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All Journal International Journal of Integrated Health Sciences Althea Medical Journal Jurnal Ilmiah Hukum dan Dinamika Masyarakat Indonesian Journal of Rheumatology Jurnal Pro Hukum : Jurnal Penelitian Bidang Hukum Universitas Gresik Unes Law Review Majalah Kedokteran Andalas UNTAG Law Review International Journal of Educational Research and Social Sciences (IJERSC) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Dewi, Sumartini
Division Of Rheumatology, Department Of Internal Medicine, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung
Humanities Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Physics Public Health Social Sciences Other

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Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. Bestari, Muhammad Begawan; Rohmawaty, Enny; Rosdianto, Aziiz Mardanarian; Usman, Hermin A.; Saragih, Winda A. M.; Zuhrotun, Ade; Hendriani, Rini; Wardhana, Yoga Windhu; Ekawardhani, Savira; Wiraswati, Hesti Lina; Agustanti, Nenny; Dewi, Sumartini; Wijaya, Muhammad Palar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023206

Abstract

Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect.Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels.Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels.Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions.
Urgensi Pengaturan Secara Khusus Judi Online Di Indonesia Sri Setiawati; Sumartini Dewi
Jurnal Pro Hukum : Jurnal Penelitian Bidang Hukum Universitas Gresik Vol 12 No 1 (2023)
Publisher : Fakultas Hukum Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/.v12i1.2482

Abstract

Meskipun berbagai peraturan-perundangan telah diberlakukan, permainan judi di Indonesia terus berkembang dan semakin marak muncul di kalangan masyarakat, meskipun termasuk kedalam perbuatan melawan hukum. Berbagai modus permainan perjudian semakin berkembang dan kembali melahirkan permasalahan sosial hingga tumbuh menjadi penyakit masyarakat. Di era disrupsi digital, judi kembali hadir dalam wadah-wadah virtual melalui website di internet. Situs-situs website permainan judi secara online mulai berkembang sejak awal perkembangan website masuk di dunia pada tahun 1990 dan mulai menjadi “internet sensation” pada awal tahun 2000-an. Tulisan ini difokuskan pada permasalahan pertama, bagaimanakah Pengaturan Judi Online dalam Hukum Positif di Indonesia, dan kedua bagaimanakah Urgensi Penanggulangan Judi Online sebagai Penyakit Masyarakat Baru. Dengan metode penelitian yuridis normatif dan pendekatan deskriptif analitis, penelitian ini bertumpu pada data sekunder berupa bahan hukum primer dan bahan hukum sekunder. Hasil penelitian menunjukkan bahwa peraturan perundangan di Indonesia yang masih konvensional, tidak mampu menanggulangi judi online. Mengingat judi online bersifat adiktif dan berkaitan erat serta menumbuh-suburkan berbagai kejahatan, yakni jual-beli nomor rekening bank, penipuan, pencurian data, pencucian uang, dan dengan mengingat karakteristik internet sangat mudah dilakukan oleh siapapun, maka penanggulangan secara menyeluruh dan sistemik terhadap judi online ini menjadi urgen.
Dasar Konseptual dan Implementasi Restorative Justice oleh Polri untuk Mewujudkan Tujuan dan Fungsi Hukum (Kepastian, Keadilan dan Kemanfaatan) Levi Heningdyah Nikolas, Dwinanda Linchia; Dewi, Sumartini
UNES Law Review Vol. 6 No. 2 (2023)
Publisher : Universitas Ekasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31933/unesrev.v6i2.1025

Abstract

Paper ini bertujuan untuk memberikan pemahaman mengenai dasar konseptual dan implementasi restorative justice oleh polri untuk mewujudkan tujuan dan fungsi hukum (kepastian, keadilan dan kemanfaatan) Penegak hukum idealnya dalam menegakkan hukum harus mampu mewujudkan tiga (3) nilai dasar hukum, atau sering disebut sebagai tujuan hukum, yaitu kepastian, keadilan, dan kemanfaatan bagi masyarakat. Adapun dengan ditetapkannya Peraturan Kepolisian Negara Republik Indonesia Nomor 8 tahun 2021 tentang penanganan tindak pidana berdasarkan keadilan restoratif diharapkan mampu memberi keadilan, kemanfaatan dan kepastian hukum bagi masyarakat, terutama bagi mereka yang sedang berperkara hukum.
Autoantibody Profile and Lung HRCT Scan in Systemic Sclerosis with Restrictive Lung Disease Saragih, Winda Agnestia Maranna; Dewi, Sumartini; Wachjudi, Rachmat Gunadi; Logito, Verina; Tjandrawati, Anna
International Journal of Integrated Health Sciences Vol 11, No 1 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v11n1.3020

Abstract

Objective: To identify auto-antibodies in systemic sclerosis with interstitial lung disease (ILD). Method: This was a descriptive categorical study on auto-antibody profile in systemic sclerosis patients visiting the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital, West Java, and Bandung during the period of January 2018 to December 2019 who were registered in the West Java Systemic Sclerosis Registry. Auto-antibody identification was performed using the Euroline immunoblot assays.Results: Thirty six cases were identified during the study period with most of the cases involved women (n=35, 97.2%). The average age of patients participating in this study was 40 years, with an average duration of disease of 18 months. Diffuse cutaneous systemic sclerosis was found in 22 (61.1%) cases and limited cutaneous systemic sclerosis was observed in 14 (38.9%) cases. Specific autoantibodies were positive in 33 (91.6%) cases, with anti-topoisomerase I as the largest group, positive in 22 (52.9.3%) cases. This was followed by anti-Th/To in eight (15.7%) cases; anti-Ro52 in four (7.8%) cases; anti-centromere in three (5.9%) cases; anti-RNA polymerase in three (5.9%) cases; anti-fibrillarin in three (5.9%) cases; anti-Ku in two (3.9%) cases; and anti-PDGF in one (2.0%) case. High-resolution computed tomography of the lung showed 34 (94.4%) cases with ILD and 22 (61.1%) cases with severe lung fibrosis. Usual interstitial pneumonia was seen in 19 (52.8%) cases and non-specific interstitial pneumonia in 15 (41.7%) cases.Conclusion: Anti-topoisomerase I, anti-Th/To, and anti-Ro52 are the most common autoantibodies observed in systemic sclerosis patients with ILD as the most prevalent feature detected with lung HRCT.
Implementation of Sanctions for Violators of the Coronavirus Disease 2019 Community Activity Restrictions hari, Ju; Dewi, Sumartini; tubi, Kas
International Journal of Educational Research & Social Sciences Vol. 3 No. 1 (2022): February 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijersc.v3i1.289

Abstract

Restriction of Community Activities is an effort made by the Government to limit activities carried out by the community in interacting with other citizens, to prevent the possible spread of coronavirus disease 2O19 (COVID-19) outbreak that uses public spaces, public transportation modes, and public buildings. Restriction of Community Activities is carried out with several supervision and enforcement activities. The research method used to compile this scientific work uses normative juridical research, namely by analyzing secondary data in the form of legal materials, especially primary legal materials and secondary legal materials, by understanding the law as a set of favorable rules or norms in the system of legislation governing human life. Violations committed by the community whether it is necessary to apply criminal sanctions for Perpetrators of Violations of Community Activity Restrictions, this certainly needs attention from the government and the need for equal perceptions about the application of criminal acts for perpetrators of violations of community activity restrictions and standards of prosecution. The function of sanctions in criminal law is not merely to scare or threaten the violators. However, more than that, the existence of sanctions must also educate and improve the perpetrator. The sanctions can be applied to violators of health protocols, especially for those who do not wear masks and do not heed the advice of physical distancing by being given administrative sanctions in the form of verbal reprimands, social sanctions, administrative sanctions, and fines.
Criminal Policy In Countermeasures Criminal Acts Of Domestic Violence Stairs To Children Sumartini Dewi; Juhari; Kastubi
International Journal of Educational Research & Social Sciences Vol. 3 No. 2 (2022): April 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijersc.v3i2.291

Abstract

Children are a bounty that must be maintained and protected by parents, families, and countries. Children must also get welfare because children are the next generation of the nation. The violence that occurs in children makes a problem that must be taken and resolved seriously because it impacts the growth and development of children. One of them is child abuse that occurs in households involving people closest to the child. It is essential to know what factors are the background to the criminal acts of domestic violence against children and how illegal policies in tackling domestic violence against children. This research uses normative juridical types with descriptive-analytical research specifications using primary and secondary data sources and qualitative analysis methods. The settlement of domestic violence crimes needs to get special attention and provide protection to children as victims of domestic violence. The Criminal Code only regulates the crime of violence in general in the Criminal Code, there are weaknesses, and to overcome these weaknesses. The violence against children occurs due to low educational factors, unhealthy environments, economic factors, and parents who vent anger at children. Applying protection to children who experience domestic violence must be enforced to protect children, both by penal and non-penal efforts.
The The Correlation Between Serum Vitamin D Level and Quality of Life inSystemic Sclerosis Patients Sumartini Dewi
Indonesian Journal of Rheumatology Vol. 16 No. 2 (2024): IJR VOL 16 No 2
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v16i2.54

Abstract

Background: Systemic sclerosis (SSc) is an autoimmune rheumatic disease that is associated with disability and a reduced quality of life. Patients with SSc have lower levels of vitamin D than healthy people. Vitamin D influences the pathological mechanisms of SSc such as autoimmunity, vasculopathy, and fibrosis. The aim of this study was to know the correlation between serum vitamin D levels and the quality of life in SSc patients. Methods: This study was a cross-sectional study. Data were taken from the SSc patient registry at the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital Bandung from September to November 2023. Vitamin D level were assessed by measuring serum 25-hydroxyvitamin D levels. The quality of life was measured using the Indonesian version of the Short Form (SF-36), which was divided into physical component summary (PCS) and mental component summary (MCS). Statistical analysis was performed using the Rank-Spearman test. Results: There were 81 SSc patients enrolled in this study. Vitamin D levels were found low in 44 subjects (54.3%), which were divided into 23 subjects deficiency and 21 subjects insufficiency. Thirty seven subjects (46.7%) had normal vitamin D levels.  The results of this study showed that there was a significant weak positive correlation between serum vitamin D levels and PCS SF-36 (r=0.222, p=0.023) and MCS SF-36 (r=0.209, p=0.031) quality of life in SSc patients.  Conclusion: Serum vitamin D levels of SSc patients had a significant weak positive correlation with physical and mental quality of life component.
Indonesian Rheumatology Association (IRA) Recommendations for Diagnosis and Management of Systemic Sclerosis Sumartini Dewi
Indonesian Journal of Rheumatology Vol. 17 No. 2 (2025): IJR VOL 17 No 2
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v17i2.67

Abstract

Background: Systemic Sclerosis (SSc) or Scleroderma is a systemic autoimmune rheumatic disease characterized by dysregulation of the immune system, fibrosis of the skin and visceral organs and vasculopathy. The global prevalence of SSc reaches 17.6 per 100,000 population and the incidence reaches 1.4 per 100,000 people per year. The prevalence and incidence of SSc in Asia reaches 6.8 per 100,000 and 0.9 per 100,000, which is lower than other continents. Women have a prevalence and incidence of SSc five times higher than men. The prevalence and incidence of SSc depends greatly on the results of the study. There has not been much research on the epidemiological studies of SSc in Indonesia. Methods: Twelve selected rheumatologists from the Indonesian Rheumatologist Association (IRA) made recommendations based on key questions formed by a steering committee from IRA. These recommendation materials were taken from several online databases such as PubMed, Science Direct, and Google Scholar. Level of evidence and grades of recommendation were then assigned, and every member of the panelist team will assign a score for level of agreement. Results: A total of 50 recommendations that discussed the diagnosis, pharmacological and non- pharmacological therapy, and prognosis for SSc were made. Conclusion: These recommendations can be used to help clinicians correctly diagnose and choose the most suitable therapy for SSc patients. All recommendation statements were created with the consideration of Indonesia’s clinical setting, facility, and drug availability.
Co-Authors A Nawawi Ade Zuhrotun Adnyana, I K Alfarish, M Arzan Alvy Syukrie Alvy Syukrie Andri Reza Rahmadi Anna Tjandrawati Antania Hanjani Irianti Bambang Setiyohadi Bambang Setiyohadi Bambang Setiyohadi Binti Ahamad Naina, Hamizah Sabrina Budiman, Annisa Meivira Dania Artriana Riswandi Destiani, Nadia Ayu Dolvy Girawan Eldi Sauma Emmy Hermiyanti Pranggono Emmy Pranggono Enny Rohmawaty Guntur Darmawan Hamizah Sabrina Binti Ahamad Naina hari, Ju Herlina Yani Hesti Lina Wiraswati I Ketut Adnyana Iceu Dimas Kulsum Ine Kuswardinah Irianti, Antania Hanjani Kastubi Kurnianingsih, Tuti Kuswardinah, Ine Laniyati Hamijoyo Levi Heningdyah Nikolas, Dwinanda Linchia Logito, Verina M I Mokoagow Marina A. Moeliono Marina A. Moeliono, Marina A. Maslim, Y Mokoagow, M I Muchlas Rastra Samara Muksin Muhammad Begawan Bestari Nadia Ayu Destiani Nawawi, A Nenny Agustanti Nofan Pratama Maulana Oehadian, A Pang Sze Lyn Prananta, Marietta Shanti Rachmat Gunadi Wachjudi Rini Hendriani Rosdianto, Aziiz Mardanarian Salim, Susanto Saragih, Winda A. M. Saragih, Winda Agnestia Maranna Savira Ekawardhani Shelly Iskandar Siti Nur Fatimah Siti Nur Fatimah Sri D, Pratiwi Ayu Sri Setiawati Sze Lyn, Pang tubi, Kas Tuti Kurnianingsih Tuti Kurnianingsih Usman, Hermin A. Usman, Stefanie Yuliana Valentine Natasya Moenadri Valentine Natasya Moenardi Veranita Pandia Vincent Vincent, Vincent Waliyyuddin Robbani Wijaya, Muhammad Palar Yoga Windhu Wardhana