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All Journal Indonesian Journal of Tropical and Infectious Disease JURNAL PENGABDIAN KEPADA MASYARAKAT QUANTUM: Jurnal Inovasi Pendidikan Sains JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA J-PEK (JURNAL PEMBELAJARAN KIMIA) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry Jurnal Kiprah Psychology, Evaluation, and Technology in Educational Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat Asia Humanism : Jurnal Pengabdian Masyarakat Hydrogen: Jurnal Kependidikan Kimia Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Bakti Nusa Linggau UNESA Journal of Chemical Education Borneo Journal of Pharmacy Jurnal Pengabdian Farmasi dan Sains Khidmah Nusantara
Tutik Sri Wahyuni
Departemen Ilmu Kefarmasian Fakultas Farmasi Universitas Airlangga, Surabaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Aktivitas Penghambatan Ekstrak Etanol Daun Cassia Spectabilis Terhadap Pertumbuhan Plasmodium falciparum dan Plasmodium berghei Wiwied Ekasari; Nindya Tresiana; Suciati Iryani; Tutik Sri Wahyuni; Heny Arwaty
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.699 KB) | DOI: 10.20473/jfiki.v3i12016.17-21

Abstract

Background: Antimalarial screening against nine species of the genus Cassia showed that the methanol extract of leaves Cassia spectabilis have the highest activity. Since it will be used as a traditional medicine, hence it is needed further studies of antimalarial activity of these plants by choosing a safer solvent, namely ethanol. Objective: In vitro anti-malarial activity against Plasmodium falciparum was conducted using the method of Trager and Jensen. Methods: The serial solution tested were: 100, 10, 1,  0.1 and 0.01 µg/ mL, while the in vivo test was performed based on Peter's test (The days suppressive test) that using P. berghei (strain ANKA) infected mice. Results: The results showed that ethanolic extract of C. spectabilis leaves has inhibitory activity against P. falciparum with IC50 value of 12.52 µg/ mL and against P. berghei with ED50 value of 131.5 mg/kg body weight. Conclusions: A further study to see the potential of ethanol extract from C. Spectabilis leaves as anti-malaria is warranted. 
Anti-Hepatitis C Virus Activity of Various Indonesian Plants from Balikpapan Botanical Garden, East Borneo Rina Puspitasari; Tutik Sri Wahyuni; Achmad Fuad Hafid; Adita Ayu Permanasari; Lidya Tumewu; Aty Widyawaruyanti
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 1 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i12022.48-54

Abstract

Background: Hepatitis C Virus infection is a serious health problem that leads to chronic liver disease, liver cirrhosis, hepatocellular carcinoma, which causes high morbidity. Direct-Acting Antiviral Agents have been used as anti-hepatitis C Virus therapy. However, it was covered only in limited patients due to the high cost. Moreover, serious side effects and resistance cases were also reported in some HCV genotypes. Objective: This research aimed to find new anti-HCV from some Indonesia plants collected from Balikpapan Botanical Garden, East Borneo. Methods: Twenty-one leaf and stem barks extracts were successively extracted in n-hexane, dichloromethane, and methanol. Extracts were screened for their anti-HCV activity under in vitro culture cells in the concentration of 30 µg/mL. Plant extracts were inoculated in the Human Hepatocellular 7it and infected with HCV Japanese Fulminant Hepatitis strain 1a. Determination of 50% Inhibitory Concentration (IC50) value was further conducted at concentration of 100; 30; 10; 1; 0.1; 0.01 µg/ml of extracts. Results: In vitro anti-HCV activity revealed that among 21 plants extract, 11 extracts, namely, n-hexane extract from Luvunga scandens leaves, DCM extract from the leaf of L. scandens, Artocarpus sericicarpus, Artocarpus dadah, Eusideroxylon zwageri, Neolitsea cassiaefolia, methanol extract from A. sericicarpus and A. anisophyllus leaves, DCM extract from A. anisophyllus and A. elmeri stem bark, methanol extract from A. dadah stem bark, having potential inhibition with IC50 range 0.08 ± 0.05 to 12.01 ± 0.95 µg/mL. Conclusions: These results indicate that the eleven extracts could be good candidates as sources of anti-HCV agents.
Anti-Hepatitis C Activity of Combination of Ruta angustifolia Extract and Ribavirin Tutik Sri Wahyuni; Adita Ayu Permatasari; Chie Aoki-Utsubo; Aty Widyawaruyanti; Achmad Fuad
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.125-130

Abstract

Background: Hepatitis c virus infection is a global health problem which chronically infected 71 million people in the world. This infection has a risk of becoming liver cirrhosis and hepatocellular carcinoma. Since the current HCV therapy has been developed by direct-acting antivirals (DAA), however, most patients get limited access due to the high cost. Therefore, further development anti-HCV agent still greatly needed. Ruta angustifolia is a natural resource which was reported to possess anti-HCV activity. Ribavirin is an antiviral agent used to treat several virus infections, either DNA or RNA. Ribavirin was known to inhibit HCV infection by regulated immune system in host cells and interfering the replication of HCV by inhibit HCV RdRp. Objective: The current study evaluated the combination treatment of R. angustifolia extracts and ribavirin by in vitro culture cells of Huh 7it. Method: The study was conducted under an invitro cell culture of Huh 7it and infected with JFH1a. Result:  The result demonstrated an enhancement effect of the extract by increasing the anti-HCV activity 3.5-fold higher compared to ribavirin alone. The 50% inhibitory concentration of ribavirin by single treatment was 10.43 ± 0.18 µg/mL, while in combination with Ruta angustifolia extract was 2.80 ± 0.03 µg/mL. Further analysis of the combination by CompuSyn software mediated a synergistic effect among the combination with a combination index value of 0.691. Conclusion: These results suggested that combination of Ribavirin and Ruta angustifolia should be considered in developing anti-hepatitis C virus agents.
Co-Authors Abdul Rahem Achmad Fuad Achmad Fuad Hafid Adita Ayu Permanasari, Adita Ayu Adita Ayu Permatasari Adyana, Hendar Dio AGUS HARIANTO Annisa Nayla Ichyaiddina Ario Imandiri, Ario Aty Widyawaruyanti Chie Aoki-Utsubo Dahri, Baso Desi Kartikasari Dewi Isadiartuti Dewi Melani Hariyati Dinda Monika Nusantara Ratri Dini Retnowati Disi Oktarina, Rice Fadlan, Arif Fahimah Martak Fahmi Dimas Abdul Azis Farida Ifadotunnikmah Firdaus, Mochamad Abdi Rohman Halim, Moh. Kamal Handayani, Rosita Hanifah Khairun Nisa Heny Arwaty Herra Studiawan Hidayatus, Laila Nur Hilkatul Ilmi Idha Kusumawati Kholis Amalia Nofianti Lidya Tumewu Mangestuti Agil Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Muhammad Agus Syamsur Rijal Mumtazah, Ziyana Myrna Adianti Neni Purwitasari Neny Purwitasari Nindya Tresiana Nur Rahmayanti Afifah Nur Rahmiati, Nur Nurina Febriyanti Ayuningtyas Nuzul Wahyuning Diyah Oktarina, Rice Disi Pratiwi Pudjiastuti Pratiwi Soesilawati Prof. Dr. Retno Sari, M.Sc., Apt. Purwitasari, Neni Purwitasari, Neny Rakhmawati Rakhmawati Rakhmawati, Alfiana Eka Ratna Kartika Irawati Retno Sari Retno Widyowati Retno Widyowati Rice Disi Oktarina Rina Puspitasari Risqi, Sitna Windia Saipul Maulana Silfianah, Ifah Subhan Rullyansyah Suciati Suciati Suciati Suciati Sudjarwo Sudjarwo Sugeng, Santoso Sukardiman Syahrur Marta Dwi Susilo Syaiful Amri Syamsur Rizal, Agus Utami Islamiati Wahyuni, Riza Putri Widyowati, Rr. Retno Wiwied Ekasari Wiwied Ekasari Yusuf Syaril Alam