis, mainly as a second choice for patients with refractory schizophrenia and recommended to manage schizophrenia that does not respond to other therapies. Clozapine is also often associated with elevated transaminase levels without clinical symptoms. In this case, a 45-year-old man, who had been diagnosed with schizophrenia since October 2020, was undergoing treatment with various antipsychotic drugs, including clozapine. About a week before hospitalization, there was a change in the patient's behavior. Due to this condition, the patient was brought to the outpatient psychiatric clinic at Airlangga University Hospital Surabaya, the patient was given clozapine 25 mg therapy at night, but the symptoms experienced were getting worse. The patient was finally taken for hospitalization at Dr. Soetomo Hospital Surabaya. While undergoing treatment at the hospital, the patient was given clozapine 10 mg therapy in the morning and at night, in addition, Olanzapine 10 mg was given intramuscularly if needed. However, on the third day after starting treatment, the patient began complaining of low-grade fever (37.8°C), nausea, and fatigue. Laboratory tests showed an increase in liver enzyme levels. However, several cases of severe liver toxicity due to clozapine use have been reported, and there are no specific guidelines for physicians to prevent or treat this condition. Close monitoring of liver function test (LFT) results is crucial in clozapine therapy, especially in considering the decision to stop treatment early if necessary.
Fasciitis Necroticans pada Diabetes Melitus: Sebuah Laporan Kasus Cahyanti, Reni Ika; Martiniani, Endang; Wibisono, Sony; Herawati, Fauna
Indonesian Journal of Clinical Pharmacy Vol 14, No 2 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2025.v14i2.58295

Abstract

Fasciitis necroticans (FN) adalah penyakit langka penyebab nekrosis jaringan lunak secara cepat dan berpotensi menyebabkan sepsis akut hingga kematian. Diabetes merupakan salah satu faktor risiko terjadinya FN. Laporan kasus ini membahas diagnosis dini dan terapi pasien FN dengan diabetes. Seorang pria 54 tahun dengan diabetes selama 3 tahun, rutin mengonsumsi obat antidiabetes oral, dan memiliki riwayat amputasi jari kelingking kiri, didiagnosis FN pada kaki kiri. Diagnosis ditegakkan pada hari pertama perawatan dengan skor LRINEC 9. Pasien mendapat terapi injeksi seftriakson 1 gram tiap 12 jam dan metronidazol 500 mg tiap 8 jam, disertai kultur pus. Setelah 5 hari pengobatan, kadar leukosit tetap tinggi, dan kondisi belum membaik. Kultur pus sensitif terhadap seftriakson, tetapi pada hari ke-9 nilai leukosit meningkat menjadi 21,96 x 103/µL, sehingga antibiotik diganti menjadi injeksi sefoperazon sulbaktam 1 gram tiap 12 jam. Dua kali injeksi berhasil menurunkan leukosit menjadi 9,04 x 103/µL, suhu tubuh normal, dan nyeri berkurang, menunjukkan sensitivitas seftriakson bersifat intermediate dibanding sefoperazon-sulbaktam. Pembedahan dan perawatan luka bertekanan negatif tinggi meningkatkan perbaikan klinis. Pasien menolak amputasi dan meminta pulang. Pasien datang kontrol 5 hari kemudian dan direncanakan untuk rawat luka ulang. Namun, pasien meninggal sebelum jadwal kontrol berikutnya. Diagnosa dini, pemberian antibiotik, dan tindakan pembedahan dengan rawat luka intensif sangat penting untuk manajemen keberhasilan terapi FN dan merupakan tantangan yang perlu dipelajari lebih lanjut.
Pola Penggunaan Antibiotik Profilaksis pada Pasien Bedah Orthopedi: Kajian Literatur Sistematik dan Meta Analisis Tanayawati, Tri; Yulia, Rika; Herawati, Fauna
MAHESA : Malahayati Health Student Journal Vol 5, No 8 (2025): Volume 5 Nomor 8 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i8.18854

Abstract

ABSTRACT Surgical site infection (SSI) is an infection acquired after surgery or surgical procedures. It accounts for approximately 14-16% of all nosocomial infections in hospitalized patients, and almost 90% have bacterial growth in surgical incisions. This meta-analysis aims to determine the pattern of prophylactic antibiotic use in orthopedic surgery patients and the effectiveness of this practice in preventing SSI. Method of collecting articles related to the pattern of prophylactic antibiotic use in orthopedic surgery patients. The inclusion and exclusion criteria. The inclusion criteria are articles obtained according to previously determined keywords, all articles obtained by searching the last 10 years, and articles with a Randomized Controlled Trial (RCT) research design. The results of a meta-analysis of the combined data from 4 RCT articles, with a total number of patients in the intervention group of 1059 and the control group of 1003, showed no significant difference (RR = 0.83; 95% CI = 0.6 - 1.14). Prophylactic antibiotic administration in orthopedic surgery using cephalosporins did not show any significant difference compared to those who did not use antibiotics. Likewise, extended antibiotic administration did not show any significant difference in preventing postoperative infections. Keywords: Surgical Site Infection, Prophylactic Antibiotics, Orthopedic Surgery, Clean Surgery.  ABSTRAK Infeksi daerah operasi (IDO) merupakan infeksi yang diperoleh setelah tindakan operasi atau bedah. Kejadian Infeksi daerah operasi (IDO) menyumbang sekitar 14-16% dari semua infeksi nosokomial pada pasien rawat inap dan hampir 90% terdapat pertumbuhan bakteri di sayatan bedah. Untuk mengetahui pola penggunaan antibiotik profilaksis pada pasien bedah orthopedi dan mengetahui efektivitas penggunaan antibiotik profilaksis untuk mencegah terjadinya IDO melalui meta analisis. Metode pengumpulan artikel-artikel terkait dengan pola penggunaan antibiotik profilaksis pada pasien bedah orthopedi. Adapun kriteria inklusi dan ekslusi. Kriteria inklusi yaitu artikel yang diperoleh sesuai dengan keyword yang ditetapkan sebelumnya; semua artikel yang diperoleh dengan pencarian 10 tahun terakhir; artikel dengan desain peneltian Randomize Controlled Trial (RCT). Hasil meta analisis dari penggabungan data artikel 4 RCT dengan total jumlah pasien pada kelompok intervensi 1059 pasien dan kelompok kontrol 1003 pasien, menunjukkan tidak ada perbedaan signifikan (RR = 0,83; 95% CI = 0,6 - 1,14). Pemberian antibiotik profilaksis pada bedah orthopedi penggunaan sefalosporin tidak menunjukan perbedaan yang bermakna dengan yang tidak menggunakan antibiotik. Begitu juga pada pemberian antibiotik yang di-perpanjang tidak berbeda bermakna dalam mencegah terjadi infeksi post operasi Kata Kunci: Infeksi Daerah Operasi, Antibiotik Profilaksis, Bedah Orhopedi, Operasi Bersih
Suspek Difteri Tonsil Laring Pada Anak: Laporan Kasus Suharyati, Titin; Herawati, Fauna; Fatmawati, Umi
MAHESA : Malahayati Health Student Journal Vol 5, No 9 (2025): Volume 5 Nomor 9 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i9.19295

Abstract

ABSTRACT Diphtheria (DPT) is a disease caused by an infection of the bacterium Corynebacterium diphtheriae.Whereas Probable Diphtheria is a person with suspected Diphtheria plus one of the following symptoms: Had contact with a case (<2 weeks), incomplete immunization, including not having received a booster, residing in an endemic area of Diphtheria, Stridor, Bullneck, submucosal bleeding or petechiae on the skin, toxic heart failure, acute kidney failure, Myocarditis, death. This bacterium often infects the throat and nose. This bacterium produces toxins that can damage tissues and organs.The most characteristic symptom of diphtheria is the formation of a thick gray layer on the throat and tonsils. A 2-year-old child weighing 11 kg and measuring 85 cm tall presents with complaints of sore throat, swelling on the left side of the neck, fever, a breath that sounds like a snore when breathing, and a heavy voice during sleep. decreased food and drink intake. The patient was hospitalized in the Special Diphtheria Isolation Room in December 2024. History of using intermoxil injection, calmetasone injection, santagesic injection, and apetic syrup. Total Length Of Stay (LOS) for 10 days, with a family history of mumps. Received breast milk until the age of 2 years, complementary feeding until the age of 6 months, family food until the age of 1 year, developmental history of sitting with head upright at 6 months, able to roll over at 4 months, able to walk at 15 months, able to speak at 14 months, incomplete immunization history only up to DPT 1. Patient therapy PPC 900,000 IU, ADS 10,000 IU, dexamethasone, paracetamol tablet, D5 ¼ NS, RL, PPC 1.2 million IU. Diphtheria treatment is the most efficient effort to prevent the spread of Diphtheria. Nutritional status and malnutrition are closely related to diphtheria mortality. Keywords: Diphtheria, Tonsillitis, Immunization, Corynebacterium Diphtheriae, Children  ABSTRAK Difteri (DPT) merupakan penyakit yang disebabkan oleh infeksi bakteri Corynebacterium diphtheriae. Sedangkan Probable Difteri adalah orang dengan suspek Difteri ditambah dengan salah satu gejala berikut: Pernah kontak dengan kasus (<2 minggu), Imunisasi tidak lengkap, termasuk belum dilakukan booster, berada di daerah endemis Difteri, Stridor,Bullneck, pendarahan submukosa atau petechiae pada kulit, gagal jantung toxic, gagal ginjal akut, Myocarditis, meninggal. Bakteri ini sering menginfeksi bagian tenggorokan dan hidung. Bakteri ini menghasilkan toksin yang dapat merusak jaringan dan organ tubuh. Gejala difteri yang paling khas adalah terbentuknya lapisan abu-abu tebal pada tenggorokan dan amandel. Pasien anak 2 tahun berat badan 11 kg tinggi badan 85 cm dengan keluhan nyeri telan, bengkak leher sebelah kiri, demam, apabila bernapas nafas seperti mengorok, dan suara memberat saat tidur. makan minum berkurang. Pasien di rawat inap di Ruang Isolasi Khusus Difteri pada bulan Desember 2024. Riwayat penggunaan obat injeksi intermoxil, injeksi kalmetason, injeksi santagesic dan  sirup apetic. Total Length Of Stay(LOS) selama 10 hari, ada riwayat keluarga dengan mumps. Mendapatkan ASI sampai dengan usia 2 tahun, MPASI sampai usia 6 bulan, makanan keluarga sampai usia 1 tahun, riwayat tumbuh kembang duduk dengan kepala tegak pada usia 6 bulan, bisa tengkurap pada usia 4 bulan, bisa berjalan pada usia 15 bulan, dapat berbicara pada usia 14 bulan, riwayat imunisasi tidak lengkap hanya sampai DPT 1. Terapi pasien PPC 900.000 UI, ADS 10.000 UI,dexametason, paracetamol tablet, D5 ¼ NS, RL, PPC 1,2 juta UI. Pengobatan Difteri  merupakan upaya paling efisien mencegah penyebaran Difteri. Status gizi dan malnutrisi sangat berhubungan  dengan mortalitas Difteri.  Kata Kunci: Difteri, Tonsilitis, Imunisasi, Corynebacterium Diphtheriae, Anak 
Pengaruh Linezolid terhadap Timbulnya Neuropati Optik pada Tuberkulosis Paru Multidrug Resistance: Laporan Kasus Aryanti, Yuni; Herawati, Fauna; Fatmawati, Umi; Soedarsono, Soedarsono; Agustini, Lukisiari
Indonesian Journal of Clinical Pharmacy Vol 14, No 2 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2025.v14i2.58296

Abstract

Penemuan kasus tuberkulosis (TB) resisten obat (RO) di Indonesia adalah sebesar 12.531 dengan cakupan 51% di tahun 2022. Linezolid merupakan antibiotik dari kelompok oksazolidinon, dan merupakan salah satu obat dalam terapi TB RO. Linezolid memiliki farmakokinetika nonlinier, distribusi di mata 40%, ikatan obat protein 15%, diperlukan penyesuaian dosis dan frekuensi pemberian secara individual. Kasus neuropati optik akibat linezolid di Indonesia hingga kini masih jarang ditemukan, sehingga menjadi nilai lebih bagi laporan kasus di Dr. Soetomo General Academic Hospital ini. Pasien wanita 46 tahun dengan berat badan 40 kg dan tinggi badan 157 cm (underweight), didiagnosis TB multidrug resistance (MDR) primer dan hipotiroid. Pasien menjalani pemeriksaan awal mata, dinyatakan normal fundus dan tidak ada kelainan. Pasien memulai terapi TB regimen individual (pengobatan jangka panjang) sejak 25 Mei 2023 dengan fase intensif enam bulan, yaitu kombinasi bedakuinin 400 mg, levofloksasin 750 mg, linezolid 450 mg, clofazimin 100 mg, sikloserin 500 mg, dan vitamin B6 100 mg. Neuropati optik muncul setelah penggunaan linezolid selama enam bulan yang ditandai dengan skotoma sentral. Linezolid dihentikan tanggal 18 Januari 2024, dan setelah 5 bulan kondisi mata pasien mengalami perbaikan. Neuropati optik akibat linezolid adalah proses reversibel, dan memiliki kemungkinan 2,6 kali lebih besar pada BMI <18,5 kg/m2 sehingga dosis linezolid 300 mg tiap 24 jam dapat disarankan pada pasien underweight. Pemantauan awal dan berkala setiap bulan efek neuropati optik akibat linezolid selama pengobatan sangat diperlukan, terutama pada pasien underweight.
ANALISIS PENGGUNAAN ANTIBIOTIK PADA PASIEN BEDAH Ningtyas, Widia; Herawati, Fauna; Yulia, Rika
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.42655

Abstract

Penggunaan antibiotik profilaksis pada bedah SC/sectio caesarea, histerektomi, dan kuretage penting untuk mencegah infeksi daerah operasi (IDO). Penelitian ini bertujuan menganalisis penggunaan antibiotik, kesesuaian dengan PPAB Kemkes 2021, dan asosiasi faktor risiko terhadap IDO di RS Islam Surabaya. Penelitian observasional analitik ini menggunakan data rekam medis retrospektif dari 273 pasien. Hasilnya menunjukkan profil penggunaan antibiotik cefazolin dominan pada ketiga prosedur (97-100%), dengan dosis ganda 2 gram. Analisis kuantitatif ATC/DDD tertinggi pada Agustus 2024 (DDD cefazolin 36, DDD cefadroxil 24,5), dengan DU90% pada segmen cefazolin dan cefadroxil. Kesesuaian dengan PPAB Kemkes 2021 mencapai 93,5-95% pada SC dan histerektomi. Usia, komorbiditas, jenis, dosis, dan lama pemberian antibiotik profilaksis tidak ada asosiasi dengan Kejadian IDO (p>0,01). Skor ASA, lama pembedahan, lama rawat inap menunjukkan adanya asosiasi dengan kejadian IDO (p<0,01). Penelitian ini memberikan gambaran penting tentang penggunaan antibiotik profilaksis pada bedah obstetri dan ginekologi di RS Islam Surabaya, menyoroti perlunya peningkatan kesesuaian dengan pedoman dan identifikasi faktor risiko IDO.
Analisis Penggunaan Antibiotik pada Pasien COVID-19 di Rumah Sakit “X” Malang Mardianto, Rudy; Yulia, Rika; Herawati, Fauna
2-TRIK: TUNAS-TUNAS RISET KESEHATAN Vol 12, No 2 (2022): Mei 2022
Publisher : FORUM ILMIAH KESEHATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/2trik12202

Abstract

Antibiotics are used to treat co-infection in COVID-19 patients during the pandemic. Research data show that cases of bacterial co-infection in COVID-19 patients are 5%. Uncontrolled use of antibiotics will accelerate bacterial resistance. Accurate selection of antibiotics, dosage, frequency of use and duration of administration are needed to avoid nosocomial infections of resistant bacteria and reduce treatment costs. The purpose of this study was to determine the quality of antibiotic use in COVID-19 patients at dr. Soepraoen Malang. This study is a retrospective descriptive with a cross-sectional approach. Data were obtained from medical records and drugs from pharmacy installations. The population is hospitalized patients with confirmed COVID-19. Samples were hospitalized patients with confirmed COVID-19 who met the inclusion and exclusion criteria. The sample size was 258 patients selected by purposive sampling method during October 2019 to March 2020. The results of the study were patients 46-55 years old = 41%, male patients = 64%, female = 36%; moderate disease degree = 17%, severe = 83%; patients recovered = 95%, died = 5%. Choice of antibiotics, iv azithromycin; levofloxacin iv; azithromycin p.o; levofloxacin p.o is 100%. Meropenem iv 86.05%; moxifloxacin p.o 14.37%; ceftriaxone iv 10.08%; cefixime p.o 3.49%; moxifloxacin iv 2.71%; cefotaxime iv 1.94%; cefadroxil p.o 0.39%; doxycycline p.o 0.39%. The accuracy of the dose of azithromycin (iv; p.o) 100%, levofloxacin (iv; p.o) 100%, the accuracy of the frequency of use of azithromycin (iv; p.o) 100%, levofloxacin (iv; p.o) 100%. The accuracy of the administration of iv azithromycin injection was 99.57%, levofloxacin iv 98.34%, azithromycin p.o. 89.29%; levofloxacin p.o 100%. The conclusion of this study is that the use of antibiotics in COVID-19 patients has met the correct 4 criteria, namely the right selection of drugs, the right dose, the right frequency of use and the right duration of administration.Keywords: COVID-19; antibiotics; 4 rightABSTRAK Antibiotik digunakan untuk mengatasi ko-infeksi pada pasien COVID-19 di masa pandemi. Data penelitian menunjukkan bahwa kasus ko-infeksi bakteri pada pasien COVID-19 adalah <5%. Penggunaan antibiotik yang tidak terkendali akan mempercepat resistensi bakteri. Ketepatan pemilihan antibiotik, dosis, frekuensi penggunaan serta lama pemberian, diperlukan untuk menghindari infeksi nosokomial bakteri resisten serta menurunkan biaya pengobatan. Tujuan penelitian ini adalah mengetahui kualitas penggunaan antibiotik pada pasien COVID-19 di rumah sakit dr. Soepraoen Malang. Penelitian ini adalah deskriptif retrospektif dengan pendekatan cross-sectional. Dta diperoleh dari rekam medis dan obat dari instalasi farmasi. Populasi adalah pasien rawat inap yang terkonfirmasi COVID-19. Sampel merupakan pasien rawat inap yang terkonfirmasi COVID-19 yang memenuhi kriteria inklusi dan eksklusi. Ukuran sampel adalah 258 pasien yang dipilih dengan metode purposive sampling selama bulan Oktober 2019 sampai Maret 2020. Hasil penelitian pasien 46-55 tahun = 41%,  pasien laki-laki = 64%, perempuan = 36%;  derajat penyakit sedang = 17%,  berat = 83%;  pasien sembuh = 95%, meninggal = 5%. Pemilihan antibiotik, azithromycin iv; levofloxacin iv; azithromycin p.o; levofloxacin p.o adalah 100%. Meropenem iv 86,05%; moxifloxacin p.o 14,37%; ceftriaxone iv 10,08%; cefixime p.o 3,49%; moxifloxacin iv 2,71%; cefotaxime iv 1,94%; cefadroxil p.o 0,39%; doxycycline p.o 0,39%. Ketepatan dosis azithromycin (iv; p.o) 100%, levofloxacin (iv; p.o) 100%, ketepatan frekuensi penggunaan azithromycin (iv; p.o) 100%, levofloxacin (iv; p.o) 100%.  Ketepatan lama pemberian injeksi azithromycin iv 99,57%, levofloxacin iv 98,34%, azithromycin p.o 89,29%; levofloxacin p.o 100%. Kesimpulan penelitian ini adalah penggunaan antibiotik pada pasien COVID-19 telah memenuhi kriteria 4 tepat, yaitu tepat pemilihan obat, tepat dosis, tepat frekuensi penggunaan dan tepat lama pemberian.Kata kunci: COVID-19; antibiotik; 4 tepat
Olaparib As Therapy For Metastatic-Castration Resistant Prostate Cancer : Systematic Review And Meta Analysis Putra Gunawan, I Made Rian; Herawati, Fauna; Kirtishanti, Aguslina
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 11 No. 1 (2024): February
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v11i1.5284

Abstract

Prostate cancer is the second most prevalent cancer in men with approximately 1.4 million men worldwide. The main therapy for prostate cancer is androgen deprivation therapy (ADT), but patients who have received ADT may experience a condition of castration resistant prostate cancer (CRPC). More than 84% of patients have metastasized when diagnosed with CRPC (mCRPC) and median survival about 36 months. The Food & Drugs Association (FDA) has approved a new therapy for mCRPC patients, an example is olaparib. The purpose of this systematic review and meta analysis is to assess effectiveness (overall survival) and safety of olaparib in mCRPC. This research is using randomized control trial’s (RCT) article. The literature search process was carried out using the PubMed database. The quality of inclusion was assessed using the Critical Appraisal Skill Program (CASP) checklist and journal reputation. The results of the meta-analysis on the effectiveness of olaparib has showed that there was no significant difference in the patient's overall survival rate (RR=0. 81; 95% CI=0.58-1.13). The results of the meta analysis on the safety level of olaparib has showed a significant difference, seen from the side effects such as anemia (RR=3.47; 95% CI=2.59-4.65), nausea (RR=2.05; 95% CI=1.62-2.60) and fatigue (RR=1.32; 95% CI=1.10-1.59). The conclusion is olaparib as mCRPC therapy does not show significant effectiveness in improving overall survival in mCRPC. In addition, the low safety level of olaparib in mCRPC patients were seen from side effects such as anemia, nausea and fatigue
Correlation of Knowledge and Beliefs to Adherence with Antibiotic Use in Adult Patients at a Private Hospital in Sidoarjo Wattiheluw, Muhammad Hasan; Herawati, Fauna; Setiasih, Setiasih; Yulia, Rika
Kesmas Vol. 15, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Infectious diseases are one of the top ten causes of death in the world. Antibiotic therapy is administered for infectious diseases, but if bacteria are exposed to antibiotics continuously, then the bacteria are able to adapt to the medication, thereby resulting in antibiotic resistance. This condition results in an increase in mortality, long hospitalization period, and increased cost of antibiotic therapy and health services. Adherence to using antibiotics may be influenced by knowledge and beliefs about them. This study aimed to understand correlation between knowledge and belief with adherence to antibiotic use at a private hospital in Sidoarjo. This cross-sectional study, the data collected in three months period, was conducted with a questionnaire for assessment knowledge and belief. A pill count method was applied for assessment adherence to using antibiotics prescribed by doctors. The study results show that knowledge of the respondents was adequate for 76 people (69.7%), belief was adequate for 74 people (67.9%), and adherence to antibiotic use for 79 people (72%). Regression analysis showed that the variable that significantly influenced the adherence of patients in using antibiotics was perceived threat (p-value = 0,029). Sex, age, education, income, occupation, and marital status have no contribution to antibiotic knowledge, belief, and adherence.
Safety and efficacy of R21/Matrix-M vaccine against and eradicate malaria infection Rahaded, Patricia Valery; Herawati, Fauna
Science Midwifery Vol 12 No 2 (2024): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i2.1595

Abstract

Malaria continues to be a substantial health concern, characterised by elevated rates of illness and death. The development of resistance to existing treatments poses unique obstacles to infection control initiatives. To combat the increasing incidence of malaria, it is imperative to create malaria vaccines such as RTS,S/AS01 and R21/Matrix-M. This study conducted a systematic literature revieew to evaluate the safety and efficacy of malaria vaccines that are currently being developed, with a specific focus on the R21/Matrix-M vaccine. Applying the PRISMA criteria, we identified five studies that specifically examined the efficacy and safety of the R21/Matrix-M vaccination. The findings indicated that the R21/Matrix-M vaccine exhibits favourable tolerability and demonstrates substantial efficacy in clinical studies. Nevertheless, the scarcity of research on the R21/Matrix-M vaccine thus far emphasises the necessity for additional investigation to substantiate its efficacy in malaria treatment.
Co-Authors Abdul Aziz Abdul Kadir Aguslina Kirtishanti Agustini, Lukisiari Alfarendra, Muhammad Daffa Anggraeni, Reta Annisa, Sandra Aryanti, Yuni Astrini, Ni Nyoman Yuni Badriah, Rani Nur Cahyanti, Reni Ika Fawandi Fuad Alkindi Hayati, Syafira Nur Indrayanti, Mufida Irawati, Adinda Jaelani, Abdul K. Kusuma, Meradiana Widya Mardianto, Rudy Marisca Evalina Gondokesumo, Marisca Evalina Martiniani, Endang Marzuki, Jefman Efendi Massey, Firdaus Kabiru Muliani, Nurlina Ningtyas, Widia Nuraini, April Octavia, Stefani Kartika Octavianty, Clara Oktavia, Erlin Pandu Laksono, Pandu Pratama, Jainuri Erik Pribadi, Ezra Immanuelly Putra Gunawan, I Made Rian Putri, Hidayati Adi Putri, Rizky Ayu Artama Rahaded, Patricia Valery Rika Yulia Setiadi, Antonius Adji Prayitno Setiasih Setiasih, Setiasih Soedarsono Soedarsono Suharyati, Titin Tanayawati, Tri Tsamrotul Ilmi Tukan, Listiani Anggraeni Palang UMI FATMAWATI Utomo, Andri Viani, Ella Wattiheluw, Muhammad Hasan Wibisono, Sony Widya, Reta Anggraeni Wijaya, Afelia Mettania Wijono, Heru Wirda Anggraini Wiyono, Heru