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Periskila Dina Kali Kulla
Universitas Ubudiyah Indonesia
Humanities Computer Science & IT Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

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UJI EFEK KOMBINASI EKSTRAK DAUN SELEDRI (Apium graveolens L.) DAN EKSTRAK DAUN KEMANGI (Ocimum bacilicum L.) TERHADAP KADAR ASAM URAT DARAH PADA MENCIT (Mus musculus L.) YANG DIINDUKSI KALIUM OKSONAT Lestari, Widya; Meilina, Rulia; Kulla, Periskila Dina Kali; Safitri, Faradilla; Akmadia, Nur
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 9, No 2 (2023): Oktober 2023
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v9i2.4192

Abstract

Latar Belakang : Asam urat merupakan penyakit yang menyerang persendiaan tubuh, seperti jari tangan, tumit, jari kaki, lutut, hingga pergelangan tangan. Penyakit timbul karena adanya penumpukan zat purin yang kemudian berubah menjadi asam urat. Tumbuhan seledri dan kemangi berpotensi sebagai obat tradisional dalam menurunkan kadar asam urat. Karena tumbuhan tersebut mengandung senyawa flavonoid yang berpotensi sebagai antihiperurisemia dalam menurunkan kadar asam urat.Tujuan Penelitian : Untuk mengetahui efek pemberian kombinasi ekstrak etanol daun seledri dengan daun kemangi dan dosis efektif terhadap penurunan kadar asam urat.Metode Penelitian : Penelitian ini bersifat eksperimental dengan teknik pengambilan sampel secara purposive sampling yang terdiri dari kelompok perlakuan kontrol negatif (Na-CMC 5%), kontrol positif (allopurinol), kelompok 1 dosis 75 : 25 mg/kg BB, kelompok 2 dosis 50 :50 mg/kg BB dan kelompok 3 dosis 25 : 75 mg/kg BB. Penelitian ini dilakukan pada bulan Juli hingga Agustus 2023. Hasil Penelitian : Hasil penelitian menunjukkan bahwa kombinasi ekstrak etanol daun seledri dan daun kemangi mampu menurunkan kadar asam urat pada mencit. Perlakuan kombinasi ekstrak etanol daun seledri dan daun kemangi menunjukkan penurunan kadar asam urat sejak H-9 hingga H-15. Kombinasi ekstrak etanol daun seledri dan daun kemangi berpengaruh secara signifikan terhadap penurunan kadar asam urat mencit karena nilai sig > 0,05. Kesimpulan : Kombinasi ekstrak etanol daun seledri dan daun kemangi efektif dalam menurunkan kadar asam urat sekitar 21 % hingga 27% dan dosis yang paling efektif yaitu kombinasi dosis 50 :50 mg/kg BB. Kata Kunci : Asam Urat, Antihiperurisemia, Allopurinol, Kemangi, SeledriBackground : Gout is a disease that attacks the joints of the body, such as fingers, heels, toes, knees, to the wrists. The disease arises due to a buildup of purine substances which then turn into uric acid. Celery and basil plants have potential as traditional medicines for lowering uric acid levels. Because this plant contains flavonoid compounds which have the potential to act as antihyperuricemia in reducing uric acid levels. Research Objectives : To determine the effect of giving a combination of ethanol extract of celery leaves with basil leaves and the effective dose on reducing uric acid levels.Research Methods : This study was an experimental study with a purposive sampling technique consisting of a negative control group (Na-CMC 5%), positive control (allopurinol), group 1 dose 75: 25 mg/kg BW, group 2 dose 50 : 50 mg/kg BW and group 3 dose 25 : 75 mg/kg BW. This research was conducted from July to August 2023. Results : The results showed that the combination of ethanol extracts of celery leaves and basil leaves was able to reduce uric acid levels in mice. The combination treatment of ethanol extract of celery leaves and basil leaves showed a decrease in uric acid levels from D-9 to D-15. The combination of ethanol extract of celery leaves and basil leaves had a significant effect on The combination of ethanol extract of celery leaves and basil leaves had a significant effect on reducing uric acid levels in mice because the sig value was > 0.05. Conclusion : The combination of ethanol extract of celery leaves and basil leaves is effective in reducing uric acid levels around 21% to 27% and the most effective dose is the combined dose of 50:50 mg/kg BW.Keywords    : Uric Acid, Antihyperuricemia, Allopurinol, Basil, Celery
Efektivitas Antipiretik Ekstrak Etanol Daun Delima (Punica Granatum L.) pada Mencit (Mus Musculus L.) Meilina, Rulia; Izzah, Nuril; Kesumawati, Kesumawati; Safitri, Faradilla; Rezeki, Sahbainur; Kulla, Periskila Dina Kali
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 9, No 1 (2023): April 2023
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v9i1.2870

Abstract

Daun delima (Punica granatum L.) secara tradisional telah banyak digunakan untuk berbagai penyakit salah satunya untuk demam. Berbagai senyawa terdapat dalam daun delima yaitu flavonoid, tanin dan saponin, dimana senyawa flavonoid berfungsi sebagai antipiretik. Metode penelitian ini Eksperimental Laboratorium. Penelitian ini bertujuan untuk mengetahui efektivitas antipiretik dan dosis efektif ekstrak etanol daun delima pada penurunan suhu mencit. Metode penelitian yang digunakan adalah eksperimental laboratorium. Sebanyak 25 ekor dengan berat badan 20- 30 gram dibagi menjadi 5 kelompok perlakuan yang terdiri dari kelompok perlakuan kontrol negatif diberikan na-CMC 0,5%, perlakuan positif diberikan paracetamol dan 3 kelompok perlakuan dengan pemberian ekstrak daun delima dosis bertingkat yaitu 100 mg/g BB, 150 mg/g BB, 200 mg/g BB. Untuk menaikkan suhu rektal, mencit diberikan suspensi pepton 5% secara oral kemudian diukur dengan menggunakan termometer digital setiap 30 menit hingga menit ke 120. Data hasil penelitian dianalisis dengan program SPSS yang dianalisis menggunakan uji ANOVA (Analysis Of Varian) dengan hasil penelitian menunjukkan bahwa daun delima memiliki efektivitas antipiretik. Data yang dihasilkan berdistribusi normal (p>0,05). ekstrak etanol daun delima yang paling efektif sebagai antipiretik yaitu pada dosis 150 mg dan 200 mg/g BB. Kesimpulan penelitian daun delima memiliki aktivitas antipiretik.Kata kunci : Daun Delima, Antipiretik, PeptonPunica granatum L. have traditionally been used for various diseases, one of which is fever. Various compounds are found in pomegranate leaves, namely flavonoids, tannins and saponins, where flavonoid compounds function as antipyretics. This research method is Experimental Laboratory. This study aims to determine the effectiveness of antipyretics and effective doses of ethanol extract of pomegranate leaves in reducing the temperature of mice. The research method used is laboratory experimental. This study aims to determine the effectiveness of antipyretics and effective doses of ethanol extract of pomegranate leaves in reducing the temperature of mice. The research method used is laboratory experimental. Twenty five individuals weighing 20-30 grams were divided into 5 treatment groups consisting of a negative control group given 0.5% na-CMC, positive treatment given paracetamol and 3 treatment groups with graded doses of pomegranate leaf extract, namely 100 mg/day. g BW, 150 mg/g BW, 200 mg/g BW. To raise the rectal temperature, the mice were given orally 5% peptone suspension and then measured using a digital thermometer every 30 minutes until the 120th minute. Pomegranate has antipyretic effectiveness. The resulting data is normally distributed (p>0.05). The most effective ethanol extract of pomegranate leaves as an antipyretic is at doses of 150 mg and 200 mg/g BW. The conclusion of this study is that pomegranate leaves have antipyretic activity.Keywords : Punica granatum, Antipyretic, Pepton
Co-Authors Akbar, Riski Muna Akmadia, Nur Aldafi, Daevanul Aslam Alvionida, Fitra Aminuyati Andika, Fauziah Anggraini, Bunge Septiana Ardhana Yulisma Asmaul Husna Astryna, Syarifah Yanti Azkia, Hanin Dewi, Rahma Fajriati, Rafni Faradilla Safitri, Faradilla Fauziah, Nurna Fazlina, Putri Fhonna, Putrya Herawati Herawati Herrani, Retno Hikmah, Naziah Husda, Azkia Husna, Zainatul Ilhamsyah, Putra Ismail Ismail Ismayukha, Noerma Izzah, Nuril Jumianita, Novida Kesumawati, Kesumawati Lestari, Widya Maharani, Septia Marniati Marniati, Marniati Mauliati, Desria Meilina, Rulia Muhammad Faisal Musa, Suryani Mutiawati Mutiawati Ningsih, Yustika Wirda Nurul Hamdi Nuzulul Rahmi, Nuzulul Pardi Pardi, Pardi Putri Kurniawati, Putri Putri, Indah Amelia Qhamal, Syamsul Rahmawati, Rahmawati Rahmi, Elda Maisy Ramadhania, Alya Rezeki, Sahbainur Rosdiana, Eva Safrizan, Safrizan Said Ashlan, Said Samaniyah, Siti Saulie, Diffa Aprilydia Sianipar, Mastura Suri, Murnia Syafriadi Syafriadi TB, Desita Ria Yusian Ula, Irza Mazinatul Willis, Ratna Zulwanis, Zulwanis