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All Journal Indonesian Journal of Pharmaceutical Science and Technology Biota Majalah Obat Tradisional JFL : Jurnal Farmasi Lampung Journal of Fundamental and Applied Pharmaceutical Science Journal of Multidisciplinary Applied Natural Science Jurnal Abdimas Kartika Wijayakusuma Jurnal Inovasi Pembangunan Journal Of Human And Education (JAHE) Jurnal Media Pengabdian Kepada Masyarakat (JM-PKM) Jurnal Pengabdian Masyarakat Bangsa Journal of Pharmascience
Susanti, Laila
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Formulasi Salep Ekstrak Buah Mengkudu (Morinda citrifolia L.) Kombinasi Zeolit Alam Lampung (Zal) Sebagai Penstabil Sediaan Antibakteri Staphylococcus aureus Laila Susanti; Lilik Koernia Wahidah; Pratika Viogenta
Journal of Pharmascience Vol. 7 No. 1 (2020): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8086

Abstract

ABSTRAK Sediaan salep esktrak buah mengkudu telah terbukti sebagai antibakteri, namun esktrak tanaman pada umumnya sangat mudah terdegradasi oleh pH, cahaya dan suhu, oleh karena itu pemanfaatan Zeolit Alam Lampung (ZAL) dengan keistimewaan struktur morfologinya diharapkan mampu mempertahankan kestabilan sediaan salep hingga suhu tinggi. Penelitian ini bertujuan untuk mengetahui potensi ZAL sebagai penstabil sediaan salep dengan menghitung perubahan prosentase zona hambat bakteri pada sediaan salep sebelum dan sesudah dilakukan penyimpanan pada suhu 40oC. Penelitian ini meliputi tiga tahap utama yakni pertama formulasi salep ekstrak buah mengkudu kombinasi Zeolit Alam Lampung (ZAL) dengan variasi konsentrasi ekstrak 10%+ZAL, 15%+ZAL, 30%+ZAL, KZ (Kontrol Zeolit tanpa esktrak) dan KE (Kontrol Ekstrak tanpa zeolit) yang kemudian dilakukan evaluasi sediaan salep. Tahap kedua seluruh sampel dilakukan uji aktivitas antibakteri terhadap bakteri Staphylococcus aureus pada sediaan salep, dan tahap ketiga seluruh sampel disimpan pada suhu 40oC selama 24 jam, kemudian diuji aktivitas antibakteri kembali terhadap bakteri Staphylococcus aureus. Hasil penelitian menunjukkan bahwa seluruh sampel sebelum dilakukan penyimpanan pada suhu 40oC menunjukkan respon zona hambat bakteri yang kuat kecuali KZ. Setelah dilakukan penyimpanan pada suhu 40oC, terjadi penurunan zona hambat pada KE dan Ekstrak 10%+ZAL sebesar 100% dan 36,81%. Hal yang menarik terjadi pada Esktrak 15%+ZAL dan 30%+ZAL, yakni terjadi kenaikan zona hambat sebesar 35,20 % dan 31,32%. Hasil uji statistik menunjukkan nilai Asymp. Sig (0,016) <  nilai p (0,01) maka H0 ditolak sehingga dilakukan uji lanjut Tukey yang menunjukkan terjadi perbedaan yang signifikan antar kelompok uji. Dari penjelasan tersebut maka dapat disimpulkan bahwa ZAL mampu meningkatkan kinerja sediaan salep ekstrak buah mengkudu terutama pada konsentrasi 15% dan 30% dalam menghambat bakteri Staphylococcus aureus sehingga sediaan salep esktrak buah mengkudu kombinasi ZAL dapat digunakan sebagai alternatif obat pengganti obat sintetik kimiawi.  Kata kunci : Zeolit, Salep, M.citrifolia L, Staphylococcus aureus ABSTRACT             Noni extract ointment has been proven to be antibacterial, but plant extracts are generally very easily degraded by pH, light and temperature, therefore the use of Lampung Natural Zeolite (ZAL) with its special morphological structure is expected to be able to maintain the stability of ointment preparations to high temperatures. This study aims to determine the potential of ZAL as a stabilizer for ointment preparations by calculating the change in the percentage of bacterial inhibition zones in ointment preparations before and after storage at 40oC. This study includes three main stages, namely the first formulation of noni extracts from Lampung Natural Zeolite extract (ZAL) with variations in extract concentration of 10% + ZAL, 15% + ZAL, 30% + ZAL, KZ (Zeolite control without extract) and KE (Control Extract without zeolite) which then evaluated the ointment preparation. The second stage of all samples was tested for antibacterial activity against Staphylococcus aureus bacteria in ointment preparations, and the third stage all samples were stored at 40oC for 24 hours, then tested for antibacterial activity against Staphylococcus aureus. The results showed that all samples before storage at 40oC showed a strong inhibitory zone response except KZ. After storage at 40oC, there was a decrease in inhibition zones at KE and Extract 10% + ZAL by 100% and 36.81%. An interesting thing happened at the Extract 15% + ZAL and 30% + ZAL, namely an increase in inhibition zones of 35.20% and 31.32%. Statistical test results indicate the Asymp value. Sig (0.016) >p value (0.01) then H0 is accepted, so Tukey's further tests show that there are significant differences between the test groups. From this explanation it can be concluded that ZAL can improve the performance of noni fruit extract ointment especially at concentrations of 15% and 30% in inhibiting Staphylococcus aureus bacteria so that the ZAL noni extract extract can be used as an alternative drug for chemical synthetic drugs. Keywords : Zeolite, Ointment, M.citrifolia L, Staphylococcus aureus
Pendampingan Budidaya Ikan dan Tanaman dalam Ember Sebagai Implementasi Kewirausahaan Peserta Didik di PKBM Media Adaptive Kota Bandar Lampung Novi Eka Wati; Laila Susanti; Suhardi Suhardi
Journal Of Human And Education (JAHE) Vol. 6 No. 3 (2026): Journal of Human And Education (JAHE)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jh.v6i3.2788

Abstract

Abstrak Pusat Kegiatan Belajar Masyarakat (PKBM) Media Adaptive merupakan lembaga non- formal di Bandar Lampung didirikan untuk mewadahi para penyandang disabilitas untuk memperoleh pendidikan yang layak, namun seiring berjalan waktu PKBM ini juga menerima peserta didik non-disabilitas. Hampir 90% alumni PKBM tidak ada yang melanjutkan kuliah, mereka memilih untuk bekerja, namun terbentur kendala setelah lulus kesulitan mencari pekerjaan, karena kurangnya softskill sehingga banyak yang tidak terserap di dunia kerja. Hal ini mendorong upaya membantu kelompok mitra PKBM Media Adaptive dengan memberdayakan peserta didik disabilitas dan non-disabilitas melalui kegiatan pengembangan keterampilan kecakapan hidup, agar alumni PKBM ini memiliki daya saing, kreatif, inovatif dan mandiri. Salah satu upaya yang dilaksanakan untuk mengatasi masalah tersebut dengan peningkatan pengetahuan dan keterampilan peserta didik melalui pelatihan pengenalan bisnis budidaya ikan dan sayuran dalam ember (BUDIKTANBER) sebagai wujud implementasi jiwa kewirausahaan peserta didik PKBM. Kegiatan PK yang dilakukan dengan melakukan pelatihan dan pendampingan BUDIKTANBER yang bertujuan untuk Hasil evaluasi pelatihan BUDIKTANBER menunjukkan terjadi peningkatan kemampuan peserta didik sebesar 75% dalam memahami dan mempraktikkan BUDIKTANBER berdasarkan kuisioner pre-tes dan post-tes. Ikan lele dan kangkung hasil BUDIKTANBER tumbuh dengan optimal. Kata Kunci: BUDIKTANBER, ikan, sayuran, kewirausahaan, PKBM Media Adaptive
Ethanol Fraction of Seligi Leaves (Phyllanthus buxifolius (Blume) Muell. Arg) as Analgesic in Male White Mice (Mus musculus) Samsuar, Samsuar; Susanti, Laila; Isbiyantoro, Isbiyantoro; Tantia, Ulfa
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.31474

Abstract

Pain is an uncomfortable sensory and emotional feeling for the sufferer, and pain arises as a sign of tissue damage. There are various types of analgesic drugs used by the community, both traditional and synthetic. One of the plants used as a traditional medicine is Seligi (Phyllanthus buxifolius (Blume) Muell. Arg). The leaves of Seligi are known to contain flavonoid compounds that inhibit prostaglandin biosynthesis, a process that produces pain mediators. The purpose of this study is to examine the analgesic effects of the ethanol fraction of Seligi leaves on mice and to establish the optimal dose for oral analgesia in mice. In this investigation, the Sigmund approach was employed. The test animals were 25 male white mice divided into five groups: the negative control group (carboxymethyl cellulose), the positive control group (mefenamic acid) at a dose of 65 mg/kg body weight, and Groups I, II, and III, which were given the ethanol fraction of celosia leaves orally at doses of 46 mg/kg body weight, 92 mg/kg body weight, and 138 mg/kg body weight. After 15 minutes, the mice were intraperitoneally injected with 1% acetic acid, and their movements were observed and counted every 5 minutes for 1 hour. The research results revealed that Group I provided a protection percentage of 36.63% and an effectiveness percentage of 52.3%. Group II provided a protection percentage of 62.98% and an effectiveness percentage of 85.26%. Group III achieved a protection percentage of 71.1% and an effectiveness percentage of 96.26%, which is nearly comparable to the control group, which achieved a protection percentage of 73.86% and an effectiveness percentage of 100%. The results of the smallest significant difference test showed that the positive controls (doses 1, 2, and 3) were significantly different from the negative control, indicating that these groups exhibited an analgesic effect. At doses 2 and 3, there was no significant difference from the positive control, indicating that these doses are equivalent to the positive control.
Co-Authors Abdiyati, Santi Asfiyatul Affiana, Maulidya Nur Ananta, Nadia Diaz Anita Setiawati Aprilia, Linda Ayu Resa Aulia Agustina, Aulia Cindya Alfi Dhearani , Chairunnisa Dyah Rahmawati Fauzi, Fariha Qalbi Ilmillahi Hartono, Adityo Isbiyantoro Isbiyantoro Isbiyantoro Isbiyantoro, Isbiyantoro Kholida, Nilna Maya Latifah Megasari Latifah Megasari Lilik Koernia Wahidah Luthfiyah, Yosi M. Wahyu Ariawan Meidaliyantisyah Meidaliyantisyah Merinda Setyowati Mulia, Niken Ayu Dewanti Mulia, Wanda Natasya Dewanti Munadhah, Ummu Khusna Novi Eka Wati Pratiwi, Inda Putri, Alvina Adelia qurrota aini Rahmania, Nayla Rahmawati, Dyah Retno Fardila Sari Riyanti, Deski Rokiban, Akhmad Sa'adah, Isnawaitus Safitri, Andika Samsuar Samsuar Samsuar Samsuar User Samsuar, Samsuar Septiana Simanjuntak Siti Nurjanah Siti Nurjanah Sivitha, Sivitha Suhardi Suhardi Suhartina Suhartina, Suhartina Syaiful Bahri Tantia, Ulfa Viogenta, Pratika Wenny Indriasari Widiyastuti, Asih Widodo, Subur Yuli Evadianti, Yuli Yuli Wahyu Tri Mulyani Yuli Wahyu Tri Mulyani Yusuf, Mashuri